Mikael Knip

Summary

Affiliation: Helsinki University Central Hospital
Country: Finland

Publications

  1. pmc Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies
    Sven Pörksen
    Department of Pediatrics, Glostrup Hospital and University of Copenhagen, Copenhagen, Denmark
    BMC Endocr Disord 10:16. 2010
  2. doi request reprint Autoimmune mechanisms in type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Autoimmun Rev 7:550-7. 2008
  3. doi request reprint Does the secular increase in body mass in children contribute to the increasing incidence of type 1 diabetes?
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Pediatr Diabetes 9:46-9. 2008
  4. ncbi request reprint [Is diabetes mellitus, type I an autoimmune disease and can we prevent its onset?]
    Mikael Knip
    HYKS Lasten ja nuorten sairaala PL 281, 00029 HUS
    Duodecim 120:1158-65. 2004
  5. ncbi request reprint Natural course of preclinical type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Horm Res 57:6-11. 2002
  6. ncbi request reprint Humoral beta-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Am J Med Genet 115:48-54. 2002
  7. ncbi request reprint Cow's milk and the new trials for prevention of type 1 diabetes
    M Knip
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    J Endocrinol Invest 26:265-7. 2003
  8. doi request reprint Pathogenesis of type 1 diabetes: implications for incidence trends
    Mikael Knip
    Hospital for Children, University of Helsinki and Helsinki University Central Hospital, and Folkhälsan Research Center, Helsinki, Finland
    Horm Res Paediatr 76:57-64. 2011
  9. ncbi request reprint Signs of beta-cell autoimmunity and HLA-defined diabetes susceptibility in the Finnish population: the sib cohort from the Type 1 Diabetes Prediction and Prevention Study
    M Kukko
    Medical School, University of Tampere, and Department of Paediatrics, Tampere University Hospital, Tampere, Finland
    Diabetologia 46:65-70. 2003
  10. pmc Prediction of type 1 diabetes in the general population
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Diabetes Care 33:1206-12. 2010

Detail Information

Publications163 found, 100 shown here

  1. pmc Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies
    Sven Pörksen
    Department of Pediatrics, Glostrup Hospital and University of Copenhagen, Copenhagen, Denmark
    BMC Endocr Disord 10:16. 2010
    ..Furthermore the study aimed at determining whether mutations in KCNJ11, ABCC8, HNF1A, HNF4A or INS are common in AAB negative diabetes...
  2. doi request reprint Autoimmune mechanisms in type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Autoimmun Rev 7:550-7. 2008
    ....
  3. doi request reprint Does the secular increase in body mass in children contribute to the increasing incidence of type 1 diabetes?
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Pediatr Diabetes 9:46-9. 2008
    ..Objective: We set out to explore whether any relationship can be seen between the incidence of childhood type 1 diabetes and changes in linear growth and body mass in Finnish children over a 12-yr period...
  4. ncbi request reprint [Is diabetes mellitus, type I an autoimmune disease and can we prevent its onset?]
    Mikael Knip
    HYKS Lasten ja nuorten sairaala PL 281, 00029 HUS
    Duodecim 120:1158-65. 2004
  5. ncbi request reprint Natural course of preclinical type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Horm Res 57:6-11. 2002
    ..This indicates that the early prediabetic process may be a suitable target for immunomodulation aimed at delaying or preventing progression to clinical diabetes...
  6. ncbi request reprint Humoral beta-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Am J Med Genet 115:48-54. 2002
    ..In patients with newly diagnosed disease IA-2A may be a more specific marker of beta-cell damage, whereas GADA might reflect a propensity to autoimmunity in general...
  7. ncbi request reprint Cow's milk and the new trials for prevention of type 1 diabetes
    M Knip
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    J Endocrinol Invest 26:265-7. 2003
  8. doi request reprint Pathogenesis of type 1 diabetes: implications for incidence trends
    Mikael Knip
    Hospital for Children, University of Helsinki and Helsinki University Central Hospital, and Folkhälsan Research Center, Helsinki, Finland
    Horm Res Paediatr 76:57-64. 2011
    ....
  9. ncbi request reprint Signs of beta-cell autoimmunity and HLA-defined diabetes susceptibility in the Finnish population: the sib cohort from the Type 1 Diabetes Prediction and Prevention Study
    M Kukko
    Medical School, University of Tampere, and Department of Paediatrics, Tampere University Hospital, Tampere, Finland
    Diabetologia 46:65-70. 2003
    ..To assess the role of HLA-defined genetic diabetes susceptibility in the appearance of signs of beta-cell autoimmunity in a series of children derived from the general population...
  10. pmc Prediction of type 1 diabetes in the general population
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Diabetes Care 33:1206-12. 2010
    ..To evaluate the utility of GAD antibodies (GADAs) and islet antigen-2 antibodies (IA-2As) in prediction of type 1 diabetes over 27 years in the general population and to assess the 6-year rates of seroconversion...
  11. ncbi request reprint Environmental triggers and determinants of beta-cell autoimmunity and type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Rev Endocr Metab Disord 4:213-23. 2003
  12. ncbi request reprint Environmental triggers and determinants of type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, P O Box 281, FI 00029 Huch, Helsinki, Finland
    Diabetes 54:S125-36. 2005
    ..Accordingly, progression to clinical type 1 diabetes typically requires the unfortunate combination of genetic disease susceptibility, a diabetogenic trigger, and a high exposure to a driving antigen...
