Pauli Puolakkainen

Summary

Affiliation: Helsinki University Central Hospital
Country: Finland

Publications

  1. ncbi request reprint Ethanol induced NF-{kappa}B activation protects against cell injury in cultured rat gastric mucosal epithelium
    Harri Mustonen
    Dept of Surgery, Helsinki Univ Central Hospital, Box 700, 00029 HUS, Helsinki, Finland
    Am J Physiol Gastrointest Liver Physiol 292:G1614-21. 2007
  2. pmc Upregulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe acute pancreatitis
    Outi Lindstrom
    Second Department of Surgery, Helsinki University Central Hospital and University of Helsinki, Finland
    Crit Care 10:R16. 2006
  3. doi request reprint Lactobacillus acidophilus 74-2 and butyrate induce cyclooxygenase (COX)-1 expression in gastric cancer cells
    Anna Mahkonen
    Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Immunopharmacol Immunotoxicol 30:503-18. 2008
  4. ncbi request reprint SPARC-thrombospondin-2-double-null mice exhibit enhanced cutaneous wound healing and increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges
    Pauli A Puolakkainen
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, 1201 9th Ave, Seattle, WA 98101, USA
    J Histochem Cytochem 53:571-81. 2005
  5. ncbi request reprint Patients with acute pancreatitis complicated by organ failure show highly aberrant monocyte signaling profiles assessed by phospho-specific flow cytometry
    Jani Oiva
    Department of Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    Crit Care Med 38:1702-8. 2010
  6. doi request reprint Taurocholate-induced nitric oxide signaling and the ensuing production of reactive oxygen species lead to an increase in epithelial permeability in cultivated mouse gastric epithelium
    Harri Mustonen
    Department of Surgery, Helsinki University Central Hospital, Box 700, 00029 HUS, Helsinki, Finland
    Dig Dis Sci 53:3119-27. 2008
  7. doi request reprint Taurocholate potentiates ethanol-induced NF-kappaB activation and inhibits caspase-3 activity in cultured rat gastric mucosal cells
    Harri Mustonen
    Department of Surgery, Helsinki University Central Hospital, Box 700, 00029, HUS, Helsinki, Finland
    Dig Dis Sci 54:928-36. 2009
  8. pmc Acute pancreatitis with organ dysfunction associates with abnormal blood lymphocyte signaling: controlled laboratory study
    Jani Oiva
    Department of Surgery, Helsinki University Central Hospital, PO Box 340, 00290 HUS, Helsinki, Finland
    Crit Care 14:R207. 2010
  9. pmc Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma
    Shanna A Arnold
    Hamon Center for Therapeutic Oncology Research, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dis Model Mech 3:57-72. 2010
  10. ncbi request reprint The effect of nitric oxide, growth factors, and estrogen on gastric cell migration
    Outi Nylander-Koski
    Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
    J Surg Res 143:230-7. 2007

Detail Information

Publications71

  1. ncbi request reprint Ethanol induced NF-{kappa}B activation protects against cell injury in cultured rat gastric mucosal epithelium
    Harri Mustonen
    Dept of Surgery, Helsinki Univ Central Hospital, Box 700, 00029 HUS, Helsinki, Finland
    Am J Physiol Gastrointest Liver Physiol 292:G1614-21. 2007
    ..Inhibition of the NF-kappaB activation or COX-2 activity potentiates apoptosis and cell damage induced by ethanol, suggesting a protective role for NF-kappaB activation and COX-2 expression...
  2. pmc Upregulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe acute pancreatitis
    Outi Lindstrom
    Second Department of Surgery, Helsinki University Central Hospital and University of Helsinki, Finland
    Crit Care 10:R16. 2006
    ..We therefore evaluated circulating levels of PC and activated protein C (APC), evaluated monocyte deactivation in AP patients, and determined the relationship of these parameters to MOF...
