H Kokki

Summary

Affiliation: Kuopio University Hospital
Country: Finland

Publications

  1. doi request reprint Epidural blood patches are effective for postdural puncture headache in pediatrics--a 10-year experience
    Merja Kokki
    Department of Anesthesia and Operative Services, Kuopio University Hospital, Kuopio, Finland
    Paediatr Anaesth 22:1205-10. 2012
  2. doi request reprint Oxycodone for the treatment of postoperative pain
    Hannu Kokki
    Kuopio University Hospital, Department of Anaesthesia and Operative Services, Puijonlaaksontie 2, FI 70211 Kuopio, Finland
    Expert Opin Pharmacother 13:1045-58. 2012
  3. ncbi request reprint Oxycodone vs placebo in children with undifferentiated abdominal pain: a randomized, double-blind clinical trial of the effect of analgesia on diagnostic accuracy
    Hannu Kokki
    Department of Anesthesiology and Intensive Care, Kuopio University Hospital, University of Kuopio, FI 70211 Kuopio, Finland
    Arch Pediatr Adolesc Med 159:320-5. 2005
  4. ncbi request reprint Isobaric ropivacaine 5 mg/ml for spinal anesthesia in children
    Hannu Kokki
    Department of Anesthesiology and Intensive Care, Kuopio University Hospital, PO Box 1777, FI 70211 Kuopio, Finland
    Anesth Analg 100:66-70. 2005
  5. ncbi request reprint Pharmacokinetics of oxycodone after intravenous, buccal, intramuscular and gastric administration in children
    Hannu Kokki
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland
    Clin Pharmacokinet 43:613-22. 2004
  6. ncbi request reprint Levobupivacaine for pediatric spinal anesthesia
    Hannu Kokki
    Department of Anesthesiology and Intensive Care, Kuopio University Hospital, PO Box 1777, FIN 70211 Kuopio, Finland
    Anesth Analg 98:64-7, table of contents. 2004
  7. ncbi request reprint Pharmacokinetics of intravenous and rectal ketoprofen in young children
    Hannu Kokki
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland
    Clin Pharmacokinet 42:373-9. 2003
  8. ncbi request reprint Pain intensity after laseruvulopalatoplasty and tonsillectomy
    Hannu Kokki
    Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Finland
    Otolaryngol Head Neck Surg 128:273-9. 2003
  9. ncbi request reprint Current management of pediatric postoperative pain
    Hannu Kokki
    Department of Pharmacology and Toxicology, Clinical Pharmacology, University of Kuopio, PO Box 1627, FIN 70211, Kuopio, Finland
    Expert Rev Neurother 4:295-306. 2004
  10. ncbi request reprint High success rate and low incidence of headache and neurological symptoms with two spinal needle designs in children
    H Kokki
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland
    Acta Anaesthesiol Scand 49:1367-72. 2005

Collaborators

Detail Information

Publications85

  1. doi request reprint Epidural blood patches are effective for postdural puncture headache in pediatrics--a 10-year experience
    Merja Kokki
    Department of Anesthesia and Operative Services, Kuopio University Hospital, Kuopio, Finland
    Paediatr Anaesth 22:1205-10. 2012
    ..Postdural puncture headache (PDPH) is a relatively common complication after lumbar punctures (LP). If conservative treatment is not sufficient within a few days and the symptoms are severe, an epidural blood patch (EBP) may be performed...
  2. doi request reprint Oxycodone for the treatment of postoperative pain
    Hannu Kokki
    Kuopio University Hospital, Department of Anaesthesia and Operative Services, Puijonlaaksontie 2, FI 70211 Kuopio, Finland
    Expert Opin Pharmacother 13:1045-58. 2012
    ..Pain is a likely outcome of any surgical procedure. In several countries the use of oxycodone has surpassed that of morphine in postoperative pain management...
  3. ncbi request reprint Oxycodone vs placebo in children with undifferentiated abdominal pain: a randomized, double-blind clinical trial of the effect of analgesia on diagnostic accuracy
    Hannu Kokki
    Department of Anesthesiology and Intensive Care, Kuopio University Hospital, University of Kuopio, FI 70211 Kuopio, Finland
    Arch Pediatr Adolesc Med 159:320-5. 2005
    ..Analgesics for children with acute abdominal pain are often withheld for fear that they might mask physical examination findings and thus might be unsafe. This viewpoint has been challenged recently...
