Matti Viitasalo

Summary

Affiliation: Helsinki University Central Hospital
Country: Finland

Publications

  1. ncbi request reprint Ratio of late to early T-wave peak amplitude in 24-h electrocardiographic recordings as indicator of symptom history in patients with long-QT Syndrome types 1 and 2
    Matti Viitasalo
    Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    J Am Coll Cardiol 47:112-20. 2006
  2. ncbi request reprint Ambulatory electrocardiographic evidence of transmural dispersion of repolarization in patients with long-QT syndrome type 1 and 2
    Matti Viitasalo
    Department of Medicine, Cardiac Electrophysiology, University of California, San Francisco, USA
    Circulation 106:2473-8. 2002
  3. ncbi request reprint Effects of beta-blocker therapy on ventricular repolarization documented by 24-h electrocardiography in patients with type 1 long-QT syndrome
    Matti Viitasalo
    Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    J Am Coll Cardiol 48:747-53. 2006
  4. doi request reprint U-waves and T-wave peak to T-wave end intervals in patients with catecholaminergic polymorphic ventricular tachycardia, effects of beta-blockers
    Matti Viitasalo
    Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    Heart Rhythm 5:1382-8. 2008
  5. doi request reprint Short-term electrophysiological effects of losartan, bisoprolol, amlodipine, and hydrochlorothiazide in hypertensive men
    Kimmo Porthan
    Helsinki University Central Hospital, Helsinki, Finland
    Ann Med 41:29-37. 2009
  6. doi request reprint Electrocardiographic interventricular dispersion of repolarization during autonomic adaptation in LQT1 subtype of long QT syndrome
    Petri Haapalahti
    Department of Cardiology, Helsinki University Hospital, Helsinki, Finland
    Scand Cardiovasc J 42:130-6. 2008
  7. doi request reprint Electrocardiographic ventricular repolarization during cardiovascular autonomic function testing in patients with arrhythmogenic right ventricular cardiomyopathy
    Petri Haapalahti
    Department of Cardiology, Helsinki University Hospital, Helsinki, Finland
    Scand Cardiovasc J 42:375-82. 2008
  8. doi request reprint Epinephrine bolus test in detecting long QT syndrome mutation carriers with indeterminable electrocardiographic phenotype
    Anna Mari Hekkala
    Helsinki University Hospital, Department of Cardiology, Helsinki, Finland
    Ann Noninvasive Electrocardiol 16:172-9. 2011
  9. pmc Relationship of common candidate gene variants to electrocardiographic T-wave peak to T-wave end interval and T-wave morphology parameters
    Kimmo Porthan
    Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    Heart Rhythm 7:898-903. 2010
  10. ncbi request reprint QRS duration and QT interval predict mortality in hypertensive patients with left ventricular hypertrophy: the Losartan Intervention for Endpoint Reduction in Hypertension Study
    Lasse Oikarinen
    Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland
    Hypertension 43:1029-34. 2004