  3. doi request reprint Lactobacillus acidophilus 74-2 and butyrate induce cyclooxygenase (COX)-1 expression in gastric cancer cells
    Anna Mahkonen
    Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Immunopharmacol Immunotoxicol 30:503-18. 2008
    ..COX-1ir, including COX-3, was upregulated by probiotics and osmotic stress. In conclusion, consumption of L. acidophilus 74-2 could be beneficial for the expression of cytoprotective COX-1...
  4. ncbi request reprint SPARC-thrombospondin-2-double-null mice exhibit enhanced cutaneous wound healing and increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges
    Pauli A Puolakkainen
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, 1201 9th Ave, Seattle, WA 98101, USA
    J Histochem Cytochem 53:571-81. 2005
    ..SPARC and TSP-2 therefore perform similar functions in the regulation of cutaneous wound healing, but fine-tuning with respect to ECM production and remodeling could account for the enhanced response seen in ST-double-null mice...
  5. ncbi request reprint Patients with acute pancreatitis complicated by organ failure show highly aberrant monocyte signaling profiles assessed by phospho-specific flow cytometry
    Jani Oiva
    Department of Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    Crit Care Med 38:1702-8. 2010
    ..To outline signaling profiles and transmigration capacity of monocytes of patients with severe acute pancreatitis...
  6. doi request reprint Taurocholate-induced nitric oxide signaling and the ensuing production of reactive oxygen species lead to an increase in epithelial permeability in cultivated mouse gastric epithelium
    Harri Mustonen
    Department of Surgery, Helsinki University Central Hospital, Box 700, 00029 HUS, Helsinki, Finland
    Dig Dis Sci 53:3119-27. 2008
    ..ASA-induced ROS signaling might have similar effects, whereas ethanol induced direct oxidative stress, having an influence on cell viability...
  7. doi request reprint Taurocholate potentiates ethanol-induced NF-kappaB activation and inhibits caspase-3 activity in cultured rat gastric mucosal cells
    Harri Mustonen
    Department of Surgery, Helsinki University Central Hospital, Box 700, 00029, HUS, Helsinki, Finland
    Dig Dis Sci 54:928-36. 2009
    ..The TC (5 mM)-induced protection in EtOH exposed tissues seems to have two distinct pathways, inhibition of apoptosis and enhancement of NF-kappaB signaling...
  8. pmc Acute pancreatitis with organ dysfunction associates with abnormal blood lymphocyte signaling: controlled laboratory study
    Jani Oiva
    Department of Surgery, Helsinki University Central Hospital, PO Box 340, 00290 HUS, Helsinki, Finland
    Crit Care 14:R207. 2010
    ..Our study purpose was to delineate signaling profiles of circulating lymphocytes in acute pancreatitis complicated by organ dysfunction...
  9. pmc Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma
    Shanna A Arnold
    Hamon Center for Therapeutic Oncology Research, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dis Model Mech 3:57-72. 2010
    ....
  10. ncbi request reprint The effect of nitric oxide, growth factors, and estrogen on gastric cell migration
    Outi Nylander-Koski
    Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
    J Surg Res 143:230-7. 2007
    ..Also, the effects of estrogen on migration of different malignant and nonmalignant gastric epithelial cell lines were explored...
  11. doi request reprint Polymorphisms of the TNF, CD14, and HSPA1B genes in patients with acute alcohol-induced pancreatitis
    Eija Tukiainen
    Second Department of Surgery, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
    Pancreas 37:56-61. 2008
    ..To study this hypothesis, we performed genotype analysis of tumor necrosis factor (TNF) -308 A/G, CD14 -159C/T, and HSPA1B +1267 A/G polymorphisms...
  12. doi request reprint Gene expression analysis identifies over-expression of CXCL1, SPARC, SPP1, and SULF1 in gastric cancer
    Siina Junnila
    Institute of Biomedicine Medical Biochemistry and Developmental Biology, Genome Scale Biology Research Program, University of Helsinki, Helsinki, Finland
    Genes Chromosomes Cancer 49:28-39. 2010
    ..These genes represent potential biomarkers for gastric cancer...
