Sami Anttila

Summary

Affiliation: Kuopio University Hospital
Country: Finland

Publications

  1. ncbi request reprint A review of the pharmacological and clinical profile of mirtazapine
    S A Anttila
    Department of Psychogeriatrics, Tampere University Hospital, Fin 33380 Pitkäniemi, Finland
    CNS Drug Rev 7:249-64. 2001
  2. ncbi request reprint Fluvoxamine augmentation increases serum mirtazapine concentrations three- to fourfold
    A K Anttila
    Department of Psychiatry, Tampere University Hospital, Pitkaniemi, Finland
    Ann Pharmacother 35:1221-3. 2001
  3. ncbi request reprint Duloxetine Eli Lilly
    Sami Anttila
    Department of Psychogeriatrics, Tampere University Hospital, Pitkaniemi, Finland
    Curr Opin Investig Drugs 3:1217-21. 2002
  4. ncbi request reprint NOTCH4 gene promoter polymorphism is associated with the age of onset in schizophrenia
    Sami Anttila
    University of Tampere, Medical School, Tampereen yliopisto, Finland
    Psychiatr Genet 13:61-4. 2003
  5. doi request reprint RGS4 polymorphism and response to electroconvulsive therapy in major depressive disorder
    Kaija Huuhka
    University of Tampere, Medical School, Department of Psychiatry, Tampere University Hospital, Tampere, Finland
    Neurosci Lett 437:25-8. 2008
  6. ncbi request reprint Catechol-O-methyltransferase val108/158met genotype and response to antipsychotic medication in schizophrenia
    Ari Illi
    University of Tampere, Medical School, and Tampere University Hospital, Department of Psychiatry, Finland
    Hum Psychopharmacol 22:211-5. 2007
  7. ncbi request reprint Interaction of tumor necrosis alpha - G308A and epidermal growth factor gene polymorphisms in early-onset schizophrenia
    Olli Kampman
    University of Tampere, Medical School, 33014 Tampere, Finland
    Eur Arch Psychiatry Clin Neurosci 255:279-83. 2005
  8. ncbi request reprint Association between the C957T polymorphism of the dopamine D2 receptor gene and schizophrenia
    Kari Hänninen
    South Karelia Central Hospital, Department of Psychiatry, Lappeenranta, Finland
    Neurosci Lett 407:195-8. 2006
  9. doi request reprint ACE polymorphism and response to electroconvulsive therapy in major depression
    Juhani Akseli Stewart
    University of Tampere, Medical School, 33014 Tampere, Finland
    Neurosci Lett 458:122-5. 2009
  10. ncbi request reprint Catechol-O-methyltransferase (COMT) polymorphisms predict treatment response in electroconvulsive therapy
    Sami Anttila
    University of Tampere Medical School, University of Tampere, Tampere, Finland
    Pharmacogenomics J 8:113-6. 2008

