Research Topics
| T StrandbergSummaryAffiliation: Helsinki University Central Hospital Country: Finland Publications
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Detail Information
Publications
Differing effects of oral and transdermal hormone replacement therapy on cardiovascular risk factors in healthy postmenopausal womenTimo E Strandberg
Department of Medicine, Geriatric Clinic, University of Helsinki, PO Box 340, FIN-00029 HUS, Finland
Am J Cardiol 92:212-4. 2003
Diagnosis and treatment of dyslipidemia are neglected in patients with peripheral artery diseaseHeikki Poussa
Department of Surgery, University of Helsinki, Finland
Scand Cardiovasc J 41:138-41. 2007..Our aim was to investigate how dyslipidemia was diagnosed and treated in patients with peripheral artery disease (PAD) in a university vascular clinic...
C-reactive protein, cardiovascular risk factors, and mortality in a prospective study in the elderlyT E Strandberg
Department of Medicine, University of Helsinki, Helsinki, Finland
Arterioscler Thromb Vasc Biol 20:1057-60. 2000..The results indicate that CRP is associated with several cardiovascular risk factors in the elderly. CRP alone predicts overall and cardiovascular mortality, but the prediction was significant in only the 75-year-old cohort...
Twelve-week, multicenter, randomized, open-label comparison of the effects of rosuvastatin 10 mg/d and atorvastatin 10 mg/d in high-risk adults: a DISCOVERY studyTimo E Strandberg
Department of Medicine, University of Helsinki, PO Box 340 FIN 00029 HUS, Helsinki, Finland
Clin Ther 26:1821-33. 2004..However, approximately 50% to 60% of patients fail to reach recommended cholesterol goals...
Alcohol consumption, 29-y total mortality, and quality of life in men in old ageArto Y Strandberg
Department of Medicine, Geriatric Clinic, University of Helsinki, Helsinki, Finland
Am J Clin Nutr 80:1366-71. 2004..The negative effects of excessive alcohol consumption are well known, but moderate alcohol consumption is advocated for health reasons...
Benefits of optimising drug treatment in home-dwelling elderly patients with coronary artery diseaseTimo Strandberg
Department of Medicine, Geriatric Clinic, University of Helsinki, Helsinki, Finland
Drugs Aging 20:585-95. 2003..At the societal level, this would be reflected in fewer hospitalisations and institutionalisations, which means decreased cost of elderly care...
Mortality and incidence of cancer during 10-year follow-up of the Scandinavian Simvastatin Survival Study (4S)Timo E Strandberg
Department of Medicine, University of Helsinki, Helsinki, PL 340, 00029 HUS, Finland
Lancet 364:771-7. 2004..We extended post-trial follow-up of participants in the Scandinavian Simvastatin Survival Study (4S) to investigate cause-specific mortality and incidence of cancer 5 years after closure of the trial...
Low cholesterol, mortality, and quality of life in old age during a 39-year follow-upTimo E Strandberg
Department of Medicine, Geriatric Clinic, University of Helsinki, Finland
J Am Coll Cardiol 44:1002-8. 2004..We assessed the impact of serum cholesterol level in early midlife on total mortality during up to 39 years of follow-up and on the quality of life (QoL) in old age...
Impact of midlife weight change on mortality and quality of life in old age. Prospective cohort studyT E Strandberg
Department of Medicine, Geriatric Clinic, University of Helsinki, Helsinki, Finland
Int J Obes Relat Metab Disord 27:950-4. 2003..To examine the effects of weight change during midlife on long-term mortality risk and quality of life in old age...
Impact of viral and bacterial burden on cognitive impairment in elderly persons with cardiovascular diseasesTimo E Strandberg
Department of Medicine, Geriatric Clinic, University of Helsinki, PO Box 340, FIN 00029 HUS Helsinki, Finland
Stroke 34:2126-31. 2003..Inflammation and infectious etiology have been implicated in the pathogenesis of dementia. We sought to investigate whether the seropositivity of common infections was associated with cognitive function...
What is the most important component of blood pressure: systolic, diastolic or pulse pressure?Timo E Strandberg
Department of Medicine, Geriatric Clinic, University of Helsinki, Helsinki, Finland
Curr Opin Nephrol Hypertens 12:293-7. 2003..In this review we compare the relative importance of various blood pressure components...