Detail Information

Publications36

  1. ncbi request reprint Ratio of late to early T-wave peak amplitude in 24-h electrocardiographic recordings as indicator of symptom history in patients with long-QT Syndrome types 1 and 2
    Matti Viitasalo
    Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    J Am Coll Cardiol 47:112-20. 2006
    ..3 +/- 0.8; p < 0.001) and in LQT2 patients (2.6 +/- 1.0 vs. 1.7 +/- 0.5; p < 0.001). The maximal amplitude ratio between late and early T-wave peaks was independently associated with symptom history in both LQT1 and LQT2 patients...
  2. ncbi request reprint Ambulatory electrocardiographic evidence of transmural dispersion of repolarization in patients with long-QT syndrome type 1 and 2
    Matti Viitasalo
    Department of Medicine, Cardiac Electrophysiology, University of California, San Francisco, USA
    Circulation 106:2473-8. 2002
    ..The interval from T-wave peak to T-wave end (TPE interval) is the clinical counterpart of TDR. We explored the relationship of TPE interval to heart rate and to the presence of symptoms in patients with LQT1 and LQT2...
  3. ncbi request reprint Effects of beta-blocker therapy on ventricular repolarization documented by 24-h electrocardiography in patients with type 1 long-QT syndrome
    Matti Viitasalo
    Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    J Am Coll Cardiol 48:747-53. 2006
    ....
  4. doi request reprint U-waves and T-wave peak to T-wave end intervals in patients with catecholaminergic polymorphic ventricular tachycardia, effects of beta-blockers
    Matti Viitasalo
    Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    Heart Rhythm 5:1382-8. 2008
    ..U-wave and T-wave peak to T-wave end interval (TPE) are regarded as electrocardiographic counterparts of DAD and TDR, respectively...
  5. doi request reprint Short-term electrophysiological effects of losartan, bisoprolol, amlodipine, and hydrochlorothiazide in hypertensive men
    Kimmo Porthan
    Helsinki University Central Hospital, Helsinki, Finland
    Ann Med 41:29-37. 2009
    ..Hypertension-induced left ventricular structural remodelling associates with repolarization abnormalities. We investigated if antihypertensive drugs can modulate ventricular repolarization...
  6. doi request reprint Electrocardiographic interventricular dispersion of repolarization during autonomic adaptation in LQT1 subtype of long QT syndrome
    Petri Haapalahti
    Department of Cardiology, Helsinki University Hospital, Helsinki, Finland
    Scand Cardiovasc J 42:130-6. 2008
    ..Experimental studies show lower I(Ks) density and longer action potential duration in left (LV) than in right (RV) ventricle. We studied interventricular dispersion of repolarization in patients with I(Ks) defect during autonomic tests...
  7. doi request reprint Electrocardiographic ventricular repolarization during cardiovascular autonomic function testing in patients with arrhythmogenic right ventricular cardiomyopathy
    Petri Haapalahti
    Department of Cardiology, Helsinki University Hospital, Helsinki, Finland
    Scand Cardiovasc J 42:375-82. 2008
    ..Autonomic interventions might unveil repolarization abnormalities in RV...
  8. doi request reprint Epinephrine bolus test in detecting long QT syndrome mutation carriers with indeterminable electrocardiographic phenotype
    Anna Mari Hekkala
    Helsinki University Hospital, Department of Cardiology, Helsinki, Finland
    Ann Noninvasive Electrocardiol 16:172-9. 2011
    ..We examined how QT intervals are modified by epinephrine bolus in mutation carriers of three major LQTS subtypes with indefinite QT interval...
  9. pmc Relationship of common candidate gene variants to electrocardiographic T-wave peak to T-wave end interval and T-wave morphology parameters
    Kimmo Porthan
    Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    Heart Rhythm 7:898-903. 2010
    ....
  10. ncbi request reprint QRS duration and QT interval predict mortality in hypertensive patients with left ventricular hypertrophy: the Losartan Intervention for Endpoint Reduction in Hypertension Study
    Lasse Oikarinen
    Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland
    Hypertension 43:1029-34. 2004
    ....
  11. doi request reprint Predictive value of electrocardiographic T-wave morphology parameters and T-wave peak to T-wave end interval for sudden cardiac death in the general population
    Kimmo Porthan
    Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Finland
    Circ Arrhythm Electrophysiol 6:690-6. 2013
    ..We assessed the predictive value of electrocardiographic T-wave morphology parameters and TPE for SCD in an adult general population sample...
  12. doi request reprint Predictive value of electrocardiographic QT interval and T-wave morphology parameters for all-cause and cardiovascular mortality in a general population sample
    Kimmo Porthan
    Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    Heart Rhythm 6:1202-8, 1208.e1. 2009
