Mikael Kuitunen

Summary

Affiliation: Helsinki University Central Hospital
Country: Finland

Publications

  1. doi request reprint Probiotics and prebiotics in preventing food allergy and eczema
    Mikael Kuitunen
    Helsinki University Central Hospital, Children s Hospital, Helsinki, Finland
    Curr Opin Allergy Clin Immunol 13:280-6. 2013
  2. doi request reprint Impact of maternal allergy and use of probiotics during pregnancy on breast milk cytokines and food antibodies and development of allergy in children until 5 years
    Mikael Kuitunen
    Department of Allergy, Skin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland
    Int Arch Allergy Immunol 159:162-70. 2012
  3. ncbi request reprint Intestinal permeability to mannitol and lactulose in children with type 1 diabetes with the HLA-DQB1*02 allele
    Mikael Kuitunen
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Autoimmunity 35:365-8. 2002
  4. ncbi request reprint Pro- and prebiotic supplementation induces a transient reduction in hemoglobin concentration in infants
    Mikael Kuitunen
    Skin and Allergy Hospital, Finland
    J Pediatr Gastroenterol Nutr 49:626-30. 2009
  5. ncbi request reprint Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial
    Kaarina Kukkonen
    Skin and Allergy Hospital, University of Helsinki, Finland
    J Allergy Clin Immunol 119:192-8. 2007
  6. doi request reprint Probiotics prevent IgE-associated allergy until age 5 years in cesarean-delivered children but not in the total cohort
    Mikael Kuitunen
    Skin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland
    J Allergy Clin Immunol 123:335-41. 2009
  7. doi request reprint High intestinal IgA associates with reduced risk of IgE-associated allergic diseases
    Kaarina Kukkonen
    The Skin and Allergy Hospital, Department of Pediatric Allergology, University of Helsinki, Helsinki, Finland
    Pediatr Allergy Immunol 21:67-73. 2010
  8. doi request reprint Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, double-blind, placebo-controlled trial
    Kaarina Kukkonen
    Department of Pediatrics, Skin and Allergy Hospital, Helsinki University Central Hospital, Meilahdentie 2, PO Box 160, 00029 HUCH Helsinki, Finland
    Pediatrics 122:8-12. 2008
  9. ncbi request reprint Probiotic effects on faecal inflammatory markers and on faecal IgA in food allergic atopic eczema/dermatitis syndrome infants
    Mirva Viljanen
    The Skin and Allergy Hospital, University of Helsinki, Helsinki, Finland
    Pediatr Allergy Immunol 16:65-71. 2005
  10. ncbi request reprint Cow's milk and ovalbumin-specific IgG and IgA in children with eczema: low β-lactoglobulin-specific IgG4 levels are associated with cow's milk allergy
    Emma M Savilahti
    The Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Pediatr Allergy Immunol 23:590-6. 2012

