S Helisalmi

Summary

Affiliation: Kuopio University Hospital
Country: Finland

Publications

  1. ncbi request reprint Is the presenilin-1 E318G missense mutation a risk factor for Alzheimer's disease?
    S Helisalmi
    Department of Neurology, University Hospital and University of Kuopio, Finland
    Neurosci Lett 278:65-8. 2000
  2. ncbi request reprint Linkage disequilibrium in the 13q12 region in Finnish late onset Alzheimer's disease patients
    M Hiltunen
    Department of Neurology, University Hospital and University of Kuopio, Finland
    Eur J Hum Genet 7:652-8. 1999
  3. ncbi request reprint Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals
    S Helisalmi
    Department of Neurology, University Hospital and University of Kuopio, Puijonlaaksontie 2, FIN 70211 Kuopio, Finland
    J Neurol 246:821-4. 1999
  4. ncbi request reprint Identification of a novel 4.6-kb genomic deletion in presenilin-1 gene which results in exclusion of exon 9 in a Finnish early onset Alzheimer's disease family: an Alu core sequence-stimulated recombination?
    M Hiltunen
    Department of Neurology, University Hospital and University of Kuopio, Finland
    Eur J Hum Genet 8:259-66. 2000
  5. ncbi request reprint Butyrylcholinesterase K variant and apolipoprotein E4 genes do not act in synergy in Finnish late-onset Alzheimer's disease patients
    M Hiltunen
    Department of Neurology, University Hospital and University of Kuopio, Finland
    Neurosci Lett 250:69-71. 1998
  6. ncbi request reprint Polymorphisms in the CYP19 gene confer increased risk for Alzheimer disease
    S Iivonen
    Department of Neuroscience and Neurology, University Hospital and University of Kuopio, Finland
    Neurology 62:1170-6. 2004
  7. doi request reprint Combined risk effects of IDE and NEP gene variants on Alzheimer disease
    S Vepsalainen
    Department of Neurology, Kuopio University and University Hospital, PO Box 1627, 70211 Kuopio, Finland
    J Neurol Neurosurg Psychiatry 80:1268-70. 2009
  8. pmc Polymorphisms in neprilysin gene affect the risk of Alzheimer's disease in Finnish patients
    S Helisalmi
    Department of Neuroscience and Neurology, University Hospital and University of Kuopio, Kuopio, Finland
    J Neurol Neurosurg Psychiatry 75:1746-8. 2004
  9. ncbi request reprint No association between alpha1-antichymotrypsin polymorphism, apolipoprotein E and patients with late-onset Alzheimer's disease
    S Helisalmi
    Department of Neurology, University Hospital and University of Kuopio, Finland
    Neurosci Lett 231:56-8. 1997
  10. ncbi request reprint Genome-wide linkage disequilibrium mapping of late-onset Alzheimer's disease in Finland
    M Hiltunen
    Department of Neurology, University Hospital and University of Kuopio, Finland
    Neurology 57:1663-8. 2001