    ..The predictive value of ECG QT interval for mortality in the general population has been weak. Only a few population studies on the predictive value of ECG T-wave morphology parameters for mortality have been reported...
  13. ncbi request reprint Beta1-adrenergic receptor polymorphisms, QTc interval and occurrence of symptoms in type 1 of long QT syndrome
    Kristian J Paavonen
    Department of Medicine, University of Helsinki, 00290 Helsinki, Finland
    Int J Cardiol 118:197-202. 2007
    ....
  14. pmc Comparison of QT peak and QT end interval responses to autonomic adaptation in asymptomatic LQT1 mutation carriers
    Petri Haapalahti
    Department of Cardiology, Laboratory of Clinical Physiology, Helsinki University Hospital, Helsinki, Finland
    Clin Physiol Funct Imaging 31:209-14. 2011
    ..Repolarization abnormalities in LQT1 carriers may therefore be more easily detected in the QT peak intervals...
  15. pmc A common variant near the KCNJ2 gene is associated with T-peak to T-end interval
    Annukka Marjamaa
    Research Program in Molecular Medicine, University of Helsinki, Helsinki, Finland
    Heart Rhythm 9:1099-103. 2012
    ..The genetic factors affecting the TPE interval are largely unknown...
  16. doi request reprint Dynamic QT/RR relationship in post-myocardial infarction patients with and without cardiac arrest
    Jere Järvenpää
    Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    Scand Cardiovasc J 44:352-8. 2010
    ..We tested the hypothesis that dynamic QT/RR relationship might differ between post-MI patients with and without a history of VF. We also evaluated the influence of negative T-waves on the assessment of QT/RR relationship...
  17. ncbi request reprint Temporal repolarization lability differences among genotyped patients with the long QT syndrome
    Kenneth Bilchick
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 94:1312-6. 2004
    ..973 +/- 0.394, p = 0.01 vs controls) and in patients with LQT1 with mutations other than KCNQ1-FIN (-0.942 +/- 0.264, p = 0.04 vs controls) but was similar between the KCNQ1-FIN group and controls...
  18. ncbi request reprint Mutant ryanodine receptors in catecholaminergic polymorphic ventricular tachycardia generate delayed afterdepolarizations due to increased propensity to Ca2+ waves
    Jere Paavola
    Minerva Foundation Institute for Medical Research, FIN 00290, Helsinki, Finland
    Eur Heart J 28:1135-42. 2007
    ..Arrhythmias are caused by gain-of-function defects in RyR2, but cellular arrhythmogenesis remains elusive...
  19. ncbi request reprint Differentiation between LQT1 and LQT2 patients and unaffected subjects using 24-hour electrocardiographic recordings
    Matti Viitasalo
    Department of Medicine, Cardiac Electrophysiology, University of California, San Francisco, San Francisco, California, USA
    Am J Cardiol 89:679-85. 2002
    ....
  20. doi request reprint Vasomotor hot flashes and heart rate variability: a placebo-controlled trial of postmenopausal hormone therapy
    Hanna Lantto
    Division of Clinical Physiology and Nuclear Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Menopause 19:82-8. 2012
    ..The aim of the study was to compare the responses of heart rate variability (HRV) with hormone therapy in recently postmenopausal women with and without vasomotor hot flashes...
  21. pmc Search for cardiac calcium cycling gene mutations in familial ventricular arrhythmias resembling catecholaminergic polymorphic ventricular tachycardia
    Annukka Marjamaa
    Department of Cardiology, University of Helsinki, Helsinki, Finland
    BMC Med Genet 10:12. 2009
    ..We sought to identify mutations in genes affecting cardiac calcium cycling in patients with CPVT and in less typical familial exercise-related ventricular arrhythmias...
  22. ncbi request reprint The effect of antihistamine cetirizine on ventricular repolarization in congenital long QT syndrome
    Anna Mari Hekkala
    Department of Cardiology, Helsinki University Hospital, Helsinki, Finland
    J Cardiovasc Electrophysiol 18:691-5. 2007
    ..Patients with congenital long QT syndrome are particularly vulnerable, but usually electrophysiological effects of drugs have not been assessed in these patients at risk...
  23. ncbi request reprint Reproducibility of computerized measurements of QT interval from multiple leads at rest and during exercise
    Anna Mari Hekkala
    Helsinki University Hospital, Department of Cardiology, Helsinki, Finland
    Ann Noninvasive Electrocardiol 11:318-26. 2006
    ..Accurate measurement of the QT interval is important for diagnosing long QT syndrome (LQTS), and in research on determinants of ventricular repolarization time. We tested automatic analysis of QT intervals from multiple ECG leads on chest...
  24. ncbi request reprint Functional characterization of the common amino acid 897 polymorphism of the cardiac potassium channel KCNH2 (HERG)
    Kristian J Paavonen
    Institute of Biotechnology, Viikinkaari 9, PO Box 56, 00014, University of Helsinki, Helsinki, Finland
    Cardiovasc Res 59:603-11. 2003