Detail Information

Publications25

  1. doi request reprint Probiotics and prebiotics in preventing food allergy and eczema
    Mikael Kuitunen
    Helsinki University Central Hospital, Children s Hospital, Helsinki, Finland
    Curr Opin Allergy Clin Immunol 13:280-6. 2013
    ..To describe the current literature on clinical trials of probiotics for eczema and food allergy prevention in view of recent new approaches and long-term follow-ups...
  2. doi request reprint Impact of maternal allergy and use of probiotics during pregnancy on breast milk cytokines and food antibodies and development of allergy in children until 5 years
    Mikael Kuitunen
    Department of Allergy, Skin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland
    Int Arch Allergy Immunol 159:162-70. 2012
    ....
  3. ncbi request reprint Intestinal permeability to mannitol and lactulose in children with type 1 diabetes with the HLA-DQB1*02 allele
    Mikael Kuitunen
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Autoimmunity 35:365-8. 2002
    ..The higher permeability of patients with the HLA-DQB1*02 allele suggests that these patients may be more prone to develop abnormal immune responses to food antigens...
  4. ncbi request reprint Pro- and prebiotic supplementation induces a transient reduction in hemoglobin concentration in infants
    Mikael Kuitunen
    Skin and Allergy Hospital, Finland
    J Pediatr Gastroenterol Nutr 49:626-30. 2009
    ..Regarding safety, we investigated the effect of prenatal probiotic and 6 months of pro- and prebiotic supplementation of infants on their hematologic values at 6 months and 2 years and factors affecting these values...
  5. ncbi request reprint Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial
    Kaarina Kukkonen
    Skin and Allergy Hospital, University of Helsinki, Finland
    J Allergy Clin Immunol 119:192-8. 2007
    ..The increase in allergic diseases is attributed to a relative lack of microbial stimulation of the infantile gut immune system. Probiotics, live health-promoting microbes, might offer such stimulation...
  6. doi request reprint Probiotics prevent IgE-associated allergy until age 5 years in cesarean-delivered children but not in the total cohort
    Mikael Kuitunen
    Skin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland
    J Allergy Clin Immunol 123:335-41. 2009
    ..Allergic children have a different fecal microflora, with less lactobacilli and bifidobacteria. Beneficial effects regarding the development of allergy have been suggested to come through probiotic supplementation...
  7. doi request reprint High intestinal IgA associates with reduced risk of IgE-associated allergic diseases
    Kaarina Kukkonen
    The Skin and Allergy Hospital, Department of Pediatric Allergology, University of Helsinki, Helsinki, Finland
    Pediatr Allergy Immunol 21:67-73. 2010
    ..085) and significantly increased faecal alpha1-AT (p = 0.001). High intestinal IgA in early life associates with minimal intestinal inflammation and indicates reduced risk for IgE-associated allergic diseases...
  8. doi request reprint Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, double-blind, placebo-controlled trial
    Kaarina Kukkonen
    Department of Pediatrics, Skin and Allergy Hospital, Helsinki University Central Hospital, Meilahdentie 2, PO Box 160, 00029 HUCH Helsinki, Finland
    Pediatrics 122:8-12. 2008
    ..In a randomized, placebo-controlled, double-blind trial, we studied the safety and long-term effects of feeding synbiotics to newborn infants...
  9. ncbi request reprint Probiotic effects on faecal inflammatory markers and on faecal IgA in food allergic atopic eczema/dermatitis syndrome infants
    Mirva Viljanen
    The Skin and Allergy Hospital, University of Helsinki, Helsinki, Finland
    Pediatr Allergy Immunol 16:65-71. 2005
    ..014), and TNF-alpha was lower for LGG than for placebo, but non-significantly (p=0.111). In conclusion, 4-wk treatment with LGG may alleviate intestinal inflammation in infants with AEDS and CMA...
  10. ncbi request reprint Cow's milk and ovalbumin-specific IgG and IgA in children with eczema: low β-lactoglobulin-specific IgG4 levels are associated with cow's milk allergy
    Emma M Savilahti
    The Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Pediatr Allergy Immunol 23:590-6. 2012
    ..04). Our study thus shows that low β-lactoglobulin-specific serum IgG4 levels may differentiate eczematous infants with CMA from infants who have eczema with only suspected association with CM...
  11. ncbi request reprint Induction of inflammation as a possible mechanism of probiotic effect in atopic eczema-dermatitis syndrome
    Mirva Viljanen
    Skin and Allergy Hospital, University of Helsinki, Meilahdentie 2, 00250 Helsinki, Finland
    J Allergy Clin Immunol 115:1254-9. 2005
    ..The immunomodulating mechanisms of Lactobacillus GG (LGG) and other probiotics are poorly understood...
  12. ncbi request reprint Specific antibodies in oral immunotherapy for cow's milk allergy: kinetics and prediction of clinical outcome
    Emma M Savilahti
    Children s Hospital, University of Helsinki, Helsinki, Finland
    Int Arch Allergy Immunol 164:32-9. 2014
    ..METHODS for predicting the clinical outcome of specific oral immunotherapy (OIT) would improve the safety of the therapy...
  13. doi request reprint Combined T regulatory cell and Th2 expression profile identifies children with cow's milk allergy
    Emma M Savilahti