  4. ncbi request reprint Isobaric ropivacaine 5 mg/ml for spinal anesthesia in children
    Hannu Kokki
    Department of Anesthesiology and Intensive Care, Kuopio University Hospital, PO Box 1777, FI 70211 Kuopio, Finland
    Anesth Analg 100:66-70. 2005
    ..We conclude that the block performance of intrathecal isobaric ropivacaine in children (>1 yr) is similar to that obtained in adults but the safety of the larger dose used in children warrants further studies...
  5. ncbi request reprint Pharmacokinetics of oxycodone after intravenous, buccal, intramuscular and gastric administration in children
    Hannu Kokki
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland
    Clin Pharmacokinet 43:613-22. 2004
    ..To evaluate the pharmacokinetics of four administration routes of oxycodone parenteral liquid (10 mg/mL), single intravenous and intramuscular injections and buccal and gastric administration, in children...
  6. ncbi request reprint Levobupivacaine for pediatric spinal anesthesia
    Hannu Kokki
    Department of Anesthesiology and Intensive Care, Kuopio University Hospital, PO Box 1777, FIN 70211 Kuopio, Finland
    Anesth Analg 98:64-7, table of contents. 2004
    ..A complete motor block was achieved in 36 children. These results are similar to those obtained with racemic bupivacaine in subarachnoid anesthesia in children...
  7. ncbi request reprint Pharmacokinetics of intravenous and rectal ketoprofen in young children
    Hannu Kokki
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland
    Clin Pharmacokinet 42:373-9. 2003
    ..To evaluate the relative bioavailabilities of ketoprofen after intravenous and rectal administration to young children...
  8. ncbi request reprint Pain intensity after laseruvulopalatoplasty and tonsillectomy
    Hannu Kokki
    Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Finland
    Otolaryngol Head Neck Surg 128:273-9. 2003
    ....
  9. ncbi request reprint Current management of pediatric postoperative pain
    Hannu Kokki
    Department of Pharmacology and Toxicology, Clinical Pharmacology, University of Kuopio, PO Box 1627, FIN 70211, Kuopio, Finland
    Expert Rev Neurother 4:295-306. 2004
    ..Since most pediatric surgery is performed as a day-case or short-stay basic recommendations for parental guidance and pain management after discharge are also presented...
  10. ncbi request reprint High success rate and low incidence of headache and neurological symptoms with two spinal needle designs in children
    H Kokki
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland
    Acta Anaesthesiol Scand 49:1367-72. 2005
    ..In this study, we compared the success rate and incidence of post-dural puncture complaints of two small-gauge spinal needle designs used in children undergoing spinal anaesthesia (SA)...
  11. ncbi request reprint Comparison of oxycodone pharmacokinetics after buccal and sublingual administration in children
    Hannu Kokki
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland
    Clin Pharmacokinet 45:745-54. 2006
    ..We evaluated and compared the pharmacokinetics of two oral administration routes of oxycodone parenteral liquid (10 mg/mL)--single buccal and sublingual administration--in 30 generally healthy awake children, aged 6-91 months...
  12. ncbi request reprint Cerebrospinal fluid distribution of ibuprofen after intravenous administration in children
    Hannu Kokki
    Department of Pharmacology and Toxicology, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Pediatrics 120:e1002-8. 2007
    ..Nonsteroidal, antipyretic, antiinflammatory analgesics act in both the peripheral tissues and the central nervous system. The central nervous system penetration of ibuprofen has been described in adults but not in children...
  13. pmc Diclofenac readily penetrates the cerebrospinal fluid in children
    Hannu Kokki
    Department of Pharmacology and Toxicology, University of Kuopio, Kuopio, Finland
    Br J Clin Pharmacol 65:879-84. 2008
    ....
  14. doi request reprint Dose-finding studies of ketoprofen in the management of fever in children: report on two randomized, single-blind, comparator-controlled, single-dose, multicentre, phase II studies
    Hannu Kokki
    Department of Anaesthesiology and Intensive Care, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    Clin Drug Investig 30:251-8. 2010
    ..Ketoprofen is a highly effective NSAID with antipyretic and analgesic properties for the symptomatic management of pain and fever in both adults and children...
  15. doi request reprint Ketoprofen versus paracetamol (acetaminophen) or ibuprofen in the management of fever: results of two randomized, double-blind, double-dummy, parallel-group, repeated-dose, multicentre, phase III studies in children
    Hannu Kokki
    Department of Anesthesiology and Intensive Care, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    Clin Drug Investig 30:375-86. 2010
    ..Ketoprofen at the 0.5 mg/kg dose should be an effective and safe option for symptomatic management of fever in children...
  16. doi request reprint Ketoprofen pharmacokinetics, efficacy, and tolerability in pediatric patients
    Hannu Kokki
    Department of Anesthesiology and Intensive Care, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland
    Paediatr Drugs 12:313-29. 2010
    ..In conclusion, ketoprofen is effective and well tolerated in children for the control of post-surgical pain and for the control of pain and fever in inflammatory conditions...
