Research Topics
Species | J PetajaSummaryAffiliation: Helsinki University Central Hospital Country: Finland Publications
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Detail Information
Publications
Monitoring high-dose heparinization during cardiopulmonary by-pass--a comparison between prothrombinase-induced clotting time (PiCT) and two chromogenic anti-factor Xa activity assaysPeter Raivio
Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland
Thromb Haemost 99:427-34. 2008..However, coagulation-based PiCT could provide an alternative to the chromogenic anti-Xa assays. Higher heparin levels during CPB were confirmed to associate with reduced transfusion requirements...- Thrombin in myocardial ischemia-reperfusion during cardiac surgeryPeter Raivio
Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland
Ann Thorac Surg 88:318-25. 2009..Therefore, strategies to improve thrombin control during cardiopulmonary bypass might be beneficial... 
Upregulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe acute pancreatitisOuti Lindstrom
Second Department of Surgery, Helsinki University Central Hospital and University of Helsinki, Finland
Crit Care 10:R16. 2006..We therefore evaluated circulating levels of PC and activated protein C (APC), evaluated monocyte deactivation in AP patients, and determined the relationship of these parameters to MOF...- Inflammation and coagulation. An overviewJari Petaja
Director, Department of Pediatrics and Gynecology Helsinki University Central Hospital, Finland
Thromb Res 127:S34-7. 2011..Animal experiments with signaling selective APC-variants show promise in improving the therapeutic efficacy and safety of APC in sepsis... 
Protein C pathway in infants and childrenJari Petaja
Department of Pediatrics, Helsinki University Central Hospital, Jorvi Hospital, Helsinki, Finland
Semin Thromb Hemost 29:349-62. 2003..Clinical implications of the protein C pathway defects in pediatric venous thromboembolism as well as acquired disturbances of protein C pathway during sepsis are discussed...- A simple automatized audit system for following and managing practices of platelet and plasma transfusions in a neonatal intensive care unitJ Petaja
Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland
Transfus Med 14:281-8. 2004..A significant shift towards more appropriate use of plasma was demonstrated after implementation of the audit system... - Ischemic intestinal injury during cardiopulmonary bypass does not show an association with neutrophil activation: a porcine studyM Jormalainen
Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland
Eur Surg Res 42:59-69. 2009..We tested whether local post-CPB inflammatory response in the gut wall would be associated with intestinal mucosal perfusion... - Activated protein C and inflammation in human myocardium after heart surgeryJ Petaja
Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
Am J Hematol 67:210-2. 2001..Thus, physiological protein C activation may be involved in regulation of the inflammatory injury during reperfusion of human ischemic coronary circulation... - Thrombin generation during reperfusion after coronary artery bypass surgery associates with postoperative myocardial damageP Raivio
Department of Cardiothoracic Surgery, Helsinki University Central Hospital, FIN 00029 HUS, Helsinki, Finland
J Thromb Haemost 4:1523-9. 2006..Thrombin contributes to myocardial ischemia-reperfusion injury in animal studies, but the role of thrombin in myocardial damage after CABG is unknown... - Increased preoperative thrombin generation and low protein S level associated with unfavorable postoperative hemodynamics after coronary artery bypass graftingPeter M Raivio
Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland
Perfusion 26:99-106. 2011..Baseline activation of coagulation and the balance between pro-coagulant and anti-coagulant factors preoperatively might have implications for postoperative hemodynamic recovery after CABG... - Thrombophilic variables do not increase the generation or procoagulant activity of thrombin during cardiopulmonary bypassPeter Raivio
Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland
Ann Thorac Surg 85:536-42. 2008..The objective of this study was to test whether preoperative thrombophilic variables associate with increased generation of thrombin or its procoagulant activity during and after CPB... - Exchange transfusion activates coagulation and alters the coagulation profile in newborn infantsSatu Långström
