Research Topics
Species | Eija KalsoSummaryAffiliation: Helsinki University Central Hospital Country: Finland Publications
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Detail Information
Publications
Medical undergraduate students' beliefs and attitudes toward pain: how do they mature?Leila Niemi-Murola
Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Finland
Eur J Pain 11:700-6. 2007..Attitudes towards treating the pain of cancer patients and elderly patients are positive. Attention should be paid to helping students to cope with their emotions and to reducing their anxiety about meeting patients with chronic pain...- Do surgical patients benefit from perioperative gabapentin/pregabalin? A systematic review of efficacy and safetyElina M Tiippana
Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
Anesth Analg 104:1545-56, table of contents. 2007..These properties may also be beneficial in acute postoperative pain. In this study we evaluated randomized, controlled trials examining the analgesic efficacy, adverse effects, and clinical value of gabapentinoids in postoperative pain... - Do strong opioids have a role in the early management of back pain? Recommendations from a European expert panelEija Kalso
Pain Clinic, Helsinki University Central Hospital, Helsinki, Finland
Curr Med Res Opin 21:1819-28. 2005..Given the prevalence of CLBP, and the complex nature of this multifactorial condition, it was felt that specific, evidence-based recommendations, with a focus on primary-care treatment, would be helpful... 
Predicting long-term response to strong opioids in patients with low back pain: findings from a randomized, controlled trial of transdermal fentanyl and morphineEija Kalso
Pain Clinic, Helsinki University Central Hospital, Helsinki, Finland
BMC Med 5:39. 2007..We assessed data from a large-scale randomized comparison of transdermal fentanyl (TDF) and sustained-release oral morphine (slow-release morphine; SRM) to determine characteristics of treatment responders...- [Opioids in the treatment of pain--efficient weapon in the expert's hand]Eija Kalso
HYKS, anestesiologia ja tehohoito, kipuklinikka PL 340, 00029 HUS
Duodecim 120:195-6. 2004 - Recommendations for using opioids in chronic non-cancer painEija Kalso
Helsinki University Central Hospital, Finland
Eur J Pain 7:381-6. 2003..6. Treatment should be monitored. 7. A contract setting out the patient's rights and responsibilities may help to emphasize the importance of patient involvement. 8. Opioid treatment should not be considered a lifelong treatment... 
Trends in opioid consumption in the Nordic countries 2002-2006Katri Hamunen
Pain Clinic, Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Meilahti Hospital, Helsinki, HUS, Finland
Eur J Pain 13:954-62. 2009..The purpose of the study was to examine the trends in opioid consumption in the five Nordic countries between 2002 and 2006 and to explore possible explanations for changes in the quality and quantity of opioids consumed...- Amitriptyline in the prevention of chemotherapy-induced neuropathic symptomsAnna Liisa Kautio
Department of Oncology, Helsinki University Central Hospital, 00029 HUS, Finland
Anticancer Res 29:2601-6. 2009..This double-blind, randomized placebo-controlled trial assessed the efficacy of amitriptyline to prevent chemotherapy-induced neuropathic symptoms... - HLA-DRB1*01 allele and low plasma immunoglobulin G1 concentration may predispose to herpes-associated recurrent lymphocytic meningitisKatariina Kallio-Laine
Pain Clinic, Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
Hum Immunol 71:179-81. 2010..05). HLA-DRB1*01 (p = 0.009) and -B*27 (p = 0.050) were more common among patients than controls. We conclude that HLA-DRB1*01 and -B*27 alleles and low plasma IgG1 levels may be significant risk factors for RLM... - Burden of chemotherapy-induced neuropathy--a cross-sectional studyAnna Liisa Kautio
Department of Oncology, Helsinki University Central Hospital, PO Box 180, 00029 HUS, Helsinki, Finland
Support Care Cancer 19:1991-6. 2011..The aim of the study was to assess the prevalence and discomfort caused by neuropathic symptoms in relation to other adverse effects of chemotherapy... - Transdermal fentanyl in cachectic cancer patientsTarja Heiskanen
Pain Clinic, Department of Anesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, P O Box 140, 00029 HUS Helsinki, Finland
Pain 144:218-22. 2009..Absorption of transdermal fentanyl is impaired in cachectic patients compared with that of normal weight cancer pain patients... - Opioids in chronic non-cancer pain: systematic review of efficacy and safetyEija Kalso
Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, P O Box 340, FIN 00029 HUS, Finland
