S Heinonen

Summary

Affiliation: Kuopio University Hospital
Country: Finland

Publications

  1. ncbi request reprint Endothelial nitric oxide synthase polymorphism is not associated with placental abruption in Finnish women
    Sari Toivonen
    Department of Obstetrics and Gynecology, Kuopio University and University Hospital, Kuopio, Finland
    Fetal Diagn Ther 20:508-11. 2005
  2. pmc Smooth muscle tumor of the placenta - an entrapped maternal leiomyoma: a case report
    Katja Murtoniemi
    J Med Case Reports 3:7302. 2009
  3. pmc Contribution of socioeconomic status to the risk of small for gestational age infants--a population-based study of 1,390,165 singleton live births in Finland
    Sari Räisänen
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, Kuopio, Finland
    Int J Equity Health 12:28. 2013
  4. pmc Need for insulin to control gestational diabetes is reflected in the ambulatory arterial stiffness index
    Henna Kärkkäinen
    Department of Obst Gyn, Kuopio University Hospital, University of Eastern Finland, POB 1777, Kuopio FIN 70211, Finland
    BMC Pregnancy Childbirth 13:9. 2013
  5. pmc Preeclampsia complicated by advanced maternal age: a registry-based study on primiparous women in Finland 1997-2008
    Reeta Lamminpää
    Department of Nursing Science, University of Eastern Finland, PO, Box, 1627, Kuopio, 70211, Finland
    BMC Pregnancy Childbirth 12:47. 2012
  6. pmc Association of the rs1424954 polymorphism of the ACVR2A gene with the risk of pre-eclampsia is not replicated in a Finnish study population
    A Inkeri Lokki
    Department of Medical Genetics, Haartman Institute, University of Helsinki, P, O, Box 63 Haartmaninkatu 8, FI 00014 Helsinki, Finland
    BMC Res Notes 4:545. 2011
  7. pmc The role of nocturnal delivery and delivery during the holiday period in Finland on obstetric anal sphincter rupture rates- a population based observational study
    Sari Räisänen
    Department of Nursing Science, University of Eastern Finland, PO Box 1627, FI 70211 Kuopio, Finland
    BMC Res Notes 3:32. 2010
  8. pmc Up to seven-fold inter-hospital differences in obstetric anal sphincter injury rates- A birth register-based study in Finland
    Sari Räisänen
    Department of Nursing Science, University of Eastern Finland, P, O, Box 1627, 70211 Kuopio, Finland
    BMC Res Notes 3:345. 2010
  9. pmc Feasibility of a lifestyle intervention in early pregnancy to prevent deterioration of glucose tolerance
    Eeva A L Korpi-Hyövälti
    Department of Internal Medicine, Seinajoki Central Hospital, Seinajoki, Finland
    BMC Public Health 11:179. 2011
  10. pmc Does unemployment in family affect pregnancy outcome in conditions of high quality maternity care?
    Kaisa Raatikainen
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, PO Box 1777, 70211 Kuopio, Finland
    BMC Public Health 6:46. 2006

Collaborators

Detail Information

Publications106 found, 100 shown here

  1. ncbi request reprint Endothelial nitric oxide synthase polymorphism is not associated with placental abruption in Finnish women
    Sari Toivonen
    Department of Obstetrics and Gynecology, Kuopio University and University Hospital, Kuopio, Finland
    Fetal Diagn Ther 20:508-11. 2005
    ..To study whether genetic variability in the gene encoding endothelial nitric oxide synthase (eNOS) affects individual susceptibility to the development of placental abruption during pregnancy...
  2. pmc Smooth muscle tumor of the placenta - an entrapped maternal leiomyoma: a case report
    Katja Murtoniemi
    J Med Case Reports 3:7302. 2009
    ..This case is possibly the first report on this kind of a placental tumor which has been examined using both immunohistochemistry and chromosome analysis...
  3. pmc Contribution of socioeconomic status to the risk of small for gestational age infants--a population-based study of 1,390,165 singleton live births in Finland
    Sari Räisänen
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, Kuopio, Finland
    Int J Equity Health 12:28. 2013
    ..Small for gestational age (SGA) infants are at increased risk of short- and long-term adverse outcomes...
  4. pmc Need for insulin to control gestational diabetes is reflected in the ambulatory arterial stiffness index
    Henna Kärkkäinen
    Department of Obst Gyn, Kuopio University Hospital, University of Eastern Finland, POB 1777, Kuopio FIN 70211, Finland
    BMC Pregnancy Childbirth 13:9. 2013
    ..The aim was to evaluate the metabolic profile in conjunction with vascular function using the ambulatory arterial stiffness index (AASI) in women with uncomplicated pregnancies and in women with gestational diabetes mellitus (GDM)...
  5. pmc Preeclampsia complicated by advanced maternal age: a registry-based study on primiparous women in Finland 1997-2008
    Reeta Lamminpää
    Department of Nursing Science, University of Eastern Finland, PO, Box, 1627, Kuopio, 70211, Finland
    BMC Pregnancy Childbirth 12:47. 2012
    ..The purpose of this registry-based study was to compare the obstetric outcomes in primiparous and preeclamptic women younger and older than 35 years...