Hospital for Children and Adolescents, Stenbackinkatu 11, 00290 Helsinki, Finland
Thromb Haemost 96:142-8. 2006..This ET-induced procoagulant challenge may be of clinical significance in sick newborns already prone to bleeding and thrombotic complications... - Inhibition of thrombin during reperfusion improves immediate postischemic myocardial function and modulates apoptosis in a porcine model of cardiopulmonary bypassMikko Jormalainen
Department of Cardiothoracic Surgery, University of Helsinki, Helsinki, Finland
J Cardiothorac Vasc Anesth 21:224-31. 2007..The authors studied early functional recovery of the postischemic myocardium and explored potential effects of thrombin inhibition on procoagulatory, proinflammatory, and proapoptotic features of myocardial ischemia-reperfusion injury... - Activation of protein C and hemodynamic recovery after coronary artery bypass surgeryPeter Raivio
Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland
J Thorac Cardiovasc Surg 133:44-51. 2007.... - Recombinant hirudin enhances cardiac output and decreases systemic vascular resistance during reperfusion after cardiopulmonary bypass in a porcine modelMikko Jormalainen
Department of Cardiothoracic Surgery, Helsinki University Central Hospital, University of Helsinki, Haartmaninkatu 4, FIN 00290 Helsinki, Finland
J Thorac Cardiovasc Surg 128:189-96. 2004..We hypothesized that recombinant hirudin, a direct inhibitor of thrombin, could attenuate coagulation and enhance microvascular flow during reperfusion... - The procoagulant effects of factor V Leiden may be balanced against decreased levels of factor V and do not reflect in vivo thrombin formation in newbornsSatu Hyytiäinen
Hospital for Children and Adolescents, Helsinki, Finland
Thromb Haemost 95:434-40. 2006..Lack of elevated F1+2 levels in FVL-positive infants, however, suggested the existence of balancing mechanisms; one could be the observed lower level of factor V in FVL heterozygous newborns... - Fresh frozen plasma reduces thrombin formation in newborn infantsS Hyytiäinen
Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
J Thromb Haemost 1:1189-94. 2003..Fresh frozen plasma (FFP) is used in hope of preventing these complications, despite poorly defined effects on the coagulation system and lack of proven clinical efficacy... - Activated protein C reduces graft neutrophil activation in clinical renal transplantationArto J Turunen
Helsinki University Hospital, Helsinki, Finland
Am J Transplant 5:2204-12. 2005..8, p=0.001), and with both warm (r=0.6, p=0.01) and cold ischemia time (r=0.6, p=0.02) and donor age (r=0.6, p=0.01). These findings suggest that APC has an anti-inflammatory role in I/R injury in clinical renal transplantation... - Antithrombin reduces pulmonary hypertension during reperfusion after cardiopulmonary bypass in a pigM Jormalainen
Department of Cardiothoracic Surgery, University of Helsinki, Helsinki, Finland
Acta Anaesthesiol Scand 51:178-88. 2007..Using a porcine model of clinical cardiac surgery on CPB, we tested the effects of supplementary AT on myocardial and lung I/R injury... - Intragraft coagulation events and delayed graft function in clinical renal transplantationArto J Turunen
Department of Anesthesia and Intensive Care Medicine, Surgical Hospital, Helsinki University Hospital, Helsinki, Finland
Transplantation 85:693-9. 2008..Intragraft fibrin deposition may be associated with delayed graft function... - High concentrations of plasminogen activator inhibitor-1 in lungs of preterm infants with respiratory distress syndromeKatariina Cederqvist
Department of Pediatrics, University of Helsinki, Helsinki, Finland
Pediatrics 117:1226-34. 2006..We studied levels of major plasminogen activator inhibitor-1 (PAI-1), tissue-type plasminogen activator (tPA), and urokinase-type plasminogen activator (uPA) in lungs of preterm infants with RDS... - Graft protein C entrapment is associated with reduced phagocyte activation during reperfusion in human liver transplantationMinna Ilmakunnas
Transplantation and Liver Surgery Clinic, Fourth Department of Surgery, Helsinki University Central Hospital, Finland
Crit Care Med 34:426-32. 2006..Indeed, hepatic protein C entrapment is associated with reduced hepatic phagocyte activation, suggesting a regulatory role for protein C pathway in hepatic reperfusion in human liver transplantation...