Taina Sipponen

Summary

Affiliation: Helsinki University Central Hospital
Country: Finland

Publications

  1. ncbi request reprint Three-generation familial visceral myopathy with alpha-actin-positive inclusion bodies in intestinal smooth muscle
    Taina Sipponen
    Division of Gastroenterology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    J Clin Gastroenterol 43:437-43. 2009
  2. ncbi request reprint Crohn's disease activity assessed by fecal calprotectin and lactoferrin: correlation with Crohn's disease activity index and endoscopic findings
    Taina Sipponen
    Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
    Inflamm Bowel Dis 14:40-6. 2008
  3. doi request reprint Fecal calprotectin, lactoferrin, and endoscopic disease activity in monitoring anti-TNF-alpha therapy for Crohn's disease
    Taina Sipponen
    Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
    Inflamm Bowel Dis 14:1392-8. 2008
  4. ncbi request reprint Correlation of faecal calprotectin and lactoferrin with an endoscopic score for Crohn's disease and histological findings
    T Sipponen
    Division of Gastroenterology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Aliment Pharmacol Ther 28:1221-9. 2008
  5. doi request reprint Faecal calprotectin and lactoferrin are reliable surrogate markers of endoscopic response during Crohn's disease treatment
    Taina Sipponen
    Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
    Scand J Gastroenterol 45:325-31. 2010
  6. ncbi request reprint Endoscopic evaluation of Crohn's disease activity: comparison of the CDEIS and the SES-CD
    Taina Sipponen
    Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
    Inflamm Bowel Dis 16:2131-6. 2010
  7. ncbi request reprint Fecal calprotectin and S100A12 have low utility in prediction of small bowel Crohn's disease detected by wireless capsule endoscopy
    Taina Sipponen
    Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, P O B 340, 00029 HUS, Helsinki, Finland
    Scand J Gastroenterol 47:778-84. 2012
  8. doi request reprint Fecal calprotectin concentration predicts outcome in inflammatory bowel disease after induction therapy with TNFα blocking agents
    Pauliina Molander
    Maria Helsinki City Hospital and University of Helsinki, Helsinki, Finland
    Inflamm Bowel Dis 18:2011-7. 2012
  9. doi request reprint Achievement of deep remission during scheduled maintenance therapy with TNFα-blocking agents in IBD
    Pauliina Molander
    Maria Helsinki City Hospital, Helsinki, Finland
    J Crohns Colitis 7:730-5. 2013
  10. doi request reprint Mucosal healing at 3 months predicts long-term endoscopic remission in anti-TNF-treated luminal Crohn's disease
    Clas Göran af Björkesten
    Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
    Scand J Gastroenterol 48:543-51. 2013

