I T Harvima

Summary

Affiliation: Kuopio University Hospital
Country: Finland

Publications

  1. ncbi request reprint Decreased chymase activity is associated with increased levels of protease inhibitors in mast cells of psoriatic lesions
    I T Harvima
    Department of Dermatology, Kuopio University Hospital, Finland
    Acta Derm Venereol 79:98-104. 1999
  2. ncbi request reprint Hyaluronic acid inhibits the adherence and growth of monolayer keratinocytes but does not affect the growth of keratinocyte epithelium
    Ilkka T Harvima
    Department of Dermatology, Kuopio University Hospital, 70211, Kuopio, Finland
    Arch Dermatol Res 298:207-19. 2006
  3. doi request reprint Is there a role for mast cells in psoriasis?
    Ilkka T Harvima
    Department of Dermatology, Kuopio University Hospital and University of Kuopio, P O Box 1777, 70211, Kuopio, Finland
    Arch Dermatol Res 300:461-78. 2008
  4. doi request reprint Induction of matrix metalloproteinase-9 in keratinocytes by histamine
    Ilkka T Harvima
    Department of Dermatology, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
    J Invest Dermatol 128:2748-50. 2008
  5. doi request reprint Stress, the neuroendocrine system and mast cells: current understanding of their role in psoriasis
    Ilkka T Harvima
    Department of Dermatology, Kuopio University Hospital and University of Eastern Finland, 70210 Kuopio, Finland
    Expert Rev Clin Immunol 8:235-41. 2012
  6. pmc Elevated levels of serum IL-5 are associated with an increased likelihood of major depressive disorder
    Antti Pekka Elomaa
    Department of Psychiatry, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland
    BMC Psychiatry 12:2. 2012
  7. pmc Cervical squamous carcinoma cells are resistant to the combined action of tumor necrosis factor-alpha and histamine whereas normal keratinocytes undergo cytolysis
    Nicolae Costin Diaconu
    Department of Dermatology, University of Kuopio, Kuopio, Finland
    BMC Cancer 8:46. 2008
  8. ncbi request reprint Heparin modulates the growth and adherence and augments the growth-inhibitory action of TNF-alpha on cultured human keratinocytes
    Ilkka T Harvima
    Department of Dermatology, Kuopio University Hospital, Kuopio, Finland
    J Cell Biochem 92:372-86. 2004
  9. ncbi request reprint Role of mast cells and sensory nerves in skin inflammation
    I T Harvima
    Department of Dermatology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland
    G Ital Dermatol Venereol 145:195-204. 2010
  10. doi request reprint Mast cells as regulators of skin inflammation and immunity
    Ilkka T Harvima
    Department of Dermatology, University of Eastern Finland and Kuopio University Hospital, P O Box 1777, FIN 70210 Kuopio, Finland
    Acta Derm Venereol 91:644-50. 2011

