Heikki O Koskela

Summary

Affiliation: Kuopio University Hospital
Country: Finland

Publications

  1. ncbi request reprint Inhalation challenge with bovine dander allergens: who needs it?
    Heikki Koskela
    Department of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland
    Chest 124:383-91. 2003
  2. doi request reprint Asthmatic cough and airway oxidative stress
    Heikki O Koskela
    Center for Medicine and Clinical Research, Division of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland
    Respir Physiol Neurobiol 181:346-50. 2012
  3. ncbi request reprint The cough receptor TRPV1 agonists 15(S)-HETE and LTB4 in the cough response to hypertonicity
    Heikki Koskela
    Unit of Medicine and Clinical Research, Pulmonary Division, Kuopio University Hospital, Kuopio, Finland
    Inflamm Allergy Drug Targets 11:102-8. 2012
  4. pmc Cough response to isocapnic hyperpnoea of dry air and hypertonic saline are interrelated
    Minna Purokivi
    Department of Respiratory Medicine, Kuopio University Hospital, P, O, Box 1777, 70211 Kuopio, Finland
    Cough 7:8. 2011
  5. ncbi request reprint Determinants of the bronchodilation response to salbutamol on histamine-induced bronchoconstriction
    Heikki O Koskela
    Department of Respiratory Medicine, Kuopio University Hospital, PO Box 1777, 70211 Kuopio, Finland
    Respir Med 100:1760-6. 2006
  6. ncbi request reprint Interpretation of cough provoked by airway challenges
    Heikki O Koskela
    Department of Respiratory Medicine, Kuopio University Hospital, Finland
    Chest 128:3329-35. 2005
  7. ncbi request reprint Dissociation in the effect of nedocromil on mannitol-induced cough or bronchoconstriction in asthmatic subjects
    Heikki O Koskela
    Department of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland
    Respirology 10:442-8. 2005
  8. ncbi request reprint Pet- and pollen-induced upper airway symptoms in farmers and in nonfarmers
    H O Koskela
    Dept of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland
    Eur Respir J 22:135-40. 2003
  9. ncbi request reprint Responsiveness to three bronchial provocation tests in patients with asthma
    Heikki O Koskela
    Department of Respiratory Medicine, Kuopio University Hospital, PL 1777, 70210 Kuopio, Finland
    Chest 124:2171-7. 2003
  10. ncbi request reprint Coughing during mannitol challenge is associated with asthma
    Heikki O Koskela
    Department of Respiratory Medicine Drs Koskela and Hyvärinen, Kuopio University Hospital, Kuopio, Finland
    Chest 125:1985-92. 2004