  17. ncbi request reprint Nonsteroidal anti-inflammatory drugs for postoperative pain: a focus on children
    Hannu Kokki
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland
    Paediatr Drugs 5:103-23. 2003
    ..In contrast, it seems that most children with mild asthma may use NSAIDs...
  18. ncbi request reprint No difference between bupivacaine in 0.9% and 8% glucose for spinal anaesthesia in small children
    H Kokki
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Finland
    Acta Anaesthesiol Scand 44:548-51. 2000
    ..Bupivacaine is rendered hyperbaric by adding glucose. The effect of differing degrees of hyperbaricity remains to be evaluated...
  19. ncbi request reprint The effect of intravenous ketoprofen on postoperative epidural sufentanil analgesia in children
    H Kokki
    Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Finland
    Anesth Analg 88:1036-41. 1999
    ..035) and fever (3 [12%] vs 11 [48%]; P = 0.008) was less than that in the placebo group. We conclude that ketoprofen improved postoperative pain in children...
  20. ncbi request reprint Pharmacokinetics of ketoprofen following oral and intramuscular administration in young children
    H Kokki
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Finland
    Eur J Clin Pharmacol 57:643-7. 2001
    ..The pharmacokinetics of ketoprofen following intramuscular injection or oral tablet was determined in children aged 10-69 months...
  21. ncbi request reprint Tourniquet-induced enmg changes in arthroscopic anterior cruciate ligament reconstruction. A comparison of low and high-pressure tourniquet systems
    H Kokki
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Finland
    Ann Chir Gynaecol 89:313-7. 2000
    ..We compared whether a new tourniquet system using low pressure (250 mmHg) is safer than a standard tourniquet system using higher inflation pressure (350 mmHg)...
  22. ncbi request reprint Diffusion of ketoprofen into the cerebrospinal fluid of young children
    Hannu Kokki
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland
    Paediatr Anaesth 12:313-6. 2002
    ..kg-1 syrup, and to find out what is the lowest plasma concentration that will achieve a measurable level in the cerebrospinal fluid...
  23. ncbi request reprint Comparison of pre- and postoperative administration of ketoprofen for analgesia after tonsillectomy in children
    Hannu Kokki
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland
    Paediatr Anaesth 12:162-7. 2002
    ..Tonsillectomy is commonly performed in children, but unfortunately it is associated with intense postoperative pain. The use and optimal timing of nonsteroidal anti-inflammatory drugs (e.g. ketoprofen) during tonsillectomy is controversial...
  24. doi request reprint Spinal blocks
    Hannu Kokki
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland
    Paediatr Anaesth 22:56-64. 2012
    ..Epidural blood patch is effective treatment for prolonged, severe headache, and nonopioid analgesic is often sufficient for transient neurological symptoms...
  25. ncbi request reprint I.v. ketoprofen for analgesia after tonsillectomy: comparison of pre- and post-operative administration
    A Salonen
    Department of Otorhinolaryngology, Kuopio University Hospital, Finland
    Br J Anaesth 86:377-81. 2001
    ..001). Two patients (5%) in the 'pre' ketoprofen group and one (3%) in the 'post' ketoprofen group had post-operative bleeding between 4 and 14 h. All three patients required electrocautery...
  26. ncbi request reprint The effect of ketoprofen on recovery after tonsillectomy in children: a 3-week follow-up study
    Aarre Salonen
    Department of Otorhinolaryngology, Kuopio University Hospital, PO Box 1777, FIN 70211 Kuopio, Finland
    Int J Pediatr Otorhinolaryngol 62:143-50. 2002
    ..To evaluate recovery after tonsillectomy in children, and to determine the safety and efficacy of ketoprofen in pain treatment after discharge...
  27. ncbi request reprint Recovery after tonsillectomy in adults: a three-week follow-up study
    Aarre Salonen
    Department of Otorhinolaryngology, Kuopio University Hospital, FIN 70211 Kuopio, Finland
    Laryngoscope 112:94-8. 2002
    ..To evaluate recovery after tonsillectomy and safety and efficacy of ketoprofen in pain treatment after discharge...
  28. ncbi request reprint Ketoprofen for postoperative pain after uvulopalatopharyngoplasty and tonsillectomy: two-week follow-up study
    Elina Nikanne
    Department of Otorhinolaryngology, Kuopio University Hospital, Kuopio, Finland
    Otolaryngol Head Neck Surg 129:577-81. 2003
    ..To investigate the pain progression at home, we followed the same 53 patients for 14 days after surgery. Twenty-two patients underwent tonsillectomy and 31 patients underwent UPPP...