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Three-generation familial visceral myopathy with alpha-actin-positive inclusion bodies in intestinal smooth muscle
    Taina Sipponen
    Division of Gastroenterology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    J Clin Gastroenterol 43:437-43. 2009
    ..To our knowledge, this is the first reported alpha-actin-positive inclusion body finding in familial visceral myopathy...
  2. ncbi request reprint Crohn's disease activity assessed by fecal calprotectin and lactoferrin: correlation with Crohn's disease activity index and endoscopic findings
    Taina Sipponen
    Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
    Inflamm Bowel Dis 14:40-6. 2008
    ..We evaluated the clinical significance of these neutrofil-derived proteins in assessment of Crohn's disease activity by comparing them with endoscopic disease activity and with Crohn's disease activity index (CDAI) and serum CRP...
  3. doi request reprint Fecal calprotectin, lactoferrin, and endoscopic disease activity in monitoring anti-TNF-alpha therapy for Crohn's disease
    Taina Sipponen
    Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
    Inflamm Bowel Dis 14:1392-8. 2008
    ..In Crohn's disease (CD), during anti-TNF-alpha (TNF-alpha) treatment, the clinical significance of these markers has, however, been insufficiently explored...
  4. ncbi request reprint Correlation of faecal calprotectin and lactoferrin with an endoscopic score for Crohn's disease and histological findings
    T Sipponen
    Division of Gastroenterology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Aliment Pharmacol Ther 28:1221-9. 2008
    ..Aim To study the correlation of faecal calprotectin and lactoferrin with SES-CD and histology...
  5. doi request reprint Faecal calprotectin and lactoferrin are reliable surrogate markers of endoscopic response during Crohn's disease treatment
    Taina Sipponen
    Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
    Scand J Gastroenterol 45:325-31. 2010
    ..Serial monitoring data for faecal calprotectin and lactoferrin during Crohn's disease (CD) therapy are scarce. The aim of this research was to study the behaviour of faecal biomarkers during CD therapy...
  6. ncbi request reprint Endoscopic evaluation of Crohn's disease activity: comparison of the CDEIS and the SES-CD
    Taina Sipponen
    Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
    Inflamm Bowel Dis 16:2131-6. 2010
    ..Few data exist of prospective parallel scoring of the validated endoscopic scores in Crohn's disease (CD), Crohn's Disease Index of Severity (CDEIS), and Simple Endoscopic Score for Crohn's Disease (SES-CD)...
  7. ncbi request reprint Fecal calprotectin and S100A12 have low utility in prediction of small bowel Crohn's disease detected by wireless capsule endoscopy
    Taina Sipponen
    Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, P O B 340, 00029 HUS, Helsinki, Finland
    Scand J Gastroenterol 47:778-84. 2012
    ..Our aim was to study the role of calprotectin and S100A12 in predicting inflammatory lesions of small bowel in patients undergoing WCE...
  8. doi request reprint Fecal calprotectin concentration predicts outcome in inflammatory bowel disease after induction therapy with TNFα blocking agents
    Pauliina Molander
    Maria Helsinki City Hospital and University of Helsinki, Helsinki, Finland
    Inflamm Bowel Dis 18:2011-7. 2012
    ..Our aim was to evaluate whether a normal FC after induction therapy with TNFα antagonist predicts the outcome of IBD patients during maintenance therapy...
  9. doi request reprint Achievement of deep remission during scheduled maintenance therapy with TNFα-blocking agents in IBD
    Pauliina Molander
    Maria Helsinki City Hospital, Helsinki, Finland
    J Crohns Colitis 7:730-5. 2013
    ..Our aim was to study how often patients on TNF-α blocking therapy actually achieve deep remission...
  10. doi request reprint Mucosal healing at 3 months predicts long-term endoscopic remission in anti-TNF-treated luminal Crohn's disease
    Clas Göran af Björkesten
    Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
    Scand J Gastroenterol 48:543-51. 2013
    ..Our aim was to evaluate the role of early endoscopy in predicting the long-term endoscopic response to anti-TNF in active luminal CD in a clinical setting...
  11. ncbi request reprint Surrogate markers and clinical indices, alone or combined, as indicators for endoscopic remission in anti-TNF-treated luminal Crohn's disease
    Clas Göran af Björkesten
    Division of Gastroenterology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Scand J Gastroenterol 47:528-37. 2012
    ..We analyzed the role of surrogate markers and clinical indices, separately and in combination, by comparing them with endoscopically scored disease activity in biologically treated CD patients...
  12. ncbi request reprint Outcome after discontinuation of TNFα-blocking therapy in patients with inflammatory bowel disease in deep remission
    Pauliina Molander
    Department of Medicine, Division of Gastroenterology, Maria Helsinki City Hospital and University of Helsinki, Helsinki, Finland Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland Division of Gastroenterology, Department of Medicine, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland Department of Medicine, Division of Gastroenterology, Turku University Central Hospital, Turku, Finland Department of Medicine, Division of Gastroenterology, Oulu University Central Hospital, Oulu, Finland Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Jorvi Hospital, Espoo, Finland Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Peijas Hospital, Vantaa, Finland Department of Medicine, Hyvinkaa Hospital, Hyvinkaa, Finland Department of Medicine, Porvoo Hospital, Porvoo, Finland Children s Hospital, Helsinki University Central Hospital, Helsinki, Finland and Department of Surgery, Canada
    Inflamm Bowel Dis 20:1021-8. 2014
    ..In this prospective multicenter study, we evaluated the relapse rate, predictive factors, and the response to retreatment after discontinuation of TNFα-blocking therapy in patients with IBD in deep remission...
  13. doi request reprint Serum infliximab concentrations in pediatric inflammatory bowel disease
    Anssi Hämäläinen
    Children s Hospital, Helsinki University Central Hospital, Helsinki, Finland
    Scand J Gastroenterol 48:35-41. 2013
    ..To study serum infliximab (s-IFX) levels in pediatric patients with inflammatory bowel disease (IBD)...
  14. doi request reprint Human herpesvirus 6 and cytomegalovirus in ileocolonic mucosa in inflammatory bowel disease
