J Paavonen

Summary

Affiliation: Helsinki University Central Hospital
Country: Finland

Publications

  1. doi Chlamydia trachomatis infections of the female genital tract: state of the art
    Jorma Paavonen
    Department of Obstetrics and Gynecology, University Hospital, Helsinki, Finland
    Ann Med 44:18-28. 2012
  2. doi Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women
    J Paavonen
    Department of Obstetrics and Gynaecology, University of Helsinki, Helsinki, Finland
    Lancet 374:301-14. 2009
  3. ncbi Prerequisites for human papillomavirus vaccine trial: results of feasibility studies
    J Paavonen
    Department of Obstetrics and Gynecology, University of Helsinki, Haartmaninkatu 2, 00290, Helsinki, Finland
    J Clin Virol 19:25-30. 2000
  4. ncbi Vulvodynia: a therapeutic challenge
    Jorma Paavonen
    Department of Obstetrics and Gynecology, University of Helsinki, Haartmaninkatu 2, 00290 Helsinki, Finland
    Womens Health (Lond Engl) 2:289-96. 2006
  5. doi Baseline demographic characteristics of subjects enrolled in international quadrivalent HPV (types 6/11/16/18) vaccine clinical trials
    Jorma Paavonen
    Department of Obstetrics and Gynecology, University Hospital, Helsinki, Finland
    Curr Med Res Opin 24:1623-34. 2008
  6. doi Human papillomavirus infection and the development of cervical cancer and related genital neoplasias
    Jorma Paavonen
    Department of Obstetrics and Gynecology, University of Helsinki, Helsinki, Finland
    Int J Infect Dis 11:S3-9. 2007
  7. ncbi [Screening of Chlamydia]
    Jorma Paavonen
    HYKS n naistenklinikka, Helsinki
    Duodecim 121:1273-4. 2005
  8. pmc Placenta previa percreta left in situ - management by delayed hysterectomy: a case report
    Minna Tikkanen
    Helsinki University Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland
    J Med Case Reports 5:418. 2011
  9. ncbi Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blind, randomised controlled trial
    Jorma Paavonen
    University of Helsinki, Department of Obstetrics and Gynaecology, Helsinki, Finland
    Lancet 369:2161-70. 2007
  10. ncbi Human papillomavirus infection and primary fallopian tube carcinoma: a seroepidemiological study
    A Riska
    Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland
    BJOG 114:425-9. 2007

Collaborators

Detail Information

Publications107 found, 100 shown here

  1. doi Chlamydia trachomatis infections of the female genital tract: state of the art
    Jorma Paavonen
    Department of Obstetrics and Gynecology, University Hospital, Helsinki, Finland
    Ann Med 44:18-28. 2012
    ..Single-dose azithromycin remains effective against CT. Secondary prevention by screening is still the most important intervention to limit the adverse effects of CT on reproductive health...
  2. doi Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women
    J Paavonen
    Department of Obstetrics and Gynaecology, University of Helsinki, Helsinki, Finland
    Lancet 374:301-14. 2009
    ..We now assess the vaccine efficacy in the final event-driven analysis...
  3. ncbi Prerequisites for human papillomavirus vaccine trial: results of feasibility studies
    J Paavonen
    Department of Obstetrics and Gynecology, University of Helsinki, Haartmaninkatu 2, 00290, Helsinki, Finland
    J Clin Virol 19:25-30. 2000
    ..First generation preventive vaccines against HPVs are entering clinical trials. Therefore, it is time to consider prerequisites of field trials in Finland...
  4. ncbi Vulvodynia: a therapeutic challenge
    Jorma Paavonen
    Department of Obstetrics and Gynecology, University of Helsinki, Haartmaninkatu 2, 00290 Helsinki, Finland
    Womens Health (Lond Engl) 2:289-96. 2006
    ..In refractory cases, vestibulectomy has a high success rate, although the evidence is based mainly on small, descriptive studies. Comparative studies of conservative versus surgical management of vulvar vestibulitis syndrome are needed...
  5. doi Baseline demographic characteristics of subjects enrolled in international quadrivalent HPV (types 6/11/16/18) vaccine clinical trials
    Jorma Paavonen
    Department of Obstetrics and Gynecology, University Hospital, Helsinki, Finland
    Curr Med Res Opin 24:1623-34. 2008
    ..However, the makeup and extent of catch-up vaccination programs among young women is unclear, because a proportion of this population will likely already have been exposed to one or more vaccine-HPV-types...
  6. doi Human papillomavirus infection and the development of cervical cancer and related genital neoplasias
    Jorma Paavonen
    Department of Obstetrics and Gynecology, University of Helsinki, Helsinki, Finland
    Int J Infect Dis 11:S3-9. 2007
    ..Nononcogenic types HPV 6 and 11 also contribute to the overall burden of HPV disease, giving rise to CIN 1, anogenital warts, cutaneous lesions, and respiratory papillomatosis...
  7. ncbi [Screening of Chlamydia]
    Jorma Paavonen
    HYKS n naistenklinikka, Helsinki
    Duodecim 121:1273-4. 2005
  8. pmc Placenta previa percreta left in situ - management by delayed hysterectomy: a case report
    Minna Tikkanen
    Helsinki University Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland
    J Med Case Reports 5:418. 2011
    ..abstract:..