  29. ncbi request reprint Parenteral ketoprofen for pain management after adenoidectomy: comparison of intravenous and intramuscular routes of administration
    H Tuomilehto
    Department of Otorhinolaryngology, Kuopio University Hospital, Kuopio, Finland
    Acta Anaesthesiol Scand 46:184-9. 2002
    ..This study was designed to compare the analgesic efficacy of intravenous and intramuscular ketoprofen for pain management in children after day-case adenoidectomy...
  30. doi request reprint Diagnostic score in acute appendicitis. Validation of a diagnostic score (Lintula score) for adults with suspected appendicitis
    Hannu Lintula
    Department of Paediatric Surgery, Kuopio University Hospital, Kuopio, Finland
    Langenbecks Arch Surg 395:495-500. 2010
    ..The purpose of this prospective study was to validate the diagnostic score (Lintula score) in adults with suspected appendicitis...
  31. ncbi request reprint Comparison of epidural pain treatment with sufentanil-ropivacaine infusion with and without epinephrine in children
    Hannu Kokki
    Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland
    Acta Anaesthesiol Scand 46:647-53. 2002
    ....
  32. ncbi request reprint Pharmacokinetics of a 24-hour intravenous ketoprofen infusion in children
    H Kokki
    Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Finland
    Acta Anaesthesiol Scand 46:194-8. 2002
    ..No pharmacokinetic data are available with respect to the plasma concentration of ketoprofen during intravenous infusion in children...
  33. ncbi request reprint Interpleural bupivacaine and intravenous oxycodone for pain treatment after thoracotomy in children
    Hannu Kokki
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Finland
    J Opioid Manag 2:290-4. 2006
    ....
  34. doi request reprint Etoricoxib for pain management during thyroid surgery--a prospective, placebo-controlled study
    Grigori Smirnov
    Department of Otorhinolaryngology, Kuopio University Hospital, Kuopio, Finland
    Otolaryngol Head Neck Surg 138:92-7. 2008
    ..To assess the efficacy of etoricoxib in pain treatment during thyroid surgery...
  35. doi request reprint Remifentanil infusion does not induce opioid tolerance after cardiac surgery
    Pasi Lahtinen
    Department of Anesthesiology and Intensive Care, University of Kuopio, Kuopio, Finland
    J Cardiothorac Vasc Anesth 22:225-9. 2008
    ..In the present study, the authors evaluated whether high-dose remifentanil infusion induces opioid tolerance in 90 patients undergoing coronary artery bypass surgery with sternotomy...
  36. doi request reprint Prescribing for off-label use and unauthorized medicines in three paediatric wards in Finland, the status before and after the European Union Paediatric Regulation
    L Lindell-Osuagwu
    School of Pharmacy, University of Eastern Finland, Kuopio, Finland
    J Clin Pharm Ther 39:144-53. 2014
    ..To evaluate the possible impact of the Regulation on the prevalence and the frequency on such prescribing, we repeated the study in 2011 as it was conducted 10 years earlier...
  37. ncbi request reprint Single-blind randomized clinical trial of laparoscopic versus open appendicectomy in children
    H Lintula
    Department of Paediatric Surgery, Kuopio University Hospital, PO Box 1777, FIN-70211 Kuopio, Finland
    Br J Surg 88:510-4. 2001
    ..CONCLUSION: Laparoscopic appendicectomy is associated with less postoperative pain and a shorter hospital stay than open appendicectomy in children undergoing surgery for uncomplicated appendicitis...
  38. ncbi request reprint Regular tramadol use does not affect the propofol dose requirement for induction of anaesthesia
    H Kokki
    Kuopio University Hospital, Department of Anaesthesiology and Intensive Care, Kuopio, Finland
    Eur J Anaesthesiol 24:776-81. 2007
    ..An increased risk of awareness during general anaesthesia in patients receiving tramadol has been reported. We studied whether tramadol affects the amount of propofol required for induction of anaesthesia...
  39. ncbi request reprint Sensorineural hearing loss after epidural block for labor analgesia: a case report
    A Hyvarinen
    Department of Otorhinolaryngology, Kuopio University Hospital, Kuopio, Finland
    Acta Obstet Gynecol Scand 85:1403-5. 2006
  40. ncbi request reprint Fluoride metabolism in smokers and non-smokers following enflurane anaesthesia
    M Laisalmi
    Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland
    Br J Anaesth 91:800-4. 2003
    ..Tobacco smoke consists of numerous reactive compounds that can either induce or inhibit drug metabolism. Studies on the interaction of smoking with anaesthetic drug metabolism and possible toxicity are warranted...