  13. doi request reprint Food consumption and advanced β cell autoimmunity in young children with HLA-conferred susceptibility to type 1 diabetes: a nested case-control design
    Suvi M Virtanen
    Unit of Nutrition, Department of Lifestyle and Participation, National Institute for Health and Welfare, Helsinki, Finland
    Am J Clin Nutr 95:471-8. 2012
    ..Evidence for the role of food consumption during childhood in the development of β cell autoimmunity is scarce and fragmentary...
  14. doi request reprint Maternal diet during lactation and allergic sensitization in the offspring at age of 5
    Bright I Nwaru
    Tampere School of Public Health, University of Tampere, Tampere, Finland
    Pediatr Allergy Immunol 22:334-41. 2011
    ..On the other hand, intake of potatoes may decrease the risk, while vitamin C and eggs may increase the risk, of cat allergic sensitization. These effects may persist regardless of maternal or parental allergic status...
  15. doi request reprint Lower economic status and inferior hygienic environment may protect against celiac disease
    Anita Kondrashova
    Department of Virology, University of Tampere, Medical School, Tampere, Finland
    Ann Med 40:223-31. 2008
    ..The populations in adjacent Russian Karelia and Finland are equally exposed to grain products and share partly the same ancestry, but live in completely different socioeconomic environments...
  16. doi request reprint Dietary intervention in infancy and later signs of beta-cell autoimmunity
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    N Engl J Med 363:1900-8. 2010
    ..We tested the hypothesis that supplementing breast milk with highly hydrolyzed milk formula would decrease the cumulative incidence of diabetes-associated autoantibodies in such children...
  17. doi request reprint Insulin secretion and sensitivity in the prediction of type 1 diabetes in children with advanced β-cell autoimmunity
    Heli T Siljander
    Children s Hospital, University of Helsinki and Helsinki University Central Hospital, PO Box 22, FI 00014 Helsinki, Finland
    Eur J Endocrinol 169:479-85. 2013
    ..The predictive values of these markers and their relation to other risk factors of T1D were assessed in children with advanced β-cell autoimmunity, i.e. persistent positivity for two or more autoantibodies...
  18. pmc Predictive characteristics of diabetes-associated autoantibodies among children with HLA-conferred disease susceptibility in the general population
    Heli T A Siljander
    Hospital for Children and Adolescents and Folkhälsan Research Center, University of Helsinki, Helsinki, Finland
    Diabetes 58:2835-42. 2009
    ....
  19. doi request reprint Sociodemographic determinants of early weaning: a Finnish birth cohort study in infants with human leucocyte antigen-conferred susceptibility to type 1 diabetes
    Maijaliisa Erkkola
    Division of Nutrition, Department of Food and Environmental Sciences, PO Box 66, FI 00014 University of Helsinki, Helsinki, Finland
    Public Health Nutr 16:296-304. 2013
    ..To assess the most important sociodemographic determinants of age at introduction of complementary foods in infancy...
  20. doi request reprint Maternal intake of fatty acids during pregnancy and allergies in the offspring
    Bright I Nwaru
    School of Health Sciences, University of Tampere, Tampere, Finland
    Br J Nutr 108:720-32. 2012
    ..Overall, our data suggest that maternal consumption of butter, the ratio of n-6:n-3 FA and intake of PUFA and α-linolenic FA during pregnancy may be potential determinants of allergic rhinitis in the offspring...
  21. doi request reprint Enhanced levels of cow's milk antibodies in infancy in children who develop type 1 diabetes later in childhood
    Kristiina Luopajarvi
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Pediatr Diabetes 9:434-41. 2008
    ..Early exposure to cow's milk (CM) proteins have been implicated in the pathogenesis of type 1 diabetes (T1D)...
  22. doi request reprint Maternal diet during pregnancy and allergic sensitization in the offspring by 5 yrs of age: a prospective cohort study
    Bright I Nwaru
    Tampere School of Public Health, University of Tampere, Tampere, Finland
    Pediatr Allergy Immunol 21:29-37. 2010
    ..Further studies are required to define more closely the putative effect of maternal intake of polyunsaturated fatty acids on development of allergic diseases in the offspring...
  23. doi request reprint Role of insulin autoantibody affinity as a predictive marker for type 1 diabetes in young children with HLA-conferred disease susceptibility
    Heli Siljander
    Hospital for Children and Adolescents and Folkhälsan Research Center, University of Helsinki, 00014 Helsinki, Finland
    Diabetes Metab Res Rev 25:615-22. 2009
    ....
  24. doi request reprint Characterization of the humoral immune response to islet antigen 2 in children with newly diagnosed type 1 diabetes
    Anna Mäkinen
    Scientific Laboratory, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Biomedicum I, PO Box 63, FI 00014 Helsinki, Finland
    Eur J Endocrinol 159:19-26. 2008
    ....