Detail Information

Publications19

  1. ncbi request reprint Inhalation challenge with bovine dander allergens: who needs it?
    Heikki Koskela
    Department of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland
    Chest 124:383-91. 2003
    ..To identify which tests would be useful in selecting patients for a specific inhalation challenge with bovine dander allergens (bSIC)...
  2. doi request reprint Asthmatic cough and airway oxidative stress
    Heikki O Koskela
    Center for Medicine and Clinical Research, Division of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland
    Respir Physiol Neurobiol 181:346-50. 2012
    ..However, the 8-isoprostane concentrations did not differ significantly between the healthy and the asthmatic subjects. Airway oxidative stress may be associated with experienced cough severity and measured cough sensitivity in asthma...
  3. ncbi request reprint The cough receptor TRPV1 agonists 15(S)-HETE and LTB4 in the cough response to hypertonicity
    Heikki Koskela
    Unit of Medicine and Clinical Research, Pulmonary Division, Kuopio University Hospital, Kuopio, Finland
    Inflamm Allergy Drug Targets 11:102-8. 2012
    ..The TRPV1 agonists 15(S)-HETE and LTB4 seem not to be involved in the cough response to hypertonicity in asthmatic patients...
  4. pmc Cough response to isocapnic hyperpnoea of dry air and hypertonic saline are interrelated
    Minna Purokivi
    Department of Respiratory Medicine, Kuopio University Hospital, P, O, Box 1777, 70211 Kuopio, Finland
    Cough 7:8. 2011
    ..abstract:..
  5. ncbi request reprint Determinants of the bronchodilation response to salbutamol on histamine-induced bronchoconstriction
    Heikki O Koskela
    Department of Respiratory Medicine, Kuopio University Hospital, PO Box 1777, 70211 Kuopio, Finland
    Respir Med 100:1760-6. 2006
    ..It seems to be unrelated to the clinical severity of asthma and is not affected by treatment with inhaled corticosteroids. Neutrophilic airway inflammation may be associated with a poor response...
  6. ncbi request reprint Interpretation of cough provoked by airway challenges
    Heikki O Koskela
    Department of Respiratory Medicine, Kuopio University Hospital, Finland
    Chest 128:3329-35. 2005
    ..To analyze the cough response to three airway challenges in order to clarify whether the recording of the provoked coughs would be beneficial in the management of asthma...
  7. ncbi request reprint Dissociation in the effect of nedocromil on mannitol-induced cough or bronchoconstriction in asthmatic subjects
    Heikki O Koskela
    Department of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland
    Respirology 10:442-8. 2005
    ..Nedocromil sodium greatly attenuates mannitol-induced bronchoconstriction. Knowledge about the effect of nedocromil on mannitol-provoked cough might, therefore, clarify the mechanisms of this response...
  8. ncbi request reprint Pet- and pollen-induced upper airway symptoms in farmers and in nonfarmers
    H O Koskela
    Dept of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland
    Eur Respir J 22:135-40. 2003
    ..Animal husbandry often induces work-related upper airway symptoms. However, the present study among female adults suggests that it may also decrease the risk of pet- and pollen-induced upper airway symptoms...
  9. ncbi request reprint Responsiveness to three bronchial provocation tests in patients with asthma
    Heikki O Koskela
    Department of Respiratory Medicine, Kuopio University Hospital, PL 1777, 70210 Kuopio, Finland
    Chest 124:2171-7. 2003
    ..To compare a new bronchial provocation test, the mannitol challenge, with cold air and histamine challenges to demonstrate airway hyperresponsiveness (AHR) in patients with difficult-to-diagnose asthma...
  10. ncbi request reprint Coughing during mannitol challenge is associated with asthma
    Heikki O Koskela
    Department of Respiratory Medicine Drs Koskela and Hyvärinen, Kuopio University Hospital, Kuopio, Finland
    Chest 125:1985-92. 2004
    ..To define whether coughing during mannitol challenge is a nonspecific side effect of this challenge or is associated with asthma...
  11. ncbi request reprint Hypertonicity of the challenge solution may increase the diagnostic accuracy of histamine challenge
    Heikki O Koskela
    Department of Respiratory Medicine, Kuopio University Hospital, P O Box 1777, Kuopio 70211, Finland
    Respir Med 99:726-34. 2005
    ..In conclusion, compared with a conventional, isotonic histamine challenge, hypertonic histamine challenge may be more accurate in the diagnosis of asthma and also, more capable to detect the effects of inhaled corticosteroid treatment...
  12. pmc Effect of farming environment on sensitisation to allergens continues after childhood
    H O Koskela
    Department of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland
    Occup Environ Med 62:607-11. 2005
    ..The farming environment in childhood has been reported to decrease the risk of sensitisation to allergens. The purpose of the present study was to explore whether later exposure to a farming environment also could affect this sensitisation...
  13. ncbi request reprint Sensitivity and validity of three bronchial provocation tests to demonstrate the effect of inhaled corticosteroids in asthma
    Heikki O Koskela
    Department of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland
    Chest 124:1341-9. 2003
    ..To compare the sensitivity and validity of mannitol, histamine, and cold air challenges to demonstrate the effect of inhaled corticosteroids (ICS) in asthma...
  14. doi request reprint Utility of hypertonic histamine challenge in distinguishing difficult-to-diagnose asthma
    Minna Purokivi
    Department of Respiratory Medicine, Kuopio University Hospital, P O Box 1777, 70211 Kuopio, Finland
    Clin Respir J 1:91-8. 2007
    ..We have recently introduced a new method to investigate AHR, the hypertonic histamine challenge (HHC)...
  15. doi request reprint Utility of cough response during hypertonic histamine challenge in diagnosing asthma
    Minna Purokivi
    Department of Respiratory Medicine, Kuopio University Hospital, P O Box 1777, 70211 Kuopio, Finland
    Respir Med 102:1379-84. 2008
    ..22, with the specificity and sensitivity to detect asthma among symptomatic subjects being 86% and 70%. Cough response to hyperosmolar challenge may be useful in the differential diagnosis of airway diseases...
  16. ncbi request reprint Hyperglycaemia during exacerbations of asthma and chronic obstructive pulmonary disease
    Heikki O Koskela
    Unit for Medicine and Clinical Research, Pulmonary Division, Kuopio University Hospital, Kuopio, Finland
    Clin Respir J 7:382-9. 2013
    ..Hyperglycaemia is a well-known phenomenon among patients with an exacerbation of asthma or chronic obstructive pulmonary disease (COPD). It may be associated with increased risks of death and complications...
  17. doi request reprint Prevalence and determinants of hyperglycaemia in pneumonia patients
    Päivi H Salonen
    Unit of Medicine and Clinical Research, Pulmonary Division, Kuopio University Hospital, Kuopio, Finland
    Scand J Infect Dis 45:88-94. 2013
    ..Hyperglycaemia during pneumonia prolongs the hospitalization and increases the risks of complications and death. However, its prevalence and determinants have not been systematically assessed...