Nicolae Costin Diaconu
Affiliation: Kuopio University Hospital
Diaconu N, Rummukainen J, Mättö M, Naukkarinen A, Harvima R, Pelkonen J, et al
. Cervical squamous carcinoma cells are resistant to the combined action of tumor necrosis factor-alpha and histamine whereas normal keratinocytes undergo cytolysis. BMC Cancer. 2008;8:46 pubmed publisher
..In the cervix carcinoma, the malignant cells may resist this endogenous cytolytic action and TNF-alpha could even enhance carcinoma cell migration. ..
Diaconu N, Rummukainen J, Naukkarinen A, Mättö M, Harvima R, Pelkonen J, et al
. Mast cell chymase is present in uterine cervical carcinoma and it detaches viable and growing cervical squamous carcinoma cells from substratum in vitro. Arch Dermatol Res. 2011;303:499-512 pubmed publisher
..It is chymase that appears to be capable of inducing effective detachment of viable and growing SCC cells and therefore, it may release SCC cells from a tumor leading to spreading of malignant cells. ..