R Korpela

Summary

Affiliation: Helsinki University Central Hospital
Country: Finland

Publications

  1. ncbi request reprint Morphine-sparing effect of acetaminophen in pediatric day-case surgery
    R Korpela
    Department of Anesthesia, Hospital for Children and Adolescents, University of Helsinki, Finland
    Anesthesiology 91:442-7. 1999
  2. ncbi request reprint Influence of the pharmacological modification of gastric emptying on lactose digestion and gastrointestinal symptoms
    K Peuhkuri
    Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
    Aliment Pharmacol Ther 13:81-6. 1999
  3. ncbi request reprint Ibuprofen augments gastrointestinal symptoms in lactose maldigesters during a lactose tolerance test
    K Peuhkuri
    Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
    Aliment Pharmacol Ther 13:1227-33. 1999
  4. doi request reprint Effects of long-term intake of lactotripeptides on cardiovascular risk factors in hypertensive subjects
    T Jauhiainen
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    Eur J Clin Nutr 66:843-9. 2012
  5. ncbi request reprint Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3-(aminomethyl)benzyl]acetamidine
    E Kankuri
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    J Pharmacol Exp Ther 298:1128-32. 2001
  6. ncbi request reprint Proliferative effects of oxidized low-density lipoprotein on vascular smooth muscle cells: role of dietary habits
    T A Lähteenmäki
    Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
    Life Sci 63:995-1003. 1998
  7. ncbi request reprint Effect of long-term consumption of a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dental caries and caries risk in children
    L Näse
    Institute of Dentistry, University of Helsinki, Finland
    Caries Res 35:412-20. 2001
  8. ncbi request reprint Cardiovascular activity of milk casein-derived tripeptides and plant sterols in spontaneously hypertensive rats
    P Jakala
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    J Physiol Pharmacol 60:11-20. 2009
  9. pmc Long-term intervention with Lactobacillus helveticus fermented milk reduces augmentation index in hypertensive subjects
    T Jauhiainen
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    Eur J Clin Nutr 64:424-31. 2010
  10. ncbi request reprint Alpha-lactorphin lowers blood pressure measured by radiotelemetry in normotensive and spontaneously hypertensive rats
    M L Nurminen
    Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
    Life Sci 66:1535-43. 2000