  25. doi request reprint Sociodemographic and lifestyle characteristics are associated with antioxidant intake and the consumption of their dietary sources during pregnancy
    Liisa Uusitalo
    Tampere School of Public Health, University of Tampere, Tampere, Finland
    Public Health Nutr 11:1379-88. 2008
    ..To analyse the associations of selected sociodemographic and lifestyle factors with the intake of antioxidant nutrients and consumption of their main dietary sources among pregnant women...
  26. doi request reprint Dietary fatty acid composition during pregnancy and the risk of asthma in the offspring
    Mirka Lumia
    Nutrition Unit, Department of Lifestyle and Participation, National Institute of Health and Welfare, Helsinki, Finland
    Pediatr Allergy Immunol 22:827-35. 2011
    ..We explored the association of maternal dietary FA composition during pregnancy with the risk of asthma in the offspring...
  27. doi request reprint Determinants of breast-feeding in a Finnish birth cohort
    Maijaliisa Erkkola
    Division of Nutrition, Department of Applied Chemistry and Microbiology, University of Helsinki, Helsinki, Finland
    Public Health Nutr 13:504-13. 2010
    ..To assess milk feeding on the maternity ward and during infancy, and their relationship to sociodemographic determinants. The validity of our 3-month questionnaire in measuring hospital feeding was assessed...
  28. doi request reprint Risk of asthma and allergic outcomes in the offspring in relation to maternal food consumption during pregnancy: a Finnish birth cohort study
    Maijaliisa Erkkola
    Division of Nutrition, Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland
    Pediatr Allergy Immunol 23:186-94. 2012
    ....
  29. doi request reprint Food consumption and nutrient intake in Finnish 1-6-year-old children
    Pipsa Kyttälä
    Tampere School of Public Health, University of Tampere, FI 33014, Tampere, Finland
    Public Health Nutr 13:947-56. 2010
    ..To study food consumption and nutrient intake in Finnish children aged 1-6 years and to assess the effect of age and sex on food consumption and nutrient intake...
  30. doi request reprint Age at the introduction of solid foods during the first year and allergic sensitization at age 5 years
    Bright I Nwaru
    Tampere School of Public Health, University of Tampere, Finland
    Pediatrics 125:50-9. 2010
    ..The goal was to examine the relationship between age at the introduction of solid foods during the first year of life and allergic sensitization in 5-year-old children...
  31. doi request reprint Early introduction of oats associated with decreased risk of persistent asthma and early introduction of fish with decreased risk of allergic rhinitis
    Suvi M Virtanen
    Department of Lifestyles and Participation, National Institute of Health and Welfare, Helsinki, Finland
    Br J Nutr 103:266-73. 2010
    ..We confirmed the earlier observation that the age at introduction of fish is inversely related to the risk of allergic rhinitis. Clinical implications remain to be determined...
  32. doi request reprint Nutrient intake variability and number of days needed to assess intake in preschool children
    Maijaliisa Erkkola
    Division of Nutrition, Department of Food and Environmental Sciences, PO Box 66, FI 00014, University of Helsinki, Helsinki, Finland
    Br J Nutr 106:130-40. 2011
    ..The accuracy of ranking boys is greater than that for girls...
  33. ncbi request reprint Dietary insulin as an immunogen and tolerogen
    Minna Tiittanen
    Department of Viral Diseases and Immunology, Laboratory for Immunology, National Public Health Institute, Helsinki, Finland
    Pediatr Allergy Immunol 17:538-43. 2006
    ..However, our results in infants who developed beta-cell autoimmunity suggest that in this subgroup of children breast milk insulin does not promote tolerance...
  34. doi request reprint Co-occurrence of allergic sensitization and type 1 diabetes
    Tapio Seiskari
    Department of Virology, University of Tampere, Tampere, Finland
    Ann Med 42:352-9. 2010
    ..If so, these diseases should co-occur more often than expected. We investigated this phenomenon in two contrasting socio-economic environments, Finland and Russian Karelia...
  35. doi request reprint Human rhinoviruses including group C are common in stool samples of young Finnish children
    Hanna Honkanen
    University of Tampere, School of Medicine, Tampere, Finland
    J Clin Virol 56:250-4. 2013
    ..They have been widely studied in respiratory samples in hospital patient series but only a few studies have been performed to assess their occurrence in other sample types and their circulation in healthy children background population...
  36. doi request reprint Human parechoviruses are frequently detected in stool of healthy Finnish children
    Pekka Kolehmainen
    Department of Virology, School of Medicine, University of Tampere, Tampere, Finland
    J Clin Virol 54:156-61. 2012
    ..Human parechoviruses (HPeVs) are common viruses mainly infecting young children. Most infections are mild, but HPeV3 causes severe CNS infections in new-born infants...
  37. pmc Early feeding and risk of type 1 diabetes: experiences from the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR)
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Am J Clin Nutr 94:1814S-1820S. 2011
    ..The overall retention rate over the first 5 y was 87%, and protocol compliance was 94%. The randomization code will be opened when the last recruited child turns 10 y of age (ie, in 2017)...
  38. doi request reprint Some similarities in dietary clusters of pre-school children and their mothers
    Marja Leena Ovaskainen
    Nutrition Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Mannerheimintie 166, Helsinki, Finland
    Br J Nutr 102:443-52. 2009
    ..The diets of pre-school children vary by age and only a slight similarity within dietary clusters of mother-child pairs was observed...