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Clin Immunol 136:16-20. 2010
    ..The expression profile of both Th2- and T regulatory cell-related genes thus reflects the clinical activity of CMA. Tolerance, in contrast, is not characterized by activation of circulating T regulatory cells...
  14. ncbi request reprint Increased activation of GATA-3, IL-2 and IL-5 of cord blood mononuclear cells in infants with IgE sensitization
    Emma Marschan
    The Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Pediatr Allergy Immunol 19:132-9. 2008
    ..The immune deviation towards Th2-type immunity developed already in utero and seemed to modulate the pattern of immune response favoring an IgE response to environmental antigens...
  15. doi request reprint Cow's milk-associated gastrointestinal symptoms evaluated using the double-blind, placebo-controlled food challenge
    Laura Merras-Salmio
    Division of Pediatric Gastroenterology, Children s Hospital, Helsinki, Finland
    J Pediatr Gastroenterol Nutr 57:281-6. 2013
    ..The aim of this study was to evaluate the suspicion of cow's-milk allergy in infants with unspecific gastrointestinal (GI) symptoms using the double-blind, placebo-controlled food challenge...
  16. doi request reprint Cow's milk allergy is associated with changes in urinary organic acid concentrations
    Heli Salmi
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Pediatr Allergy Immunol 21:e401-6. 2010
    ..Thus, CMA is associated with changes in some urinary organic acid levels. These differences between atopic infants with and without CMA could be investigated as a novel approach for CMA diagnosis...
  17. doi request reprint Protective and risk factors for allergic diseases in high-risk children at the ages of two and five years
    Urpu Sandini
    Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland
    Int Arch Allergy Immunol 156:339-48. 2011
    ..Environmental and lifestyle factors such as breast-feeding and pets seem to affect atopic disease prevalence. We identified risk factors for allergic diseases...
  18. doi request reprint Airway inflammation in probiotic-treated children at 5 years
    Anna K Kukkonen
    The Skin and Allergy Hospital, University of Helsinki, Helsinki, Finland
    Pediatr Allergy Immunol 22:249-51. 2011
    ..009). FE(NO) correlated positively with serum total and allergen-specific IgE concentrations. Early intervention with probiotics and pre-biotics does not affect airway inflammation later in childhood...
  19. ncbi request reprint Pre and probiotics in the prevention and treatment of food allergy
    Erkki Savilahti
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Curr Opin Allergy Clin Immunol 8:243-8. 2008
    ..The interest in modulating commensal bacterial flora with prebiotics and probiotics to prevent and treat food allergy has multiplied in recent years...
  20. pmc Use of IgE and IgG4 epitope binding to predict the outcome of oral immunotherapy in cow's milk allergy
    Emma M Savilahti
    Children s Hospital, University of Helsinki, Helsinki, Finland
    Pediatr Allergy Immunol 25:227-35. 2014
    ..Our objective was to explore whether IgE and IgG4 epitope binding profiles could predict the risk of side effects during CM OIT...
  21. doi request reprint The prognosis of wheat hypersensitivity in children
    Anne Kotaniemi-Syrjänen
    Department of Allergology, Helsinki University Central Hospital, Helsinki, Finland
    Pediatr Allergy Immunol 21:e421-8. 2010
    ..001). In conclusion, almost all children with wheat hypersensitivity can tolerate wheat by adolescence. Sensitization to gliadin is associated with a slower achievement of tolerance and an increased risk of asthma...
  22. ncbi request reprint Effect of probiotics on vaccine antibody responses in infancy--a randomized placebo-controlled double-blind trial
    Kaarina Kukkonen
    Skin and Allergy Hospital, University of Helsinki, Helsinki, Finland
    Pediatr Allergy Immunol 17:416-21. 2006
    ..49) vs. 0.81 (0.56-1.39) IU/ml (p = 0.310), IgG titers were comparable. In conclusion, in allergy-prone infants probiotics seem not to impair antibody responses to diphtheria, tetanus, or Hib, but may improve response to Hib immunization...
  23. doi request reprint Allergy in children: practical recommendations of the Finnish Allergy Programme 2008-2018 for prevention, diagnosis, and treatment
    Anna S Pelkonen
    Department of Allergy, Helsinki University Central Hospital, Helsinki, Finland
    Pediatr Allergy Immunol 23:103-16. 2012
    ..The guidelines aimed to facilitate pattern recognition and clinical decision making for public health nurses and doctors are described in this paper...
  24. pmc Probiotics in the treatment and prevention of allergy in children
    Erkki Savilahti
    From the Hospital for Children and Adolescents, Skin and Allergy Hospital, University of Helsinki, Helsinki, Finland
    World Allergy Organ J 2:69-76. 2009
    ..This may be reached by finding new strains of probiotics affecting stronger stimulation of immune system, together with longer lasting and varying treatment schedules. However, safety issues have to be observed...
  25. ncbi request reprint Lactobacillus GG effect in increasing IFN-gamma production in infants with cow's milk allergy
    Emma Pohjavuori
    Hospital for Children and Adolescents, University of Helsinki, Finland
    J Allergy Clin Immunol 114:131-6. 2004
    ..Probiotic bacteria are potentially beneficial to maturation of the infant's immune system...