  6. pmc Association of the rs1424954 polymorphism of the ACVR2A gene with the risk of pre-eclampsia is not replicated in a Finnish study population
    A Inkeri Lokki
    Department of Medical Genetics, Haartman Institute, University of Helsinki, P, O, Box 63 Haartmaninkatu 8, FI 00014 Helsinki, Finland
    BMC Res Notes 4:545. 2011
    ..abstract:..
  7. pmc The role of nocturnal delivery and delivery during the holiday period in Finland on obstetric anal sphincter rupture rates- a population based observational study
    Sari Räisänen
    Department of Nursing Science, University of Eastern Finland, PO Box 1627, FI 70211 Kuopio, Finland
    BMC Res Notes 3:32. 2010
    ..Women (n = 2,849) with OASR were compared in terms of possible risk factors to women without OASR using stepwise logistic regression analysis...
  8. pmc Up to seven-fold inter-hospital differences in obstetric anal sphincter injury rates- A birth register-based study in Finland
    Sari Räisänen
    Department of Nursing Science, University of Eastern Finland, P, O, Box 1627, 70211 Kuopio, Finland
    BMC Res Notes 3:345. 2010
    ..abstract:..
  9. pmc Feasibility of a lifestyle intervention in early pregnancy to prevent deterioration of glucose tolerance
    Eeva A L Korpi-Hyövälti
    Department of Internal Medicine, Seinajoki Central Hospital, Seinajoki, Finland
    BMC Public Health 11:179. 2011
    ..The aim of the study was to evaluate if a lifestyle intervention since early pregnancy is feasible in improving the glucose tolerance of women at a high-risk for GDM in Finland...
  10. pmc Does unemployment in family affect pregnancy outcome in conditions of high quality maternity care?
    Kaisa Raatikainen
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, PO Box 1777, 70211 Kuopio, Finland
    BMC Public Health 6:46. 2006
    ..The objective of this study was to assess the effects of unemployment of one or both parents on obstetric outcome in conditions of free antenatal care attended by the entire pregnant population...
  11. pmc Under-attending free antenatal care is associated with adverse pregnancy outcomes
    Kaisa Raatikainen
    Department of Obstetrics and Gynecology, PO Box 1777, Kuopio University Hospital, 70211 Kuopio, Finland
    BMC Public Health 7:268. 2007
    ..The objective of this study was to assess the outcome of pregnancies when free and easily accessible antenatal care has been either totally lacking or low in number of visits...
  12. pmc Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma
    Timo K Nykopp
    Institute of Clinical Medicine, Department of Pathology and Forensic Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    BMC Cancer 10:512. 2010
    ....
  13. ncbi request reprint Maternal susceptibility locus for obstetric cholestasis maps to chromosome region 2p13 in Finnish patients
    S Heinonen
    Dept of Obstetrics and Gynecology, Kuopio University Hospital, Finland
    Scand J Gastroenterol 36:766-70. 2001
    ..Carriership of long-chain 3-hydroxyacyl-coenzyme A dehydrogenase (LCHAD) deficiency has been reported to be associated with an increased risk of obstetric cholestasis and the gene is located in the p23 region of chromosome 2...
  14. pmc Need for critical care in gynaecology: a population-based analysis
    Seppo Heinonen
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland
    Crit Care 6:371-5. 2002
    ..The purpose of this study was to note potential gynaecological risk factors leading to intensive care and to estimate the frequency, costs and outcome of management...
  15. ncbi request reprint Weights of placentae from small-for-gestational age infants revisited
    S Heinonen
    Department of Obstetrics and Gynecology, University Hospital of Kuopio, Finland
    Placenta 22:399-404. 2001
    ..Future studies should evaluate whether growth restriction could be reversed by therapeutic approaches increasing placental weight...
  16. pmc The effects on fetal development of high alpha-fetoprotein and maternal smoking
    S Heinonen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Finland
    Am J Public Health 89:561-3. 1999
    ..This study determined the risk of impaired fetal growth resulting from the interaction between maternal smoking during pregnancy and unexplained elevated concentrations of maternal serum alpha-fetoprotein (MSAFP)...
  17. ncbi request reprint Associations between two single nucleotide polymorphisms in the adiponectin gene and polycystic ovary syndrome
    Seppo Heinonen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Gynecol Endocrinol 21:165-9. 2005
    ..9%) than in the control group (32.7%) ( p = 0.058). We conclude that polymorphisms of the adiponectin gene may be implicated in individual susceptibility to PCOS...
  18. ncbi request reprint Pregnancy outcome with intrahepatic cholestasis
    S Heinonen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Finland
    Obstet Gynecol 94:189-93. 1999
    ..To determine the risk of adverse pregnancy outcomes resulting from intrahepatic cholestasis...
  19. ncbi request reprint Unexplained elevated serum hCG is associated with raised amniotic fluid erythropoietin levels in second-trimester pregnancies
    S Heinonen
    Department of Obstetrics and Gynecology, University Hospital of Kuopio, Finland
    Fetal Diagn Ther 14:286-90. 1999
    ..This study was designed to investigate the association between the concentrations of maternal serum hCG and amniotic fluid erythropoietin during the second trimester of pregnancy...