  39. ncbi request reprint Geographical variation in risk HLA-DQB1 genotypes for type 1 diabetes and signs of beta-cell autoimmunity in a high-incidence country
    Marika Kukko
    Juvenile Diabetes Research Foundation Center for the Prevention of Type 1 Diabetes in Finland, Tampere, Finland
    Diabetes Care 27:676-81. 2004
    ..To assess possible differences in the frequency of HLA-DQB1 risk genotypes and the emergence of signs of beta-cell autoimmunity among three geographical regions in Finland...
  40. doi request reprint Diet composition of pregnant Finnish women: changes over time and across seasons
    Marianne Prasad
    Department of Lifestyle and Participation, National Institute for Health and Welfare, PO Box 27, FI 00271, Helsinki, Finland
    Public Health Nutr 13:939-46. 2010
    ..To describe the diet of a population of pregnant Finnish women over a period of 7 years, with special attention paid to seasonal fluctuations in food consumption and nutrient intake...
  41. ncbi request reprint Serological evidence of thyroid autoimmunity among schoolchildren in two different socioeconomic environments
    Anita Kondrashova
    Department of Virology, University of Tampere, Medical School, Biokatu 10, FI 33520 Tampere, and Department of Clinical Microbiology, Tampere Pirkanmaa Hospital District, Finland
    J Clin Endocrinol Metab 93:729-34. 2008
    ..The mechanisms leading to thyroid autoimmunity are largely unknown...
  42. ncbi request reprint Intake of antioxidant vitamins and trace elements during pregnancy and risk of advanced beta cell autoimmunity in the child
    Liisa Uusitalo
    Tampere School of Public Health, University of Tampere, Tampere, Finland
    Am J Clin Nutr 88:458-64. 2008
    ..Type 1 diabetes may have its origins in the fetal period of life. Free radicals were implicated in the cause of type 1 diabetes. It was hypothesized that antioxidant nutrients could protect against type 1 diabetes...
  43. doi request reprint Timing of infant feeding in relation to childhood asthma and allergic diseases
    Bright I Nwaru
    School of Health Sciences, University of Tampere, Tampere, Finland
    J Allergy Clin Immunol 131:78-86. 2013
    ..Emerging evidence questions current recommendations on the timing of infant feeding for the prevention of childhood allergies. The evidence for asthma is inconclusive...
  44. pmc Maternal enterovirus infection as a risk factor for type 1 diabetes in the exposed offspring
    Hanna Viskari
    Department of Virology, University of Tampere, School of Medicine, Tampere, Finland
    Diabetes Care 35:1328-32. 2012
    ..The aim of this study was to evaluate this association in a unique series of pregnant mothers whose child progressed to clinical type 1 diabetes...
  45. doi request reprint Temporal relationship between human parechovirus 1 infection and otitis media in young children
    Sisko Tauriainen
    Dept of Virology, University of Tampere Medical School, 33014 University of Tampere, Tampere, Finland
    J Infect Dis 198:35-40. 2008
    ..Because clinical symptoms are poorly documented, we evaluated the symptoms associated with HPeV1 infection in a cohort of children followed prospectively from birth at 3-month intervals...
  46. ncbi request reprint Human parechovirus 1 infections in young children--no association with type 1 diabetes
    Sisko Tauriainen
    JDRF Center for Prevention of Type 1 Diabetes, Tampere, Finland
    J Med Virol 79:457-62. 2007
    ..No difference was found in infection frequency between boys and girls, nor between prediabetic, diabetic and control subjects. Most infections (87%) occurred during autumn, winter and spring...
  47. pmc Impact of intranasal insulin on insulin antibody affinity and isotypes in young children with HLA-conferred susceptibility to type 1 diabetes
    Samppa J Ryhänen
    Scientific Laboratory, Hospital for Children and Adolescents and Folkhälsan Research Center, University of Helsinki, Helsinki, Finland
    Diabetes Care 34:1383-8. 2011
    ..To analyze whether the insulin dose was inadequate to elicit an immunomodulatory response, we compared the changes observed in insulin antibody (IA) affinity and isotypes after treatment with nasal insulin or placebo...
  48. pmc Enterovirus RNA in blood is linked to the development of type 1 diabetes
    Sami Oikarinen
    Department of Virology, University of Tampere, Finland
    Diabetes 60:276-9. 2011
    ..Further, to study the role of enteroviruses in both the initiation of the process and the progression to type 1 diabetes...
  49. doi request reprint Food consumption and nutrient intake in day care and at home in 3-year-old Finnish children
    Jenni Lehtisalo
    Department of Lifestyle and Participation, Nutrition Unit, National Institute for Health and Welfare, PO Box 30, FI 00271, Helsinki, Finland
    Public Health Nutr 13:957-64. 2010
    ..To assess and compare the food consumption and nutrient intake between 3-year-old children cared for at home full-time and those attending day care outside the home. Nutrient intake on weekdays and weekends was also studied...
  50. doi request reprint Extended family history of autoimmune diseases and phenotype and genotype of children with newly diagnosed type 1 diabetes
    Anna Parkkola
    Children s Hospital, University of Helsinki and Helsinki University Central Hospital, PO Box 22, FI 00014 Helsinki, Finland
    Eur J Endocrinol 169:171-8. 2013
    ....