  9. ncbi Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blind, randomised controlled trial
    Jorma Paavonen
    University of Helsinki, Department of Obstetrics and Gynaecology, Helsinki, Finland
    Lancet 369:2161-70. 2007
    ....
  10. ncbi Human papillomavirus infection and primary fallopian tube carcinoma: a seroepidemiological study
    A Riska
    Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland
    BJOG 114:425-9. 2007
    ..To evaluate the role of human papillomavirus (HPV) types 6, 11, 16, 18, 31 or 33 infection in primary fallopian tube carcinoma (PFTC)...
  11. ncbi Serotypes of Chlamydia trachomatis and risk for development of cervical squamous cell carcinoma
    T Anttila
    Department of Obstetrics and Gynecology, University of Helsinki, Haartmaninkatu 2, 00290 Helsinki, Finland
    JAMA 285:47-51. 2001
    ..Increasing numbers of exposures to different C trachomatis serotypes also increases risk. Our results strengthen the evidence that there is a link between past C trachomatis infection and cervical SCC...
  12. doi The effect of hysterectomy or levonorgestrel-releasing intrauterine system on cardiovascular disease risk factors in menorrhagia patients: a 10-year follow-up of a randomised trial
    S Heliövaara-Peippo
    Department of Obstetrics and Gynaecology, Helsinki University Hospital, Helsinki, Finland
    Maturitas 69:354-8. 2011
    ..To compare, whether women with menorrhagia, treated with either hysterectomy or LNG-IUS, differ in their cardiovascular risk profile during 10-year follow-up...
  13. doi The effect of hysterectomy or levonorgestrel-releasing intrauterine system on lower urinary tract symptoms: a 10-year follow-up study of a randomised trial
    S Heliövaara-Peippo
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
    BJOG 117:602-9. 2010
    ..To evaluate the effect of hysterectomy and levonorgestrel-releasing intrauterine system (LNG-IUS) on lower urinary tract symptoms (LUTS) among women treated for menorrhagia...
  14. ncbi The effect of hysterectomy or levonorgestrel-releasing intrauterine system on sexual functioning among women with menorrhagia: a 5-year randomised controlled trial
    K Halmesmäki
    Department of Obstetrics and Gynecology, University of Helsinki, Helsinki, Finland
    BJOG 114:563-8. 2007
    ..To compare among women with menorrhagia the effect of hysterectomy or levonorgestrel-releasing intrauterine system (LNG-IUS) on sexual functioning...
  15. ncbi Chlamydia trachomatis and chlamydial heat shock protein 60-specific antibody and cell-mediated responses predict tubal factor infertility
    A Tiitinen
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
    Hum Reprod 21:1533-8. 2006
    ..To evaluate the role of Chlamydia trachomatis-induced humoral and cell-mediated immune (CMI) responses in predicting tubal factor infertility (TFI)...
  16. ncbi Human papillomavirus infection, risk for subsequent development of cervical neoplasia and associated population attributable fraction
    M Lehtinen
    National Public Health, Institute, FIN 00300, Helsinki, Finland
    J Clin Virol 22:117-24. 2001
    ..PAR% has not been derived from longitudinal studies although assessment of HPV exposure prior to the neoplasia diagnosis should increase validity of such estimates...
  17. ncbi Vaginal clindamycin in preventing preterm birth and peripartal infections in asymptomatic women with bacterial vaginosis: a randomized, controlled trial
    M Kekki
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Obstet Gynecol 97:643-8. 2001
    ..To determine whether treatment of bacterial vaginosis (BV) in early pregnancy decreases the risk of preterm delivery and peripartum infectious morbidity...
  18. ncbi Insulin-like growth factor-binding protein-1 in cervical secretion as a predictor of preterm delivery
    M Kekki
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, and Medix Biochemica, Kauniainen, Finland
    Acta Obstet Gynecol Scand 80:546-51. 2001
    ..CONCLUSIONS: Pregnant women who are in preterm labor with intact fetal membranes and who have a positive phIGFBP-1 test result in cervical secretion have an increased risk of preterm delivery...
  19. ncbi Poor antibody response against human papillomavirus in adult-onset laryngeal papillomatosis
    L M Aaltonen
    Department of Virology, Haartman Institute, University of Helsinki, Helsinki University Central Hospital, Finland
    J Med Microbiol 50:468-71. 2001
    ..The high prevalence of abnormal Pap smears indicates that gynaecological examination of female adult-onset laryngeal papilloma patients is warranted...
  20. doi Elevated levels of decidual insulin-like growth factor binding protein-1 in cervical fluid in early and mid-pregnancy are associated with an increased risk of spontaneous preterm delivery
    L Rahkonen
    Department of Obstetrics and Gynaecology, Helsinki University Hospital, Helsinki, Finland
    BJOG 117:701-10. 2010
    ..To study whether elevated levels of decidual insulin-like growth factor binding protein-1 (IGFBP-1) in the cervical fluid of unselected asymptomatic women in early or mid-pregnancy are associated with spontaneous preterm delivery (PTD)...
  21. ncbi A randomised controlled trial of vaginal clindamycin for early pregnancy bacterial vaginosis
    M Kurkinen-Räty
    Department of Obstetrics and Gynaecology, Oulu University, Finland
    BJOG 107:1427-32. 2000
    ..To determine whether treatment of bacterial vaginosis (BV) with vaginal clindamycin affects pregnancy outcome...