  20. ncbi request reprint Critical evaluation of evidence: a lesson to learn from a recent meta-analysis
    Seppo Heinonen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Finland
    Acta Obstet Gynecol Scand 85:260-2. 2006
  21. ncbi request reprint Reproductive risk factors of fetal asphyxia at delivery: a population based analysis
    S Heinonen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Finland
    J Clin Epidemiol 54:407-10. 2001
    ..33, respectively. Most cases of intrapartum fetal asphyxia occur in low-risk pregnancies and, therefore, risk screening in antenatal care cannot accurately predict which women will eventually need emergency care for fetal asphyxia...
  22. ncbi request reprint Apolipoprotein E alleles in women with polycystic ovary syndrome
    S Heinonen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Fertil Steril 75:878-80. 2001
    ..To investigate the frequency of apoE alleles among women with polycystic ovary syndrome...
  23. ncbi request reprint Gene therapy and ovarian cancer: more questions than answers
    Seppo Heinonen
    Department of Obstetrics Gynecology, Kuopio University Hospital, Kuopio, Finland
    Acta Obstet Gynecol Scand 85:1411-3. 2006
  24. ncbi request reprint The 121Q allele of the plasma cell membrane glycoprotein 1 gene predisposes to polycystic ovary syndrome
    Seppo Heinonen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, 70211 Kuopio, Finland
    Fertil Steril 82:743-5. 2004
    ..121Q allele) having an odds ratio of 1.90 (95% confidence interval 1.11-3.26). This suggests that impaired insulin signaling is of etiologic importance in PCOS...
  25. ncbi request reprint Angiographically guided utero-placental gene transfer in rabbits with adenoviruses, plasmid/liposomes and plasmid/polyethyleneimine complexes
    A Heikkilä
    AI Virtanen Institute, University of Kuopio, Kuopio, Finland
    Gene Ther 8:784-8. 2001
    ..Therefore, if gene therapy is developed for the treatment of placental disorders, the gene-vector combination should not be harmful to the fetus and the expression of the transgene should only occur in placenta...
  26. ncbi request reprint Apolipoprotein E alleles in women with intrahepatic cholestasis of pregnancy
    M L Eloranta
    Dept of Obstetrics and Gynecology, Kuopio University Hospital, Finland
    Scand J Gastroenterol 35:966-8. 2000
    ..To investigate the frequency of apolipoprotein E (apoE) alleles among women with intrahepatic cholestasis of pregnancy...
  27. ncbi request reprint Polymorphism in the peroxisome proliferator-activated receptor-gamma gene in women with polycystic ovary syndrome
    S Korhonen
    Department of Obstetrics and Gynaecology, Central Hospital of Mikkeli, 50100 Mikkeli, Finland
    Hum Reprod 18:540-3. 2003
    ....
  28. ncbi request reprint Elevated maternal serum hCG in the second trimester increases prematurity rate and need for neonatal intensive care in primiparous preeclamptic pregnancies
    A Heikkilä
    Department of Obstetrics and Gynecology, University Hospital of Kuopio, Kuopio, Finland
    Hypertens Pregnancy 20:99-106. 2001
    ..This study was designed to investigate the association between the serum concentrations of maternal second trimester human chorionic gonadotropin (hCG) and the severity of preeclampsia...
  29. pmc Apolipoprotein E alleles in women with pre-eclampsia
    N Makkonen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, 70211 Kuopio, Finland
    J Clin Pathol 54:652-4. 2001
    ..To investigate the frequency of three apolipoprotein E (apoE) alleles among women with pre-eclampsia...
  30. ncbi request reprint Antenatal gene tests in low-risk pregnancies: molecular screening for aspartylglucosaminuria (AGU) and infantile neuronal ceroid lipofuscinosis (INCL) in Finland
    J Kallinen
    Department of Obstetrics and Gynecology, University Hospital of Kuopio, Finland
    Prenat Diagn 21:409-12. 2001
    ..Antenatal screening for gene defects was feasible and well accepted, and it provided an effective way to find carriers of genetic diseases and to incorporate prenatal testing into this process...
  31. ncbi request reprint M385T polymorphism in the factor V gene, but not Leiden mutation, is associated with placental abruption in Finnish women
    E Jaaskelainen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, 70211 Kuopio, Finland
    Placenta 25:730-4. 2004
    ..519 (95% CI 0.272-0.987). We conclude that T385 is less frequent among the patient group than in the control group. The M385T variant in the factor V gene other than the Leiden mutation may play a role in disease susceptibility...
  32. ncbi request reprint Screening for BRCA1 and BRCA2 mutations in Eastern Finnish breast/ovarian cancer families
    J M Hartikainen
    Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Kuopio, Kuopio, Finland
    Clin Genet 72:311-20. 2007
    ....
  33. ncbi request reprint Lack of association between C-850T polymorphism of the gene encoding tumor necrosis factor-alpha and polycystic ovary syndrome
    S Korhonen
    Department of Obstetrics and Gynecology, Mikkeli Central Hospital, Kuopio, Finland
    Gynecol Endocrinol 16:271-4. 2002
    ..The observed profiles of allele and genotype frequencies confirm an equilibrium state between C-850T polymorphism and PCOS and suggest that polymorphism of the TNF-alpha gene is unlikely to contribute to the risk of PCOS...
