J Petaja

Summary

Affiliation: Helsinki University Central Hospital
Country: Finland

Publications

  1. doi request reprint Monitoring high-dose heparinization during cardiopulmonary by-pass--a comparison between prothrombinase-induced clotting time (PiCT) and two chromogenic anti-factor Xa activity assays
    Peter Raivio
    Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Thromb Haemost 99:427-34. 2008
  2. doi request reprint Thrombin in myocardial ischemia-reperfusion during cardiac surgery
    Peter Raivio
    Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Ann Thorac Surg 88:318-25. 2009
  3. pmc Upregulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe acute pancreatitis
    Outi Lindstrom
    Second Department of Surgery, Helsinki University Central Hospital and University of Helsinki, Finland
    Crit Care 10:R16. 2006
  4. doi request reprint Inflammation and coagulation. An overview
    Jari Petaja
    Director, Department of Pediatrics and Gynecology Helsinki University Central Hospital, Finland
    Thromb Res 127:S34-7. 2011
  5. ncbi request reprint Protein C pathway in infants and children
    Jari Petaja
    Department of Pediatrics, Helsinki University Central Hospital, Jorvi Hospital, Helsinki, Finland
    Semin Thromb Hemost 29:349-62. 2003
  6. ncbi request reprint A simple automatized audit system for following and managing practices of platelet and plasma transfusions in a neonatal intensive care unit
    J Petaja
    Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland
    Transfus Med 14:281-8. 2004
  7. doi request reprint Ischemic intestinal injury during cardiopulmonary bypass does not show an association with neutrophil activation: a porcine study
    M Jormalainen
    Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Eur Surg Res 42:59-69. 2009
  8. ncbi request reprint Activated protein C and inflammation in human myocardium after heart surgery
    J Petaja
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Am J Hematol 67:210-2. 2001
  9. ncbi request reprint Thrombin generation during reperfusion after coronary artery bypass surgery associates with postoperative myocardial damage
    P Raivio
    Department of Cardiothoracic Surgery, Helsinki University Central Hospital, FIN 00029 HUS, Helsinki, Finland
    J Thromb Haemost 4:1523-9. 2006
  10. doi request reprint Increased preoperative thrombin generation and low protein S level associated with unfavorable postoperative hemodynamics after coronary artery bypass grafting
    Peter M Raivio
    Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Perfusion 26:99-106. 2011