  13. ncbi request reprint Hemostatic gene polymorphisms in severe acute pancreatitis
    Eija Tukiainen
    Second Department of Surgery, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
    Pancreas 38:e43-6. 2009
    ..This prompted us to study the occurrence of FVL and PAI-1 4G/5G polymorphisms in patients with AP...
  14. pmc Genome-wide gene copy number and expression analysis of primary gastric tumors and gastric cancer cell lines
    Siina Junnila
    Institute of Biomedicine, Medical Biochemistry and Developmental Biology, Genome Scale Biology Research Program, University of Helsinki, Helsinki, Finland
    BMC Cancer 10:73. 2010
    ....
  15. doi request reprint Patients with acute pancreatitis complicated by organ dysfunction show abnormal peripheral blood polymorphonuclear leukocyte signaling
    Jani Oiva
    Department of Surgery, Helsinki University Central Hospital, Haartmaninkatu 8, 00290 Helsinki, Finland
    Pancreatology 13:118-24. 2013
    ..We outlined aberrations in PMNL signaling profiles in patients with AP complicated by organ dysfunction and immune suppression...
  16. ncbi request reprint Helicobacter pylori infection and low serum pepsinogen I level as risk factors for gastric carcinoma
    Arto Kokkola
    Department of Surgery, Meilahti Hospital, PO Box 340 Haartmaninkatu 4, FIN 00029 HUS, Finland
    World J Gastroenterol 11:1032-6. 2005
    ..To study whether examination of CagA antibodies could increase the odds ratio for gastric cancer in a case-control study, and how often other serum markers of gastric cancer risk could be found in Helicobacter pylori -negative patients...
  17. doi request reprint Specific immunoassay reveals increased serum trypsinogen 3 in acute pancreatitis
    Jani Oiva
    Department of Surgery, Helsinki University, Central Hospital, Finland
    Clin Chem 57:1506-13. 2011
    ..We developed an immunoassay for trypsinogen 3 and studied whether an assay of serum trypsinogen 3 is of clinical utility in the diagnosis of AP...
  18. ncbi request reprint Integrated gene copy number and expression microarray analysis of gastric cancer highlights potential target genes
    Samuel Myllykangas
    Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Int J Cancer 123:817-25. 2008
    ..In conclusion, our results demonstrate that intestinal and diffuse type gastric cancers as well as cancers located in different sites of the stomach have distinct molecular profiles which may have clinical value...
  19. pmc APCAP--activated protein C in acute pancreatitis: a double-blind randomized human pilot trial
    Ville Pettila
    Department of Anesthesia and Intensive Care Medicine, Helsinki University Central Hospital, Haartmaninkatu 2, Helsinki 00029, Finland
    Crit Care 14:R139. 2010
    ..We, therefore, evaluated its effect on multiple organ dysfunction (MOD) measured by the SOFA (Sequential Organ Failure Assessment) and on organ-failure-free days, and the safety of APC in SAP...
  20. doi request reprint Circulating levels of a soluble form of receptor for advanced glycation end products and high-mobility group box chromosomal protein 1 in patients with acute pancreatitis
    Outi Lindstrom
    Department of Surgery, University of Helsinki, Helsinki, Finland
    Pancreas 38:e215-20. 2009
    ....
  21. pmc Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM
    Rolf A Brekken
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104 2046, USA
    J Clin Invest 111:487-95. 2003
    ..These data indicate that host-derived SPARC is important for the appropriate organization of the ECM in response to implanted tumors and highlight the importance of the ECM in regulating tumor growth...
  22. ncbi request reprint Early sequential changes in serum markers of acute pancreatitis induced by endoscopic retrograde cholangiopancreatography
    Marko Lempinen
    Second Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Pancreatology 5:157-64. 2005
    ....
