Ville Pettila

Summary

Affiliation: Helsinki University Central Hospital
Country: Finland

Publications

  1. ncbi request reprint Multiple organ dysfunction associated with severe acute pancreatitis
    Kimmo I Halonen
    Department of Gastroenterological and General Surgery, Meilahti Hospital, Helsinki University Central Hospital, Finland
    Crit Care Med 30:1274-9. 2002
  2. ncbi request reprint Predictive value of N-terminal pro-brain natriuretic peptide in severe sepsis and septic shock
    Marjut Varpula
    Department of Surgery, Helsinki University Hospital, Finland
    Crit Care Med 35:1277-83. 2007
  3. pmc Transfusion requirements in septic shock (TRISS) trial - comparing the effects and safety of liberal versus restrictive red blood cell transfusion in septic shock patients in the ICU: protocol for a randomised controlled trial
    Lars B Holst
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Denmark
    Trials 14:150. 2013
  4. pmc Comparing the effect of hydroxyethyl starch 130/0.4 with balanced crystalloid solution on mortality and kidney failure in patients with severe sepsis (6S--Scandinavian Starch for Severe Sepsis/Septic Shock trial): study protocol, design and rationale for
    Anders Perner
    Department of Intensive Care, Centre of Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Denmark
    Trials 12:24. 2011
  5. pmc Predictive value of procalcitonin decrease in patients with severe sepsis: a prospective observational study
    Sari Karlsson
    Department of Intensive Care Medicine, Tampere University Hospital, Teiskontie 35, 33521 Tampere, Finland
    Crit Care 14:R205. 2010
  6. ncbi request reprint [Use of albumin in the intensive care unit]
    Ville Pettila
    HYKS, Meilahden sairaala, teho osasto, HUS
    Duodecim 120:2497-8. 2004
  7. doi request reprint Acute kidney injury in patients with influenza A (H1N1) 2009
    Ville Pettila
    Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Vic, Australia
    Intensive Care Med 37:763-7. 2011
  8. ncbi request reprint [How successful is the intensive care of patients with multiple organ dysfunction?]
    Ville Pettila
    Meilahden sairaala, teho osasto 00290 HUS
    Duodecim 118:1663-70. 2002
  9. ncbi request reprint Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis
    Ville Pettila
    Department of Surgery, Division of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, P O Box 340, 00029 HUS, Helsinki, Finland
    Intensive Care Med 28:1220-5. 2002
  10. pmc APCAP--activated protein C in acute pancreatitis: a double-blind randomized human pilot trial
    Ville Pettilä
    Department of Anesthesia and Intensive Care Medicine, Helsinki University Central Hospital, Haartmaninkatu 2, Helsinki 00029, Finland
    Crit Care 14:R139. 2010

Detail Information

Publications69

  1. ncbi request reprint Multiple organ dysfunction associated with severe acute pancreatitis
    Kimmo I Halonen
    Department of Gastroenterological and General Surgery, Meilahti Hospital, Helsinki University Central Hospital, Finland
    Crit Care Med 30:1274-9. 2002
    ....
  2. ncbi request reprint Predictive value of N-terminal pro-brain natriuretic peptide in severe sepsis and septic shock
    Marjut Varpula
    Department of Surgery, Helsinki University Hospital, Finland
    Crit Care Med 35:1277-83. 2007
    ..The aim of this study was to evaluate the predictive value of N-terminal pro-brain natriuretic peptide (NT-proBNP) on mortality in a large, unselected patient population with severe sepsis and septic shock...
  3. pmc Transfusion requirements in septic shock (TRISS) trial - comparing the effects and safety of liberal versus restrictive red blood cell transfusion in septic shock patients in the ICU: protocol for a randomised controlled trial
    Lars B Holst
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Denmark
    Trials 14:150. 2013
    ..However, benefit and harm of RBCs have not been established in this group of high-risk patients...
  4. pmc Comparing the effect of hydroxyethyl starch 130/0.4 with balanced crystalloid solution on mortality and kidney failure in patients with severe sepsis (6S--Scandinavian Starch for Severe Sepsis/Septic Shock trial): study protocol, design and rationale for
    Anders Perner
    Department of Intensive Care, Centre of Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Denmark
    Trials 12:24. 2011
    ..Now lower molecular weight HES 130/0.4 is the preferred colloid in Scandinavian intensive care units (ICUs) and 1st choice fluid for patients with severe sepsis. However, HES 130/0.4 is largely unstudied in patients with severe sepsis...