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Decreased chymase activity is associated with increased levels of protease inhibitors in mast cells of psoriatic lesions
    I T Harvima
    Department of Dermatology, Kuopio University Hospital, Finland
    Acta Derm Venereol 79:98-104. 1999
    ..Thus, active tryptase could promote inflammation but chymase seems not to be an important mediator in the pathomechanism of psoriasis...
  2. ncbi request reprint Hyaluronic acid inhibits the adherence and growth of monolayer keratinocytes but does not affect the growth of keratinocyte epithelium
    Ilkka T Harvima
    Department of Dermatology, Kuopio University Hospital, 70211, Kuopio, Finland
    Arch Dermatol Res 298:207-19. 2006
    ..In conclusion, HA can inhibit the growth and adherence of proliferating monolayer keratinocytes, but it has no apparent effect on the growth and migration of keratinocyte epithelium...
  3. doi request reprint Is there a role for mast cells in psoriasis?
    Ilkka T Harvima
    Department of Dermatology, Kuopio University Hospital and University of Kuopio, P O Box 1777, 70211, Kuopio, Finland
    Arch Dermatol Res 300:461-78. 2008
    ..Due to the intimate involvement of mast cells in immunity and chronic inflammation the role of mast cells in psoriasis is discussed in this review...
  4. doi request reprint Induction of matrix metalloproteinase-9 in keratinocytes by histamine
    Ilkka T Harvima
    Department of Dermatology, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
    J Invest Dermatol 128:2748-50. 2008
    ....
  5. doi request reprint Stress, the neuroendocrine system and mast cells: current understanding of their role in psoriasis
    Ilkka T Harvima
    Department of Dermatology, Kuopio University Hospital and University of Eastern Finland, 70210 Kuopio, Finland
    Expert Rev Clin Immunol 8:235-41. 2012
    ..Therefore, the role of stress, the neuroendocrine system and mast cells in psoriasis is discussed in this article...
  6. pmc Elevated levels of serum IL-5 are associated with an increased likelihood of major depressive disorder
    Antti Pekka Elomaa
    Department of Psychiatry, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland
    BMC Psychiatry 12:2. 2012
    ..Nevertheless, relatively little is known about the role of the T-helper (Th)-2 effector cytokines interleukin (IL)-5 and IL-13 in MDD...
  7. pmc Cervical squamous carcinoma cells are resistant to the combined action of tumor necrosis factor-alpha and histamine whereas normal keratinocytes undergo cytolysis
    Nicolae Costin Diaconu
    Department of Dermatology, University of Kuopio, Kuopio, Finland
    BMC Cancer 8:46. 2008
    ..Both histamine and TNF-alpha are potent preformed mast cell mediators and they can act simultaneously after release from mast cells. Thus, the effect of TNF-alpha and histamine on cervical carcinoma cell lines was studied...
  8. ncbi request reprint Heparin modulates the growth and adherence and augments the growth-inhibitory action of TNF-alpha on cultured human keratinocytes
    Ilkka T Harvima
    Department of Dermatology, Kuopio University Hospital, Kuopio, Finland
    J Cell Biochem 92:372-86. 2004
    ..In conclusion, heparin not only inhibits or modulates keratinocyte growth and adherence but it also binds and potentiates the growth-inhibitory function of TNF-alpha...
  9. ncbi request reprint Role of mast cells and sensory nerves in skin inflammation
    I T Harvima
    Department of Dermatology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland
    G Ital Dermatol Venereol 145:195-204. 2010
    ..Hence, in this review the current understanding of the role of cutaneous mast cells and sensory nerves and their activation in psychic stress is discussed...
  10. doi request reprint Mast cells as regulators of skin inflammation and immunity
    Ilkka T Harvima
    Department of Dermatology, University of Eastern Finland and Kuopio University Hospital, P O Box 1777, FIN 70210 Kuopio, Finland
    Acta Derm Venereol 91:644-50. 2011
    ..However, the mechanisms that switch the proinflammatory function of mast cells to an immunosuppressive one are unknown. In this review, the immunoregulatory function of mast cells and its relation to skin inflammation are discussed...
  11. ncbi request reprint Interleukin-4-positive mast cells are highly associated with the extent of immediate allergic wheal reaction in the skin
    J V Saarinen
    Department of Dermatology, Kuopio University Hospital, Finland
    Allergy 56:58-64. 2001
    ..CONCLUSIONS: The novel finding was that IL-4-positive, but not tryptase- and chymase-positive, mast cells are intimately associated with the extent of the prick-test wheal...
  12. ncbi request reprint The release of histamine is associated with the inactivation of mast cell chymase during immediate allergic wheal reaction in the skin
    J V Saarinen
    Departments of Dermatology and Clinical Pathology, Kuopio University Hospital, Kuopio, Finland
    Clin Exp Allergy 31:593-601. 2001
    ..This inactivation is associated with the release of histamine...
  13. ncbi request reprint Alterations in mast cells showing tryptase and chymase activity in epithelializating and chronic wounds
    M Huttunen
    Department of Dermatology, Kuopio University Hospital, Finland
    Exp Dermatol 9:258-65. 2000
    ..Thus it seems, that mast cells attempt to control hyperproliferation of epidermis in chronic wounds...
  14. ncbi request reprint Inhibition of keratinocyte growth in cell culture and whole skin culture by mast cell mediators
    M Huttunen
    Department of Dermatology, Kuopio University Hospital, Kuopio, Finland
    Exp Dermatol 10:184-92. 2001
    ..Thus, mast cells are assumed to control epidermal regeneration and to impair epithelialization of chronic ulcers...
  15. ncbi request reprint Quantitative digital image analysis applied to demonstrate the stratified distribution of involucrin in organ cultured human skin
    P K Kivinen
    Department of Dermatology, University of Kuopio, Finland
    Arch Dermatol Res 291:217-23. 1999
    ..Although the detection method was used to study the histochemistry of skin, it could easily be applied to other tissues as well...