  23. doi request reprint Obesity correlates with early hyperglycemia in patients with acute pancreatitis who developed organ failure
    Panu Mentula
    Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Pancreas 36:e21-5. 2008
    ..Obesity, another risk factor for severe AP, is associated with impaired glucose regulation. We hypothesized that obesity is related to early hyperglycemia in patients with severe AP...
  24. ncbi request reprint Epidermal growth factor enhances intracellular pH regulation via calcium signaling in acid-exposed primary cultured rabbit gastric epithelial cells
    Outi Nylander-Koski
    Department of Gastrointestinal Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Dig Dis Sci 51:1322-30. 2006
    ..EGF enhances gastric epithelial defense against luminal acid by inducing intracellular calcium signaling via plasma membrane verapamil-sensitive calcium channels and thereby enhancing the function of the Na+/H+ antiport...
  25. ncbi request reprint Matricellular hevin regulates decorin production and collagen assembly
    Millicent M Sullivan
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA
    J Biol Chem 281:27621-32. 2006
    ..Our observations support the capacity of hevin to modulate the structure of dermal extracellular matrix, specifically by its regulation of decorin levels and collagen fibril assembly...
  26. ncbi request reprint Disialotransferrin, determined by capillary electrophoresis, is an accurate biomarker for alcoholic cause of acute pancreatitis
    Taina Methuen
    Research Unit of Substance Abuse Medicine, University of Helsinki, Helsinki, Finland
    Pancreas 34:405-9. 2007
    ..Serum disialotransferrin is a specific marker of heavy alcohol consumption. We tested its accuracy and probability in detecting alcoholic cause of acute pancreatitis (AP)...
  27. pmc Compromised production of extracellular matrix in mice lacking secreted protein, acidic and rich in cysteine (SPARC) leads to a reduced foreign body reaction to implanted biomaterials
    Pauli Puolakkainen
    Department of Vascular Biology, The Hope Heart Institute, University of Washington, Seattle, Washington 98104, USA
    Am J Pathol 162:627-35. 2003
    ..The altered ECM resulting in decreased capsular thickness, indicative of an altered foreign body reaction in SPARC-null mice, implicates SPARC as an important modulator of the encapsulation of implanted biomaterials...
  28. doi request reprint Elevated levels of the complement regulator protein CD59 in severe acute pancreatitis
    Outi Lindstrom
    Department of Surgery, University of Helsinki, Helsinki, Finland
    Scand J Gastroenterol 43:350-5. 2008
    ..Because a number of enzymes are released during AP that could influence the complement inhibitor CD59, the purpose of this study was to examine serum levels of CD59 in relation to severity of AP...
  29. ncbi request reprint Cleavage of the matricellular protein SPARC by matrix metalloproteinase 3 produces polypeptides that influence angiogenesis
    E Helene Sage
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Biol Chem 278:37849-57. 2003
    ..One of these peptides containing KHGK also demonstrated a concentration-dependent effect on angiogenesis...
  30. ncbi request reprint Effect of the ulcerogenic agents ethanol, acetylsalicylic acid and taurocholate on actin cytoskeleton and cell motility in cultured rat gastric mucosal cells
    Siamak Bidel
    Helsinki University Central Hospital, Department of Surgery, Biomedicum Helsinki, Haartmaninkatu 8, Helsinki 00290, Finland
    World J Gastroenterol 11:4032-9. 2005
    ..To assess the effects of ulcerogenic agents on actin cytoskeleton and cell motility and the contribution of oxidative stress...
  31. ncbi request reprint Development of Barrett's esophagus after 'spontaneous' healing of atrophic corpus gastritis
    Arto Kokkola
    Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Helicobacter 8:590-3. 2003
    ..pylori antibody titers declined to normal levels without eradication therapy, and atrophic gastritis healed. The patient developed first erosive esophagitis, and, 5 years later, a 3-cm-long Barrett's esophagus was detected...
