R Kaaja

Summary

Affiliation: Helsinki University Central Hospital
Country: Finland

Publications

  1. ncbi Treatment of acute pulmonary embolism during pregnancy with low molecular weight heparin: three case reports
    R J Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Hospital, Finland
    Blood Coagul Fibrinolysis 13:637-40. 2002
  2. doi Metabolic syndrome and the menopause
    Risto J Kaaja
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
    Menopause Int 14:21-5. 2008
  3. ncbi Insulin resistance and sympathetic overactivity in women
    Risto J Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Haartmaninkatu, Helsinki, Finland
    J Hypertens 24:131-41. 2006
  4. ncbi Effect of changes in body posture on vasoactive hormones in pre-eclamptic women
    R J Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland
    J Hum Hypertens 18:789-94. 2004
  5. ncbi Evidence of high circulating testosterone in women with prior preeclampsia
    H Laivuori
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    J Clin Endocrinol Metab 83:344-7. 1998
  6. ncbi Increased thromboxane production in women with a history of venous thromboembolic event: effect of heparins
    R Kaaja
    Department of Obstetrics and Gynaecology, Helsinki University Hospital, Helsinki, Finland
    Br J Haematol 114:655-9. 2001
  7. ncbi Macular blood flow during pregnancy in patients with early diabetic retinopathy measured by blue-field entoptic simulation
    T Hellstedt
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    Graefes Arch Clin Exp Ophthalmol 234:659-63. 1996
  8. ncbi Thromboprophylaxis with low molecular weight heparin (dalteparin) in pregnancy
    V Pettila
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Finland
    Thromb Res 96:275-82. 1999
  9. ncbi Pre-eclampsia but not pregnancy-induced hypertension is a risk factor for diabetic nephropathy in type 1 diabetic women
    D Gordin
    Folkhalsan Research Center, Biomedicum Helsinki, University of Helsinki, and Department of Medicine, Helsinki University Central Hospital, Finland
    Diabetologia 50:516-22. 2007
  10. ncbi Effects of sympatholytic therapy on insulin sensitivity indices in hypertensive postmenopausal women
    R Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Int J Clin Pharmacol Ther 45:394-401. 2007