  41. ncbi request reprint Effects of cigarette smoking on serum fluoride concentrations and renal function integrity after 1 MAC-h sevoflurane anaesthesia
    M Laisalmi
    Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland
    Acta Anaesthesiol Scand 50:982-7. 2006
    ..Whether smokers develop high S-F(-) and associated disturbances in renal function is not known...
  42. ncbi request reprint Does coronary artery bypass surgery affect metoprolol bioavailability
    Antti Valtola
    Department of Cardiothoracic Surgery, Kuopio University Hospital, Kuopio, Finland
    Eur J Clin Pharmacol 63:471-8. 2007
    ..In this pharmacokinetics study, in which the patients acted as their own controls, we have evaluated the bioavailability of perioperative metoprolol tablets in CABG surgery patients...
  43. ncbi request reprint Paracetamol (acetaminophen) penetrates readily into the cerebrospinal fluid of children after intravenous administration
    Elina Kumpulainen
    Department of Pharmacology and Toxicology, University of Kuopio, Kuopio, Finland
    Pediatrics 119:766-71. 2007
    ..The central nervous system penetration of paracetamol has been described in children with intracranial pathologies but not in children with an intact blood-brain barrier...
  44. ncbi request reprint Pain treatment and recovery after endoscopic sinus surgery
    Tatu P Kemppainen
    Department of Otorhinolaryngology, Kuopio University Hospital, Kuopio, Finland
    Laryngoscope 117:1434-8. 2007
    ....
  45. ncbi request reprint Video-assisted thoracoscopic versus open surgery for persistent ductus arteriosus
    Kari Vanamo
    Department of Pediatric Surgery 2206, Kuopio University Hospital, FIN 70211 Kuopio, Finland
    J Pediatr Surg 41:1226-9. 2006
    ..The aim of this study is to compare the experience with video-assisted thoracoscopic surgery (VATS) for patent ductus arteriosus (PDA) since 1995 with the results of conventional open surgery from the preceding 10 years...
  46. doi request reprint Laparoscopic versus open orchidopexy in children with intra-abdominal testes
    Hannu Lintula
    Department of Pediatric Surgery, Kuopio University Hospital, Kuopio, Finland
    J Laparoendosc Adv Surg Tech A 18:449-56. 2008
    ..The aim of our study was to evaluate the success rate of laparoscopic orchidopexy (LO) compared with that of open orchidopexy (OO)...
  47. doi request reprint Appendicitis score for children with suspected appendicitis. A randomized clinical trial
    Hannu Lintula
    Department of Pediatric Surgery, Kuopio University Hospital, Kuopio, Finland
    Langenbecks Arch Surg 394:999-1004. 2009
    ..The purpose of this prospective study was to determine whether diagnosis by using the appendicitis score may improve clinical outcomes for children with suspected appendicitis...
  48. doi request reprint Potentially detrimental effects of N-acetylcysteine on renal function in knee arthroplasty
    Merja Laisalmi-Kokki
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland
    Free Radic Res 43:691-6. 2009
    ..The two sensitive indicators of proximal tubular damage and function used in the present study suggest that use of NAC in clinical setting of ischaemia/reperfusion injury may increase the risk of remote kidney injury...
  49. doi request reprint Serotonin and dopamine transporter binding in children with autism determined by SPECT
    Ismo Makkonen
    Department of Paediatrics, Unit of Child Neurology, Kuopio University Hospital, Kuopio, Finland
    Dev Med Child Neurol 50:593-7. 2008
    ..The low SERT binding reported here and the low serotonin synthesis capacity shown elsewhere may indicate maturation of a lesser number of serotonergic nerve terminals in individuals with autism...
  50. doi request reprint Somatosensory evoked potentials by median nerve stimulation in children during thiopental/sevoflurane anesthesia and the additive effects of ketoprofen and fentanyl
    Susanna Westerén-Punnonen
    Department of Clinical Neurophysiology, Kuopio University Hospital, P O Box 1777, FI 70211 Kuopio, Finland
    Anesth Analg 107:799-805. 2008
    ..In addition, the effects of two analgesics (ketoprofen and fentanyl) on SEPs were evaluated...
  51. ncbi request reprint Repeated early debridement does not provide significant symptomatic benefit after ESS
    Tatu Kemppainen
    Department of Otorhinolaryngology, Kuopio University, Kuopio, Finland
    Rhinology 46:238-42. 2008
    ..Postoperative saline douching was used in both groups. The primary outcome measure was the postoperative Lund-MacKay Symptom Score...