Pain 112:372-80. 2004..The small number of selected patients and the short follow-ups do not allow conclusions concerning problems such as tolerance and addiction... - Oxaliplatin scale and National Cancer Institute-Common Toxicity Criteria in the assessment of chemotherapy-induced peripheral neuropathyAnna Liisa Kautio
Department of Oncology, Helsinki University Central Hospital, P O Box 180, 00029 HUS, Helsinki, Finland
Anticancer Res 31:3493-6. 2011..The aim of the study was to compare two different neurotoxicity scales in grading chemotherapy-induced neurotoxicity... - Five easy pieces on evidence based medicine (5). Trading benefit against harm--pain relief vs. adverse effectsEija Kalso
Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland
Eur J Pain 6:409-12. 2002 - Improving opioid effectiveness: from ideas to evidenceEija Kalso
Department of Anaesthesia and Intensive Care Medicine, Pain Clinic, Helsinki University Central Hospital, P O Box 340, FIN 00029 HUS, Finland
Eur J Pain 9:131-5. 2005..The theoretical background and the clinical evidence of these combinations will be discussed... - A systematic review of trial methodology, using the placebo groups of randomized controlled trials in paediatric postoperative painKatri Hamunen
Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, P O Box 140, FIN 00029 HUS, Finland
Pain 116:146-58. 2005..In conclusion, analysis of the methodology showed several aspects of trial design that can be improved in future studies. Placebo control groups can be used in paediatric analgesic studies to demonstrate internal sensitivity... - Pain intensity influences the relationship between anger management style and depressionAnn Mari Estlander
Helsinki University Central Hospital, Pain Clinic, Mannerheimvagen 110 A 4, 00250 Helsinki, Finland
Pain 140:387-92. 2008..However, analysing separately the two subscales of the BDI, negative view and physical function, significant positive relationships between pain intensity and both subscales appeared... - Psychiatric disorders as assessed with SCID in chronic pain patients: the anxiety disorders precede the onset of painPeter Knaster
Department of Psychiatry, Helsinki University Central Hospital, PO Box 590, FIN 00029 HUS, Helsinki, Finland
Gen Hosp Psychiatry 34:46-52. 2012..The temporal relationship between the onset of pain and depression and anxiety and the association of psychiatric disorders with pain intensity were also analyzed... - Stress-induced analgesia and morphine responses are changed in catechol-O-methyltransferase-deficient male miceOleg Kambur
Department of Pharmacology, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
Basic Clin Pharmacol Toxicol 103:367-73. 2008..COMT activity seems to take part in the modulation of nociception not only in the brain, as suggested earlier, but also at the spinal/peripheral level... - No pain, no gain: clinical excellence and scientific rigour--lessons learned from IA morphineEija Kalso
Pain Clinic, Department of Anaesthesia and Intensive Care, Helsinki University Hospital, P O Box 340, Helsinki, FIN 00029 HUS, Finland
Pain 98:269-75. 2002..A minimum of 30% of the maximum possible pain intensity is needed for an analgesic effect to be detected in a study... - The burden of symptoms predicts early retirement: a twin cohort study on fibromyalgia-associated symptomsRitva Markkula
Helsinki University Central Hospital, Pain Clinic, Department of Anaesthesiology and Intensive Care Medicine, Finland
Eur J Pain 15:741-7. 2011..To assess whether symptoms of fibromyalgia (FM) predict disability retirement or mortality... - Analgesic effects of dextromethorphan and morphine in patients with chronic painTarja Heiskanen
Pain Clinic, Helsinki University Hospital, P O Box 340, 00029 HUS, Helsinki, Finland
Pain 96:261-7. 2002..There were no significant differences in either the incidence or severity of adverse effects. In conclusion, oral dextromethorphan 100 mg had no effect on pain relief by intravenous morphine 15 mg in patients with chronic pain... - Temperament traits and chronic pain: the association of harm avoidance and pain-related anxietyPeter Knaster
Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
PLoS ONE 7:e45672. 2012..Proneness to anxiety has a large interindividual variation. The aim of the study was to determine whether the anxiety-related temperament trait Harm Avoidance (HA), is associated with pain-related anxiety... - What do different databases tell about the use of opioids in seven European countries in 2002?Katri Hamunen
Pain Clinic, Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, P O Box 140, FIN 00029 HUS, Finland
Eur J Pain 12:705-15. 2008..The objective of this paper was to analyse opioid consumption in a number European countries using different sources of data... - Amitriptyline in the treatment of chemotherapy-induced neuropathic symptomsAnna Liisa Kautio
Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