  51. doi request reprint Role of enterovirus infections in IgE sensitization
    Tapio Seiskari
    Department of Virology, University of Tampere, Tampere, Finland
    J Med Virol 84:268-71. 2012
    ..001; OR = 0.35, 95% CI: 0.18-0.67). The results support previous observations suggesting that infections by certain enterovirus types are associated with protection against IgE sensitization...
  52. doi request reprint Infant feeding and the risk of type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents and Folkhälsan Research Center, University of Helsinki, Finland
    Am J Clin Nutr 91:1506S-1513S. 2010
    ..Additional work, which includes the application of modern approaches such as metabolomics and epigenomics, is needed to discern the contribution of dietary factors in infancy to the diabetic disease process...
  53. ncbi request reprint Maternal antibodies in breast milk protect the child from enterovirus infections
    Karita Sadeharju
    Department of Virology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Pediatrics 119:941-6. 2007
    ..We set out to assess whether breastfeeding can protect against these infections and whether such an effect is related to maternal antibodies in breast milk or in the peripheral circulation of the infant...
  54. doi request reprint Zinc transporter type 8 autoantibodies (ZnT8A): prevalence and phenotypic associations in latent autoimmune diabetes patients and patients with adult onset type 1 diabetes
    Mette K Andersen
    Research Program for Molecular Medicine, Helsinki University and Department of Medicine, Helsinki University Hospital, Helsinki, Finland
    Autoimmunity 46:251-8. 2013
    ..Our aim was to assess the prevalence of ZnT8 autoantibodies (ZnT8A) in patients with adult-onset diabetes, and to characterize associations between ZnT8A and phenotype, as well as SLC30A8 and HLA-DQB1 genotypes...
  55. pmc Environmental triggers of type 1 diabetes
    Mikael Knip
    Children s Hospital, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland Folkhälsan Research Center, FI 00290 Helsinki, Finland
    Cold Spring Harb Perspect Med 2:a007690. 2012
    ....
  56. doi request reprint The 'Hygiene hypothesis' and the sharp gradient in the incidence of autoimmune and allergic diseases between Russian Karelia and Finland
    Anita Kondrashova
    Department of Virology, University of Tampere, Tampere, Finland
    APMIS 121:478-93. 2013
    ..Infections, or lack of them, may indeed be strongly involved in the development of both autoimmune and allergic diseases...
  57. doi request reprint Expansion of CD4+CD25+FOXP3+ regulatory T cells in infants of mothers with type 1 diabetes
    Kristiina Luopajarvi
    Immune Response Unit, Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    Pediatr Diabetes 13:400-7. 2012
    ..Reduced risk for type 1 diabetes (T1D) has been reported in the offspring of mothers with T1D when compared with children of affected fathers...
  58. ncbi request reprint Cow milk is not responsible for most gastrointestinal immune-like syndromes--evidence from a population-based study
    Laura Paajanen
    Foundation for Nutrition Research, Helsinki, Finland
    Am J Clin Nutr 82:1327-35. 2005
    ..Gastrointestinal hypersensitivity to cow milk (CM) may be more common among school-aged children and young adults than previously thought...
  59. ncbi request reprint Short-term exclusive breastfeeding predisposes young children with increased genetic risk of Type I diabetes to progressive beta-cell autoimmunity
    T Kimpimäki
    Department of Pediatrics, Tampere University Hospital, Finland
    Diabetologia 44:63-9. 2001
    ..This study aimed to establish the relation between early infant nutrition and signs of beta-cell autoimmunity in young children...
  60. doi request reprint Fatty acids in serum and diet--a canonical correlation analysis among toddlers
    Liisa Uusitalo
    School of Health Sciences, University of Tampere, Tampere, Finland
    Matern Child Nutr 9:381-95. 2013
    ..The correlation between intake of milk fat and serum proportion of CLA is a novel finding...
  61. doi request reprint Validation of the Finnish ISAAC questionnaire on asthma against anti-asthmatic medication reimbursement database in 5-year-old children
    Bright Ibeabughichi Nwaru
    Tampere School of Public Health, University of Tampere, Finland
    Clin Respir J 5:211-8. 2011
    ..We aimed at validating the Finnish version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire based on parental-reported childhood asthma...
  62. ncbi request reprint Maternal consumption of dairy products during pregnancy and lactation, and the development of cow's milk antibodies in the offspring
    Maijaliisa Erkkola
    Department of Epidemiology and Health Promotion, Nutrition Unit, National Public Health Institute, Helsinki, Finland
    Acta Paediatr 94:696-704. 2005
    ..To assess whether the maternal consumption of milk and milk products affects development of cow's milk (CM) antibodies in infants...
  63. doi request reprint Collecting high-quality pancreatic tissue for experimental study from organ donors with signs of β-cell autoimmunity
    Sisko Tauriainen
    Department of Virology, University of Tampere, Medical School, Tampere, Finland
    Diabetes Metab Res Rev 26:585-92. 2010
    ....