Collaborators

Detail Information

Publications26

  1. ncbi request reprint A review of the pharmacological and clinical profile of mirtazapine
    S A Anttila
    Department of Psychogeriatrics, Tampere University Hospital, Fin 33380 Pitkäniemi, Finland
    CNS Drug Rev 7:249-64. 2001
    ..Mirtazapine also appears to be useful in patients suffering from depression comorbid with anxiety symptoms and sleep disturbance. It seems to be safe and effective during long-term use...
  2. ncbi request reprint Fluvoxamine augmentation increases serum mirtazapine concentrations three- to fourfold
    A K Anttila
    Department of Psychiatry, Tampere University Hospital, Pitkaniemi, Finland
    Ann Pharmacother 35:1221-3. 2001
    ..To report two cases of interaction between fluvoxamine and mirtazapine...
  3. ncbi request reprint Duloxetine Eli Lilly
    Sami Anttila
    Department of Psychogeriatrics, Tampere University Hospital, Pitkaniemi, Finland
    Curr Opin Investig Drugs 3:1217-21. 2002
    ..At the same time, Credit Suisse First Boston anticipated launch for late 2002, with US $220 million in duloxetine revenues in 2003 and US $457 million in 2004 [450936]...
  4. ncbi request reprint NOTCH4 gene promoter polymorphism is associated with the age of onset in schizophrenia
    Sami Anttila
    University of Tampere, Medical School, Tampereen yliopisto, Finland
    Psychiatr Genet 13:61-4. 2003
    ..We conducted a prospective case-control study to explore the impact of NOTCH4 T-25C polymorphism on the factors associated with schizophrenia...
  5. doi request reprint RGS4 polymorphism and response to electroconvulsive therapy in major depressive disorder
    Kaija Huuhka
    University of Tampere, Medical School, Department of Psychiatry, Tampere University Hospital, Tampere, Finland
    Neurosci Lett 437:25-8. 2008
    ..According to the present data, the impact of RGS4 genotype is not decisive in major depressive disorder. The results provide preliminary data on the impact of RGS4 polymorphism in treatment response in ECT...
  6. ncbi request reprint Catechol-O-methyltransferase val108/158met genotype and response to antipsychotic medication in schizophrenia
    Ari Illi
    University of Tampere, Medical School, and Tampere University Hospital, Department of Psychiatry, Finland
    Hum Psychopharmacol 22:211-5. 2007
    ..We could not demonstrate any clearly significant effect of this particular COMT genotype in relation to the daily maintenance dosages of antipsychotics in patients with schizophrenia...
  7. ncbi request reprint Interaction of tumor necrosis alpha - G308A and epidermal growth factor gene polymorphisms in early-onset schizophrenia
    Olli Kampman
    University of Tampere, Medical School, 33014 Tampere, Finland
    Eur Arch Psychiatry Clin Neurosci 255:279-83. 2005
    ..On the other hand, the role of cytokines in schizophrenia may involve genetic interactions predisposing early onset of illness...
  8. ncbi request reprint Association between the C957T polymorphism of the dopamine D2 receptor gene and schizophrenia
    Kari Hänninen
    South Karelia Central Hospital, Department of Psychiatry, Lappeenranta, Finland
    Neurosci Lett 407:195-8. 2006
    ..05). Our results are in agreement with an earlier association study suggesting that the C957T C-allele plays a role in the genetic vulnerability for schizophrenia and support the involvement of the DRD2 gene in schizophrenia pathogenesis...
  9. doi request reprint ACE polymorphism and response to electroconvulsive therapy in major depression
    Juhani Akseli Stewart
    University of Tampere, Medical School, 33014 Tampere, Finland
    Neurosci Lett 458:122-5. 2009
    ..Distributions of these genotypes or alleles did not differ between patients and controls. The studied ACE genotype was not associated with ECT results but may be associated with age of onset of the illness in patients with MDD...
  10. ncbi request reprint Catechol-O-methyltransferase (COMT) polymorphisms predict treatment response in electroconvulsive therapy
    Sami Anttila
    University of Tampere Medical School, University of Tampere, Tampere, Finland
    Pharmacogenomics J 8:113-6. 2008
    ..In the present sample, those homozygous to high-active allele of COMT responded significantly more frequently to ECT...
  11. doi request reprint Dopamine 2 receptor C957T and catechol-o-methyltransferase Val158Met polymorphisms are associated with treatment response in electroconvulsive therapy
    Kaija Huuhka
    University of Tampere, Medical School, 33014 University of Tampere, Finland
    Neurosci Lett 448:79-83. 2008
    ..Thus the interaction of these polymorphisms may be associated with response to ECT...
  12. doi request reprint Vascular endothelial growth factor (VEGF) polymorphism is associated with treatment resistant depression
    Merja Viikki
    University of Tampere, Medical School, Tampere, Finland
    Neurosci Lett 477:105-8. 2010
    ..The finding suggests an association between VEGF 2578 C/A polymorphism and treatment resistant depression which is reported for the first time. Further studies with larger samples will be required to confirm the results...
  13. ncbi request reprint Interaction between NOTCH4 and catechol-O-methyltransferase genotypes in schizophrenia patients with poor response to typical neuroleptics
    Sami Anttila
    University of Tampere, Medical School, 33014 University of Tampere, Finland
    Pharmacogenetics 14:303-7. 2004
    ..Our sample consisted of 94 Finnish patients with DSM-IV schizophrenia and 98 controls...
  14. doi request reprint TPH1 218A/C polymorphism is associated with major depressive disorder and its treatment response