  5. pmc Predictive value of procalcitonin decrease in patients with severe sepsis: a prospective observational study
    Sari Karlsson
    Department of Intensive Care Medicine, Tampere University Hospital, Teiskontie 35, 33521 Tampere, Finland
    Crit Care 14:R205. 2010
    ..This prospective study investigated the predictive value of procalcitonin (PCT) for survival in 242 adult patients with severe sepsis and septic shock treated in intensive care...
  6. ncbi request reprint [Use of albumin in the intensive care unit]
    Ville Pettila
    HYKS, Meilahden sairaala, teho osasto, HUS
    Duodecim 120:2497-8. 2004
  7. doi request reprint Acute kidney injury in patients with influenza A (H1N1) 2009
    Ville Pettila
    Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Vic, Australia
    Intensive Care Med 37:763-7. 2011
    ..We aim to evaluate the incidence and outcome of acute kidney injury (AKI) among critically ill adult patients with H1N1 2009 infection...
  8. ncbi request reprint [How successful is the intensive care of patients with multiple organ dysfunction?]
    Ville Pettila
    Meilahden sairaala, teho osasto 00290 HUS
    Duodecim 118:1663-70. 2002
  9. ncbi request reprint Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis
    Ville Pettila
    Department of Surgery, Division of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, P O Box 340, 00029 HUS, Helsinki, Finland
    Intensive Care Med 28:1220-5. 2002
    ....
  10. pmc APCAP--activated protein C in acute pancreatitis: a double-blind randomized human pilot trial
    Ville Pettilä
    Department of Anesthesia and Intensive Care Medicine, Helsinki University Central Hospital, Haartmaninkatu 2, Helsinki 00029, Finland
    Crit Care 14:R139. 2010
    ..We, therefore, evaluated its effect on multiple organ dysfunction (MOD) measured by the SOFA (Sequential Organ Failure Assessment) and on organ-failure-free days, and the safety of APC in SAP...
  11. pmc Age of red blood cells and mortality in the critically ill
    Ville Pettila
    Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Commercial Road, Melbourne 3004, Victoria, Australia
    Crit Care 15:R116. 2011
    ..We hypothesized that exposure to even a single unit of older RBCs may be associated with an increased risk of death...
  12. doi request reprint Predictive power of serum NSE and OHCA score regarding 6-month neurologic outcome after out-of-hospital ventricular fibrillation and therapeutic hypothermia
    Tuomas Oksanen
    Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Finland
    Resuscitation 80:165-70. 2009
    ....
  13. doi request reprint Cell-free plasma DNA as a predictor of outcome in severe sepsis and septic shock
    Katri Saukkonen
    Departments of Medicine and Emergency Care, Helsinki University Central Hospital, Helsinki, Finland
    Clin Chem 54:1000-7. 2008
    ..We investigated the value of plasma DNA for the prediction of intensive care unit (ICU) and hospital mortality and its association with the degree of organ dysfunction and disease severity in patients with severe sepsis...
  14. doi request reprint Early hemodynamic variables and outcome in severe acute pancreatitis: a retrospective single-center cohort study
    Erika Wilkman
    Intensive Care Units, Division of Anaesthesia and Intensive Care Medicine, Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Pancreas 42:272-8. 2013
    ..The aim of this study was to assess the association of hemodynamic factors with 90-day mortality in critically ill patients with severe acute pancreatitis (SAP)...
  15. ncbi request reprint Long-term survival, quality of life, and quality-adjusted life-years among critically ill elderly patients
    Anne Kaarlola
    Department of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Crit Care Med 34:2120-6. 2006
    ..To assess mortality, quality of life (QOL), and quality-adjusted life-years (QALYs) for critically ill elderly patients...
  16. ncbi request reprint Association of cell-free plasma DNA with hospital mortality and organ dysfunction in intensive care unit patients
    Katri Saukkonen
    Helsinki University Central Hospital, Emergency Care, Department of Medicine, PO Box 340, 00029 Helsinki, Finland
    Intensive Care Med 33:1624-7. 2007
    ..To investigate the concentration of cell-free plasma DNA and its association with organ dysfunction and hospital mortality in intensive care unit patients...