  22. ncbi Pelvic inflammatory disease. From diagnosis to prevention
    J Paavonen
    Department of Obstetrics and Gynecology, University of Helsinki, Finland
    Dermatol Clin 16:747-56, xii. 1998
    ..Emerging evidence from randomized controlled trials provides strong evidence that intervention with selective screening for chlamydial infection effectively reduces the incidence of PID...
  23. ncbi Psychosocial and other characteristics of women complaining of menorrhagia, with and without actual increased menstrual blood loss
    R Hurskainen
    Department of Obstetrics and Gynaecology, University of Helsinki, Finland
    BJOG 108:281-5. 2001
    ..Better understanding of the factors, which explain complaints of menorrhagia in women with normal bleeding could improve both medical outcomes and reduce the cost of treatment for menorrhagia...
  24. pmc A population-based study on the risk of cervical cancer and cervical intraepithelial neoplasia among grand multiparous women in Finland
    M Hinkula
    Department of Obstetrics and Gynecology, University of Oulu, PL 24, FIN 90029 OYS, Finland
    Br J Cancer 90:1025-9. 2004
    ..2 and 1.4 should be interpreted to represent increased risk attributable to grand multiparity. The increased incidence of CC and CIN3 among young GM women suggests causal association to HPV 16 and Chlamydia trachomatis infections...
  25. ncbi Chlamydia trachomatis: impact on human reproduction
    J Paavonen
    Department of Obstetrics and Gynecology, University of Helsinki, Finland
    Hum Reprod Update 5:433-47. 1999
    ..Thus, the case for screening is clearly made, but much detail remains to be worked out...
  26. ncbi Population-based enrolment of adolescents in a long-term follow-up trial of human papillomavirus vaccine efficacy
    M Lehtinen
    University of Tampere, Helsinki, Finland
    Int J STD AIDS 17:237-46. 2006
    ..Population-based enrollment of large cohorts of vaccinated and unvaccinated adolescents for passive registry-based follow-up with cervical carcinoma as the end-point is feasible and currently going on in Finland...
  27. doi Prediction of placental abruption by testing for C-reactive protein and chlamydial antibody levels in early pregnancy
    M Tikkanen
    Department of Obstetrics and Gynaecology, University Central Hospital, Helsinki, Finland
    BJOG 115:486-91. 2008
    ..We wanted to assess the association of first-trimester serum C-reactive protein (CRP), Chlamydia pneumoniae antibodies, Chlamydia trachomatis antibodies or chlamydial heat-shock protein 60 (CHSP60) antibodies to placental abruption...
  28. pmc Comparison of performances of two commercially available tests, a PCR assay and a ligase chain reaction test, in detection of urogenital Chlamydia trachomatis infection
    M Puolakkainen
    Haartman Institute, Department of Virology, University of Helsinki, Finland
    J Clin Microbiol 36:1489-93. 1998
    ..trachomatis infection. In conclusion, both tests can be recommended for use in the clinical laboratory and for the screening of asymptomatic C. trachomatis infections...
  29. doi Long-term mortality in women treated for cervical intraepithelial neoplasia
    M Jakobsson
    Department of Obstetrics and Gynaecology, University Hospital, Helsinki, Finland
    BJOG 116:838-44. 2009
    ..We also wanted to study whether pregnancy beyond 22 weeks post-treatment affects the risk...
  30. ncbi Repeated human papillomavirus DNA findings among female university students
    E Auvinen
    Department of Virology, HUSLAB Clinical Microbiology and Haartman Institute, University of Helsinki, Helsinki, Finland
    Int J STD AIDS 18:839-41. 2007
    ..hrHPV DNA was repeatedly found twice as often as lrHPV DNA. HPV DNA prevalence was higher among oral contraceptive users than among patients using other contraception...
  31. ncbi Chlamydial pelvic inflammatory disease
    J Paavonen
    Department of Obstetrics and Gynecology, University of Helsinki, Finland
    Hum Reprod Update 2:519-29. 1996
    ..The development and implementation of new and effective intervention programmes for prevention and control of PID is one of the major challenges for the year 2000 and beyond...
  32. ncbi Expression of sex steroid receptors and Ki-67 in the endometria of menorrhagic women: effects of intrauterine levonorgestrel
    R Hurskainen
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, PO Box 140, Helsinki, Finland
    Mol Hum Reprod 6:1013-8. 2000
    ..No significant differences were found in the parameters studied between the women with and without breakthrough bleeding 6 months after insertion of an LNG-IUS...
  33. doi Factors affecting decidual IGFBP-1 levels in the vagina and cervix in the first and mid-second trimester of pregnancy
    L Rahkonen
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
    BJOG 116:45-54. 2009
    ..The aim of this study was to determine the concentrations of and factors associated with decidual insulin-like growth factor-binding protein-1 (IGFBP-1) in the lower genital tract in early- and mid-gestation in singleton pregnancies...
  34. ncbi Vaginal clindamycin and oral metronidazole for bacterial vaginosis: a randomized trial
    J Paavonen
    Department of Obstetrics and Gynecology, University of Helsinki, Helsinki, Finland
    Obstet Gynecol 96:256-60. 2000
    ..To compare the efficacy and safety of clindamycin vaginal ovules with oral metronidazole for treatment of bacterial vaginosis...