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Morphine-sparing effect of acetaminophen in pediatric day-case surgery
    R Korpela
    Department of Anesthesia, Hospital for Children and Adolescents, University of Helsinki, Finland
    Anesthesiology 91:442-7. 1999
    ..The aim of this study was to evaluate the efficacy of different doses of rectal acetaminophen in day-case surgery in children...
  2. ncbi request reprint Influence of the pharmacological modification of gastric emptying on lactose digestion and gastrointestinal symptoms
    K Peuhkuri
    Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
    Aliment Pharmacol Ther 13:81-6. 1999
    ..In lactose maldigesters the ingestion of food which retards gastric emptying improves tolerance to lactose...
  3. ncbi request reprint Ibuprofen augments gastrointestinal symptoms in lactose maldigesters during a lactose tolerance test
    K Peuhkuri
    Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
    Aliment Pharmacol Ther 13:1227-33. 1999
    ..Clinical symptoms during lactose tolerance test mimic those seen after therapeutic administration of prostaglandins, and resemble inflammatory processes...
  4. doi request reprint Effects of long-term intake of lactotripeptides on cardiovascular risk factors in hypertensive subjects
    T Jauhiainen
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    Eur J Clin Nutr 66:843-9. 2012
    ..The present study was aimed to evaluate the effects of two doses of these lactotripeptides on 24-h ambulatory blood pressure and lipidomics profiles in mildly hypertensive subjects...
  5. ncbi request reprint Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3-(aminomethyl)benzyl]acetamidine
    E Kankuri
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    J Pharmacol Exp Ther 298:1128-32. 2001
    ..In contrast, nonselective nitric-oxide synthase inhibition with L-NAME provided no benefit. These results support the idea that selective iNOS inhibitors have a promise in the treatment of colitis...
  6. ncbi request reprint Proliferative effects of oxidized low-density lipoprotein on vascular smooth muscle cells: role of dietary habits
    T A Lähteenmäki
    Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
    Life Sci 63:995-1003. 1998
    ..The native and totally-oxidized LDL induced a significant increase in DNA synthesis, if they were obtained from the fish diet group. This study suggests an enhanced proliferative effect of partially-oxidized LDL on VSMC growth...
  7. ncbi request reprint Effect of long-term consumption of a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dental caries and caries risk in children
    L Näse
    Institute of Dentistry, University of Helsinki, Finland
    Caries Res 35:412-20. 2001
    ..56, p = 0.01; controlled for age and gender, OR = 0.51, p = 0.004). The effect was particularly clear in the 3- to 4-year-olds. Thus, milk containing the probiotic LGG bacteria may have beneficial effects on children's dental health...
  8. ncbi request reprint Cardiovascular activity of milk casein-derived tripeptides and plant sterols in spontaneously hypertensive rats
    P Jakala
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    J Physiol Pharmacol 60:11-20. 2009
    ..Vascular responses did not markedly differ between the groups, except that endothelium-derived hyperpolarizing factor (EDHF) -related aortic relaxation was demonstrated in the test product +sterols group...
  9. pmc Long-term intervention with Lactobacillus helveticus fermented milk reduces augmentation index in hypertensive subjects
    T Jauhiainen
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    Eur J Clin Nutr 64:424-31. 2010
    ..Our aim was to evaluate whether the milk-based drink containing Ile-Pro-Pro and Val-Pro-Pro influence arterial stiffness, measured as augmentation index (AIx), and endothelial function in man...
  10. ncbi request reprint Alpha-lactorphin lowers blood pressure measured by radiotelemetry in normotensive and spontaneously hypertensive rats
    M L Nurminen
    Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
    Life Sci 66:1535-43. 2000
    ....
  11. ncbi request reprint Soy based diet attenuates the development of hypertension when compared to casein based diet in spontaneously hypertensive rat
    R Nevala
    Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
    Life Sci 66:115-24. 2000
    ..These effects were independent of gender. The mechanisms and clinical importance of these findings remain to be clarified...
  12. ncbi request reprint Effects of Lactobacillus rhamnosus GG and Lactobacillus reuteri R2LC on acetic acid-induced colitis in rats
    R Holma
    Institute of Biomedicine, Dept. of Pharmacology and Toxicology, P.O. Box 63, FIN-00014, University of Helsinki, Finland
    Scand J Gastroenterol 36:630-5. 2001
    ..These results suggest that it is not the total amount of Lactobacillus but the particular species or strain of Lactobacillus that is important in attenuating experimental colitis...
  13. ncbi request reprint Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota
    K Kajander
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    Aliment Pharmacol Ther 27:48-57. 2008
    ..Irritable bowel syndrome is the most common diagnosis in gastroenterology. Trials suggest certain probiotics to be beneficial...
  14. doi request reprint Effects of milk casein derived tripeptides on endothelial enzymes in vitro; a study with synthetic tripeptides
    A Siltari
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    Arzneimittelforschung 62:477-81. 2012
    ..Inhibition of POP and activation of cathepsin G do not explain the blood pressure lowering effects of the tripeptides. Thus the inhibition of ACE-1 remains the most plausible mechanism of the antihypertensive effects of the tripeptides...
  15. ncbi request reprint Temperature of a test solution influences abdominal symptoms in lactose tolerance tests
    K Peuhkuri
    Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