  17. ncbi request reprint Predictive value of antithrombin III and serum C-reactive protein concentration in critically ill patients with suspected sepsis
    Ville Pettila
    Intensive Care Unit, Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland
    Crit Care Med 30:271-5. 2002
    ....
  18. pmc Dynamic lactate indices as predictors of outcome in critically ill patients
    Alistair Nichol
    Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Commercial Road, Melbourne, Vic, Australia
    Crit Care 15:R242. 2011
    ..We aimed to compare the predictive value of dynamic indices of lactatemia in the first 24 hours of intensive care unit (ICU) admission with the value of more commonly used static indices...
  19. ncbi request reprint Comparison of multiple organ dysfunction scores in the prediction of hospital mortality in the critically ill
    Ville Pettila
    Intensive Care Unit, Division of Anesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Crit Care Med 30:1705-11. 2002
    ..To compare the scales and predictive power for hospital mortality of three recent multiple organ dysfunction scores...
  20. ncbi request reprint Comparison of 2 acute renal failure severity scores to general scoring systems in the critically ill
    Annika Ahlström
    Intensive Care Unit, Department of Surgery, Division of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Am J Kidney Dis 48:262-8. 2006
    ..We evaluated the ability to predict hospital mortality in 2 ARF-specific severity-of-illness scoring methods, the Risk, Injury, Failure, Loss, End-Stage Renal Disease (RIFLE) score and the score presented by Bellomo et al in 2001...
  21. doi request reprint Serum MMP-8, -9 and TIMP-1 in sepsis: high serum levels of MMP-8 and TIMP-1 are associated with fatal outcome in a multicentre, prospective cohort study. Hypothetical impact of tetracyclines
    Anneli Lauhio
    Division of Infectious Diseases, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Pharmacol Res 64:590-4. 2011
    ....
  22. ncbi request reprint Decrease of mortality of ruptured abdominal aortic aneurysm after centralization and in-hospital quality improvement of vascular service
    Sani Joanna Laukontaus
    Department of Vascular Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Ann Vasc Surg 21:580-5. 2007
    ....
  23. ncbi request reprint Universal leukocyte reduction of transfused red cells does not provide benefit to patients undergoing cardiac surgery
    Leena Capraro
    Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
    J Cardiothorac Vasc Anesth 21:232-6. 2007
    ..The aim of the present evaluation was to determine the potential role of leukocyte-reduced red blood cells in decreasing postoperative infections...
  24. ncbi request reprint [Sepsis and kidney]
    Ville Pettila
    HYKS, kirurgian toimiala, anestesiologia ja tehohoito, HUS
    Duodecim 122:231-5. 2006
  25. doi request reprint Serum matrix metalloproteinases in patients resuscitated from cardiac arrest. The association with therapeutic hypothermia
    Johanna Hästbacka
    Department of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Resuscitation 83:197-201. 2012
    ..To study the systemic levels of matrix metalloproteinases (MMP) -7, -8 and -9 and their inhibitor TIMP-1 in cardiac arrest patients and the association with mild therapeutic hypothermia treatment on the serum concentration of these enzymes...
  26. pmc One-year mortality, quality of life and predicted life-time cost-utility in critically ill patients with acute respiratory failure
    Rita Linko
    Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Sairaalakatu 1, Helsinki, Finland
    Crit Care 14:R60. 2010
    ....
  27. pmc Plasma cell-free DNA in patients needing mechanical ventilation
    Marjatta Okkonen
    Division of Anaesthesia and Intensive Care Medicine, Department of Surgery, Helsinki University Central Hospital, Haartmaninkatu 4, PO Box 340, 00029 HUS, Helsinki, Finland
    Crit Care 15:R196. 2011
    ..We evaluated levels of plasma cell-free DNA and their prognostic value in patients needing mechanical ventilation...
  28. ncbi request reprint Predictive value of paediatric risk of mortality score and risk adjustment for congenital heart surgery score after paediatric open-heart surgery
    Leena Mildh
    Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Hospital for Children and Adolescents, PO Box 281, 00029 HUS, Helsinki, Finland
    Interact Cardiovasc Thorac Surg 6:628-31. 2007
    ..With only a moderate discriminating AUC, RACHS-1 failed to adequately predict death after paediatric open-heart surgery. The predictive power of PRISM in this patient group was poor. Both scores overestimated the actual mortality rate...