  35. ncbi The use of serologic tests for the diagnosis of chlamydial infections
    T Tuuminen
    Labsystems Research Laboratories, Labsystems OY, Sorvaajankatu 15, 00811, Helsinki, Finland
    J Microbiol Methods 42:265-79. 2000
    ....
  36. ncbi Heat shock protein 60 specific T-cell response in chlamydial infections
    A Kinnunen
    Department of Obstetrics and Gynaecology, University of Helsinki, Helsinki and National Public Health Institute, Oulu, Finland
    Scand J Immunol 54:76-81. 2001
    ..Our review highlights the available knowledge between immune responses to chlamydial HSP60 and chronic chlamydial infections in human...
  37. ncbi Pregnancy outcome among HIV-infected women in the Helsinki metropolitan area
    Päivi Lehtovirta
    Department of Obstetrics and Gynecology, University of Helsinki, Helsinki, Finland
    Acta Obstet Gynecol Scand 84:945-50. 2005
    ..The incidence of HIV infection has remained low in Finland. Universal antenatal screening has been offered to all pregnant women since 1998...
  38. ncbi Preterm delivery after surgical treatment for cervical intraepithelial neoplasia
    Maija Jakobsson
    Department of Obstetrics and Gynaecology, University Hospital, FIN 00029 Helsinki, Finland
    Obstet Gynecol 109:309-13. 2007
    ..To study whether a treatment of cervical intraepithelial neoplasia (CIN) is associated with an adverse outcome in the subsequent pregnancies...
  39. doi Risk factors, diagnosis and prognosis of cervical intraepithelial neoplasia among HIV-infected women
    Päivi Lehtovirta
    Department of Obstetrics and Gynaecology, University of Helsinki, PO Box 140, SF00029, Helsinki, Finland
    Int J STD AIDS 19:37-41. 2008
    ..However, the patients with and without CIN could not be distinguished on the basis of previously described risk factors. Regular follow-up by means of Pap smears is warranted in all HIV-infected women...
  40. ncbi Associations between three types of maternal bacterial infection and risk of leukemia in the offspring
    Matti Lehtinen
    National Public Health Institute, Helsinki, Finland
    Am J Epidemiol 162:662-7. 2005
    ..8, 95% confidence interval: 1.1, 6.9). Since H. pylori immunoglobulin G indicates chronic carriage of the microorganism, early colonization of the offspring probably differs between Iceland and Finland, two affluent countries...
  41. pmc Enhanced tenascin expression in cervical and vulvar koilocytotic lesions
    O Tiitta
    Department of Anatomy, University of Helsinki, Finland
    Am J Pathol 141:907-13. 1992
    ..Enhancement was most consistently strong and extensive in in situ carcinomas, suggesting a correlation with active phases of epithelial growth and stromal remodeling...
  42. pmc Chlamydia trachomatis heat shock protein-60 induced interferon-gamma and interleukin-10 production in infertile women
    A Kinnunen
    National Public Health Institute, Oulu, Department of Obstetrics and Gynecology, University of Helsinki, Finland
    Clin Exp Immunol 131:299-303. 2003
    ....
  43. ncbi Past chlamydial infection is not associated with primary fallopian tube carcinoma
    A Riska
    Department of Obstetrics and Gynaecology, Helsinki University Hospital, Haartmaninkatu 2, 00290, Finland
    Eur J Cancer 42:1835-8. 2006
    ..However, because chlamydial infection is common at young age and PFTC develops decades later, we cannot definitively exclude the possibility that C.trachomatis contributes to the development of PFTC...
  44. ncbi Effectiveness of preventive human papillomavirus vaccination
    M Lehtinen
    National Public Health Institute and the Department of Obstetrics and Gynaecology, University of Helsinki, Helsinki, Finland
    Int J STD AIDS 14:787-92. 2003
    ....
  45. ncbi Efficacy of preventive human papillomavirus vaccination
    M Lehtinen
    National Public Health Institute and the Department of Obstetrics and Gynecology, University of Helsinki, Helsinki, Finland
    Int J STD AIDS 12:771-6. 2001
    ..The present review attempts to answer one fundamental question: which of the vaccine candidates is likely to be most successful...
  46. ncbi Transvaginal sonography in the diagnosis of acute appendicitis
    P Molander
    Department of Obstetrics and Gynecology, University of Helsinki, Helsinki, Finland
    Ultrasound Obstet Gynecol 20:496-501. 2002
    ..To evaluate transvaginal sonography with power Doppler capacity in the diagnosis of acute appendicitis and in discriminating appendicitis from pelvic inflammatory disease...
  47. ncbi A nationwide sentinel clinic survey of chlamydia trachomatis infection in Finland
    E Hiltunen-Back
    Department of Dermatology and Venerology, University of Helsinki and University Hospital of Helsini, Finland
    Sex Transm Dis 28:252-8. 2001
    ..Chlamydia trachomatis has been recognized as a major sexually transmitted infection in North America and Western Europe during the past two decades. The incidence of C trachomatis in Finland has been continuously high throughout the 1990s...
  48. ncbi Clinical presentation and risk factors of placental abruption
    Minna Tikkanen
    Department of Obstetrics and Gynecology, University Central Hospital, Helsinki, Finland
    Acta Obstet Gynecol Scand 85:700-5. 2006
    ..To study the risk factors of placental abruption during the index pregnancy...