J Pain Symptom Manage 35:31-9. 2008..No statistical significance was reached, probably due to the small number of patients and too low dose of amitriptyline. Amitriptyline was well tolerated... - Widespread unilateral pain associated with herpes simplex virus infectionsKatariina Kallio-Laine
Pain Clinic, Department of Anesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, HUS, Helsinki, Finland
J Pain 9:658-65. 2008..HSV reactivations and the accompanying inflammatory process cause dysfunction of the central nervous system that manifests as neuropathic pain. Studies using functional brain imaging are needed to clarify this syndrome... - How palliative care of cancer patients is organised between a university hospital and primary care in FinlandTiina Tasmuth
Cancer Society of Finland
Acta Oncol 45:325-31. 2006..Every third patient reported of poor quality of palliative care in the primary care. Also the physicians reported a need for training in palliative care... - Sodium channel blockers in neuropathic painEija Kalso
University of Helsinki, Institute of Clinical Medicine, Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, P O Box 340, FIN 00029 HUS, Finland
Curr Pharm Des 11:3005-11. 2005..An oral local anesthetic type sodium channel blocker, mexiletine is an antiarrhythmic agent that is effective in neuropathic pain. However, effective doses may be difficult to achieve because of adverse effects... - Five easy pieces on evidence-based medicine (4)Eija Kalso
Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland
Eur J Pain 6:89-93. 2002 - Recurrent lymphocytic meningitis positive for herpes simplex virus type 2Katariina Kallio-Laine
Helsinki University Central Hospital, Helsinki, Finland
Emerg Infect Dis 15:1119-22. 2009..2/100,000 population in Finland during 1996-2006, higher than previous estimates. PCR was most sensitive in detecting HSV-2 DNA from cerebrospinal fluid if the sample was taken 2-5 days after symptom onset... - Clustering of symptoms associated with fibromyalgia in a Finnish Twin CohortRitva Markkula
Helsinki University Central Hospital, Pain Clinic, Department of Anaesthesiology and Intensive Care Medicine, 00029 HUS Helsinki, Finland
Eur J Pain 13:744-50. 2009..The symptoms known to be associated with fibromyalgia seem to have a strong genetic background... - OxycodoneEija Kalso
University of Helsinki, and Department of Anesthesia and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
J Pain Symptom Manage 29:S47-56. 2005..Oxycodone closely resembles morphine but it has some distinct differences, particularly in its pharmacokinetic profile. Being an old drug, the basic pharmacology of oxycodone has been a neglected field of research... - Placebo and opioid analgesia-- imaging a shared neuronal networkPredrag Petrovic
Cognitive Neurophysiology Research Group, Department of Clinical Neuroscience, Karolinska Institute, Stockholm 171 76, Sweden, Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Finland
Science 295:1737-40. 2002..These findings indicate a related neural mechanism in placebo and opioid analgesia... - Non-analgesic effects of opioids: interactions between opioids and other drugsTarja Heiskanen
Pain Clinic, Helsinki University Central Hospital, Finland
Curr Pharm Des 18:6079-89. 2012..The literature in this field is mainly based on case reports. Interindividual differences play an important role. Other potential interactions include prolongation of the QT-interval and lowering of the threshold for convulsions... - The effect of paracetamol and tropisetron on pain: experimental studies and a review of published dataElina Tiippana
Department of Anesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Medicine, Helsinki University Central Hospital, Helsinki, Finland
Basic Clin Pharmacol Toxicol 112:124-31. 2013..However, tropisetron may have an analgesic effect of its own. Clinicians should not avoid using these drugs together, unless larger clinical studies indicate otherwise... - Acute opioid effects on human brain as revealed by functional magnetic resonance imagingMika Leppä
Department of Anesthesia and Intensive Care Medicine, Helsinki University Central Hospital, P O Box 340, FIN 00029 HUS, Finland
Neuroimage 31:661-9. 2006..These areas belong to a circuitry that modulates the affective experience of sensory stimuli... - Venlafaxine in neuropathic pain following treatment of breast cancerTiina Tasmuth
Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, FIN-00029 HUS, Helsinki, Finland
Eur J Pain 6:17-24. 2002..The two poor responders had low venlafaxine concentrations whereas the two slow hydroxylizers had high venlafaxine concentrations and excellent pain relief. Thus, higher doses could be used in order to improve pain relief... - Cardiovascular and lifestyle risk factors in lumbar radicular pain or clinically defined sciatica: a systematic reviewRahman Shiri