  64. ncbi request reprint Serum alpha-tocopherol concentrations and risk of type 1 diabetes mellitus: a cohort study in siblings of affected children
    Liisa Uusitalo
    Tampere School of Public Health, University of Tampere, Finland
    J Pediatr Endocrinol Metab 18:1409-16. 2005
    ..08 and 0.09, respectively). Although the results did not reach statistical significance, they support the hypothesis that high alpha-tocopherol levels may protect against DM1...
  65. ncbi request reprint Environmental factors in the etiology of type 1 diabetes
    Hans K Akerblom
    University of Helsinki, Finland
    Am J Med Genet 115:18-29. 2002
    ..Among toxins, N-nitroso compounds are the main candidates. An interaction of genetic and environmental factors is important in evaluating the possible role of a certain environmental factor in the etiology of type 1 diabetes...
  66. doi request reprint Viral interference induced by live attenuated virus vaccine (OPV) can prevent otitis media
    Elina Seppälä
    Department of Virology, University of Tampere, Tampere, Finland
    Vaccine 29:8615-8. 2011
    ..The goal of this study was to evaluate whether a live attenuated poliovirus vaccine (OPV) has clinically relevant interfering effect with non-polio infections causing otitis media in young children...
  67. doi request reprint Breastfeeding patterns of mothers with type 1 diabetes: results from an infant feeding trial
    Susa Sorkio
    Nutrition Unit, National Institute for Health and Welfare, Helsinki, Finland
    Diabetes Metab Res Rev 26:206-11. 2010
    ..The aim of this study was to prospectively examine the breastfeeding patterns among mothers with and without T1D participating in a large international randomized infant feeding trial (TRIGR)...
  68. ncbi request reprint Signs of beta-cell autoimmunity in nondiabetic schoolchildren: a comparison between Russian Karelia with a low incidence of type 1 diabetes and Finland with a high incidence rate
    Anita Kondrashova
    Department of Virology, University of Tampere Medical School, Tampere, Finland
    Diabetes Care 30:95-100. 2007
    ..We sought to study the prevalence of autoantibodies to various islet cell antigens in the background population of two neighboring countries with a sixfold difference in the incidence of type 1 diabetes...
  69. ncbi request reprint Models for predicting type 1 diabetes in siblings of affected children
    Samy Mrena
    Hospital for Children and Adolescents, University of Helsinki, P O Box 281, FI 00029 Huch, Helsinki, Finland
    Diabetes Care 29:662-7. 2006
    ..To generate predictive models for the assessment of risk of type 1 diabetes and age at diagnosis in siblings of children with newly diagnosed type 1 diabetes...
  70. doi request reprint IL-17 immunity in human type 1 diabetes
    Jarno Honkanen
    Immune Response Unit, National Institute for Health and Welfare, Helsinki, Finland
    J Immunol 185:1959-67. 2010
    ..Our findings highlight the role of IL-17 immunity in the pathogenesis of human T1D and point to a potential therapeutic strategy...
  71. ncbi request reprint IA-2 antibody epitopes and isotypes during the prediabetic process in siblings of children with type 1 diabetes
    Sanna Hoppu
    Pediatric Research Center, University of Tampere, and Tampere University Hospital, Tampere, Finland
    J Autoimmun 23:361-70. 2004
    ..This study demonstrates that JM-reactive IA-2 antibodies are associated with an increased risk of progression to overt T1D, whereas an IgE response to IA-2 confers relative protection against clinical disease...
  72. ncbi request reprint Anti-insulin activity in IgG-fractions from children with newly-diagnosed type 1 diabetes and negative for insulin autoantibodies
    Minna Tiittanen
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Autoimmunity 37:45-9. 2004
    ..Our results suggest that formation of immune complexes results in false negative results in tests for IAA but not for GADA...
  73. doi request reprint Clinical significance of glutamic acid decarboxylase antibodies in patients with epilepsy
    Suvi Liimatainen
    Department of Neurology and Rehabilitation, Tampere University Hospital, Tampere, Finland
    Epilepsia 51:760-7. 2010
    ..Glutamic acid decarboxylase antibodies (GADAs) have been detected in patients with epilepsy, but the clinical determinants of epilepsy associated with GADA have not been defined...
  74. ncbi request reprint The first signs of beta-cell autoimmunity appear in infancy in genetically susceptible children from the general population: the Finnish Type 1 Diabetes Prediction and Prevention Study
    T Kimpimäki
    The Juvenile Diabetes Research Foundation Center for Type 1 Diabetes Prevention in Finland, Department of Pediatrics, Medical School, University of Tampere, FIN 33014 Tampere, Finland
    J Clin Endocrinol Metab 86:4782-8. 2001
    ..The seasonal variation in the emergence of the first signs of beta-cell autoimmunity suggests that infectious agents may play a role in the induction of such autoimmunity...
  75. ncbi request reprint Cow's milk formula feeding induces primary immunization to insulin in infants at genetic risk for type 1 diabetes
    O Vaarala
    Department of Biochemistry, National Public Health Institute, Helsinki, Finland
    Diabetes 48:1389-94. 1999
    ..This immune response to insulin may later be diverted into autoaggressive immunity against beta-cells in some individuals, as indicated by our findings in children with diabetes-associated autoantibodies...