[Prevention of dementia]Timo Strandberg
HYKS:n geriatrian klinikka PL 340, 00029 HUS
Duodecim 119:1525-32. 2003
Associations between change in C-reactive protein and serum lipids during statin treatmentT E Strandberg
Department of Medicine, University of Helsinki, Finland
Ann Med 32:579-83. 2000..The change in HDL cholesterol explained 20% of the change in CRP during statin treatment. The results are in line with previous suggestions that HDL has anti-inflammatory properties...
Blood pressure and mortality during an up to 32-year follow-upT E Strandberg
Department of Medicine, University of Helsinki, Finland
J Hypertens 19:35-9. 2001..Elevated blood pressure is an established risk factor of cardiovascular diseases, but there is a constant debate whether the association is continuous or with a threshold...
Birth outcome in relation to licorice consumption during pregnancyT E Strandberg
Department of Medicine, Faculty of Medicine, University of Helsinki, Helsinki, Finland
Am J Epidemiol 153:1085-8. 2001..In conclusion, heavy glycyrrhizin exposure during pregnancy did not significantly affect birth weight or maternal blood pressure, but it was significantly associated with lower gestational age...
Use of cardiovascular drugs by home-dwelling coronary patients aged 75 years and older. A population-based cross-sectional survey in Helsinki, FinlandT E Strandberg
Department of Medicine, Geriatric Clinic, University of Helsinki, Finland
Eur J Clin Pharmacol 57:513-6. 2001..Elderly individuals constitute an increasing proportion of coronary patients, and up-to-date information is needed of their treatments in the community...
Multifactorial cardiovascular disease prevention in patients aged 75 years and older: A randomized controlled trial: Drugs and Evidence Based Medicine in the Elderly (DEBATE) StudyT E Strandberg
Department of Medicine, Geriatric Clinic, and the Division of Cardiology, University of Helsinki, Helsinki, Finland
Am Heart J 142:945-51. 2001..The aim of the Drug and Evidence Based Medicine in the Elderly (DEBATE) study is to test the applicability and effectiveness of established CVD treatments in elderly patients...
Isolated diastolic hypertension, pulse pressure, and mean arterial pressure as predictors of mortality during a follow-up of up to 32 yearsTimo E Strandberg
Department of Medicine, Geriatric Clinic, University of Helsinki
J Hypertens 20:399-404. 2002..To compare mortality associated with various blood pressure components in middle-aged men during up to 32 years of follow-up...
Possibilities of multifactorial cardiovascular disease prevention in patients aged 75 and older: a randomized controlled trial: Drugs and Evidence Based Medicine in the Elderly (DEBATE) StudyTimo E Strandberg
Department of Medicine, Geriatric Clinic and Division of Cardiology, University of Helsinki, Helsinki, Finland
Eur Heart J 24:1216-22. 2003..The aim of this pre-planned, first-year analysis of the Drugs and Evidence-Based Medicine in the Elderly (DEBATE) Study was to determine the feasibility of prevention efforts in elderly cardiovascular patients...
[Hypertension among very elderly]Timo Strandberg
, HUS
Duodecim 121:1421-6. 2005
Living will, resuscitation preferences, and attitudes towards life in an aged populationMarja Liisa Laakkonen
Helsinki City Hospital Koskela, Helsinki, Finland
Gerontology 50:247-54. 2004..The growth of life-sustaining medical technology and greater attention to medical care at the end of life have provoked interest in issues related to advance care planning...
Use of inappropriate medications and their prognostic significance among in-hospital and nursing home patients with and without dementia in FinlandMinna M Raivio
Department of General Internal Medicine and Geriatrics, University of Helsinki, Finland
Drugs Aging 23:333-43. 2006..This study examines the use of inappropriate drugs and their impact on mortality and use of health services among Finnish elderly nursing home and hospital patients. Patients with dementia were studied as a special subgroup...
Management of nonmalignant pain in home-dwelling older people: a population-based surveyKaisu H Pitkala
Helsinki University Hospital, Department of Medicine, Geriatric Clinic, Helsinki, Finland
J Am Geriatr Soc 50:1861-5. 2002....
The effect of smoking in midlife on health-related quality of life in old age: a 26-year prospective studyArto Y Strandberg
Department of Medicine, Geriatric Clinic, University of Helsinki, PL 340, 00029 Helsinki, Finland
Arch Intern Med 168:1968-74. 2008..This study evaluates the long-term effect of smoking in midlife on health-related quality of life (HRQoL) in old age...
Association between anticholinergic drugs and apolipoprotein E epsilon4 allele and poorer cognitive function in older cardiovascular patients: a cross-sectional studyJuho Uusvaara
Unit of General Practice, Helsinki University Hospital, Helsinki, Finland
J Am Geriatr Soc 57:427-31. 2009..To clarify the association between anticholinergic drugs and apolipoprotein E epsilon4 allele carrier status (APOE4) and cognitive dysfunction...