  32. doi request reprint Biomaterial topography alters healing in vivo and monocyte/macrophage activation in vitro
    Paige C S Bota
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    J Biomed Mater Res A 95:649-57. 2010
    ..These results demonstrate the effect of biomaterial topography on early proinflammatory cytokine production and gene transcription by monocytes/macrophages in vitro and decreased fibrous capsule thickness in vivo...
  33. ncbi request reprint Leptin and adiponectin levels in acute pancreatitis
    Eija Tukiainen
    Division of Geriatrics, Second Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Pancreas 32:211-4. 2006
    ..Because the underlying mechanisms are poorly known, we studied relationship between the severity of AP and plasma levels of leptin and adiponectin, 2 adipokines regulating the course of systemic inflammation...
  34. ncbi request reprint Early inflammatory response in acute pancreatitis is little affected by body mass index
    Panu Mentula
    Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Scand J Gastroenterol 42:1362-8. 2007
    ..The main objective of this study was to investigate the relationship between obesity and inflammatory markers in AP...
  35. doi request reprint Long-term results of ablation with antireflux surgery for Barrett's esophagus: a clinical and molecular biologic study
    Tuuli Kauttu
    Division of General Thoracic and Esophageal Surgery, Helsinki University Central Hospital, Haartmaninkatu 4, PO Box 340, 00029 HUS Helsinki, Finland
    Surg Endosc 26:1892-7. 2012
    ..The initial results from ablation therapy for metaplastic/dysplastic Barrett's esophagus (BE) are promising, but the results of extended follow-up evaluation are seldom reported...
  36. ncbi request reprint Increased expression of matrix metalloproteinases-21 and -26 and TIMP-4 in pancreatic adenocarcinoma
    Ville Bister
    Department of Dermatology, Helsinki University Central Hospital and Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Mod Pathol 20:1128-40. 2007
    ..The putative role of MMP-26 as a marker of metastases warrants further studies. Unlike other TIMPs, TIMP-4 was not upregulated in relation to aggressiveness of pancreatic cancer...
  37. doi request reprint Low TNF-induced NF-kappaB and p38 phosphorylation levels in leucocytes in tumour necrosis factor receptor-associated periodic syndrome
    Susanna Stjernberg-Salmela
    Department of Dermatology and Allergology, University of Helsinki, Helsinki, Finland
    Rheumatology (Oxford) 49:382-90. 2010
    ....
  38. ncbi request reprint Monocyte anergy is present in patients with severe acute pancreatitis and is significantly alleviated by granulocyte-macrophage colony-stimulating factor and interferon-gamma in vitro
    Marja Leena Kylanpaa
    Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Pancreas 31:23-7. 2005
    ....
  39. ncbi request reprint SPARC-null mice display abnormalities in the dermis characterized by decreased collagen fibril diameter and reduced tensile strength
    Amy D Bradshaw
    The Hope Heart Institute, Seattle, Washington 98104, USA
    J Invest Dermatol 120:949-55. 2003
    ..Thus the absence of SPARC compromises the mechanical properties of the dermis, an effect that we attribute, at least in part, to the changes in the structure and composition of its collagenous extracellular matrix...
  40. ncbi request reprint Decreased HLA (human leucocyte antigen)-DR expression on peripheral blood monocytes predicts the development of organ failure in patients with acute pancreatitis
    Panu Mentula
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Clin Sci (Lond) 105:409-17. 2003
    ..3. In conclusion, monocyte HLA-DR expression predicts the development of organ dysfunction that occurs early in patients with acute pancreatitis...
  41. pmc Activated Protein C Does Not Alleviate the Course of Systemic Inflammation in the APCAP Trial
    Lea Kyhälä
    Department of Surgery, Helsinki University Central Hospital, 00029 Helsinki, Finland
    Int J Inflam 2012:712739. 2012
    ..Our finding is in accordance with the clinical findings in the APCAP trial indicating that the intervention did not affect evolution of multiple organ dysfunctions...