  76. ncbi request reprint Increased frequency of islet cell antibodies in unaffected brothers of children with type 1 diabetes
    Vesa Eskola
    University of Tampere Medical School and Department of Paediatrics, Tampere University Hospital, Tampere, Finland
    Horm Res 59:195-200. 2003
    ..To assess the relation between islet cell antibody (ICA) positivity and demographic characteristics in an extensive series of first-degree relatives of children with type 1 diabetes (T1D)...
  77. ncbi request reprint Densin and filtrin in the pancreas and in the kidney, targets for humoral autoimmunity in patients with type 1 diabetes
    Johanna Rinta-Valkama
    Biomedicum Helsinki, Department of Bacteriology and Immunology, University of Helsinki, Finland
    Diabetes Metab Res Rev 23:119-26. 2007
    ....
  78. ncbi request reprint Soluble adhesion molecules in Finnish schoolchildren with signs of preclinical type 1 diabetes
    Anna Toivonen
    Paediatric Research Centre, University of Tampere, Tampere, Finland
    Diabetes Metab Res Rev 20:48-54. 2004
    ....
  79. ncbi request reprint Early nutrition and later diabetes risk
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, P O Box 281, FI 00029 Huch, Helsinki, Finland
    Adv Exp Med Biol 569:142-50. 2005
    ....
  80. pmc Humoral beta-cell autoimmunity is rare in patients with the congenital rubella syndrome
    H Viskari
    JDRF Center for Prevention of Type I Diabetes in Finland, Department of Virology, University of Tampere, Finland
    Clin Exp Immunol 133:378-83. 2003
    ..These results provide no evidence of an increased frequency of markers for humoral beta-cell autoimmunity in patients with CRS suggesting that diabetes in CRS may be caused by other than autoimmune mechanisms...
  81. ncbi request reprint Islet cell antibodies are less predictive of IDDM among unaffected children in the general population than in sibs of children with diabetes. The Childhood Diabetes in Finland Study Group
    M Knip
    Medical School and the Department of Pediatrics, Tampere University Hospital, University of Tampere, Finland
    Diabetes Care 21:1670-3. 1998
    ..To examine the controversial issue of whether islet cell antibodies (ICAs) have a higher predictive value for progression to clinical IDDM in first-degree relatives of patients with diabetes than in the general population...
  82. ncbi request reprint Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes: a pilot study
    H K Akerblom
    Hospital for Children and Adolescents, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, PO Box 700, 00029 Helsinki, Finland
    Diabetologia 48:829-37. 2005
    ....
  83. ncbi request reprint Unaltered antioxidant activity of plasma in subjects at increased risk for IDDM
    J S Leinonen
    Medical School, University of Tampere, and Department of Clinical Chemistry, Tampere University Hospital, Finland
    Free Radic Res 29:159-64. 1998
    ..Furthermore, the results suggest that the clinical onset of IDDM is not preceded by signs of increased systemic oxidative stress in plasma...
  84. doi request reprint Serum alpha- and gamma-tocopherol concentrations and risk of advanced beta cell autoimmunity in children with HLA-conferred susceptibility to type 1 diabetes mellitus
    L Uusitalo
    Tampere School of Public Health, University of Tampere, Tampere, Finland
    Diabetologia 51:773-80. 2008
    ..The aim of our study was to assess the associations of serum alpha- and gamma-tocopherol concentrations with the risk of advanced beta cell autoimmunity in children with HLA-conferred genetic susceptibility to type 1 diabetes mellitus...
  85. pmc The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study: recruitment, intervention and follow-up
    H K Akerblom
    Hospital for Children and Adolescents, University of Helsinki, Biomedicum Helsinki 2 U, PO Box 20, 00014, Helsinki, Finland
    Diabetologia 54:627-33. 2011
    ..The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study was designed to establish whether weaning to a highly hydrolysed formula in infancy subsequently reduces the risk of type 1 diabetes...
  86. ncbi request reprint Prevalence of Celiac disease among children in Finland
    Markku Maki
    Pediatric Research Center, Medical School, University of Tampere, Tampere, Finland
    N Engl J Med 348:2517-24. 2003
    ....
  87. doi request reprint Poor in vitro induction of FOXP3 and ICOS in type 1 cytokine environment activated T-cells from children with type 1 diabetes
    Jarno Honkanen
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    Diabetes Metab Res Rev 24:635-41. 2008
    ..We set out to study whether an impaired induction of regulatory mechanisms during the generation of T-cell responses upon stimulation is associated with T1D...
  88. ncbi request reprint Autoimmunity and familial risk of type 1 diabetes
    Anu Maaria Hämäläinen
    Department of Pediatrics, Jorvi Hospital, Helsinki University Hospital, Turuntie 150, Espoo FIN 02740, Finland
    Curr Diab Rep 2:347-53. 2002
    ..The possible protective or predisposing effect of diabetes-associated antibodies detectable at birth on progression to clinical type I diabetes later will be assessed in ongoing prospective birth cohort studies...
  89. ncbi request reprint Effect of cow's milk exposure and maternal type 1 diabetes on cellular and humoral immunization to dietary insulin in infants at genetic risk for type 1 diabetes. Finnish Trial to Reduce IDDM in the Genetically at Risk Study Group
    J Paronen
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Diabetes 49:1657-65. 2000
    ..The priming of insulin-specific humoral and T-cell immunity occurs in early infancy by dietary insulin, and this phenomenon is influenced by maternal type 1 diabetes...