  34. ncbi request reprint Polymorphism of the interleukin 1 receptor antagonist (IL1Ra) gene and placental abruption
    E Jaaskelainen
    Department of Obstetrics and Gynaecology, University Hospital of Kuopio, Kuopio 70211, Finland
    J Reprod Immunol 79:58-62. 2008
    ..4%) and the general population (1.0%) but the difference was not statistically significant. We conclude that there is no significant difference in IL1Ra polymorphisms between patients with and without placental abruption...
  35. ncbi request reprint Association of single nucleotide polymorphisms of the bile salt export pump gene with intrahepatic cholestasis of pregnancy
    M L Eloranta
    Dept of Obstetrics and Gynecology, Kuopio University and University Hospital, Kuopio, Finland
    Scand J Gastroenterol 38:648-52. 2003
    ..We determined whether genetic variability in the gene encoding the bile salt export pump (BSEP) contributes to individual differences in susceptibility to the development of intrahepatic cholestasis of pregnancy (ICP)...
  36. ncbi request reprint Antenatal genetic screening for congenital nephrosis
    J Kallinen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Finland
    Prenat Diagn 21:81-4. 2001
    ..The results indicate that in single-gene disorders genetic testing is suitable for antenatal screening...
  37. doi request reprint Cotargeting of VEGFR-1 and -3 and angiopoietin receptor Tie2 reduces the growth of solid human ovarian cancer in mice
    H Sallinen
    Department of Molecular Medicine, AI Virtanen Institute, University of Eastern Finland, Kuopio, Finland
    Cancer Gene Ther 18:100-9. 2011
    ..In conclusion, combined inhibition of VEGFR-1, VEGFR-3 and Tie2 pathways was safe and provided efficient therapy for ovarian cancer in mice...
  38. ncbi request reprint Wide scope prenatal diagnosis at Kuopio University Hospital 1997-1998: integration of gene tests and fetal karyotyping
    J Kallinen
    Department of Obstetrics and Gynaecology, University Hospital of Kuopio, Finland
    BJOG 108:505-9. 2001
    ..The major benefit is that there is no need to consider extra invasive tests when carriership is detected. Incorporation of genetic testing into fetal karyotyping gives more security to future parents...
  39. ncbi request reprint Feasibility and acceptance of screening for fragile X mutations in low-risk pregnancies
    M Ryynanen
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland
    Eur J Hum Genet 7:212-6. 1999
    ..This observational and interventional study demonstrates that antenatal screening provides an effective way of identifying carriers and incorporating prenatal testing into this process...
  40. doi request reprint The effects of pre- and post-pregnancy inflammatory bowel disease diagnosis on birth outcomes
    K Raatikainen
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland
    Aliment Pharmacol Ther 33:333-9. 2011
    ..Inflammatory bowel diseases are frequent in women at their optimum age for reproduction. Possible effects on pregnancy are therefore of interest...
  41. ncbi request reprint Obstetric prognosis in second pregnancy after preeclampsia in first pregnancy
    N Makkonen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Finland
    Hypertens Pregnancy 19:173-81. 2000
    ..A genetic susceptibility to preeclampsia alone has minor effects on pregnancy outcome in a second pregnancy if the disease does not recur...
  42. ncbi request reprint Risk of obstetric cholestasis in sisters of index patients
    M L Eloranta
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland
    Clin Genet 60:42-5. 2001
    ..The sisters of index patients are at an increased risk of the disorder and may benefit from close obstetric care...
  43. ncbi request reprint Recurrence risk of a serious, noninherited chromosomal abnormality
    M Ryynanen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Finland
    Fertil Steril 68:439-42. 1997
    ..To investigate the recurrence risk of a serious, noninherited chromosomal abnormality...
  44. ncbi request reprint Sensorineural hearing loss after epidural block for labor analgesia: a case report
    A Hyvarinen
    Department of Otorhinolaryngology, Kuopio University Hospital, Kuopio, Finland
    Acta Obstet Gynecol Scand 85:1403-5. 2006
  45. ncbi request reprint Low-dose aspirin does not improve ovarian responsiveness or pregnancy rate in IVF and ICSI patients: a randomized, placebo-controlled double-blind study
    M Pakkila
    Department of Obstetrics and Gynecology, University of Oulu, Infertility Clinic, Family Federation of Finland, 90220 Oulu, Finland
    Hum Reprod 20:2211-4. 2005
    ..The aim of the present study was to test the hypothesis that low-dose aspirin started prior to controlled ovarian stimulation improves ovarian responsiveness, pregnancy rate (PR) and pregnancy outcome...
  46. ncbi request reprint Elevated serum erythropoietin concentration is associated with coordinated changes in red blood cell and reticulocyte indices of pregnant women at term
    M Ervasti
    Laboratory Center, Department of Clinical Chemistry and Hematology, Kuopio University Hospital, Kuopio, Finland
    Scand J Clin Lab Invest 68:160-5. 2008
    ..This could be explained by subclinical iron deficiency being accompanied by a compensatory EPO response...
  47. ncbi request reprint Psoriasin, a calcium-binding protein with chemotactic properties is present in the third trimester amniotic fluid
    S Porre
    Department of Clinical Microbiology, University of Kuopio, FIN 70211, Kuopio, Finland
    Mol Hum Reprod 11:87-92. 2005
    ..Because of its chemokine-like activity, psoriasin present in the amniotic fluid might have consequential immunobiological effects during the fetal development...