  49. ncbi Prevalence and risk factors of squamous intraepithelial lesions of the cervix among HIV-infected women - a long-term follow-up study in a low-prevalence population
    Päivi Lehtovirta
    Department of Obstetrics and Gynaecology, University of Helsinki, Finland
    Int J STD AIDS 17:831-4. 2006
    ..04) as well as in women displaying high initial HIV viral load (P = 0.01). Our results from a low HIV-incidence population re-emphasize the importance of guidelines for cytologic screening of HIV-seropositive women...
  50. doi Male fetal sex is associated with earlier onset of placental abruption
    Minna Tikkanen
    Department of Obstetrics and Gynecology, University Central Hospital, Helsinki, Finland
    Acta Obstet Gynecol Scand 89:916-23. 2010
    ..Although more common with male fetuses, outcomes have not been evaluated by sex. Our aim was to find out whether short-term morbidity differs by infant sex in cases with placental abruption and in controls...
  51. doi Factors affecting matrix metalloproteinase-8 levels in the vaginal and cervical fluids in the first and second trimester of pregnancy
    Leena Rahkonen
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Haartmaninkatu 2, 00029 Helsinki, Finland
    Hum Reprod 24:2693-702. 2009
    ..Matrix metalloproteinases (MMPs), particularly MMP-8, have been linked to inflammatory processes. We studied the concentrations of, and factors associated with, MMP-8 in the lower genital tract fluids in the first and second trimesters...
  52. ncbi Experience with the levonorgestrel-releasing intrauterine system among HIV-infected women
    Päivi Lehtovirta
    Department of Obstetrics and Gynecology, University of Helsinki, SF 00029 Helsinki, Finland
    Contraception 75:37-9. 2007
    ..Yet, little is known about LNG-IUS use in HIV-infected women...
  53. doi Cervical length measurement and cervical phosphorylated insulin-like growth factor binding protein-1 testing in prediction of preterm birth in patients reporting uterine contractions
    Leena Rahkonen
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
    Acta Obstet Gynecol Scand 88:901-8. 2009
    ....
  54. doi The effect of hysterectomy or levonorgestrel-releasing intrauterine system on lower abdominal pain and back pain among women treated for menorrhagia: a five-year randomized controlled trial
    Satu Heliövaara-Peippo
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Acta Obstet Gynecol Scand 88:1389-96. 2009
    ..The purpose of this study was to evaluate the changes in lower abdominal pain and back pain among women with menorrhagia treated by hysterectomy or levonorgestrel-releasing intrauterine system (LNG-IUS)...
  55. ncbi Depressive symptoms as predictors of discontinuation of treatment of menorrhagia by levonorgestrel-releasing intrauterine system
    Marko Elovainio
    National Research and Development Centre for Welfare and Health, P O Box 220, FIN 00531, Helsinki, Finland
    Int J Behav Med 14:70-5. 2007
    ..Our findings suggest that diagnosing and treating depression among patients having menstrual problems may improve the continuity of LNG-IUS treatment of menorrhagia...
  56. ncbi Outcome of primary repair of obstetric anal sphincter rupture using the overlap technique
    Pontus Molander
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Jorvi Hospital, Espoo, Finland
    Acta Obstet Gynecol Scand 86:1458-62. 2007
    ..Grade III and IV anal sphincter ruptures after vaginal delivery are an increasing problem. We assessed the outcome of an overlap technique in primary repair...
  57. ncbi Failure of second-trimester measurement of soluble endoglin and other angiogenic factors to predict placental abruption
    Minna Tikkanen
    Department of Obstetrics and Gynecology, University Central Hospital, Helsinki, Finland
    Prenat Diagn 27:1143-6. 2007
    ..Proangiogenic placental growth factor (PlGF) and antiangiogenic soluble fms-like tyrosine kinase 1 (sFlt-1) were also studied...
  58. ncbi Criteria for selective screening for Chlamydia trachomatis
    Maarit Paukku
    Department of Obstetrics and Gynecology and Haartman Institute, University of Helsinki, Finland
    Sex Transm Dis 30:120-3. 2003
    ..On the basis of studies in ethnically diverse populations, it appears that the best strategy for prevention of infections is screening of all women aged 25 years or younger...
  59. ncbi Transient urinary retention and chronic neuropathic pain associated with genital herpes simplex virus infection
    Maija Haanpää
    Pain Clinic, Department of Anaesthesia and Intensive Care Medicine and Department of Neurosurgery, University Hospital, Helsinki, Finland
    Acta Obstet Gynecol Scand 83:946-9. 2004
    ..Genital herpes (GH) causes genital ulcer disease, severe transient pain, and often paresthesias. Whether or not GH can cause urinary retention or chronic neuropathic pain is not well known...
  60. ncbi Cost-effectiveness of screening and treatment for bacterial vaginosis in early pregnancy among women at low risk for preterm birth
    Minnamaija Kekki
    Department of Obstetrics and Gynecology, University of Helsinki, Helsinki University Central Hospital, PO Box 140, Haartmaninkatu 2, FIN 00290 HUS, Helsinki, Finland
    Acta Obstet Gynecol Scand 83:27-36. 2004
    ..We performed a cost-effectiveness analysis of screening and treatment for BV in early pregnancy among asymptomatic women at low risk for preterm delivery...