  29. ncbi request reprint Predictive value of monocyte histocompatibility leukocyte antigen-DR expression and plasma interleukin-4 and -10 levels in critically ill patients with sepsis
    Marja Hynninen
    Department of Anesthesia and Intensive Care Medicine, Helsinki University Central Hospital, PO Box 340, 00029 HUS, Helsinki, Finland
    Shock 20:1-4. 2003
    ..763). In conclusion, APACHE II and SOFA scores on admission showed better discriminatory power than HLA-DR expression and IL-10 and IL-4 levels in prediction of hospital mortality in critically ill patients with sepsis...
  30. pmc Relative hyperlactatemia and hospital mortality in critically ill patients: a retrospective multi-centre study
    Alistair D Nichol
    Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital Campus, 75 Commercial Road, Prahran, VIC 31821, Australia
    Crit Care 14:R25. 2010
    ..We tested the hypothesis that relative hyperlactatemia is independently associated with an increased risk of hospital death...
  31. doi request reprint Heme oxygenase 1 polymorphisms and plasma concentrations in critically ill patients
    Katri Saukkonen
    Emergency Care, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Shock 34:558-64. 2010
    ..The HO-1 plasma concentrations are significantly increased among critically ill patients and associated with the degree of organ dysfunction...
  32. doi request reprint Effect of health-related quality-of-life instrument and quality-adjusted life year calculation method on the number of life years gained in the critical care setting
    Tarja Vainiola
    National Institute for Health and Welfare, Helsinki, Finland
    Value Health 14:1130-4. 2011
    ..We examined the effect of these factors on the number of QALYs gained and the cost per QALY in the critical care setting...
  33. doi request reprint Acute kidney injury and 2009 H1N1 influenza-related critical illness
    Rinaldo Bellomo
    Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC Australia
    Contrib Nephrol 165:310-4. 2010
    ..There was no evidence of viral infiltration on kidney biopsy and the recipient did not develop H1N1 infection...
  34. doi request reprint Junctional ectopic tachycardia after surgery for congenital heart disease: incidence, risk factors and outcome
    Leena Mildh
    Department of Anaesthesia and Intensive Care, Helsinki University Hospital, Helsinki, Finland
    Eur J Cardiothorac Surg 39:75-80. 2011
    ..The incidence, risk factors and outcome of this tachyarrhythmia were evaluated in this population-based, case-control patient cohort...
  35. doi request reprint Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome
    Andrew Davies
    FRACP, FJFICM, Intensive Care Unit, Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia
    JAMA 302:1888-95. 2009
    ..It caused an epidemic of critical illness and some patients developed severe acute respiratory distress syndrome (ARDS) and were treated with extracorporeal membrane oxygenation (ECMO)...
  36. ncbi request reprint Relation of the Sequential Organ Failure Assessment score to morbidity and mortality after cardiac surgery
    Tommi Pätilä
    Department of Cardiothoracic Surgery, Helsinki University Meilahti Hospital, Helsinki, Finland
    Ann Thorac Surg 82:2072-8. 2006
    ..The purpose of this study was to evaluate the utility of SOFA in prediction of mortality and morbidity in a cohort of heterogeneous consecutive adult cardiac surgical patients...
  37. ncbi request reprint Performance of two measures of general health-related quality of life, the EQ-5D and the RAND-36 among critically ill patients
    Anne Kaarlola
    Department of Anaesthesiology and Intensive Care Medicine, Meilahti Hospital, Helsinki University Central Hospital, P O Box 340, 00029, Finland
    Intensive Care Med 30:2245-52. 2004
    ..To compare two health-related quality of life measures, the preference-based EQ-5D with five questions and the profile-based RAND-36 with 36 questions, in previous critically ill patients...
  38. ncbi request reprint Hemodynamic variables related to outcome in septic shock
    Marjut Varpula
    Emergency Ward, Department of Medicine, P O Box 340, 00029, Helsinki, Finland
    Intensive Care Med 31:1066-71. 2005
    ....
  39. pmc Population-based incidence, mortality and quality of life in critically ill patients treated with renal replacement therapy: a nationwide retrospective cohort study in finnish intensive care units
    Suvi T Vaara
    Intensive Care Unit, Division of Anaesthesia and Intensive Care Medicine, Department of Surgery, Helsinki University Central Hospital, Box 340, 00029 HUS, Finland
    Crit Care 16:R13. 2012
    ..We aimed to evaluate the nationwide incidence of RRT-treated AKI in Finland, hospital and six-month mortality, and health-related quality of life (HRQoL) of these patients...