Inflammation markers and malnutrition as risk factors for infections and impaired health-related quality of life among older nursing home residentsLiisa K Kuikka
University of Helsinki, Department of General Practice and Helsinki University Hospital, Unit of General Practice, Mannerheimintie 172 PL 41, Helsinki, Finland
J Am Med Dir Assoc 10:348-53. 2009..To explore malnutrition and inflammation markers as risk factors for poor outcome such as infections and impaired health-related quality-of-life (HRQoL) among nursing home residents...
Prognostic significance of delirium in frail older peopleKaisu H Pitkala
Department of Medicine, Geriatric Clinic, Helsinki University Hospital, Helsinki, Finland
Dement Geriatr Cogn Disord 19:158-63. 2005..86, 95% CI 1.1-3.1), at 2 years (OR 1.76, 95% CI 1.1-2.8), and for permanent institutionalization (OR 2.45, 95% CI 1.2-4.9). Delirious patients with prior dementia tended to have a better prognosis than those without...
Interaction of herpesviridae, APOE gene, and education in cognitive impairmentTimo E Strandberg
Department of Medicine, Geriatric Clinic, University of Helsinki, P O Box 340, FIN 00029 HUS, Finland
Neurobiol Aging 26:1001-4. 2005....
Preterm birth and licorice consumption during pregnancyTimo E Strandberg
Department of Medicine, University of Helsinki, Finland
Am J Epidemiol 156:803-5. 2002..07, 95% confidence interval: 1.17, 8.05 for the fully adjusted model). In conclusion, heavy glycyrrhizin exposure was associated with preterm delivery and may be a novel marker of this condition...
Predictors of cognitive decline and mortality of aged people over a 10-year periodReijo S Tilvis
Geriatric Clinic, Department of Medicine, Helsinki University Central Hospital, Finland
J Gerontol A Biol Sci Med Sci 59:268-74. 2004..According to the hypothesis of our 10-year prospective study, the predictive values of different risk indicators change over time in a general 75+ population...
Inappropriate drug prescribing in home-dwelling, elderly patients: a population-based surveyKaisu H Pitkala
Department of Medicine, Geriatric Clinic, Helsinki University Hospital, Finland
Arch Intern Med 162:1707-12. 2002..In 1997, a US expert panel developed explicit criteria on potentially inappropriate drugs for the general elderly population...
Clinical findings, outcome and treatment in patients > or = 75 years with acute myocardial infarctionMervi Kotamäki
Department of Medicine, Division of Cardiology, University of Helsinki, Finland
Eur J Epidemiol 18:781-6. 2003..Our aim was to characterize current clinical course, medication and invasive treatment in elderly patients with AMI, compare treatment between sexes and also with data from 1994...
Do gestational age and weight for gestational age predict concordance in parental perceptions of infant temperament?Anu-Katriina Pesonen
Department of Psychology, University of Helsinki, PO Box 9, FI-00014 Helsinki, Finland
J Pediatr Psychol 31:331-6. 2006..Concordance in parental perceptions of an infant born SGA emphasizes the clinical significance of the findings...
Delirium among patients with and without dementia: does the diagnosis according to the DSM-IV differ from the previous classifications?Jouko V Laurila
Department of Medicine, Helsinki University Hospital, Geriatric Clinic, Helsinki, Finland
Int J Geriatr Psychiatry 19:271-7. 2004..The symptom profile of delirium was slightly different among individuals with and without dementia...
Exercise rehabilitation on home-dwelling patients with Alzheimer's disease--a randomized, controlled trial. Study protocolKaisu H Pitkala
Unit of General Practice, Helsinki University Central Hospital, University of Helsinki, PO Box 20, 00014 University of Helsinki, Finland
Trials 11:92. 2010..The aim of this study is to investigate the effectiveness of intensive exercise rehabilitation lasting for one year on mobility and physical functioning of home-dwelling patients with AD...
A follow-up study found that cardiovascular risk in middle age predicted mortality and quality of life in old ageArto Strandberg
Department of Medicine, Geriatric Clinic, University of Helsinki, Haartmaninkatu 4, FIN-00029 Helsinki, Finland
J Clin Epidemiol 57:415-21. 2004..CONCLUSION: Low cardiovascular risk in middle age was associated with lower mortality, morbidity, and better quality of life in old age 26 years later. The results may support the theory of compression of morbidity...