  42. ncbi request reprint CD2AP contributes to cell migration and adhesion in cultured gastric epithelium
    Harri Mustonen
    Department of Surgery, Helsinki University Central Hospital, Finland
    Biochem Biophys Res Commun 332:426-32. 2005
    ..It is concluded that CD2AP interacts with E-cadherin and co-localizes with F-actin in the leading edge of migrating cells, and significantly contributes to cell migration in restituting gastric epithelium...
  43. doi request reprint Surgical decompression for abdominal compartment syndrome in severe acute pancreatitis
    Panu Mentula
    Department of Gastroenterologic and General Surgery, Helsinki University Central Hospital, PO Box 340, 00029 HUS, Helsinki, Finland
    Arch Surg 145:764-9. 2010
    ..In patients with severe acute pancreatitis and abdominal compartment syndrome, establishment of the indications and optimal time for surgical decompression may avoid exacerbation of multiple-organ dysfunction syndrome...
  44. doi request reprint Does the eradication of Helicobacter pylori delay the diagnosis of gastric cancer?
    Arto Kokkola
    Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Scand J Gastroenterol 43:1456-60. 2008
    ....
  45. pmc Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity
    Camilla Norrmen
    Molecular and Cancer Biology Program, Biomedicum Helsinki, Helsinki, Finland
    Blood 115:906-9. 2010
    ....
  46. ncbi request reprint Calcium signaling is involved in ethanol-induced volume decrease and gap junction closure in cultured rat gastric mucosal cells
    Harri Mustonen
    Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Dig Dis Sci 50:103-10. 2005
    ..These actions are mediated by intracellular calcium signaling...
  47. doi request reprint Does non-curative gastrectomy improve survival in patients with metastatic gastric cancer?
    Arto Kokkola
    Department of Gastrointestinal Surgery, Helsinki University Central Hospital, Helsinki, Finland
    J Surg Oncol 106:193-6. 2012
    ..The role of non-curative or palliative gastrectomy remains controversial. Our aim was to compare retrospective patients who have undergone non-curative gastrectomy to the patients with surgical exploration only...
  48. doi request reprint The PSORS1 locus gene CCHCR1 affects keratinocyte proliferation in transgenic mice
    Inkeri Tiala
    Department of Medical Genetics, University of Helsinkiand Helsinki University Central Hospital, Helsinki, Finland
    Hum Mol Genet 17:1043-51. 2008
    ..Our data show that CCHCR1 may function as a negative regulator of keratinocyte proliferation. Thus, aberrant function of CCHCR1 may lead to abnormal keratinocyte proliferation which is a key feature of psoriatic epidermis...
  49. ncbi request reprint Wound repair in aging. A review
    May J Reed
    Division of Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA, USA
    Methods Mol Med 78:217-37. 2003
  50. ncbi request reprint The effect of transforming growth factor-beta1, released from a bioabsorbable self-reinforced polylactide pin, on a bone defect
    Laura Tieline
    Department of Surgery, Helsinki University Hospital, Finland
    Biomaterials 23:3817-23. 2002
    ..In the radiographic examination at 3 weeks there was an increase in the amount of new periosteal bone on the bone defect in the TGF-beta1-treated rats...
  51. ncbi request reprint [Severe acute pancreatitis as a systemic disease--can multiorgan failure be predicted and prevented?]
    Leena Kylanpaa
    HUS n kirurgian klinikka, Meilahden sairaala
    Duodecim 122:563-9. 2006
  52. doi request reprint Anti-inflammatory macrophages activate invasion in pancreatic adenocarcinoma by increasing the MMP9 and ADAM8 expression
    Pauli Puolakkainen
    Department of Surgery, Helsinki University Central Hospital, University of Helsinki, Post Box 263, 00029, Helsinki, Finland
    Med Oncol 31:884. 2014
    ..2 μm/h (p<0.01). Anti-inflammatory macrophages increase pancreatic cancer cell migration rate in basement membrane matrix by inducing ADAM8 and MMP9 expression in cancer cells, thereby possibly enhancing the invasiveness of cancer...