  40. doi request reprint Therapeutic hypothermia after out-of-hospital cardiac arrest in Finnish intensive care units: the FINNRESUSCI study
    Jukka Vaahersalo
    Department of Surgery, Intensive Care Units, Helsinki University Hospital, Helsinki, Finland
    Intensive Care Med 39:826-37. 2013
    ..We aimed to evaluate post-resuscitation care, implementation of therapeutic hypothermia (TH) and outcomes of intensive care unit (ICU)-treated out-of-hospital cardiac arrest (OHCA) patients in Finland...
  41. ncbi request reprint Expensive care - a rationale for economic evaluations in intensive care
    Alisa M Higgins
    Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic
    Crit Care Resusc 12:62-6. 2010
    ..Here, we outline the rationale for conducting economic evaluations in the critical care setting and argue that these evaluations need to be routinely incorporated into all large-scale clinical trials...
  42. doi request reprint Thromboelastometry in patients with severe sepsis and disseminated intravascular coagulation
    Mirka Sivula
    Intensive Care Units, Department of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland
    Blood Coagul Fibrinolysis 20:419-26. 2009
    ..We conclude that thromboelastometry may be a valuable tool in assessing whole blood coagulation capacity in patients with severe sepsis with and without overt DIC...
  43. ncbi request reprint Strict versus moderate glucose control after resuscitation from ventricular fibrillation
    Tuomas Oksanen
    Helsinki University Hospital, Intensive Care Units, Jorvi Hospital, Turuntie 150, 02740 Espoo, Finland
    Intensive Care Med 33:2093-100. 2007
    ..Our aim was to determine whether strict glucose control with intensive insulin treatment improves outcome of OHCA patients...
  44. ncbi request reprint Mixed venous oxygen saturation cannot be estimated by central venous oxygen saturation in septic shock
    Marjut Varpula
    Helsinki University Hospital, POB 340, 00029 HUS, Helsinki, Finland
    Intensive Care Med 32:1336-43. 2006
    ..The aim of our study was to assess the correlation and agreement of ScvO2 and SvO2 and compare ScvO2-SvO2 difference to lactate, oxygen-derived and hemodynamic parameters in early septic shock in ICU after initial resuscitation...
  45. ncbi request reprint Outcome from severe accidental hypothermia in Southern Finland--a 10-year review
    Tom Silfvast
    Department of Anaesthesia and Intensive Care Medicine, Meilahti Hospital, Helsinki University Central Hospital, P O Box 340, FIN 00029 Helsinki, Finland
    Resuscitation 59:285-90. 2003
    ..It is concluded that patients with cardiac arrest due to primary hypothermia tolerate long periods of conventional CPR before institution of CPB. The possible predictive role of serum potassium and arterial pCO2 needs further evaluation...
  46. pmc Heparin binding protein in patients with acute respiratory failure treated with granulocyte colony-stimulating factor (filgrastim)--a prospective, placebo-controlled, double-blind study
    Kirsi Maija Kaukonen
    Intensive Care Unit, Helsinki University Central Hospital, Helsinki, Finland
    BMC Infect Dis 13:51. 2013
    ..Filgrastim induces the production of new neutrophils and modulates their bacterial-killing activity. We evaluated the effect of filgrastim on HBP -concentrations in critically ill patients with acute respiratory failure...
  47. doi request reprint Incidence, risk factors and 90-day mortality of patients with acute kidney injury in Finnish intensive care units: the FINNAKI study
    Sara Nisula
    Division of Anaesthesia and Intensive Care Medicine Department of Surgery, Intensive Care Units, Helsinki University Central Hospital, Box 340, 00029 HUS Helsinki, Finland
    Intensive Care Med 39:420-8. 2013
    ..We aimed to determine the incidence, risk factors and outcome of acute kidney injury (AKI) in Finnish ICUs...
  48. ncbi request reprint Modified score for disseminated intravascular coagulation in the critically ill
    Mirka Sivula
    Intensive Care Unit, Division of Anesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, P O Box 340, 00029 Helsinki, Finland
    Intensive Care Med 31:1209-14. 2005
    ..Also, to assess the value of the components of the score in the diagnosis of overt DIC...