  52. ncbi request reprint Early-phase pharmacokinetics of enteral and parenteral nimodipine in patients with acute subarachnoid haemorrhage - a pilot study
    Ville Soppi
    Department of Neurosurgery, Kuopio University Hospital, P O Box 1777, 70211, Kuopio, Finland
    Eur J Clin Pharmacol 63:355-61. 2007
    ....
  53. ncbi request reprint Laparoscopy in children with complicated appendicitis
    Hannu Lintula
    Department of Pediatric Surgery, Kuopio University Hospital, Kuopio, Finland
    J Pediatr Surg 37:1317-20. 2002
    ..The role of laparoscopy in complicated acute appendicitis is more controversial. The purpose of this trial was to compare laparoscopic appendectomy with open appendectomy in children with complicated appendicitis...
  54. ncbi request reprint Parents' perceptions and use of analgesics at home after children's day surgery
    Päivi Kankkunen
    Department of Nursing Science, University of Kuopio, Kuopio University Hospital, PO Box 1627, 70211 Kuopio, Finland
    Paediatr Anaesth 13:132-40. 2003
    ..The purpose of this study was to describe parents' perceptions and use of analgesics for children after discharge at home...
  55. ncbi request reprint The costs and effects of laparoscopic appendectomy in children
    Hannu Lintula
    Department of Paediatric Surgery, Kuopio University Hospital, Finland
    Arch Pediatr Adolesc Med 158:34-7. 2004
    ..Laparoscopic procedures are performed commonly in children. In general, the cost containment of laparoscopic surgery in children has not been evaluated...
  56. ncbi request reprint Laparoscopic fundoplication in children with a preexisting gastrostomy
    Hannu Lintula
    Department of Pediatric Surgery, Kuopio University Hospital, Kuopio, Finland
    J Laparoendosc Adv Surg Tech A 13:381-5. 2003
    ..Children with a gastrostomy may require laparoscopic fundoplication (LF)...
  57. ncbi request reprint Postoperative behavioral changes in children after adenoidectomy
    Henri Tuomilehto
    Department of Otorhinolaryngology, Kuopio University Hospital, Finland
    Arch Otolaryngol Head Neck Surg 128:1159-64. 2002
    ..Behavioral changes, when a proactive pain treatment has been used, have not been systematically studied...
  58. ncbi request reprint S(+)-ketamine as an analgesic adjunct reduces opioid consumption after cardiac surgery
    Pasi Lahtinen
    Department of Anesthesiology and Intensive Care, Kuopio University Hospital, FIN 70210 Kuopio, Finland
    Anesth Analg 99:1295-301; table of contents. 2004
    ..In conclusion, small-dose S(+)-ketamine decreased opioid consumption in CABG patients during the first 48 h after surgery...
  59. ncbi request reprint Propacetamol as adjunctive treatment for postoperative pain after cardiac surgery
    Pasi Lahtinen
    Department of Anesthesia and Intensive Care and Department of Surgery, Kuopio University Hospital, Kuopio, Finland
    Anesth Analg 95:813-9, table of contents. 2002
    ..However, post hoc analysis showed that oxycodone requirement was reduced within the first 24 h in the propacetamol group...
  60. ncbi request reprint A diagnostic score for children with suspected appendicitis
    Hannu Lintula
    Department of Pediatric Surgery, Kuopio University Hospital, PO Box 1777, 70211 Kuopio, Finland
    Langenbecks Arch Surg 390:164-70. 2005
    ..Appendicectomy is an operation that is often performed without certainty of diagnosis. This study aimed to construct and to validate a prognostic score for the diagnosis of acute appendicitis in children...
  61. ncbi request reprint Acetaminophen is highly effective in pain treatment after endoscopic sinus surgery
    Tatu Kemppainen
    Department of Otorhinolaryngology, Kuopio University Hospital, Kuopio, Finland
    Laryngoscope 116:2125-8. 2006
    ..In the present study, we have evaluated the incidence and severity of pain and the efficacy and safety of acetaminophen (paracetamol) for pain management in patients undergoing ESS...
  62. ncbi request reprint Pain after cardiac surgery: a prospective cohort study of 1-year incidence and intensity
    Pasi Lahtinen
    Department of Anesthesiology and Intensive Care, Kuopio University Hospital, 70210 Kuopio, Finland
    Anesthesiology 105:794-800. 2006
    ..Therefore, the authors conducted a follow-up survey for the first 12 months after cardiac surgery in 213 patients who had a sternotomy...
  63. doi request reprint Stability of an epidural analgesic admixture of levobupivacaine, fentanyl and epinephrine
    M Helin-Tanninen
    Department of Pharmacy, Kuopio University Hospital, Kuopio, Finland
    J Clin Pharm Ther 38:104-8. 2013
    ....