  53. ncbi request reprint Coamplified and overexpressed genes at ERBB2 locus in gastric cancer
    Asta Varis
    Departments of Pathology and Medical Genetics, Haartman Institute, University of Helsinki and Helsinki University Central Hospital Laboratory Diagnostics, Helsinki, Finland
    Int J Cancer 109:548-53. 2004
    ..Additional studies are required to thoroughly understand the biological significance of these genes in gastric cancer...
  54. ncbi request reprint Non-alcoholic etiologies of acute pancreatitis - exclusion of other etiologic factors besides alcohol and gallstones
    Esko Kemppainen
    Department of Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    Pancreatology 7:142-6. 2007
    ..recurring) have effects on efforts to detect the causing factor of AP. This review focuses on the search for other etiologic factors once alcohol and gallstones have been excluded...
  55. ncbi request reprint Inhibition of TIMP1 enhances angiogenesis in vivo and cell migration in vitro
    May J Reed
    Division of Gerontology and Geriatric Medicine and Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Microvasc Res 65:9-17. 2003
    ..We propose that blocking TIMP1 improves angiogenesis by increasing cell motility during fibrovascular invasion...
  56. ncbi request reprint Proinflammatory effects of pancreatic elastase are mediated through TLR4 and NF-kappaB
    Antti Hietaranta
    Department of General and Gastroenterological Surgery, Helsinki University Central Hospital, Haartmaninkatu 4, 00029 HUS, Helsinki, Finland
    Biochem Biophys Res Commun 323:192-6. 2004
    ..Our results suggest that pancreatic elastase-induced proinflammatory effects are mediated by TLR4 and NF-kappaB in human myeloid cells...
  57. ncbi request reprint Trypsinogen-2 and trypsinogen activation peptide (TAP) in urine of patients with acute pancreatitis
    Marko Lempinen
    Second Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
    J Surg Res 111:267-73. 2003
    ..In this work we compared urinary trypsinogen-2 with urinary trypsinogen activation peptide (TAP) and serum C-reactive protein (CRP) for early differentiation between mild and severe acute pancreatitis...
  58. doi request reprint Novel focal adhesion protein kindlin-2 promotes the invasion of gastric cancer cells through phosphorylation of integrin β1 and β3
    Zhanlong Shen
    Department of Gastroenterological Surgery, Peking University People s Hospital, Beijing, PR China
    J Surg Oncol 108:106-12. 2013
    ..However, the mechanism by which kindlin-2 acts in gastric cancer warrants further evaluation...
  59. doi request reprint Esophageal adenocarcinoma arising after antireflux surgery: a population-based analysis
    Tuuli M E Kauttu
    Division of General Thoracic and Esophageal Surgery, Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Cardiothorac Surg 40:1450-4; discussion 1454. 2011
    ..Whether it diminishes the development of esophageal adenocarcinoma (EAC) is, however, controversial. Our aim was to define, at the national level in Finland, frequency and predisposing factors for post-fundoplication EAC...
  60. ncbi request reprint Trypsin-based laboratory methods and carboxypeptidase activation peptide in acute pancreatitis
    Marja Leena Kylänpää-Bäck
    Department of Surgery, Helsinki University Central Hospital Helsinki, Finland
    JOP 3:34-48. 2002
    ..Here we review the current knowledge and clinical implications of trypsin based laboratory methods and carboxypeptidase activation peptide (CAPAP) in the diagnosis and severity assessment of acute pancreatitis...