Maternal licorice consumption and detrimental cognitive and psychiatric outcomes in childrenKatri Raikkonen
Department of Psychology, University of Helsinki, Helsinki, Finland
Am J Epidemiol 170:1137-46. 2009..Data are compatible with adverse fetal "programming" by overexposure to glucocorticoids and caution against excessive intake of licorice-containing foodstuffs during pregnancy...
Interest in healthy lifestyle and adherence to medications: Impact on mortality among elderly cardiovascular patients in the DEBATE StudyKaisu H Pitkala
University of Helsinki, Department of Primary Care and General Practice, Helsinki, Finland
Patient Educ Couns 67:44-9. 2007..We examined how a patient-centered consultation can help the physician to evaluate older patients' adherence to medical care and a healthy lifestyle. We hypothesised that an accurate estimate of adherence should be shown in their prognosis...
Multicomponent geriatric intervention for elderly inpatients with delirium: effects on costs and health-related quality of lifeKaisu H Pitkala
Unit of General Practice, University of Helsinki, Finland
J Gerontol A Biol Sci Med Sci 63:56-61. 2008..We studied the effects of multicomponent geriatric treatment on costs of care and HRQoL in delirious inpatients...
Detection and documentation of dementia and delirium in acute geriatric wardsJouko V Laurila
Department of Medicine, Helsinki University Hospital, Geriatric Clinic, Helsinki, Finland
Gen Hosp Psychiatry 26:31-5. 2004..3%) in medical records. In 64/77 (83.1%) cases signs of confusion were recorded in nurses' notes. Poor detection and documentation may lead to undertreatment of both disorders...
The impact of different diagnostic criteria on prevalence rates for deliriumJouko V Laurila
Geriatric Clinic, Department of Medicine, Helsinki University Hospital, HUS, Finland
Dement Geriatr Cogn Disord 16:156-62. 2003..The DSM-IV and ICD-10 had the largest number of patients not overlapping with any other diagnostic group. The newest DSM-IV classification found more cases of delirium especially among acutely ill, hospitalized patients...
Impact of different diagnostic criteria on prognosis of delirium: a prospective studyJouko V Laurila
Geriatric Clinic, Department of Medicine, Helsinki University Hospital, Helsinki, Finland
Dement Geriatr Cogn Disord 18:240-4. 2004..The DSM-IV has simplified the criteria of delirium. It identifies new, acutely ill and relatively nondependent subjects as delirious who share the poor prognosis of patients diagnosed with the previous criteria...
Depressive vulnerability in parents and their 5-year-old child's temperament: a family system perspectiveAnu-Katriina Pesonen
Department of Psychology, University of Helsinki, Helsinki, Finland
J Fam Psychol 20:648-55. 2006..The influence of personality-based depressive traits on child temperamental outcomes and effective parenting is discussed with reference to between-dyad family dynamics...
Fetal programming of temperamental negative affectivity among children born healthy at termAnu-Katriina Pesonen
Department of Psychology, University of Helsinki, P.O. Box 9, 00014, University of Helsinki, Helsinki, Finland
Dev Psychobiol 48:633-43. 2006....
Continuity of father-rated temperament from infancy to middle childhoodNiina Komsi
Department of Psychology, University of Helsinki, Finland
Infant Behav Dev 31:239-54. 2008..These findings give empirical credence to Rothbart's theory and to father-rated temperamental continuity from infancy onwards...
Poor sleep and altered hypothalamic-pituitary-adrenocortical and sympatho-adrenal-medullary system activity in childrenKatri Raikkonen
Department of Psychology, University of Helsinki, P O Box 9 Siltavuorenpenger 20 D, 00014 Helsinki, Finland
J Clin Endocrinol Metab 95:2254-61. 2010..Neuroendocrine alterations, with well-known links with health, may offer insight into why poor sleep is associated with poor health. Yet, studies testing associations between sleep and neuroendocrine activity in children are scarce...
Low low-density lipoprotein cholesterol and cancer riskTimo E Strandberg
J Am Coll Cardiol 51:91-2; author reply 92. 2008
The association between weight gain up to midlife, 30-year mortality, and quality of life in older menTimo E Strandberg
Arch Intern Med 167:2260-1. 2007
Statin treatment is associated with clearly reduced mortality risk of cardiovascular patients aged 75 years and olderTimo E Strandberg
J Gerontol A Biol Sci Med Sci 63:213-4; author reply 214. 2008
Frailty in elderly peopleTimo E Strandberg
University of Oulu, Oulu, FIN-90014, Finland
Lancet 369:1328-9. 2007
Neither atypical nor conventional antipsychotics increase mortality or hospital admissions among elderly patients with dementia: a two-year prospective studyMinna M Raivio
Memory Research and Treatment Centers Finland Medical Center Hemo Oy, Lahti, Finland
Am J Geriatr Psychiatry 15:416-24. 2007..Antipsychotics are widely used to manage behavioral disorders in patients with dementia. Recently, serious concerns have been raised about the stroke and mortality risk of atypical antipsychotics when administered to patients with dementia...