  90. ncbi request reprint Neonatal Type I diabetes associated with maternal echovirus 6 infection: a case report
    T Otonkoski
    Hospital for Children and Adolescents and Haartman Institute, Transplantation Laboratory, University of Helsinki, Finland
    Diabetologia 43:1235-8. 2000
    ..Exocrine pancreatic insufficiency was diagnosed at the age of 1 year. CONCLUSION/INTERPRETATION: These observations suggests that enteroviral infections may induce beta-cell autoimmunity even in utero...
  91. ncbi request reprint Infant feeding patterns in the Finnish type I diabetes prediction and prevention nutrition study cohort
    M Erkkola
    Tampere School of Public Health, University of Tampere, Tampere, Finland
    Eur J Clin Nutr 59:107-13. 2005
    ..To investigate infant feeding patterns during the first 2 y and their relation to sociodemographic factors...
  92. ncbi request reprint Cow's milk consumption, HLA-DQB1 genotype, and type 1 diabetes: a nested case-control study of siblings of children with diabetes. Childhood diabetes in Finland study group
    S M Virtanen
    School of Public Health, University of Tampere, Finland
    Diabetes 49:912-7. 2000
    ..However, further studies are needed to assess the possible interaction between genetic disease susceptibility and dietary exposures in the development of this disease...
  93. ncbi request reprint Several different enterovirus serotypes can be associated with prediabetic autoimmune episodes and onset of overt IDDM. Childhood Diabetes in Finland (DiMe) Study Group
    M Roivainen
    Department of Virology, National Public Health Institute, Helsinki, Finland
    J Med Virol 56:74-8. 1998
    ....
  94. ncbi request reprint Enterovirus RNA in serum is a risk factor for beta-cell autoimmunity and clinical type 1 diabetes: a prospective study. Childhood Diabetes in Finland (DiMe) Study Group
    M Lonnrot
    JDFI Center for Prevention of Type 1 Diabetes in Finland, Tampere, Finland
    J Med Virol 61:214-20. 2000
    ....
  95. ncbi request reprint Age at introduction of new foods and advanced beta cell autoimmunity in young children with HLA-conferred susceptibility to type 1 diabetes
    S M Virtanen
    Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Mannerheimintie 166, 00300, Helsinki, Finland
    Diabetologia 49:1512-21. 2006
    ..We set out to study the effects of breastfeeding and of age at introduction of supplementary foods on the development of beta cell autoimmunity...
  96. pmc Enterovirus infections as a risk factor for type I diabetes: virus analyses in a dietary intervention trial
    K Sadeharju
    JDRF Center for Prevention of Type 1 Diabetes in Finland, Department of Virology, University of Tampere Medical School and Tampere University Hospital, Tampere, Finland
    Clin Exp Immunol 132:271-7. 2003
    ..These results suggest that enterovirus infections are associated with the induction of beta-cell autoimmunity in young children with increased genetic susceptibility to type I diabetes...
  97. ncbi request reprint Genetic modification of risk assessment based on staging of preclinical type 1 diabetes in siblings of affected children
    S Mrena
    Hospital for Children and Adolescents, University of Helsinki, FIN 00029 Helsinki, Finland
    J Clin Endocrinol Metab 88:2682-9. 2003
    ..Genetic susceptibility has an impact on both the initiation and progression of the autoimmune process leading to clinical diabetes in siblings of affected children...
  98. ncbi request reprint Intake of vitamin D by Finnish children aged 3 months to 3 years in relation to sociodemographic factors
    M Rasanen
    Tampere School of Public Health, University of Tampere, Finland
    Eur J Clin Nutr 60:1317-22. 2006
    ..To study the total daily intake of vitamin D from food and supplements among Finnish children aged 3 months to 3 years, the dietary sources of vitamin D and the association between vitamin D intake and sociodemographic factors...
  99. ncbi request reprint Disease-associated autoimmunity and prevention of insulin-dependent diabetes mellitus
    M Knip
    University of Tampere, Department of Pediatrics, Tampere University Hospital, Finland
    Ann Med 29:447-51. 1997
    ..Substantially more data have to be generated, however, on the mechanisms, efficacy and safety of such therapy before it is possible to judge its clinical applicability...
  100. doi request reprint Relation among mannose-binding lectin 2 genotype, beta-cell autoantibodies, and risk for type 1 diabetes in Finnish children
    J Aittoniemi
    Department of Clinical Microbiology, Centre for Laboratory Medicine, Pirkanmaa Hospital District, Tampere, Finland
    Hum Immunol 69:108-11. 2008
    ..The association of the biallelic variant genotype with positivity for multiple autoantibodies suggests that intermolecular epitope spreading may be linked with impaired clearance of autoantigens as a result of MBL deficiency...
  101. doi request reprint Analysis of pancreas tissue in a child positive for islet cell antibodies
    M Oikarinen
    Department of Virology, Medical School, University of Tampere, Biokatu 10, Tampere, Finland
    Diabetologia 51:1796-802. 2008
    ..The present study assesses whether positivity for a single autoantibody correlates with pathological changes in the pancreas...