  61. ncbi request reprint Migration of primary cultured rabbit gastric epithelial cells requires intact protein kinase C and Ca2+/calmodulin activity
    Tuula Ranta-Knuuttila
    Department of Gastroenterologic Surgery, Helsinki University Central Hospital, Finland
    Dig Dis Sci 47:1008-14. 2002
    ..Gastric epithelial cell migration implies activation of receptor tyrosine kinase. It is associated with increased [Ca2+]i and requires an intact Ca2+/calmodulin complex. Intact PKC activity also is needed...
  62. ncbi request reprint Spontaneous disappearance of Helicobacter pylori antibodies in patients with advanced atrophic corpus gastritis
    Arto Kokkola
    Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
    APMIS 111:619-24. 2003
    ..The disappearance of H. pylori antibodies is accompanied by no or more than a mild improvement of the gastric mucosa...
  63. ncbi request reprint Pancreatic secretory trypsin inhibitor (SPINK1) gene mutations in patients with acute pancreatitis
    Eija Tukiainen
    Second Department of Surgery, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Pancreas 30:239-42. 2005
    ..Mutations in the secretory trypsin inhibitor (SPINK1) gene have been found to be associated with hereditary and chronic pancreatitis. There are no previous reports on SPINK1 mutations in patients with acute pancreatitis (AP)...
  64. pmc FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1
    Camilla Norrmen
    Molecular Cancer Biology Program, Biomedicum Helsinki, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    J Cell Biol 185:439-57. 2009
    ..As damage to collecting vessels is a major cause of lymphatic dysfunction in humans, our results suggest that FOXC2 and NFATc1 are potential targets for therapeutic intervention...
  65. ncbi request reprint Transforming growth factor beta released from natural coral implant enhances bone growth at calvarium of mature rat
    Jyrki Vuola
    Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki, Finland
    J Biomed Mater Res 59:152-9. 2002
    ..The data suggested that TGF-beta1 induced enhanced but limited bone formation in mature rats and prevented resorption of the coral calcium carbonate matrix, possibly by hindering reactive cell formation and fibrous tissue ingrowth...
  66. ncbi request reprint Serum levels of mast cell tryptase, vascular endothelial growth factor and basic fibroblast growth factor in patients with acute pancreatitis
    Panu Mentula
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Finland
    Pancreas 27:e29-33. 2003
    ..The aim is to describe their serum levels in relation to severity of AP...
  67. ncbi request reprint [Early prediction of organ failure in acute pancreatitis]
    Panu Mentula
    Duodecim 121:1331. 2005
  68. ncbi request reprint A role for decorin in cutaneous wound healing and angiogenesis
    Hannu Jarvelainen
    Department of Medicine, University of Turku, Turku, Finland
    Wound Repair Regen 14:443-52. 2006
    ..Thus, regulated production of decorin may serve as an excellent therapeutic approach for modifying impaired wound healing and harmful foreign body reactions...
  69. ncbi request reprint Severe acute pancreatitis is related to increased early urinary levels of the activation Peptide of pancreatic phospholipase A(2)
    Jens M Mayer
    Department of General Surgery, University Hospital of Ulm, Germany
    Pancreatology 2:535-42. 2002
    ..The aim of this study was to assess time course and level of activation of sPLA(2)-I and trypsinogen in acute pancreatitis, relative to severity...
  70. doi request reprint Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype
    Tatiana V Petrova
    Molecular and Cancer Biology Research Program, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P O B 63, 00014 Helsinki, Finland
    Cancer Cell 13:407-19. 2008
    ..Our data underscore the complexity of cancer pathogenesis and implicate PROX1 in malignant tumor progression through the regulation of cell polarity and adhesion...
  71. ncbi request reprint Neuropeptide s receptor 1 gene polymorphism is associated with susceptibility to inflammatory bowel disease
    Mauro D'Amato
    Strategic Research Center IRIS, Karolinska Institutet, Stockholm, Sweden
    Gastroenterology 133:808-17. 2007
    ..We tested NPSR1 gene polymorphism for association with IBD and verified whether the expression of its 2 major isoforms (NPSR1-A and NPSR1-B) is altered in the intestine of IBD patients...