Health-related quality of life in elderly patients with familial hypercholesterolemiaLaura Hyttinen
North Karelia Central Hospital, Joensuu, Finland
Int J Technol Assess Health Care 24:228-34. 2008..The aim of this study was to analyze the health-related quality of life (HRQoL) of elderly patients with FH...
Psychotropic medication and stroke outcomeMinna M Raivio
Am J Psychiatry 162:1027; author reply 1027-8. 2005
Secondary prevention of stroke is important: but all hypertensive drugs are not created equal?Timo E Strandberg
Stroke 36:1225-6. 2005
Physical and cognitive functioning and resuscitation preferences of aged patientsMarja-Lilsa Laakkonen
J Am Geriatr Soc 53:168-70. 2005
Cholesterol and glucose metabolism and recurrent cardiovascular events among the elderly: a prospective studyTimo E Strandberg
Department of Public Health Science and General Practice, University of Oulu, Oulu, Finland
J Am Coll Cardiol 48:708-14. 2006....
Cardiovascular risk in midlife and psychological well-being among older menTimo E Strandberg
Department of Public Health Science and General Practice, University of Oulu, Oulu, Finland
Arch Intern Med 166:2266-71. 2006..We investigated whether cardiovascular disease risk in midlife is related to psychological well-being in older men (aged 69-84 years old)...
Long waiting list for by-pass surgeryTimo E Strandberg
Age Ageing 32:360. 2003
Alcoholic beverage preference, 29-year mortality, and quality of life in men in old ageTimo E Strandberg
Department of Public Health Science and General Practice, University of Oulu, Finland
J Gerontol A Biol Sci Med Sci 62:213-8. 2007..We compared 29-year mortality and quality of life in old age by alcoholic beverage preference (beer, wine, or spirits) in a cohort of men whose socioeconomic status was similar in their adult life...
Alzheimer's disease and angiogenesisTimo E Strandberg
Lancet 361:1298-9; author reply 1299-300. 2003
Risk factors for preterm deliveryTimo E Strandberg
Lancet 361:436; author reply 436-7. 2003
Multicomponent geriatric intervention for elderly inpatients with delirium: a randomized, controlled trialKaisu H Pitkala
The Central Union for the Welfare of the Aged, Malmin Kauppatie 26, 00700 Helsinki, Finland
J Gerontol A Biol Sci Med Sci 61:176-81. 2006..Treatment is mainly based on common sense with wide variations in practice. We investigated whether intensified, multicomponent geriatric treatment could improve the prognosis of delirious patients...
Older people's reasoning for resuscitation preferences and their role in the decision-making processMarja Liisa Laakkonen
Helsinki City Hospital Koskela, P O Box 6410, FIN 00099 Helsinki, Finland
Resuscitation 65:165-71. 2005..To investigate older patients' reasoning for their cardiopulmonary resuscitation (CPR) preferences and the related decision-making process (DMP)...
Isolated systolic blood pressure measurementTimo E Strandberg
Lancet 372:1033-4. 2008
Social contacts and their relationship to loneliness among aged people - a population-based studyPirkko E Routasalo
Department of Nursing Science, University of Turku, Finland
Gerontology 52:181-7. 2006..This has implications for practice. Interventions aiming at relieving loneliness should be focused on enabling an individual to reflect her own expectations and inner feelings of loneliness...
Multifactorial intervention to prevent recurrent cardiovascular events in patients 75 years or older: the Drugs and Evidence-Based Medicine in the Elderly (DEBATE) study: a randomized, controlled trialTimo E Strandberg
Department of Public Health Science and General Practice, University of Oulu, University Hospital, Oulu, Finland
Am Heart J 152:585-92. 2006..We aimed to examine whether better use of preventive methods and treatments of cardiovascular disease would reduce recurrent events in home-dwelling patients 75 years or older...
The MEGA studyTimo E Strandberg
Lancet 368:2051-2; author reply 2052. 2006
Re: Education and dementia: what lies behind the association?Timo E Strandberg
Neurology 71:1555-6; author reply 1556. 2008