  64. ncbi request reprint Epidural blood patch for management of postdural puncture headache in adolescents
    P Ylönen
    Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Finland
    Acta Anaesthesiol Scand 46:794-8. 2002
    ..The aim of this survey was to review requests for EBPs and to evaluate the effectiveness of EBP in patients aged 13-18 years during a 6.5 year period ending in June 2001...
  65. ncbi request reprint Antidromic corticospinal tract potential of the brain
    J Partanen
    Department of Clinical Neurophysiology, University Hospital, University of Kuopio, Kuopio, Finland
    Clin Neurophysiol 111:489-95. 2000
    ..To study the origin of this component and to compare its source to known sources of the somatosensory evoked potentials (SEPs)...
  66. ncbi request reprint Training of medical staff positively influences postoperative pain management at home in children
    K Sepponen
    Department of Social Pharmacy, University of Kuopio, Finland
    Pharm World Sci 21:168-72. 1999
    ..A training program for doctors and nurses can improve the treatment of children's pain even at home. Since some children dislike suppositories, it would be worth considering the use of small tablets or mixtures instead...
  67. ncbi request reprint Plasma and cerebrospinal fluid concentrations of indomethacin in children after intravenous administration
    Anne Mannila
    Department of Pharmaceutical Chemistry, University of Kuopio, PO Box 1627, FI 70211 Kuopio, Finland
    J Clin Pharmacol 47:94-100. 2007
    ..In conclusion, indomethacin permeated into the CSF of children, which enables both desired and adverse CNS effects of indomethacin...
  68. ncbi request reprint Cerebrospinal fluid distribution of ketoprofen after intravenous administration in young children
    Anne Mannila
    Department of Pharmaceutical Chemistry, University of Kuopio, Kuopio, Finland
    Clin Pharmacokinet 45:737-43. 2006
    ..The purpose of this study was to evaluate the cerebrospinal fluid (CSF) distribution of an NSAID, ketoprofen, in children. Ketoprofen concentrations were determined from the CSF, plasma and protein-free plasma samples...
  69. doi request reprint A tale of two countries: comparison of the perceptions of analgesics among Finnish and American parents
    Päivi M Kankkunen
    Department of Nursing Science, University of Kuopio, Kuopio, Finland
    Pain Manag Nurs 9:113-9. 2008
    ..Nurses should be aware of parents' incorrect perceptions which may be barriers to children's pain relief...
  70. doi request reprint Serum and CSF soluble CD26 and CD30 concentrations in healthy pediatric surgical outpatients
    W Delezuch
    Department of Clinical Chemistry, University of Kuopio and Eastern Finland Laboratory Centre, Kuopio, Finland
    Tissue Antigens 80:368-75. 2012
    ..For sCD30; reference limits of 80-190 IU/ml were established in the youngest age group and 10-90 IU/ml in adolescents...
  71. ncbi request reprint Promoting children's pharmacological postoperative pain alleviation at home
    Päivi Kankkunen
    University of Kuopio, Department of Nursing Science, Kuopio, Finland
    Pediatr Nurs 35:298-303; quiz 304-5. 2009
    ..In conclusion, the use the PPPM may promote parents' management of their child's post-operative pain at home. Larger samples in further studies are needed to verify the findings of this study...
  72. doi request reprint How readily does ketorolac penetrate cerebrospinal fluid in children?
    Elina Kumpulainen
    Department of Pharmacology and Toxicology, University of Kuopio, Kuopio, Finland
    J Clin Pharmacol 48:495-501. 2008
    ..6 microg x L(-1)). The cerebrospinal fluid to unbound plasma concentration-ratio ranged between 0.01 and 0.69 (median, 0.08). These low concentrations indicate that ketorolac does not readily penetrate cerebrospinal fluid in children...
  73. doi request reprint Parental reporting of adverse drug events and other drug-related problems in children in Finland
    L Lindell-Osuagwu
    School of Pharmacy, Social Pharmacy, Faculty of Health Sciences, University of Eastern Finland, P O Box 1627, 70211 Kuopio, Finland
    Eur J Clin Pharmacol 69:985-94. 2013
    ..Drug-related problems (DRPs) are common in paediatric pharmacotherapy, but few studies describe them from the parents' perspective. In the present survey, we have investigated the lifetime prevalence and type of DRPs in children in Finland...