  48. ncbi request reprint Transfection of oocytes and other types of ovarian cells in rabbits after direct injection into uterine arteries of adenoviruses and plasmid/liposomes
    A Laurema
    A I Virtanen Institute, Kuopio, Finland
    Gene Ther 10:580-4. 2003
    ..It is concluded that the presence of a high concentration of adenovirus or plasmid vectors via the uterine artery may lead to transfection of zona-pellucida-free oocytes and other ovarian cells...
  49. doi request reprint MR pelvimetry measurements, analysis of inter- and intra-observer variation
    U Korhonen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Finland
    Eur J Radiol 75:e56-61. 2010
    ..To set reference standards and then to evaluate the measurement variation in magnetic resonance (MR) pelvimetry between observations and observers...
  50. ncbi request reprint Evaluation of first trimester maternal serum and ultrasound screening for Down's syndrome in Eastern and Northern Finland
    M Niemimaa
    Department of Obstetrics and Gynaecology, Oulu University Hospital, Oulo, Finland
    Eur J Hum Genet 9:404-8. 2001
    ....
  51. doi request reprint Umbilical cord length in singleton gestations: a Finnish population-based retrospective register study
    L Georgiadis
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, P O Box 100, 70029 Kuopio, Finland University of Eastern Finland, Department of Clinical Medicine, P O Box 1627, 70211 Kuopio, Finland Electronic address
    Placenta 35:275-80. 2014
    ..It is important to examine the variation in length, in order to identify normal and abnormal conditions. Moreover, the factors influencing cord growth and development are not precisely known...
  52. ncbi request reprint Fear of childbirth in nulliparous and multiparous women: a population-based analysis of all singleton births in Finland in 1997-2010
    S Raisanen
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, Kuopio, Finland
    BJOG 121:965-70. 2014
    ..To identify risk factors for fear of childbirth (FOC) according to parity and socioeconomic status, and to evaluate associations between FOC and adverse perinatal outcomes...
  53. doi request reprint Ethical aspects of human placental perfusion: interview of the mothers donating placenta
    A Halkoaho
    Faculty of Health Sciences, University of Eastern Finland, Research Unit, University Hospital of Kuopio, KYS, Research Ethics Committee, Kuopio, Finland
    Placenta 31:686-90. 2010
    ..Third, the trust of participants depended on the multidisciplinary collaboration between the researchers and hospital personnel and this trust was enhanced by a thorough, objective and fair informed consent procedure...
  54. ncbi request reprint Reproductive risk factors, pregnancy characteristics and obstetric outcome in female doctors
    Seppo Heinonen
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland
    BJOG 109:261-4. 2002
    ..To compare maternal risk factors, pregnancy characteristics and outcome in female doctors, teachers, and the general obstetric population...
  55. ncbi request reprint Anaemia in the first but not in the second or third trimester is a risk factor for low birth weight
    Henna Hämäläinen
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland
    Clin Nutr 22:271-5. 2003
    ..To assess pregnancy outcome in women with anaemia during pregnancy...
  56. ncbi request reprint Transduction patterns and efficiencies in rabbit uterine tissues after intraluminal uterine adenovirus administration vary with the reproductive cycle
    Anniina Laurema
    A I Virtanen Institute, Kuopio, Finland
    Acta Obstet Gynecol Scand 86:1035-40. 2007
    ..This study was undertaken to investigate the potential of gene therapy to transfect and destroy endometriun at different stages of the reproductive cycle in rabbits...
  57. ncbi request reprint Placental ratio and risk of velamentous umbilical cord insertion are increased in women with placenta previa
    Marjo Papinniemi
    Department of Obstetrics and Gynecology, Kuopio University and University Hospital, Kuopio, Finland
    Am J Perinatol 24:353-7. 2007
    ..4, and 3.4, respectively. In conclusion, placenta previa is an infrequent pregnancy complication associated with multiparity, advanced maternal age, infertility problems, elevated placental ratio, and velamentous umbilical cord insertion...
  58. ncbi request reprint Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are associated with polycystic ovary syndrome
    Seija Korhonen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Fertil Steril 79:1353-7. 2003
    ..To determine whether genetic variability in the gene encoding microsomal epoxide hydrolase (EPHX) contributes to individual differences in susceptibility to the development of polycystic ovary syndrome (PCOS)...
  59. ncbi request reprint Smoking in early gestation or through pregnancy: a decision crucial to pregnancy outcome
    Kaisa Raatikainen
    Department of Obstetrics and Gynaecology, PO Box 1777, Kuopio University Hospital, 70211 Kuopio, Finland
    Prev Med 44:59-63. 2007
    ..To assess maternal risk profile and pregnancy outcome of women who continued to smoke, reduced smoking to less than five cigarettes per day or did not smoke during pregnancy...
  60. ncbi request reprint MTHFR C677T polymorphism is not associated with placental abruption or preeclampsia in Finnish women
    Ester Jääskeläinen
    Department of Obstetrics and Gynecology, Kuopio University and University Hospital, Kuopio, Finland
    Hypertens Pregnancy 25:73-80. 2006
    ..The aim of our study was to examine genetic variability in the gene encoding methylenetetrahydrofolate reductase (MTHFR) and individual susceptibility to the placental abruption or preeclampsia...