Collaborators

Detail Information

Publications22

  1. doi request reprint Monitoring high-dose heparinization during cardiopulmonary by-pass--a comparison between prothrombinase-induced clotting time (PiCT) and two chromogenic anti-factor Xa activity assays
    Peter Raivio
    Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Thromb Haemost 99:427-34. 2008
    ..However, coagulation-based PiCT could provide an alternative to the chromogenic anti-Xa assays. Higher heparin levels during CPB were confirmed to associate with reduced transfusion requirements...
  2. doi request reprint Thrombin in myocardial ischemia-reperfusion during cardiac surgery
    Peter Raivio
    Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Ann Thorac Surg 88:318-25. 2009
    ..Therefore, strategies to improve thrombin control during cardiopulmonary bypass might be beneficial...
  3. pmc Upregulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe acute pancreatitis
    Outi Lindstrom
    Second Department of Surgery, Helsinki University Central Hospital and University of Helsinki, Finland
    Crit Care 10:R16. 2006
    ..We therefore evaluated circulating levels of PC and activated protein C (APC), evaluated monocyte deactivation in AP patients, and determined the relationship of these parameters to MOF...
  4. doi request reprint Inflammation and coagulation. An overview
    Jari Petaja
    Director, Department of Pediatrics and Gynecology Helsinki University Central Hospital, Finland
    Thromb Res 127:S34-7. 2011
    ..Animal experiments with signaling selective APC-variants show promise in improving the therapeutic efficacy and safety of APC in sepsis...
  5. ncbi request reprint Protein C pathway in infants and children
    Jari Petaja
    Department of Pediatrics, Helsinki University Central Hospital, Jorvi Hospital, Helsinki, Finland
    Semin Thromb Hemost 29:349-62. 2003
    ..Clinical implications of the protein C pathway defects in pediatric venous thromboembolism as well as acquired disturbances of protein C pathway during sepsis are discussed...
  6. ncbi request reprint A simple automatized audit system for following and managing practices of platelet and plasma transfusions in a neonatal intensive care unit
    J Petaja
    Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland
    Transfus Med 14:281-8. 2004
    ..A significant shift towards more appropriate use of plasma was demonstrated after implementation of the audit system...
  7. doi request reprint Ischemic intestinal injury during cardiopulmonary bypass does not show an association with neutrophil activation: a porcine study
    M Jormalainen
    Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Eur Surg Res 42:59-69. 2009
    ..We tested whether local post-CPB inflammatory response in the gut wall would be associated with intestinal mucosal perfusion...
  8. ncbi request reprint Activated protein C and inflammation in human myocardium after heart surgery
    J Petaja
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Am J Hematol 67:210-2. 2001
    ..Thus, physiological protein C activation may be involved in regulation of the inflammatory injury during reperfusion of human ischemic coronary circulation...
  9. ncbi request reprint Thrombin generation during reperfusion after coronary artery bypass surgery associates with postoperative myocardial damage
    P Raivio
    Department of Cardiothoracic Surgery, Helsinki University Central Hospital, FIN 00029 HUS, Helsinki, Finland
    J Thromb Haemost 4:1523-9. 2006
    ..Thrombin contributes to myocardial ischemia-reperfusion injury in animal studies, but the role of thrombin in myocardial damage after CABG is unknown...
  10. doi request reprint Increased preoperative thrombin generation and low protein S level associated with unfavorable postoperative hemodynamics after coronary artery bypass grafting
    Peter M Raivio
    Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Perfusion 26:99-106. 2011
    ..Baseline activation of coagulation and the balance between pro-coagulant and anti-coagulant factors preoperatively might have implications for postoperative hemodynamic recovery after CABG...
  11. doi request reprint Thrombophilic variables do not increase the generation or procoagulant activity of thrombin during cardiopulmonary bypass
    Peter Raivio
    Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Ann Thorac Surg 85:536-42. 2008
    ..The objective of this study was to test whether preoperative thrombophilic variables associate with increased generation of thrombin or its procoagulant activity during and after CPB...
  12. ncbi request reprint Exchange transfusion activates coagulation and alters the coagulation profile in newborn infants
    Satu Långström
    Hospital for Children and Adolescents, Stenbackinkatu 11, 00290 Helsinki, Finland
    Thromb Haemost 96:142-8. 2006
    ..This ET-induced procoagulant challenge may be of clinical significance in sick newborns already prone to bleeding and thrombotic complications...
  13. ncbi request reprint Inhibition of thrombin during reperfusion improves immediate postischemic myocardial function and modulates apoptosis in a porcine model of cardiopulmonary bypass
    Mikko Jormalainen
    Department of Cardiothoracic Surgery, University of Helsinki, Helsinki, Finland
    J Cardiothorac Vasc Anesth 21:224-31. 2007
    ..The authors studied early functional recovery of the postischemic myocardium and explored potential effects of thrombin inhibition on procoagulatory, proinflammatory, and proapoptotic features of myocardial ischemia-reperfusion injury...
  14. ncbi request reprint Activation of protein C and hemodynamic recovery after coronary artery bypass surgery
    Peter Raivio
    Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland
    J Thorac Cardiovasc Surg 133:44-51. 2007
    ....
  15. ncbi request reprint Recombinant hirudin enhances cardiac output and decreases systemic vascular resistance during reperfusion after cardiopulmonary bypass in a porcine model
    Mikko Jormalainen
    Department of Cardiothoracic Surgery, Helsinki University Central Hospital, University of Helsinki, Haartmaninkatu 4, FIN 00290 Helsinki, Finland
    J Thorac Cardiovasc Surg 128:189-96. 2004
    ..We hypothesized that recombinant hirudin, a direct inhibitor of thrombin, could attenuate coagulation and enhance microvascular flow during reperfusion...
  16. ncbi request reprint The procoagulant effects of factor V Leiden may be balanced against decreased levels of factor V and do not reflect in vivo thrombin formation in newborns
    Satu Hyytiäinen
    Hospital for Children and Adolescents, Helsinki, Finland
    Thromb Haemost 95:434-40. 2006
    ..Lack of elevated F1+2 levels in FVL-positive infants, however, suggested the existence of balancing mechanisms; one could be the observed lower level of factor V in FVL heterozygous newborns...
  17. ncbi request reprint Fresh frozen plasma reduces thrombin formation in newborn infants
    S Hyytiäinen
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    J Thromb Haemost 1:1189-94. 2003
    ..Fresh frozen plasma (FFP) is used in hope of preventing these complications, despite poorly defined effects on the coagulation system and lack of proven clinical efficacy...
  18. ncbi request reprint Activated protein C reduces graft neutrophil activation in clinical renal transplantation
    Arto J Turunen
    Helsinki University Hospital, Helsinki, Finland
    Am J Transplant 5:2204-12. 2005
    ..8, p=0.001), and with both warm (r=0.6, p=0.01) and cold ischemia time (r=0.6, p=0.02) and donor age (r=0.6, p=0.01). These findings suggest that APC has an anti-inflammatory role in I/R injury in clinical renal transplantation...
  19. ncbi request reprint Antithrombin reduces pulmonary hypertension during reperfusion after cardiopulmonary bypass in a pig
    M Jormalainen
    Department of Cardiothoracic Surgery, University of Helsinki, Helsinki, Finland
    Acta Anaesthesiol Scand 51:178-88. 2007
    ..Using a porcine model of clinical cardiac surgery on CPB, we tested the effects of supplementary AT on myocardial and lung I/R injury...
  20. doi request reprint Intragraft coagulation events and delayed graft function in clinical renal transplantation
    Arto J Turunen
    Department of Anesthesia and Intensive Care Medicine, Surgical Hospital, Helsinki University Hospital, Helsinki, Finland
    Transplantation 85:693-9. 2008
    ..Intragraft fibrin deposition may be associated with delayed graft function...
  21. ncbi request reprint High concentrations of plasminogen activator inhibitor-1 in lungs of preterm infants with respiratory distress syndrome
    Katariina Cederqvist
    Department of Pediatrics, University of Helsinki, Helsinki, Finland
    Pediatrics 117:1226-34. 2006
    ..We studied levels of major plasminogen activator inhibitor-1 (PAI-1), tissue-type plasminogen activator (tPA), and urokinase-type plasminogen activator (uPA) in lungs of preterm infants with RDS...
  22. ncbi request reprint Graft protein C entrapment is associated with reduced phagocyte activation during reperfusion in human liver transplantation
    Minna Ilmakunnas
    Transplantation and Liver Surgery Clinic, Fourth Department of Surgery, Helsinki University Central Hospital, Finland
    Crit Care Med 34:426-32. 2006
    ..To explore the potential anti-inflammatory role of protein C pathway in ischemia-reperfusion injury during liver transplantation...