  16. ncbi request reprint Release of soluble tryptase but only minor amounts of chymase activity from cutaneous mast cells
    P K Kivinen
    Department of Dermatology, Kuopio University Hospital, P.O.B. 1777, Kuopio, Finland
    Exp Dermatol 10:246-55. 2001
    ..Instead, chymase is partially inactivated and the remaining chymase activity persists at the site of degranulation having only local effects...
  17. pmc Experimentally induced psoriatic lesion associates with interleukin (IL)-6 in mast cells and appearance of dermal cells expressing IL-33 and IL-6 receptor
    M M Suttle
    Department of Dermatology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    Clin Exp Immunol 169:311-9. 2012
    ..This suggests that a previously unrecognized vicious circle may develop in the early psoriatic lesion...
  18. ncbi request reprint Mast cell tryptase and chymase in chronic leg ulcers: chymase is potentially destructive to epithelium and is controlled by proteinase inhibitors
    M Huttunen
    Department of Dermatology, Kuopio University Hospital, POB 1777, 70211 Kuopio, Finland
    Br J Dermatol 152:1149-60. 2005
    ..Tryptase and chymase are the major mediators of mast cells, but their significance is mostly dependent on their activity. In addition, the proteinases may affect ulcer epithelialization...
  19. ncbi request reprint The allosteric effect of salt on human mast cell tryptase
    I T Harvima
    Department of Dermatology, University of Kuopio, Finland
    Biochim Biophys Acta 956:133-9. 1988
    ..The present results indicate that the salt acts on tryptase as an allosteric effector, and this should be carefully considered when enzyme kinetic parameters and enzyme activity of skin tryptase are measured...
  20. ncbi request reprint The increase in tryptase- and chymase-positive mast cells is associated with partial inactivation of chymase and increase in protease inhibitors in basal cell carcinoma
    N C Diaconu
    Department of Dermatology, University Hospital, University of Kuopio, 70211 Kuopio, Finland
    J Eur Acad Dermatol Venereol 21:908-15. 2007
    ..The serine proteinases tryptase and chymase are the major mediators in mast cell granules and they may exert their enzymatic activity in the BCC lesion by inducing matrix remodeling and epithelial cell detachment...
  21. ncbi request reprint Modulation of the immediate allergic wheal reaction in the skin by drugs inhibiting the effects of leukotriene C4 and prostaglandin D2
    J V Saarinen
    Department of Dermatology, Kuopio University Hospital, P.O. Box 1777, FIN-70211 Kuopio, Finland
    Eur J Clin Pharmacol 57:1-4. 2001
    ....
  22. doi request reprint OX40 ligand and OX40 are increased in atopic dermatitis lesions but do not correlate with clinical severity
    T Ilves
    Department of Dermatology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    J Eur Acad Dermatol Venereol 27:e197-205. 2013
    ..The interaction between the OX40 ligand (OX40L) and OX40 has been suggested to have pathogenetic significance in atopic dermatitis (AD)...
  23. ncbi request reprint Retinoic acid inhibits in vitro development of mast cells but has no marked effect on mature human skin tryptase- and chymase-positive mast cells
    Malin Hjertson
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    J Invest Dermatol 120:239-45. 2003
    ..Our results suggest that retinoic acid suppresses commitment of progenitor cells into the mast cell lineage and/or acts on early mast cell progenitors, whereas mature cutaneous mast cells are less susceptible to retinoic acid...
  24. ncbi request reprint Mast cell survival and apoptosis in organ-cultured human skin
    Petri K Kivinen
    Department of Dermatology, Kuopio University Hospital, Kuopio, Finland
    Exp Dermatol 12:53-60. 2003
    ..Stem cell factor could not prevent the rapid decrease in mast cell numbers. Histamine and tumor necrosis factor-alpha are possible factors promoting the decline in mast cells...
  25. ncbi request reprint Mast cells, nerves and neuropeptides in atopic dermatitis and nummular eczema
    Anitta Järvikallio
    Department of Dermatology, Kuopio University Hospital, Kuopio, Finland
    Arch Dermatol Res 295:2-7. 2003
    ..The increased SP/CGRP nerves in the epidermis of AD and NE lesions may stimulate keratinocytes to release cytokines which affect various cell types enhancing inflammation...
  26. ncbi request reprint The production of collagen and the activity of mast-cell chymase increase in human skin after irradiation therapy
    Riitta Riekki
    Department of Dermatology, University of Oulu, Oulu, Finland
    Exp Dermatol 13:364-71. 2004
    ..These findings suggest a possible role of mast cells in enhanced skin collagen synthesis and fibrosis induced by radiotherapy...
  27. ncbi request reprint Increase in CD30 ligand/CD153 and TNF-alpha expressing mast cells in basal cell carcinoma
    Nicolae Costin Diaconu
    Department of Dermatology, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Cancer Immunol Immunother 56:1407-15. 2007
    ..These data suggest plausible pathways whereby mast cells can be activated and to interact with other cells and thereby contribute to the tumorigenesis in BCC...
  28. pmc Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion
    Marie Fischer
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Clin Invest 116:2748-56. 2006
    ..These diseases include Hodgkin lymphoma, atopic dermatitis, and psoriasis...
  29. ncbi request reprint Transient production of stem cell factor in dermal cells but increasing expression of Kit receptor in mast cells during normal wound healing
    Maria Huttunen
    Department of Dermatology, Kuopio University Hospital, Finland
    Arch Dermatol Res 294:324-30. 2002
    ....
  30. ncbi request reprint Histamine, but not leukotriene C4, is an essential mediator in cold urticaria wheals
    Pauliina Nuutinen
    Hospital for Skin and Allergic Diseases, Helsinki University Central Hospital, Finland
    Acta Derm Venereol 87:9-13. 2007
    ..In conclusion, the antihistamine is effective and histamine is released, whereas the leukotriene antagonist is not effective and LTC4 is not released in the cold urticaria wheal...