  61. ncbi Nationwide increase of Chlamydia trachomatis infection in Finland: highest rise among adolescent women and men
    Eija Hiltunen-Back
    Department of Dermatology and Venereology, Helsinki University Hospital, Helsinki, Finland
    Sex Transm Dis 30:737-41. 2003
    ..Since 1995, the incidence of Chlamydia trachomatis infection has been increasing in Finland, although there have been no major changes in public sexually transmitted disease (STD) services or screening practice...
  62. ncbi Levonorgestrel-releasing intrauterine system or hysterectomy in the treatment of essential menorrhagia: predictors of outcome
    Ritva Hurskainen
    Departments of Obstetrics and Gynecology, University Hospitals of Helsinki, Finland
    Acta Obstet Gynecol Scand 83:401-3. 2004
    ..However, the treatment with LNG-IUS seemed to be an appropriate alternative to hysterectomy for all women who perceived their MBL heavy...
  63. ncbi Clinical outcomes and costs with the levonorgestrel-releasing intrauterine system or hysterectomy for treatment of menorrhagia: randomized trial 5-year follow-up
    Ritva Hurskainen
    Department of Obstetrics and Gynecology, University of Helsinki, Finland
    JAMA 291:1456-63. 2004
    ..Both the levonorgestrel-releasing intrauterine system (LNG-IUS) and hysterectomy have proven effective for treatment of menorrhagia but there are no long-term comparative studies measuring cost and quality of life...
  64. ncbi Levonorgestrel-releasing intrauterine system in the treatment of heavy menstrual bleeding
    Ritva Hurskainen
    Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, PL 140, 0029 HUS, Helsinki, Finland
    Curr Opin Obstet Gynecol 16:487-90. 2004
    ..The levonorgestrel-releasing intrauterine system is an effective medical treatment for menorrhagia. Emerging clinical and research evidence suggests that this new treatment modality has major health benefits...
  65. doi Self-reported smoking habits and serum cotinine levels in women with placental abruption
    Minna Tikkanen
    Department of Obstetrics and Gynecology, University Central Hospital, Helsinki, Finland
    Acta Obstet Gynecol Scand 89:1538-44. 2010
    ..We examined the accuracy between self-reported smoking habits and early pregnancy serum cotinine levels in women with or without placental abruption...
  66. ncbi Extralaryngeal HPV infections in male patients with adult-onset laryngeal papillomatosis
    Leena Maija Aaltonen
    Department of Virology, Haartman Institute of the University of Helsinki, Helsinki, Finland
    Eur Arch Otorhinolaryngol 262:708-12. 2005
    ..Patients with adult-onset laryngeal papillomatosis seem to be prone to HPV infections. Primary laryngeal HPV infection in adolescence may remain latent, requiring cofactors to develop into the clinical disease...
  67. ncbi [What is causing preterm delivery?]
    Minnamaija Kekki
    HYKS n naistenklinikka PL 140, 00029 Helsinki
    Duodecim 119:1137-45. 2003
  68. ncbi Observer agreement with laparoscopic diagnosis of pelvic inflammatory disease using photographs
    Pontus Molander
    Department of Obstetrics and Gynecology, University of Helsinki, Helsinki, Finland
    Obstet Gynecol 101:875-80. 2003
    ....
  69. doi Matrix metalloproteinase-8 in cervical fluid in early and mid pregnancy: relation to spontaneous preterm delivery
    Leena Rahkonen
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
    Prenat Diagn 30:1079-85. 2010
    ....
  70. ncbi Portfolios as a learning tool in obstetrics and gynaecology undergraduate training
    K Lonka
    Development and Research Unit, Faculty of Medicine, University of Helsinki, Finland
    Med Educ 35:1125-30. 2001
    ..The main objective was to support the learning process of the students. We also wanted feedback information to enhance teaching...
  71. ncbi Cost-benefit analysis of first-void urine Chlamydia trachomatis screening program
    J Paavonen
    Department of Obstetrics and Gynecology and the Haartman Institute, University of Helsinki, Finland
    Obstet Gynecol 92:292-8. 1998
    ..To perform a cost-benefit analysis of a Chlamydia trachomatis screening program based on first-void urine testing of asymptomatic women using a polymerase chain reaction (PCR) test...
  72. doi The role of Chlamydia trachomatis infection in male infertility
    Paivi Joki-Korpela
    Department of Obstetrics and Gynecology, University of Helsinki, Finland
    Fertil Steril 91:1448-50. 2009
    ..The prevalence of plasma IgG antibodies to C. trachomatis was higher among men from infertile couples than control men, and men with chlamydial antibodies had lower sperm counts than those without...
  73. doi Treatment for cervical intraepithelial neoplasia and subsequent IVF deliveries
    Maija Jakobsson
    Department of Obstetrics and Gynaecology, University Hospital, PO Box 140, FIN 00029 Helsinki, Finland
    Hum Reprod 23:2252-5. 2008
    ....
  74. ncbi Prepregnancy risk factors for placental abruption
    Minna Tikkanen
    Department of Obstetrics and Gynecology, University Central Hospital, Helsinki, Finland
    Acta Obstet Gynecol Scand 85:40-4. 2006
    ..To define the prepregnancy risk factors for placental abruption...