    Taina Sipponen
    Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
    Scand J Gastroenterol 46:1324-33. 2011
    ..Data of human herpesvirus 6 (HHV-6)--a close relative to CMV--in active IBD are scarce. The aim of this study was to detect HHV-6 and CMV antigens in the mucosa of active and inactive IBD...
  15. ncbi request reprint Capsule endoscopy in pediatric patients: technique and results in our first 100 consecutive children
    Hannu Nuutinen
    Clinic of Gastroenterology, Helsinki University Central Hospital, University of Helsinki, Finland
    Scand J Gastroenterol 46:1138-43. 2011
    ..In this study, we report our results of 100 consecutive CE in children...
  16. ncbi request reprint IL-23/IL-17 immunity as a hallmark of Crohn's disease
    Veera Hölttä
    Laboratory for Immunobiology, Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    Inflamm Bowel Dis 14:1175-84. 2008
    ..We studied the balance between ileal T-effector cells versus T-regulatory cells in active and inactive Crohn's disease (CD)...
  17. ncbi request reprint Diagnostics and prognostics of inflammatory bowel disease with fecal neutrophil-derived biomarkers calprotectin and lactoferrin
    Taina Sipponen
    Department of Medicine, Clinic of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
    Dig Dis 31:336-44. 2013
    ..In this review an overview will be given to the role of fecal neutrophil-derived biomarkers calprotectin and lactoferrin in diagnostics and prognostics of IBD...
  18. pmc Infliximab in pediatric inflammatory bowel disease rapidly decreases fecal calprotectin levels
    Anssi Hämäläinen
    Hospital for Children and Adolescents, Helsinki University Central Hospital, University of Helsinki, Helsinki FIN 00029, Finland
    World J Gastroenterol 17:5166-71. 2011
    ..To study the response to infliximab in pediatric inflammatory bowel disease (IBD), as reflected in fecal calprotectin levels...
  19. doi request reprint Faecal calprotectin in children with clinically quiescent inflammatory bowel disease
    Taina Sipponen
    Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
    Scand J Gastroenterol 45:872-7. 2010
    ..Our aim was to study faecal calprotectin levels in paediatric IBD during clinically quiescent disease and to investigate if high levels were associated with a flare-up of the disease...
  20. pmc Dendritic cells from Crohn's disease patients show aberrant STAT1 and STAT3 signaling
    Janne K Nieminen
    Immune Response Unit, Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    PLoS ONE 8:e70738. 2013
    ..Our results implicate DC signaling in human CD. Reduced IL-6 responsiveness in pDCs, together with the attenuated IFN-α-induced signaling in both DC subtypes, may contribute to the immunological dysregulation in CD patients...
  21. doi request reprint Segregation of a missense variant in enteric smooth muscle actin γ-2 with autosomal dominant familial visceral myopathy
    Heli J Lehtonen
    Department of Medical Genetics, Genome Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Gastroenterology 143:1482-1491.e3. 2012
    ..FVM is characterized by impaired functions of enteric smooth muscle cells, resulting in abnormal intestinal motility, severe abdominal pain, malnutrition, and even death. We searched for genetic factors that might cause this disorder...
  22. pmc Serum immune-activation potency and response to anti-TNF-α therapy in Crohn's disease
    Hanne Rintamäki
    Division of Gastroenterology, Hospital for Children and Adolescents and Helsinki University Central Hospital, University of Helsinki, Helsinki, FIN 00029, Finland
    World J Gastroenterol 16:5845-51. 2010
    ..To study whether immune-activation stage in serum of adult Crohn's disease (CD) patients correlates with disease activity and with treatment response to anti-tumor necrosis factor-α (TNF-α) therapy...
  23. ncbi request reprint Changes in matrix metalloproteinase (MMP) and tissue inhibitors of metalloproteinases (TIMP) expression profile in Crohn's disease after immunosuppressive treatment correlate with histological score and calprotectin values
    Laura Mäkitalo
    Department of Dermatology, Helsinki University Central Hospital and Biomedicum Helsinki, University of Helsinki, Meilahdentie 2, 00250, Helsinki, Finland
    Int J Colorectal Dis 24:1157-67. 2009
    ....
  24. ncbi request reprint Skin Reactions During Anti-TNFα Therapy for Pediatric Inflammatory Bowel Disease: A 2-year Prospective Study
    Tarja Mälkönen
    Skin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland Children s Hospital, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland Department of Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland and Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
    Inflamm Bowel Dis 20:1309-15. 2014
    ....
  25. doi request reprint Endoscopic monitoring of infliximab therapy in Crohn's disease
    Clas Göran af Björkesten
    Division of Gastroenterology, Department of Medicine, Helsinki University Central Hospital, Helsinki Finland
    Inflamm Bowel Dis 17:947-53. 2011
    ..The aims of this study were to measure the endoscopic response rate during IFX induction and maintenance therapy in luminal CD, and also evaluate the role of endoscopy in monitoring IFX therapy...
  26. ncbi request reprint The long-term outcome of anti-tumor necrosis factor-α therapy related to fecal calprotectin values during induction therapy in pediatric inflammatory bowel disease
    Kaija Leena Kolho
    Children s Hospital, Helsinki University Central Hospital, Helsinki, FIN 00029, Finland
    Scand J Gastroenterol 49:434-41. 2014
    ..There are few studies on long-term prognosis related to the FC value response to infliximab induction therapy, thus providing the aim of this study on pediatric patients...
  27. doi request reprint Radiation exposure during nasojejunal intubation for MRI enteroclysis
    Lauri Puustinen
    Division of Gastroenterology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Scand J Gastroenterol 47:658-61. 2012
    ..Only few data exist of the radiation dose used in fluoroscopy prior to MRI enteroclysis...
  28. doi request reprint Sexual functions in adulthood after restorative proctocolectomy for paediatric onset ulcerative colitis
    Antti Koivusalo
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Pediatr Surg Int 25:881-4. 2009
    ..Pelvic dissection may damage structures essential for sexual functions (SF). We compared SF in adults with ST during childhood or adolescence with adults with medical treatment (MT)...