  49. doi request reprint Acute respiratory failure in intensive care units. FINNALI: a prospective cohort study
    Rita Linko
    Intensive Care Units, Department of Anaesthesia and Intensive Care Medicine, Division of Surgery, Helsinki University Hospital, Helsinki, Finland
    Intensive Care Med 35:1352-61. 2009
    ..To evaluate the incidence, treatment and mortality of acute respiratory failure (ARF) in Finnish intensive care units (ICUs)...
  50. ncbi request reprint Collagenase 2/matrix metalloproteinase 8 in critically ill patients with secondary peritonitis
    Johanna Hästbacka
    Division of Anesthesiology and Intensive Care Medicine, Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Shock 27:145-50. 2007
    ..0-0.05 microg/L) (P=0.013). Our data demonstrate for the first time that MMP-8 levels are remarkably elevated and in an active and catalytically competent form in the peritoneal fluid samples of patients with secondary peritonitis...
  51. ncbi request reprint Long-term health-related quality of life in survivors of severe acute pancreatitis
    Kimmo I Halonen
    Department of Gastroenterological and General Surgery, Meilahti Hospital, Helsinki University Central Hospital, P O Box 340, 00029 Helsinki, Finland
    Intensive Care Med 29:782-6. 2003
    ..To evaluate the health-related quality of life (HRQL) and postdischarge outcome after severe acute pancreatitis...
  52. doi request reprint The effects of ventilatory mode on lung aeration assessed with computer tomography: a randomized controlled study
    Tero Varpula
    Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Hospital District of Helsinki and Uusimaa, Finland
    J Intensive Care Med 24:122-30. 2009
    ..6% (-1.4 to 18.62) in the SIMV group (n = 10), (P = .65, difference in mean 4.9%, 95% confidence interval -9.0% to 19.0%). The effects of APRV and SIMV on lung aeration are similar after 7 days of mechanical ventilation...
  53. ncbi request reprint Serum neuron-specific enolase and S-100B protein in cardiac arrest patients treated with hypothermia
    Marjaana Tiainen
    Department of Neurology, Helsinki University Central Hospital, Finland
    Stroke 34:2881-6. 2003
    ..The aim of this study was to evaluate the effect of therapeutic hypothermia on levels of serum NSE and S-100B protein, their time course, and their prognostic value in predicting unfavorable outcome after out-of-hospital cardiac arrest...
  54. ncbi request reprint Treatment of postpartum thrombotic microangiopathy with plasma exchange using cryosupernatant as replacement
    Katja Lampinen
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    Acta Obstet Gynecol Scand 83:175-9. 2004
    ..This small analysis lends weight to early plasma exchange with cryosupernatant as part of the treatment of postpartum HUS/TTP and suggests that persistent thrombocytopenia is a signal of more serious disease...
  55. doi request reprint Indirect measurement of the vascular endothelial glycocalyx layer thickness in human submucosal capillaries with a plug-in for ImageJ
    Sasu Liuhanen
    Intensive Care Units, Division of Anesthesia and Intensive Care Medicine, Department of Surgery, Helsinki University Hospital, PB 340, 00029 HUS, Finland
    Comput Methods Programs Biomed 110:38-47. 2013
    ..We created and validated a semi-automatic plug-in for ImageJ to measure the endothelial glycocalyx layer thickness...
  56. doi request reprint Biochemical injury markers and mortality after coronary artery bypass grafting: a systematic review
    Liisa Petäjä
    Department of Anesthesiology and Intensive Care Medicine of Helsinki University Central Hospital, Helsinki, Finland
    Ann Thorac Surg 87:1981-92. 2009
    ....
  57. pmc Comparison of two utility instruments, the EQ-5D and the 15D, in the critical care setting
    Tarja Vainiola
    Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, P O Box 340, 00029, HUS, Helsinki, Finland
    Intensive Care Med 36:2090-3. 2010
    ..No gold standard is available, but the EQ-5D health-related quality of life instrument (HRQoL) has been proposed. Our aim was to compare the EQ-5D with another utility measure, the 15D, after critical illness...
  58. ncbi request reprint Survival and quality of life of patients requiring acute renal replacement therapy
    Annika Ahlström
    Intensive Care Unit, Division of Anesthesiology and Intensive Care Medicine, Department of Surgery, Helsinki University Central Hospital, Finland
    Intensive Care Med 31:1222-8. 2005
    ..To assess long-term survival and health-related quality of life in patients with acute renal failure...