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Is the presenilin-1 E318G missense mutation a risk factor for Alzheimer's disease?
    S Helisalmi
    Department of Neurology, University Hospital and University of Kuopio, Finland
    Neurosci Lett 278:65-8. 2000
    ..It may be in linkage disequilibrium with a pathogenic change somewhere else in the PSEN-1 gene or in close proximity to the PSEN-1 gene...
  2. ncbi request reprint Linkage disequilibrium in the 13q12 region in Finnish late onset Alzheimer's disease patients
    M Hiltunen
    Department of Neurology, University Hospital and University of Kuopio, Finland
    Eur J Hum Genet 7:652-8. 1999
    ..The localisation of these sequences at the linkage disequilibrium region suggests that they may be candidate genes involved in a sex-specific effect during development of AD...
  3. ncbi request reprint Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals
    S Helisalmi
    Department of Neurology, University Hospital and University of Kuopio, Puijonlaaksontie 2, FIN 70211 Kuopio, Finland
    J Neurol 246:821-4. 1999
    ..49). However, haplotype estimation analysis indicated linkage disequilibrium between APOE -491A/T polymorphism and the APOE epsilon4 allele. Our findings confirm APOE polymorphism still to be the most efficient predictor of risk in AD...
  4. ncbi request reprint Identification of a novel 4.6-kb genomic deletion in presenilin-1 gene which results in exclusion of exon 9 in a Finnish early onset Alzheimer's disease family: an Alu core sequence-stimulated recombination?
    M Hiltunen
    Department of Neurology, University Hospital and University of Kuopio, Finland
    Eur J Hum Genet 8:259-66. 2000
    ..This study shows that large genomic rearrangements can affect the EOAD gene PS-1 through a mechanism, which may involve Alu core sequence-stimulated recombination...
  5. ncbi request reprint Butyrylcholinesterase K variant and apolipoprotein E4 genes do not act in synergy in Finnish late-onset Alzheimer's disease patients
    M Hiltunen
    Department of Neurology, University Hospital and University of Kuopio, Finland
    Neurosci Lett 250:69-71. 1998
    ..01; odds-ratio 0.22, 95% CI 0.07-0.71). These results are in contrast to a previous study on English AD patients, in which the genes for BChE-K and ApoE4 were suggested to act in synergy...
  6. ncbi request reprint Polymorphisms in the CYP19 gene confer increased risk for Alzheimer disease
    S Iivonen
    Department of Neuroscience and Neurology, University Hospital and University of Kuopio, Finland
    Neurology 62:1170-6. 2004
    ..Aromatase is encoded by the CYP19 gene located at 15q21.1, a chromosomal region in linkage disequilibrium (LD) with Alzheimer disease (AD) in this sample...
  7. doi request reprint Combined risk effects of IDE and NEP gene variants on Alzheimer disease
    S Vepsalainen
    Department of Neurology, Kuopio University and University Hospital, PO Box 1627, 70211 Kuopio, Finland
    J Neurol Neurosurg Psychiatry 80:1268-70. 2009
    ..Although no significant interaction was observed between NEP and IDE genes, these data suggest that NEP and IDE exhibit an additive risk effect in AD...
  8. pmc Polymorphisms in neprilysin gene affect the risk of Alzheimer's disease in Finnish patients
    S Helisalmi
    Department of Neuroscience and Neurology, University Hospital and University of Kuopio, Kuopio, Finland
    J Neurol Neurosurg Psychiatry 75:1746-8. 2004
    ..In this study we investigated whether polymorphisms in the NEP gene have an effect on the risk for AD...
  9. ncbi request reprint No association between alpha1-antichymotrypsin polymorphism, apolipoprotein E and patients with late-onset Alzheimer's disease
    S Helisalmi
    Department of Neurology, University Hospital and University of Kuopio, Finland
    Neurosci Lett 231:56-8. 1997
    ..Our data failed to detect any effect of polymorphism in the ACT genotypes associated with the APOE alleles, suggesting that in this population ACT does not increase the risk of AD...
  10. ncbi request reprint Genome-wide linkage disequilibrium mapping of late-onset Alzheimer's disease in Finland
    M Hiltunen
    Department of Neurology, University Hospital and University of Kuopio, Finland
    Neurology 57:1663-8. 2001
    ..To find novel susceptibility genes for late-onset AD, a population-based genome-wide search using linkage disequilibrium (LD) mapping approach has been performed...
  11. ncbi request reprint The leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide Y is not associated with Alzheimer's disease or the link apolipoprotein E
    S Helisalmi
    Department of Neurology, University Hospital and University of Kuopio, P O Box 1777, FIN 70211, Kuopio, Finland
    Neurosci Lett 287:25-8. 2000
    ..We conclude that APOE varepsilon4 allele represents a strong predictor of risk for AD...
  12. ncbi request reprint Screening for amyloid beta precursor protein codon 665, 670/671 and 717 mutations in Finnish patients with Alzheimer's disease
    S Helisalmi
    Department of Neurology, University of Kuopio, Finland
    Neurosci Lett 205:68-70. 1996
    ..We conclude that these mutations in the APP gene may be a very rare cause of AD in Eastern Finland and thus most Finnish familial AD will likely be due to other gene defects...
  13. ncbi request reprint A longitudinal quantitative EEG study of Alzheimer's disease: relation to apolipoprotein E polymorphism
    M Lehtovirta
    Department of Neurology, University Hospital and University of Kuopio, Finland
    Dement Geriatr Cogn Disord 11:29-35. 2000
    ..The differences in EEG may suggest differences in the degree of the cholinergic deficit in these subgroups...
  14. ncbi request reprint Effects of estradiol on spatial learning, hippocampal cytochrome P450 19, and estrogen alpha and beta mRNA levels in ovariectomized female mice
    S Iivonen
    Department of Neuroscience and Neurology, University Hospital and University of Kuopio, P O Box 1627, 70211, Kuopio, Finland
    Neuroscience 137:1143-52. 2006
    ..The results also suggest that tonic rather than cyclic estrogen treatment might be more beneficial for cognitive functions...
  15. ncbi request reprint Seladin-1 transcription is linked to neuronal degeneration in Alzheimer's disease
    S Iivonen
    Department of Neuroscience and Neurology, University Hospital and University of Kuopio, P O Box 1627, FIN 70211, Kuopio, Finland
    Neuroscience 113:301-10. 2002
    ..The results presented here indicate that seladin-1 transcription is selectively down-regulated in brain regions vulnerable to Alzheimer's disease and this down-regulation is associated with the hyperphosphorylation of tau protein...