  75. pmc Periodontal disease and bacterial vaginosis increase the risk for adverse pregnancy outcome
    Juha Oittinen
    Institute of Dentistry, Oral and Maxillofacial Diseases, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland
    Infect Dis Obstet Gynecol 13:213-6. 2005
    ..To determine whether periodontal disease or bacterial vaginosis (BV) diagnosed before pregnancy increase the risk for adverse pregnancy outcome...
  76. ncbi The incidence of preterm deliveries decreases in Finland
    M Jakobsson
    Department of Obstetrics and Gynaecology, University Hospital, Helsinki, Finland
    BJOG 115:38-43. 2008
    ..OBJECTIVE; We examined the trends and risk factors of preterm delivery...
  77. pmc Evaluation of the Oricult-N dipslide for laboratory diagnosis of vaginal candidiasis
    P Carlson
    Division of Bacteriology, HUCH Diagnostics, Haartman Institute, University of Helsinki, Helsinki, Finland
    J Clin Microbiol 38:1063-5. 2000
    ..The Oricult-N method was technically simple and could be applied in primary health care. Further studies are required, however, before Oricult-N can be recommended as a routine diagnostic tool...
  78. ncbi Evaluation of antibody response to human papillomavirus early proteins in women in whom cervical cancer developed 1 to 20 years later
    Matti Lehtinen
    Department of Infectious Disease Epidemiology and Microbiology, National Public Health Institute, Helsinki, Finland
    Am J Obstet Gynecol 188:49-55. 2003
    ..Our purpose was to evaluate whether antibodies to HPV16 and HPV18 E6 and E7 proteins are useful for early diagnosis of cervical cancer by measuring the antibody response in women in whom cervical cancer later developed...
  79. doi Loop electrosurgical excision procedure and the risk for preterm birth
    Maija Jakobsson
    Department of Obstetrics and Gynaecology, University Hospital, Helsinki, Finland
    Obstet Gynecol 114:504-10. 2009
    ..To study whether loop electrosurgical excision procedure (LEEP) conization is associated with preterm birth and to study the effect of cone size on preterm birth...
  80. ncbi Elevated maternal second-trimester serum alpha-fetoprotein as a risk factor for placental abruption
    Minna Tikkanen
    Department of Obstetrics and Gynecology, University Central Hospital, Helsinki, Finland
    Prenat Diagn 27:240-3. 2007
    ..To analyze the association of second-trimester maternal serum alpha-fetoprotein (MSAFP) and free beta human chorionic gonadotrophin (MSbeta-hCG) levels to placental abruption...
  81. doi Maternal deaths in Finland: focus on placental abruption
    Minna Tikkanen
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Acta Obstet Gynecol Scand 88:1124-7. 2009
    ..The main causes to maternal death are thromboembolism and obstetric hemorrhage. Deaths to placental abruption are rare, but still seven times higher than the overall MMR...
  82. ncbi Wound complications in patients with carcinoma of the vulva. Comparison between radical and modified vulvectomies
    A Leminen
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Obstet Gynecol Reprod Biol 93:193-7. 2000
    ..To evaluate complications after different vulvectomies performed because of vulvar cancer...
  83. ncbi Transvaginal power Doppler findings in laparoscopically proven acute pelvic inflammatory disease
    P Molander
    Department of Obstetrics and Gynecology, University of Helsinki, Helsinki, Finland
    Ultrasound Obstet Gynecol 17:233-8. 2001
    ..Specific sonographic landmark findings and power Doppler findings augment the clinical diagnosis of PID and allow simple classification of the severity of the disease...
  84. ncbi A randomized controlled trial of hysterectomy or levonorgestrel-releasing intrauterine system in the treatment of menorrhagia-effect on FSH levels and menopausal symptoms
    K Halmesmäki
    Department of Obstetrics and Gynecology, Central Hospital of Päijät Häme, Keskussairaalankatu 7, 15850 Lahti, Finland
    Hum Reprod 19:378-82. 2004
    ..The purpose of this study was to compare the effects of hysterectomy and a levonorgestrel-releasing intrauterine system (LNG-IUS) on serum FSH levels and menopausal symptoms...
  85. ncbi Sexually transmitted diseases. Lower genital tract infections in women
    J Paavonen
    Department of Obstetrics and Gynecology, University Central Hospital, Helsinki, Finland
    Infect Dis Clin North Am 1:179-98. 1987
    ..Recent studies have considerably improved our understanding of the etiology, pathophysiology, diagnosis, and treatment of these infections...
  86. doi Introducing human papillomavirus vaccines - questions remain
    Jorma Paavonen
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    Ann Med 40:162-6. 2008
    ..Implementing HPV vaccine is a great opportunity but also a great challenge. However, mandatory HPV vaccination may raise many questions, and more answers are needed...
  87. ncbi The levonorgestrel-releasing intrauterine system (LNG-IUS) in HIV-infected women--effects on bleeding patterns, ovarian function and genital shedding of HIV
    Oskari Heikinheimo
    Department of Obstetrics and Gynaecology, University of Helsinki, Finland
    Hum Reprod 21:2857-61. 2006
    ..The levonorgestrel-releasing intrauterine system (LNG-IUS) is a highly effective contraceptive with additional health benefits. The objective of this study was to evaluate the effects of the LNG-IUS among HIV-infected women...