  61. ncbi request reprint Obstetric outcome in post-term pregnancies: time for reappraisal in clinical management
    Minna Hovi
    Department of Gynaecology and Obstetrics, Kuopio University Hospital, Kuopio, Finland
    Acta Obstet Gynecol Scand 85:805-9. 2006
    ..The objective of this study was to determine the outcome of pregnancy in post-term cases compared with term cases in a well defined population receiving modern obstetric care...
  62. ncbi request reprint CTLA-4 polymorphism 49A-G is associated with placental abruption and preeclampsia in Finnish women
    Ester Jääskeläinen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Clin Chem Lab Med 46:169-73. 2008
    ..Our aim was to study genetic variability in the gene encoding cytotoxic T-lymphocyte antigen (CTLA-4) and individual susceptibility to the development of preeclampsia or placental abruption...
  63. ncbi request reprint Subtle changes in ADMA and l-arginine concentrations in normal pregnancies are unlikely to account for pregnancy-related increased flow-mediated dilatation
    Heli Saarelainen
    Department of Ob Gyn, Kuopio University Hospital, University of Kuopio, Kuopio, Finland
    Clin Physiol Funct Imaging 28:120-4. 2008
    ..Our objective was to investigate whether serum concentrations of asymmetric dimethylarginine (ADMA) or l-arginine correlate to hyperlipidemia or endothelial function in normal pregnancy compared with the non-pregnant subjects...
  64. ncbi request reprint A BRCA2 mutation, 4088insA, in a Finnish breast and ovarian cancer family associated with favourable clinical course
    Jaana M Hartikainen
    Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Kuopio, Finland
    Anticancer Res 27:4295-300. 2007
    ..The clinical course and response to treatment in mutation carriers have been reported infrequently and are assumed to be worse than in sporadic breast cancer...
  65. doi request reprint Androgen receptor gene CAG repeat length in women with metabolic syndrome
    Jarmo Jääskeläinen
    Department of Pediatrics, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Gynecol Endocrinol 24:411-6. 2008
    ..We hypothesized that shorter AR (CAG)(n) is associated with metabolic syndrome (MBS) or its components in women...
  66. pmc Polymorphism in the tumor necrosis factor-alpha gene in women with preeclampsia
    Jaana Heiskanen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Finland
    J Assist Reprod Genet 19:220-3. 2002
    ..We determined whether genetic variability in the gene encoding for tumor necrosis factor-alpha (TNF-alpha) contributes to individual differences in susceptibility to the development of preeclampsia...
  67. ncbi request reprint Reproductive risk factors, Doppler findings, and outcome of affected births in placental abruption: a population-based analysis
    Sari Toivonen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Finland
    Am J Perinatol 19:451-60. 2002
    ..Current antepartum methods of detecting uteroplacental problems, including Doppler ultrasonography, are not effective in prenatal prediction of placental abruption. The outcome of affected births is still poor...
  68. ncbi request reprint Polymorphism in the peroxisome proliferator-activated receptor-gamma gene in women with preeclampsia
    Jaana Laasanen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Early Hum Dev 69:77-82. 2002
    ..To investigate peroxisome proliferator-activated receptor-gamma (PPARgamma) genotype frequencies in women with preeclampsia and elucidate its role in the pathogenesis of preeclampsia...
  69. ncbi request reprint Obstetric prognosis after placental abruption
    Sari Toivonen
    Department of Obstetrics Gynecology, Kuopio University Hospital, Kuopio, Finland
    Fetal Diagn Ther 19:336-41. 2004
    ..To assess obstetric outcome in women with a history of placental abruption...
  70. ncbi request reprint Clinical significance of true umbilical knots: a population-based analysis
    Urpu Airas
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Finland
    Am J Perinatol 19:127-32. 2002
    ..Surviving fetuses with true knots are likely to suffer temporary distress during delivery, but affected newborns recover soon after birth. Thus, monitored vaginal delivery appears to be a safe option for fetuses with true knots...
  71. ncbi request reprint Pregnancy-related hyperlipidemia and endothelial function in healthy women
    Heli Saarelainen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, University of Kuopio, Finland
    Circ J 70:768-72. 2006
    ..The purpose of the present study was to investigate pregnancy-related changes in the maternal serum lipid profile and endothelial function...
  72. ncbi request reprint Induced abortion: not an independent risk factor for pregnancy outcome, but a challenge for health counseling
    Kaisa Raatikainen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Finland
    Ann Epidemiol 16:587-92. 2006
    ..The objective of this study is to assess the effects of prior induced abortions on obstetric risk factors and pregnancy outcome in conditions of free high-standard maternity care used by almost the entire pregnant population in Finland...
  73. ncbi request reprint Preeclampsia and androgen receptor gene CAG repeat length: results from both children and women
    Tanja Saarela
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, University of Kuopio, Finland
    J Assist Reprod Genet 22:269-75. 2005
    ..We studied whether the CAG (encoding glutamine) repeat length polymorphism in the first exon of the androgen receptor (AR) gene is predictive of preeclampsia...
  74. ncbi request reprint Androgen receptor gene CAG length polymorphism in women with polycystic ovary syndrome
    Jarmo Jääskeläinen
    Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland
    Fertil Steril 83:1724-8. 2005
    ..To determine whether the CAG repeat length of the androgen receptor (AR) gene contributes to individual differences in the susceptibility to the development of polycystic ovary syndrome (PCOS)...