    ..To determine whether the amino acid 897 threonine (T) to lysine (K) polymorphism of the KCNH2 (HERG) potassium channel influences channel performance or patient phenotype...
  25. doi request reprint Abnormal repolarization dynamics revealed in exercise test in long QT syndrome mutation carriers with normal resting QT interval
    Anna Mari Hekkala
    Department of Cardiology, Helsinki University Hospital, Helsinki, Finland
    Europace 12:1296-301. 2010
    ..We examined whether physical exercise test could increase the ability to detect the mutation carrier status in phenotypically normal LQTS family members...
  26. ncbi request reprint Relationship of electrocardiographic repolarization measures to echocardiographic left ventricular mass in men with hypertension
    Kimmo Porthan
    Department of Cardiology, Helsinki University Central Hospital, Finland
    J Hypertens 25:1951-7. 2007
    ..We studied whether electrocardiographic repolarization changes are already detectable in mild LVM increase associated with hypertension...
  27. doi request reprint Electrocardiographic transmural dispersion of repolarization in patients with inherited short QT syndrome
    Olli Anttonen
    Department of Medicine, Paijat Hame Central Hospital, Lahti, Finland
    Ann Noninvasive Electrocardiol 13:295-300. 2008
    ..In a clinical study with acquired long QT syndrome patients, TPE/QT ratio > 0.28 indicated arrhythmia risk. We hypothesized that the TPE/QT ratio would be greater in SQTS patients than in control subjects...
  28. pmc High prevalence of four long QT syndrome founder mutations in the Finnish population
    Annukka Marjamaa
    Research Program in Molecular Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Ann Med 41:234-40. 2009
    ..In the present survey, we sought to estimate the actual prevalence of the founder mutations and to determine their effect sizes in the general Finnish population...
  29. ncbi request reprint Ventricular repolarization and heart rate responses during cardiovascular autonomic function testing in LQT1 subtype of long QT syndrome
    Petri Haapalahti
    Department of Cardiology, Helsinki University Hospital, Helsinki, Finland
    Pacing Clin Electrophysiol 29:1122-9. 2006
    ..Sympathetic stimulation aggravates repolarization abnormalities in experimental LQT1 models. We hypothesized that autonomic function tests might reveal the abnormal repolarization in asymptomatic LQT1 patients...
  30. ncbi request reprint Catecholaminergic polymorphic ventricular tachycardia: recent mechanistic insights
    Kimmo Kontula
    Department of Medicine, University of Helsinki, 00290 Helsinki, Finland
    Cardiovasc Res 67:379-87. 2005
    ....
  31. ncbi request reprint Changing capacity of electrocardiographic ventricular repolarization in post-myocardial infarction patients with and without nonfatal cardiac arrest
    Jere Järvenpää
    Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    Am J Cardiol 99:295-9. 2007
    ..01 to <0.001, respectively). In conclusion, long maximal QT interval may not be the key factor exposing patients after MI to VF. Impaired capacity to change QT and TPE intervals seems to be associated with risk of VF after MI...
  32. ncbi request reprint Relation of twelve-lead electrocardiographic T-wave morphology descriptors to left ventricular mass
    Lasse Oikarinen
    Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Am J Cardiol 90:1032-5. 2002
  33. ncbi request reprint Relation of QT interval and QT dispersion to regression of echocardiographic and electrocardiographic left ventricular hypertrophy in hypertensive patients: the Losartan Intervention For Endpoint Reduction (LIFE) study
    Lasse Oikarinen
    Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Am Heart J 145:919-25. 2003
    ..Experimentally, regression of LVH normalizes ventricular electrophysiology...
  34. doi request reprint Association between vasomotor hot flashes and heart rate variability in recently postmenopausal women
    Hanna Hoikkala
    Division of Clinical Physiology and Nuclear Medicine Laboratory Department, Helsinki University Central Hospital, Helsinki, Finland
    Menopause 17:315-20. 2010
    ..The aim of this study was to investigate whether cardiovascular autonomic reactivity and risk profile are associated with the frequency and severity of hot flashes in recently postmenopausal women...
  35. ncbi request reprint Effects of epinephrine on right ventricular monophasic action potentials in the LQT1 versus LQT2 form of long QT syndrome: preferential enhancement of "triangulation" in LQT1
    Matti Viitasalo
    Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    Pacing Clin Electrophysiol 28:219-27. 2005
    ..To explore effects of epinephrine and phenylephrine on the behavior of right ventricular monophasic action potentials (MAPs) in symptomatic LQT1 and LQT2 patients...
  36. pmc Risk stratification in Brugada syndrome
    Kathryn A Glatter
    Department of Cardiology, University of California, Davis, Sacramento, CA 95817, USA
    Lancet 366:530-1. 2005