  88. ncbi Comparison of ovarian cyst formation in women using the levonorgestrel-releasing intrauterine system vs. hysterectomy
    P Inki
    Department of Obstetrics and Gynecology, University Hospital of Turku, Finland
    Ultrasound Obstet Gynecol 20:381-5. 2002
    ..To analyze the effect of the levonorgestrel-releasing intrauterine system (LNG-IUS) on ovarian cyst formation, endometrial thickness and the size of uterus and uterine fibroids by ultrasonography...
  89. ncbi Serum antibody response to the heat shock protein 60 of Chlamydia trachomatis in women with developing cervical cancer
    Jorma Paavonen
    Department of Obstetrics and Gynecology, University of Helsinki, Haartmaninkatu 2, 00290 Helsinki, Finland
    Am J Obstet Gynecol 189:1287-92. 2003
    ..The purpose of this study was to determine whether serum antibody response to the three versions of chlamydial heat shock protein 60 is associated with an increased risk for cervical cancer...
  90. ncbi A population-based prospective study of Chlamydia trachomatis infection and cervical carcinoma
    Keng Ling Wallin
    Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Int J Cancer 101:371-4. 2002
    ..trachomatis in both the prediagnostic smear and in the subsequent cervical cancer. In conclusion, a prior cervical C. trachomatis infection was associated with an increased risk for development of invasive cervical cancer...
  91. ncbi The effectiveness of the levonorgestrel-releasing intrauterine system in menorrhagia: a systematic review
    Ritva Hurskainen
    BJOG 110:87-8. 2003
  92. ncbi [Preventive vaccines against papillomavirus and cervix cancer will soon enter clinical practice]
    Matti Lehtinen
    Folkhälsoinstitutet, Helsingfors
    Lakartidningen 100:3408-12. 2003
    ..Recruitment of adolescents into population-based phase III vaccination studies should be large to allow reliable cancer registry based evaluation of protective effect against grave dysplasia and cervical cancer...
  93. ncbi Efficacy of a quadrivalent prophylactic human papillomavirus (types 6, 11, 16, and 18) L1 virus-like-particle vaccine against high-grade vulval and vaginal lesions: a combined analysis of three randomised clinical trials
    Elmar A Joura
    Department of Gynecology and Obstetrics, Medical University of Vienna, Vienna, Austria
    Lancet 369:1693-702. 2007
    ..Our aim was to do a combined analysis of three randomised clinical trials to assess the effect of a prophylactic quadrivalent HPV vaccine on the incidence of these diseases...
  94. ncbi [HPV vaccination--a possibility for prevention of cervical cancer]
    Jorma Paavonen
    Duodecim 118:2159-60. 2002
  95. ncbi The accuracy and efficacy of screening tests for Chlamydia trachomatis: a systematic review
    Emma J Watson
    Department of Obstetrics and Gynaecology, Aberdeen University, Aberdeen, Scotland
    J Med Microbiol 51:1021-31. 2002
    ....
  96. ncbi [The chlamydia epidemics is continuing--what should be done?]
    Jorma Paavonen
    HYKS n naistenklinikka Haartmaninkatu 2 00290 Helsinki
    Duodecim 118:1369-73. 2002
  97. doi Strengthening prevention programs to eliminate cervical cancer in the Nordic countries
    Lena Dillner
    WHO Global Reference Laboratory for HPV Diagnosis and Control, Department of Clinical Microbiology, University Hospital, Malmo, Sweden
    Acta Obstet Gynecol Scand 87:489-98. 2008
    ..The same principles as set up for organized programs and new HPV technologies may apply for screening and vaccination as key tools to eliminate cervical cancer in the Nordic countries and globally...
  98. ncbi Chlamydial heat shock protein 60--specific T cells in inflamed salpingeal tissue
    Anne Kinnunen
    National Public Health Institute, Oulu, Finland
    Fertil Steril 77:162-6. 2002
    ..To evaluate the role of chlamydial heat shock protein 60 (CHSP60)-specific T-lymphocytes in tubal factor infertility...
  99. ncbi Age for HPV vaccination
    Diane M Harper
    Dartmouth College, Department of Women s and Gender Studies, Obstetrics and Gynecology, Community and Family Medicine, Hanover, NH, USA
    Vaccine 26:A7-11. 2008
    ..The need for booster shots must therefore be addressed with patients as unknown. Continued cervical cancer screening is necessary regardless of vaccination. Vaccination alone will not eliminate cervical cancer...
  100. ncbi Enrolment of 22,000 adolescent women to cancer registry follow-up for long-term human papillomavirus vaccine efficacy: guarding against guessing
    Matti Lehtinen
    University of Tampere, Tampere, Finland
    Int J STD AIDS 17:517-21. 2006
    ..This enrolment in addition to our earlier enrolment in another phase III trial guarantees enough power so that by 2020 we can ultimately provide data on the efficacy of HPV16/18 vaccination against CIS+...
  101. ncbi Chapter 28: Studies to assess the long-term efficacy and effectiveness of HPV vaccination in developed and developing countries
    Matti Lehtinen
    National Public Health Institute, Department of Infectious Disease Epidemiology, KTL, Oulu, Finland
    Vaccine 24:S3/233-41. 2006
    ..Much of the research is already ongoing. Depending on the results of the planned immuno bridging studies among HIV-negative and HIV-positive women, further phase III and/or phase IV trials may be warranted...