Musculoskeletal Disorders, Finnish Institute of Occupational Health, Topeliuksenkatu 41a A, 00250, Helsinki, Finland
Eur Spine J 16:2043-54. 2007..However, more prospective studies are needed in order to further clarify these associations and the mechanisms of action... - Radiofrequency denervation for neck and back pain: a systematic review within the framework of the cochrane collaboration back review groupLeena Niemistö
ORTON Orthopaedic Hospital, Invalid Foundation, Helsinki, Finland
Spine (Phila Pa 1976) 28:1877-88. 2003..Systematic review... - Ketamine as adjuvant to opioids for cancer pain. A qualitative systematic reviewRae F Bell
Pain Clinic, Department of Anesthesia and Intensive Care, Haukeland University Hospital, 5021 Bergen, Norway
J Pain Symptom Manage 26:867-75. 2003..High quality, randomized, controlled trials with larger numbers of patients and standardized, clinically relevant routes of administration of ketamine are needed... - Is intranasal ketamine an appropriate treatment for chronic non-cancer breakthrough pain?Rae F Bell
Pain 108:1-2. 2004 - Venlafaxine in the treatment of atypical facial pain: a randomized controlled trialHeli Forssell
Department of Oral Diseases Pain Clinic, Turku University Central Hospital Turku, Finland
J Orofac Pain 18:131-7. 2004..To study in a randomized placebo-controlled design the efficacy of the antidepressant venlafaxine, a serotonin and a weak noradrenaline reuptake inhibitor, in the treatment of atypical facial pain (AFP)... - Of mice and men: what can we predict from the effects of morphine in a mouse model of bone cancer?Vesa K Kontinen
Pain 132:5-7. 2007 - The compassionate brain: humans detect intensity of pain from another's faceMiiamaaria V Saarela
Brain Research Unit, Low Temperature Laboratory, Helsinki University of Technology, Espoo, Finland
Cereb Cortex 17:230-7. 2007..These findings imply that the intersubjective representation of pain in the human brain is more detailed than has been previously thought... - Subanesthetic ketamine for cancer pain and scientific rigor in cancer pain trials. A reply to Jackson et alRae Frances Bell
J Pain Symptom Manage 31:386. 2006 - Morphine, oxycodone, methadone and its enantiomers in different models of nociception in the ratKim Lemberg
Department of Pharmacology, Institute of Biomedicine, University of Helsinki, Finland
Anesth Analg 102:1768-74. 2006..Opioids seem to have different profiles in different pain models. l-methadone should be studied for neuropathic pain in humans... - Successful and unsuccessful outcomes with long-term opioid therapy: a survey of physicians' opinionsMina Nishimori
The MGH Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts 02114, USA
J Palliat Med 9:50-6. 2006..The attitudes, beliefs, and experience of physicians will influence how they view the use of opioids for chronic nonterminal pain... - Biomarkers for painEija Kalso
Pain 107:199-201. 2004 - Prolactin-releasing peptide affects pain, allodynia and autonomic reflexes through medullary mechanismsMaija Liisa Kalliomäki
Department of Biology, Abo Akademi University, Biocity Artillerigatan 6A, 20520 Turku, SF, Finland
Neuropharmacology 46:412-24. 2004..The results show that PrRP modulates nociception due to supraspinal rather than spinal action, and that its antinociceptive mechanism differs from that previously characterized for NPFF... - Application of principles of evidence-based medicine to occlusal treatment for temporomandibular disorders: are there lessons to be learned?Heli Forssell
Department of Oral Diseases Pain Clinic, Turku University Central Hospital, Turku, Finland
J Orofac Pain 18:9-22; discussion 23-32. 2004..None of the occlusal adjustment studies provided evidence supporting the use of this treatment method. The clinical implications of the findings and future perspectives are discussed... - [Only placebo?]Eija Kalso
Duodecim 118:1733-4. 2002 - Pain- and morphine-associated transcriptional regulation of neuropeptide FF and the G-protein-coupled NPFF2 receptor geneJohanna M Nystedt
Department of Biology, Abo Akademi University, Turku, Finland
Neurobiol Dis 16:254-62. 2004..Acute, but not chronic, morphine activated the genes supraspinally. The results give further evidence for the involvement of the NPFF system in pain modulation and may provide new therapeutic opportunities for pathologic pain... - Opioids for persistent non-cancer painEija Kalso
BMJ 330:156-7. 2005 - Breakthrough pain in malignant and non-malignant diseases: a review of prevalence, characteristics and mechanismsKristina B Svendsen
Danish Pain Research Center, University Hospital of Aarhus, Noerrebrogade 44, Building 1A, 8000 Aarhus, Denmark
Eur J Pain 9:195-206. 2005..It is suggested that sensitization could be the common denominator of BTP in malignant and non-malignant pain... - How different is oxycodone from morphine?Eija Kalso
Pain 132:227-8. 2007