  75. ncbi request reprint Good outcome of teenage pregnancies in high-quality maternity care
    Kaisa Raatikainen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Eur J Public Health 16:157-61. 2006
    ....
  76. ncbi request reprint Marriage still protects pregnancy
    Kaisa Raatikainen
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland
    BJOG 112:1411-6. 2005
    ..To assess the risk factors and outcome of pregnancy outside marriage in the 1990s, in conditions of a high percentage of extramarital pregnancies and high standard maternity care, used by the entire pregnant population...
  77. ncbi request reprint Plasma cell membrane glycoprotein-1 K121Q polymorphism in preeclampsia
    Tanja Saarela
    Department of Obstetrics and Gynaecology, University of Kuopio, Kuopio, Finland
    Gynecol Obstet Invest 61:124-7. 2006
    ..We wanted to determine whether genetic variability in the gene encoding plasma cell membrane glycoprotein-1 (PC-1) contributes to individual susceptibility to the development of preeclampsia...
  78. ncbi request reprint Low-activity haplotype of the microsomal epoxide hydrolase gene is protective against placental abruption
    Sari Toivonen
    Department of Obstetrics and Gynaecology, Kuopio University and University Hospital, Kuopio, Finland
    J Soc Gynecol Investig 11:540-4. 2004
    ..We wanted to determine whether genetic variability in the gene encoding microsomal epoxide hydrolase (EPHX) contributes to individual differences in susceptibility to the occurrence of placental abruption...
  79. ncbi request reprint Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation
    Fareeza Faisel
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Eur J Hum Genet 12:187-91. 2004
    ..2-5.5). We conclude that the T-A-G haplotype was more frequent among the patient group than in the control group, and genetic variations in the factor V gene other than the Leiden mutation may play a role in disease susceptibility...
  80. ncbi request reprint Community-based, prospective, controlled study of obstetric and neonatal outcome of 179 pregnancies in women with epilepsy
    Katriina Viinikainen
    Department of Neurology, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
    Epilepsia 47:186-92. 2006
    ..This study evaluated obstetric and neonatal outcome in a community-based cohort of women with active epilepsy (WWAE) compared with the general pregnant population receiving modern obstetric care...
  81. ncbi request reprint Polymorphisms of interleukin-6, hepatic lipase and calpain-10 genes, and preeclampsia
    Tanja Saarela
    Department of Obstetrics and Gynecology, University of Kuopio, Finland
    Eur J Obstet Gynecol Reprod Biol 128:175-9. 2006
    ..We determined whether single nucleotide polymorphisms (SNPs) in interleukin-6 (IL-6), hepatic lipase (HL) and calpain-10 (CAPN-10) genes contribute to susceptibility to develop preeclampsia...
  82. ncbi request reprint Transition from overweight to obesity worsens pregnancy outcome in a BMI-dependent manner
    Kaisa Raatikainen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, 70211 Kuopio, Finland
    Obesity (Silver Spring) 14:165-71. 2006
    ..To assess pregnancy outcomes in different BMI groups...
  83. ncbi request reprint [How to improve screening of Down syndrome]
    Markku Ryynanen
    Duodecim 120:354-5; author reply 355-6. 2004
  84. ncbi request reprint Fetal macrosomia--a continuing obstetric challenge
    Nonna Heiskanen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Biol Neonate 90:98-103. 2006
    ..Macrosomic fetuses represent a continuing challenge in obstetrics...
  85. ncbi request reprint Tumour necrosis factor-alpha gene haplotype is associated with pre-eclampsia
    Tanja Saarela
    Department of Obstetrics and Gynaecology, University of Kuopio, Kuopio, Finland
    Mol Hum Reprod 11:437-40. 2005
    ..035+/-0.003), compared with the controls. In conclusion, the polymorphisms of the TNF-alpha gene showed a significant haplotype association with susceptibility to pre-eclampsia in the Finnish population...
  86. ncbi request reprint Adiponectin gene haplotype is associated with preeclampsia
    Tanja Saarela
    Department of Obstetrics and Gynaecology, University of Kuopio, Kuopio, Finland
    Genet Test 10:35-9. 2006
    ..042 +/- 0.005). Polymorphisms of the adiponectin gene show a weak, but statistically significant, haplotype association with susceptibility to preeclampsia in Finnish women...
  87. ncbi request reprint Plasminogen activator inhibitor-1 polymorphism in women with pre-eclampsia
    Tanja Häkli
    Department of Obstetrics and Gynecology, Kuopio University and University Hospital, 70211 Kuopio, Finland
    Genet Test 7:265-8. 2003
    ..These results are not suggestive of an important contribution of the PAI1 genotype on preeclampsia across populations...
  88. ncbi request reprint Haplotypic association of DDAH1 with susceptibility to pre-eclampsia
    Fareeza Akbar
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, University of Kuopio, Kuopio, Finland
    Mol Hum Reprod 11:73-7. 2005
    ..93; 95% confidence interval: 1.54-9.99) who had two copies of the high-risk haplotypes (H2 or H3). The observed haplotypic association provides the first evidence of the importance of DDAH1 polymorphisms in pre-eclampsia susceptibility...