  59. ncbi request reprint Can untrained laypersons use a defibrillator with dispatcher assistance?
    Heini Harve
    Department of Anesthesia and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Acad Emerg Med 14:624-8. 2007
    ....
  60. ncbi request reprint Quality of life six years after intensive care
    Anne Kaarlola
    Department of Anaesthesia and Intensive Care Medicine, Meilahti Hospital, Helsinki University Central Hospital, P O Box 340, 00029 HUS, Helsinki, Finland
    Intensive Care Med 29:1294-9. 2003
    ..To assess the degree of change in long-term quality of life (QOL) in critically ill patients 1 and 6 years after discharge from the intensive care unit (ICU)...
  61. ncbi request reprint Acute renal failure after cardiac surgery: evaluation of the RIFLE classification
    Anne Kuitunen
    Department of Anesthesia and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Ann Thorac Surg 81:542-6. 2006
    ..The aim of the present study was to evaluate this determination of postoperative renal impairment in cardiac surgical patients, and its association with mortality...
  62. ncbi request reprint Cardiac troponin T levels for risk stratification in pediatric open heart surgery
    Leena H Mildh
    Department of Anesthesiology and Intensive Care, Hospital for Children and Adolescents, Helsinki, Finland
    Ann Thorac Surg 82:1643-8. 2006
    ..The purpose of this study was to determine whether troponin T could predict death after pediatric open cardiac surgery...
  63. pmc Activated Protein C Does Not Alleviate the Course of Systemic Inflammation in the APCAP Trial
    Lea Kyhälä
    Department of Surgery, Helsinki University Central Hospital, 00029 Helsinki, Finland
    Int J Inflam 2012:712739. 2012
    ..Our finding is in accordance with the clinical findings in the APCAP trial indicating that the intervention did not affect evolution of multiple organ dysfunctions...
  64. ncbi request reprint Postpartum bone mineral density in women treated for thromboprophylaxis with unfractionated heparin or LMW heparin
    Ville Pettila
    Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Finland
    Thromb Haemost 87:182-6. 2002
    ..Therefore we recommend use of dalteparin instead of UF heparin for long-term thromboprophylaxis during and after pregnancy...
  65. ncbi request reprint Utility of surgery for ruptured abdominal aortic aneurysm
    Sani Joanna Laukontaus
    Department of Vascular Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Ann Vasc Surg 20:42-8. 2006
    ..Young age and low Glasgow Aneurysm Score were associated with a high number of QALYs irrespective of the statistical method used for analysis. Successful repair of RAAA was able to lend considerable benefit as measured by QALYs...
  66. ncbi request reprint Effect of protocol compliance to cardiac arrest identification by emergency medical dispatchers
    Jouni Nurmi
    Uusimaa EMS, Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Finland
    Resuscitation 70:463-9. 2006
    ..The objective of the study was to assess the effect of protocol compliance to the accuracy of cardiac arrest (CA) identification by the dispatchers...
  67. doi request reprint Clinical spectrum of bacteraemic Fusobacterium infections: from septic shock to nosocomial bacteraemia
    Elina Nohrström
    Department of Otorhinolaryngology, Helsinki University Central Hospital, Haartmaninkatu, Helsinki, Finland
    Scand J Infect Dis 43:463-70. 2011
    ..Fusobacterium species are anaerobic bacteria that relatively rarely cause sepsis with a variable clinical presentation...
  68. doi request reprint Five-year cost-utility analysis of acute renal replacement therapy: a societal perspective
    Annika Laukkanen
    Intensive Care Unit, Division of Anaesthesiology and Intensive Care Medicine, Department of Surgery, Helsinki University Central Hospital, PO Box 340, 00029 HUS Helsinki, Finland
    Intensive Care Med 39:406-13. 2013
    ..Assessment of the cost utility (CU) of acute renal replacement therapy (RRT) from a societal perspective during a 5-year follow-up...
  69. ncbi request reprint Purulent pneumococcal pericarditis: a rarity in the antibiotic era
    Johanna Hästbacka
    Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
    J Crit Care 17:251-4. 2002
    ..The purpose of this report is to show that even while properly treated, pneumococcal disease may proceed to a life-threatening condition including purulent pericarditis and multiple organ failure...