Nicolae Costin Diaconu
Affiliation: Kuopio University Hospital
- Increase in CD30 ligand/CD153 and TNF-alpha expressing mast cells in basal cell carcinomaNicolae Costin Diaconu
Department of Dermatology, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
Cancer Immunol Immunother 56:1407-15. 2007..These data suggest plausible pathways whereby mast cells can be activated and to interact with other cells and thereby contribute to the tumorigenesis in BCC...
- Cervical squamous carcinoma cells are resistant to the combined action of tumor necrosis factor-alpha and histamine whereas normal keratinocytes undergo cytolysisNicolae Costin Diaconu
Department of Dermatology, University of Kuopio, Kuopio, Finland
BMC Cancer 8:46. 2008..Both histamine and TNF-alpha are potent preformed mast cell mediators and they can act simultaneously after release from mast cells. Thus, the effect of TNF-alpha and histamine on cervical carcinoma cell lines was studied...
- Mast cell chymase is present in uterine cervical carcinoma and it detaches viable and growing cervical squamous carcinoma cells from substratum in vitroNicolae Costin Diaconu
Department of Dermatology, University of Eastern Finland and Kuopio University Hospital
Arch Dermatol Res 303:499-512. 2011..It is chymase that appears to be capable of inducing effective detachment of viable and growing SCC cells and therefore, it may release SCC cells from a tumor leading to spreading of malignant cells...