    Scand J Clin Lab Invest 60:75-80. 2000
    ..The constant tendencies observed suggest that a room temperature solution is to be recommended for testing lactose digestion...
  16. ncbi request reprint Coffee, caffeine and blood pressure: a critical review
    M L Nurminen
    Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
    Eur J Clin Nutr 53:831-9. 1999
    ..We review the published data relating to intake of coffee and caffeine on blood pressure in man. We also refer to studies on the possible mechanisms of actions of these effects of caffeine...
  17. ncbi request reprint Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut
    E Kankuri
    Institute of Biomedicine, Pharmacology, University of Helsinki, Biomedicum, Finland
    Inflammation 25:301-10. 2001
    ..In addition, nimesulide inhibited neutrophil infiltration into inflamed mucosa mimicking the action of dexamethasone...
  18. doi request reprint Probiotics in infancy induce protective immune profiles that are characteristic for chronic low-grade inflammation
    E Marschan
    The Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Clin Exp Allergy 38:611-8. 2008
    ..Probiotics are widely studied both in the treatment and prevention of allergic diseases, but their mode of action is poorly known...
  19. ncbi request reprint Dietary factors in the pathogenesis and treatment of hypertension
    M L Nurminen
    Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
    Ann Med 30:143-50. 1998
    ..In some patients antihypertensive medication may not be at all necessary...
  20. ncbi request reprint Galacto-oligosaccharides relieve constipation in elderly people
    U Teuri
    Valio Ltd, R and D Centre, Department of Pharmacology and Toxicology, University of Helsinki, Finland
    Ann Nutr Metab 42:319-27. 1998
    ..07). The adverse gastrointestinal symptoms were similar during both the control and the GOS periods. GOS seem to relieve constipation in most elderly people but the responses differ individually...
  21. ncbi request reprint Oral naproxen but not oral paracetamol reduces the need for rescue analgesic after adenoidectomy in children
    R Korpela
    Department of Anaesthesia and Intensive Care, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Acta Anaesthesiol Scand 51:726-30. 2007
    ..The primary outcome was the requirement of rescue analgesic for post-operative pain and the secondary outcome was post-operative nausea and vomiting (PONV)...
  22. ncbi request reprint Calcium-sensitive potassium channel inhibitors antagonize genistein- and daidzein-induced arterial relaxation in vitro
    R Nevala
    Biomedicum, Institute of Biomedicine Pharmacology, University of Helsinki, Finland
    Life Sci 69:1407-17. 2001
    ....
  23. ncbi request reprint Long-term intake of milk peptides attenuates development of hypertension in spontaneously hypertensive rats
    M Sipola
    Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, University of Helsinki, Finland
    J Physiol Pharmacol 52:745-54. 2001
    ..In conclusion, long-term intake of IPP and VPP, or a sour milk containing these tripeptides attenuated the development of hypertension in SHR. One possible mechanism underlying this effect is ACE inhibition...
  24. ncbi request reprint Prophylactic potential of montelukast against mild colitis induced by dextran sulphate sodium in rats
    R Holma
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    J Physiol Pharmacol 58:455-67. 2007
    ..The results indicate that montelukast has some potential to ameliorate mild experimental colitis induced by DSS...
  25. ncbi request reprint Oxidized LDL from subjects with different dietary habits modifies atherogenic processes in endothelial and smooth muscle cells
    T A Lähteenmäki
    Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
    Life Sci 66:455-65. 2000
    ..In EC culture only the extensively oxidized LDLs obtained from the vegetarian diet group were able to induce PGI2 production. The LDLs did not affect basal cGMP production in either EC or VSMC culture...
  26. ncbi request reprint Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome
    K Kajander
    Institute of Biomedicine, Pharmacology, Faculty of Medicine, University of Helsinki, Helsinki, Finland
    Aliment Pharmacol Ther 26:463-73. 2007
    ..A multispecies probiotic has shown beneficial effects in irritable bowel syndrome. In addition, certain other probiotics have demonstrated advantageous effects, but the mechanisms behind this are poorly understood...
  27. ncbi request reprint Wide variations in the testing of lactose tolerance: results of a questionnaire study in Finnish health care centres
    K Peuhkuri
    Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
    Scand J Clin Lab Invest 60:291-7. 2000
    ..The aim of this questionnaire study was to clarify the situation centres with adult patients in Finnish health care and to try to standardize procedures for administering lactose tolerance tests...
  28. pmc Lactobacillus rhamnosus GG and Streptococcus thermophilus induce suppressor of cytokine signalling 3 (SOCS3) gene expression directly and indirectly via interleukin-10 in human primary macrophages
    S Latvala
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare THL, University of Helsinki, Finland
    Clin Exp Immunol 165:94-103. 2011
    ..Enhanced IL-10 production and SOCS3 gene expression induced by live non-pathogenic Lactobacillus and Streptococcus is also likely to contribute to their immunoregulatory effects in vivo...
  29. ncbi request reprint Removing lactose from milk does not delay bowel function or harden stool consistency in lactose-tolerant women
    S Seppanen
    Department of Applied Chemistry and Microbiology, Nutrition, University of Helsinki, Helsinki, Finland
    Eur J Clin Nutr 62:727-32. 2008
    ..We also examined how well the participants' subjective evaluation of the stool consistency according to the Bristol Stool Form Scale correlated with values obtained by dry matter analysis and penetrometry...