  74. ncbi request reprint Sevoflurane anaesthesia in children after induction of anaesthesia with midazolam and thiopental does not cause epileptiform EEG
    K Nieminen
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, PO Box 1777, FIN 70211 Kuopio, Finland
    Br J Anaesth 89:853-6. 2002
    ..v. induction with benzodiazepine and barbiturate, which is another common induction technique in children...
  75. ncbi request reprint Management of postdural puncture headache with epidural blood patch in children
    Paula Ylönen
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Finland
    Paediatr Anaesth 12:526-9. 2002
    ..When the symptoms are severe and are not relieved within a few days with analgesics, forced hydration and bed rest, then epidural blood patch (EBP) might be performed...
  76. doi request reprint Perioperative chronic use of statins and the risk of muscle complaints in patients undergoing knee and hip endoprosthesis surgery
    Merja Laisalmi-Kokki
    Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Kuopio FI 70211, Finland
    J Clin Anesth 22:81-7. 2010
    ..To assess whether regular statin therapy enhances muscular and hepatic deterioration and muscle complaints in patients undergoing elective arthroplasty...
  77. ncbi request reprint Cerebrospinal fluid insulin-like growth factors IGF-1 and IGF-2 in infantile autism
    Raili Riikonen
    Department of Child Neurology, Kuopio University Central Hospital, Kuopio, Finland
    Dev Med Child Neurol 48:751-5. 2006
    ..The head growth might be explained by the actions of IGF-1 and -2 reflected in CSF concentrations...
  78. ncbi request reprint Intravenous ketoprofen as an adjunct to patient-controlled analgesia morphine in adolescents with thoracic surgery: a placebo controlled double-blinded study
    Danguole Rugyte
    Department of Anesthesiology, Kaunas University of Medicine, Eiveniu 2, Kaunas, Lithuania
    Eur J Pain 11:694-9. 2007
    ..Surgery to correct pectus deformities entail substantial destruction of the thoracic skeleton and thus may cause significant postoperative pain...
  79. ncbi request reprint Stability of sufentanil and levobupivacaine solutions and a mixture in a 0.9% sodium chloride infusion stored in polypropylene syringes
    Annaliisa Jäppinen
    Central Finland Hospital, Pharmacy, Keskussairaalantie 19, FIN 40620 Jyväskylä, Finland
    Eur J Pharm Sci 19:31-6. 2003
    ..According to the chemical and microbiological stability studies, the sufentanil-levobupivacaine mixture in PP syringes could be stored for 28 days at 4 and 21 degrees C...
  80. ncbi request reprint A ketamine-propofol admixture does not reduce the pain on injection compared with a lidocaine-propofol admixture
    Olfa Kaabachi
    Department of Anesthesiology and Intensive Care, Kassab Orthopedic Institute, Tunis, Tunisia
    Paediatr Anaesth 17:734-7. 2007
    ..The purpose of this prospective, double-blind randomized, clinical trial with active control was to evaluate the efficacy of premixing propofol with ketamine in the prevention of injection pain in children...
  81. ncbi request reprint Clonidine 1 microg/kg is a safe and effective adjuvant to plain bupivacaine in spinal anesthesia in adolescents
    Olfa Kaabachi
    Department of Anesthesiology and Intensive Care, Kassab Orthopedic Institute, Tunis, Tunisia
    Anesth Analg 105:516-9. 2007
    ..In the present study, we investigated the efficacy and safety of intrathecal clonidine 1 mug/kg in adjunction to bupivacaine in spinal anesthesia in adolescents...
  82. ncbi request reprint Celecoxib and ketoprofen for pain management during tonsillectomy: a placebo-controlled clinical trial
    Elina Nikanne
    Department of Otorhinolaryngology, Central Hospital, Finland
    Otolaryngol Head Neck Surg 132:287-94. 2005
    ..To evaluate the efficacy and safety of celecoxib and ketoprofen in pain management during tonsillectomy in 120 patients...
  83. ncbi request reprint Population pharmacokinetics of oxycodone in children 6 months to 7 years old
    Ahmed El-Tahtawy
    Metrum Research Group, Tariffville, CT, USA
    J Clin Pharmacol 46:433-42. 2006
    ..This model confirms using a weight-based dose for oxycodone without adjustment for age between 6 months and 7 years and is valuable for evaluating dosing schedules and dosing routes...
  84. ncbi request reprint Use of spinal anaesthesia in paediatric patients: a single centre experience with 1132 cases
    Franco Puncuh
    Department of Anaesthesiology and Intensive Care, G Gaslini Children Hospital, L go G Gaslini, Genova, Italy
    Paediatr Anaesth 14:564-7. 2004
    ..Spinal anaesthesia has been used in children for over 100 years and in the last two decades its popularity for newborns and infants has increased, but there are still unanswered questions with the technique...