  89. ncbi request reprint Maternal serum human chorionic gonadotrophin and pregnancy-associated plasma protein A in twin pregnancies in the first trimester
    Marko Niemimaa
    Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland
    Prenat Diagn 22:183-5. 2002
    ..To determine the levels of free beta-human chorionic gonadotrophin (beta-hCG) and pregnancy-associated plasma protein A (PAPP-A) in twin pregnancies in the first trimester...
  90. ncbi request reprint Normalization of vasoactive changes in preeclampsia precedes clinical recovery
    Nonna Makkonen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, 70211 Kuopio, Finland
    Hypertens Pregnancy 21:51-64. 2002
    ..The objective of this study is to compare the serum levels of fibronectin, nitric oxide (NO), cyclic guanosine-monophosphate, endothelin-1, and 6-keto-prostaglandin-F 1alpha in women with and without preeclampsia before and after delivery...
  91. ncbi request reprint Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia
    Jaana Laasanen
    Department of Obstetrics and Gynecology, Kuopio University and University Hospital, Kuopio, Finland
    Eur J Hum Genet 10:569-73. 2002
    ..61 (95% CI: 1.12-2.32). The use of two intragenic SNPs jointly in haplotype analysis of association demonstrated that the genetically determined high-activity haplotype T-A (Tyr113-His139) was significantly associated with preeclampsia...
  92. ncbi request reprint Genetic alterations in the peritumoral stromal cells of malignant and borderline epithelial ovarian tumors as indicated by allelic imbalance on chromosome 3p
    Hanna Tuhkanen
    Department of Pathology and Forensic Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Int J Cancer 109:247-52. 2004
    ....
  93. ncbi request reprint Fetal membranes act as a barrier for adenoviruses: gene transfer into exocoelomic cavity of rat fetuses does not affect cells in the fetus
    Anniina Laurema
    A I Virtanen Institute, University of Kuopio, Finland
    Am J Obstet Gynecol 190:264-7. 2004
    ..Our aim was to examine whether the exocoelomic cavity between amniotic and chorionic membranes offers a minimally invasive route for gene transfer to the fetus during early pregnancy...
  94. ncbi request reprint A survey of the attitudes of infertile and parous women towards the availability of assisted reproductive technology
    Katri Heikkilä
    Department of Obstetrics and Gynaecology, Kuopio University and University Hospital, 70211 Kuopio, Finland
    BJOG 111:1229-35. 2004
    ..The aim of the study was to assess differences in attitudes towards aspects of assisted reproduction technology between infertile and parous women...
  95. ncbi request reprint Fibrinogen and factor VII promoter polymorphisms in women with preeclampsia
    Jaana Laasanen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Obstet Gynecol 100:317-20. 2002
    ..To determine whether genetic variability in the promoter regions of the genes encoding fibrinogen and factor VII contribute to individual differences in susceptibility to the development of preeclampsia...
  96. ncbi request reprint Tumor suppressor and growth regulatory genes are overexpressed in severe early-onset preeclampsia--an array study on case-specific human preeclamptic placental tissue
    Annaleena Heikkilä
    A I Virtanen Institute, University of Kuopio, Kuopio, Finland
    Acta Obstet Gynecol Scand 84:679-89. 2005
    ..We used DNA array technique to compare placental gene expression profile in severe early-onset preeclampsia from 25 to 27 gestational weeks with strictly non-affected placental samples from similar gestational weeks...
  97. ncbi request reprint A highly reproducible xenograft model for human ovarian carcinoma and application of MRI and ultrasound in longitudinal follow-up
    Hanna Sallinen
    Department of Molecular Medicine, A I Virtanen Institute, University of Kuopio, PO Box 1627, FIN 70211, Finland
    Gynecol Oncol 103:315-20. 2006
    ..We have established and characterized a new animal model for human ovarian cancer in nude mouse...
  98. ncbi request reprint Polymorphism in the interleukin 1 receptor antagonist gene in women with preeclampsia
    Fareeza Faisel
    Department of Obstetrics and Gynecology, Kuopio University and University Hospital, 70211 Kuopio, Finland
    J Reprod Immunol 60:61-70. 2003
    ..Using population frequencies as a reference, an association between IL1Ra polymorphism and preeclampsia was apparent, although the clinical importance of this finding is not clear...
  99. ncbi request reprint First trimester Down's syndrome screening shows high detection rate for trisomy 21, but poor performance in structural abnormalities--regional outcome results
    Anne Rissanen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Fetal Diagn Ther 22:45-50. 2007
    ....
  100. ncbi request reprint The influence of smoking on the pregnancy-associated plasma protein A, free beta human chorionic gonadotrophin and nuchal translucency
    Marko Niemimaa
    Department of Obstetrics and Gynaecology, Oulu University Hospital, Finland
    BJOG 110:664-7. 2003
    ..To analyse the effects of smoking on first trimester parameters used in prenatal screening for Down's Syndrome...
  101. ncbi request reprint The androgenic sex hormone profile is an essential feature of metabolic syndrome in premenopausal women: a controlled community-based study
    Seija Korhonen
    Department of Obstetrics and Gynecology, Mikkeli Central Hospital, Mikkeli, Finland
    Fertil Steril 79:1327-34. 2003
    ..To evaluate sex hormones in premenopausal white women with metabolic syndrome (MBS)...