    Merja Viikki
    University of Tampere, Medical School, Tampere, Finland Tampere Mental Health Centre, Tampere, Finland
    Neurosci Lett 468:80-4. 2010
    ..Further studies with larger samples will be required to confirm the results...
  15. ncbi request reprint Catechol-O-methyltransferase and monoamine oxidase A genotypes and drug response to conventional neuroleptics in schizophrenia
    Ari Illi
    Department of Psychiatry, Tampere University Hospital, Tampere, Finland
    J Clin Psychopharmacol 23:429-34. 2003
    ..The role of monoamine oxidase A genotype seems to be additive in this respect...
  16. ncbi request reprint Apolipoprotein E polymorphism is associated with age of onset in schizophrenia
    Olli Kampman
    Medical School, University of Tampere, 33014 Tampere, Finland
    J Hum Genet 49:355-9. 2004
    ..APOE epsilon 4/epsilon 4 genotype may be associated with early onset schizophrenia. APOE epsilon 3 allele may function protectively in later onset in this disease...
  17. pmc Association between 5-HT2A, TPH1 and GNB3 genotypes and response to typical neuroleptics: a serotonergic approach
    Sami Anttila
    University of Tampere, Medical School, University of Tampere, Finland
    BMC Psychiatry 7:22. 2007
    ..One major problem in the treatment is finding the right the drug for the right patients. However, pharmacogenetic results in psychiatry can seldom be replicated...
  18. ncbi request reprint Neuregulin genotype and medication response in Finnish patients with schizophrenia
    Olli Kampman
    University of Tampere, Medical School, Tampere, Finland
    Neuroreport 15:2517-20. 2004
    ..The TT genotype was overrepresented in the non-responders group compared with the responders (p=0.013). Further studies are needed to ascertain the significance of neuregulin genotype in medication response to schizophrenia...
  19. ncbi request reprint Dopamine receptor D2 -141C Insertion/Deletion polymorphism in a Finnish population with schizophrenia
    Olli Kampman
    Department of Psychiatry, University of Tampere, Medical School, Tampere, FIN 33014, Finland
    Psychiatry Res 121:89-92. 2003
    ..The findings suggest that the frequency of the -141C Ins/Del polymorphism is lower in Northern Europe compared to other Caucasian and Japanese populations...
  20. ncbi request reprint Brain-derived neurotrophic factor (BDNF) polymorphisms G196A and C270T are not associated with response to electroconvulsive therapy in major depressive disorder
    Kaija Huuhka
    Medical School, University of Tampere, 33014 Tampere, Finland
    Eur Arch Psychiatry Clin Neurosci 257:31-5. 2007
    ..However, within subgroups such as in psychotic and in late-onset depression CC genotype of C270T may predict good response. BDNF may not be associated with response to ECT in general, but some association in subgroups may exist...
  21. doi request reprint TPH2 polymorphisms may modify clinical picture in treatment-resistant depression
    Sami Anttila
    University of Tampere, Medical School, 33014 University of Tampere, Finland
    Neurosci Lett 464:43-6. 2009
    ..03). This polymorphism may be associated with the severity of treatment-resistant depression. ECT may able to counteract a putative genetically driven worse depressive phenotype...
  22. doi request reprint P2RX7 polymorphisms Gln460Arg and His155Tyr are not associated with major depressive disorder or remission after SSRI or ECT
    Merja Viikki
    University of Tampere, Medical School, 33014 University of Tampere, Finland
    Neurosci Lett 493:127-30. 2011
    ..The results suggest that P2RX7 gene polymorphisms Gln460Arg (rs2230912) and His155Tyr (rs208294) are not associated with MDD or remission after SSRI or ECT...
  23. ncbi request reprint The apolipoprotein E polymorphism is not associated with response to electroconvulsive therapy in major depressive disorder
    Martti Huuhka
    University of Tampere, Medical School, 33014 University of Tampere, Finland
    J ECT 21:7-11. 2005
    ..In women, however, epsilon2 allele may play a protective and epsilon4 allele a deleterious role in cognition during ECT...
  24. ncbi request reprint Association of EGF polymorphism with schizophrenia in Finnish men
    Sami Anttila
    University of Tampere, Medical School, Finland
    Neuroreport 15:1215-8. 2004
    ..594 (95% CI 1.347-9.591), p = 0.008). The G allele was also associated with a later age at onset in male patients with schizophrenia. However, no association was found between treatment response and EGF polymorphism...
  25. ncbi request reprint Interaction between angiotensin-converting enzyme and catechol-O-methyltransferase genotypes in schizophrenics with poor response to conventional neuroleptics
    Ari Illi
    Tampere University Hospital, Department of Psychiatry, Tampere, Finland
    Eur Neuropsychopharmacol 13:147-51. 2003
    ..ACE genotype alone did not differ between any groups. This finding may suggest a possible interaction with low activity COMT and high activity ACE genotype in association with poor response to conventional neuroleptics...
  26. ncbi request reprint Epidermal growth factor a61g polymorphism is associated with the age of onset of schizophrenia in male patients
    Kari Hänninen
    Department of Psychiatry, South Karelia Central Hospital, Valto Käkelän katu 14C 6, FIN 53130 Lappeenranta, Finland
    J Psychiatr Res 41:8-14. 2007
    ..However, the EGF G/G genotype, which has been suggested to involve abundant production of EGF, was associated with early onset of schizophrenia in male patients...