Collaborators

Detail Information

Publications30

  1. ncbi Treatment of acute pulmonary embolism during pregnancy with low molecular weight heparin: three case reports
    R J Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Hospital, Finland
    Blood Coagul Fibrinolysis 13:637-40. 2002
    ..We conclude that low molecular weight heparin seems to be an efficient and practical treatment of PE during pregnancy...
  2. doi Metabolic syndrome and the menopause
    Risto J Kaaja
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
    Menopause Int 14:21-5. 2008
    ..If blood pressure, lipid and glycaemic control are not achieved through these interventions then pharmacological therapy will be required...
  3. ncbi Insulin resistance and sympathetic overactivity in women
    Risto J Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Haartmaninkatu, Helsinki, Finland
    J Hypertens 24:131-41. 2006
    ..g. metformin) to decrease insulin resistance, central sympatholytics (e.g. moxonidine), and AT-receptor blockers or angiotensin-converting enzyme (ACE) inhibitors to overcome sympathetic overactivity, hypertension and inflammation...
  4. ncbi Effect of changes in body posture on vasoactive hormones in pre-eclamptic women
    R J Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland
    J Hum Hypertens 18:789-94. 2004
    ..These data strengthen the premise that pre-eclampsia is associated with sympathetic overactivity as reflected by plasma norepinephrine levels, most obviously observed in the upright position...
  5. ncbi Evidence of high circulating testosterone in women with prior preeclampsia
    H Laivuori
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    J Clin Endocrinol Metab 83:344-7. 1998
    ..A history of preeclampsia an average of 17 yr earlier thus appears to be associated with elevated levels of testosterone, which may contribute to the increased risk of vascular morbidity in such women...
  6. ncbi Increased thromboxane production in women with a history of venous thromboembolic event: effect of heparins
    R Kaaja
    Department of Obstetrics and Gynaecology, Helsinki University Hospital, Helsinki, Finland
    Br J Haematol 114:655-9. 2001
    ..Thus, women with a history of venous thromboembolic events have thromboxane dominance during and after pregnancy, but this dominance can be eliminated through the use of heparins...
  7. ncbi Macular blood flow during pregnancy in patients with early diabetic retinopathy measured by blue-field entoptic simulation
    T Hellstedt
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    Graefes Arch Clin Exp Ophthalmol 234:659-63. 1996
    ....
  8. ncbi Thromboprophylaxis with low molecular weight heparin (dalteparin) in pregnancy
    V Pettila
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Finland
    Thromb Res 96:275-82. 1999
    ..Recurrence of venous thromboembolism and safety of treatments were assessed. Dalteparin administered once daily was safe and effective in thromboprophylaxis during pregnancy and postpartum...
  9. ncbi Pre-eclampsia but not pregnancy-induced hypertension is a risk factor for diabetic nephropathy in type 1 diabetic women
    D Gordin
    Folkhalsan Research Center, Biomedicum Helsinki, University of Helsinki, and Department of Medicine, Helsinki University Central Hospital, Finland
    Diabetologia 50:516-22. 2007
    ..Our aim was to study whether pre-eclampsia and pregnancy-induced hypertension are predictors of diabetic nephropathy in type 1 diabetic women...
  10. ncbi Effects of sympatholytic therapy on insulin sensitivity indices in hypertensive postmenopausal women
    R Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Int J Clin Pharmacol Ther 45:394-401. 2007
    ....
  11. ncbi Plasma homocysteine levels elevated and inversely related to insulin sensitivity in preeclampsia
    H Laivuori
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    Obstet Gynecol 93:489-93. 1999
    ..To study the plasma levels of homocysteine in preeclampsia and relate them to insulin sensitivity...
  12. doi Factor V Leiden as a risk factor for preterm birth--a population-based nested case-control study
    L M Hiltunen
    Department of Hemostasis, Finnish Red Cross Blood Service, Helsinki, Finland
    J Thromb Haemost 9:71-8. 2011
    ..Genetic thrombophilia can theoretically contribute to the induction of preterm delivery, but the role of thrombophilia as risk factor is unclear...
  13. ncbi 677 C-->T polymorphism of the methylenetetrahydrofolate reductase gene and preeclampsia
    H Laivuori
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Obstet Gynecol 96:277-80. 2000
    ..To evaluate C to T substitution at nucleotide 677 of N(5), N(10)-methylenetetrahydrofolate reductase gene in women with prior preeclamptic or normotensive pregnancies...
  14. doi Imbalance of the autonomic nervous system at night in women with gestational diabetes
    M Pöyhönen-Alho
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Diabet Med 27:988-94. 2010
    ..Because activity of the sympathetic nervous system tends to be relatively stable in the nocturnal hours, we performed the study at night...
  15. ncbi Diurnal blood glucose profiles in women with gestational diabetes with or without hypertension
    A Leinonen
    Department of Obstetrics and Gynaecology, Helsinki University Hospital, Haartmanninkatu 2, 00029 HUCH, Helsinki, Finland
    Diabet Med 21:1181-4. 2004
    ..The aim of the study was to establish whether diurnal blood glucose profiles differed in women with gestational diabetes (GDM) with different forms of hypertensive complications...
  16. doi Decreased variation of inflammatory markers in gestational diabetes
    Maritta Pöyhönen-Alho
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital Jorvi Hospital, Helsinki, Finland
    Diabetes Metab Res Rev 27:269-76. 2011
    ..We aimed to study the association of the sympathetic nervous system and sub-clinical inflammation in women with gestational diabetes...
  17. doi Pre-eclampsia is a risk factor of carotid artery atherosclerosis
    L Haukkamaa
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
    Cerebrovasc Dis 27:599-607. 2009
    ..The aim of this study was to examine whether women with a history of pre-eclampsia more often show signs of atherosclerosis compared with 2 control groups...
  18. doi Fertility in people with childhood-onset type 1 diabetes
    L Sjoberg
    Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland
    Diabetologia 56:78-81. 2013
    ..To assess the number of live births in a population-based, retrospective cohort of women and men with childhood-onset type 1 diabetes, and matched controls...
  19. doi The effect of hysterectomy or levonorgestrel-releasing intrauterine system on cardiovascular disease risk factors in menorrhagia patients: a 10-year follow-up of a randomised trial
    S Heliövaara-Peippo
    Department of Obstetrics and Gynaecology, Helsinki University Hospital, Helsinki, Finland
    Maturitas 69:354-8. 2011
    ..To compare, whether women with menorrhagia, treated with either hysterectomy or LNG-IUS, differ in their cardiovascular risk profile during 10-year follow-up...
  20. ncbi Pregnancy-associated recurrent liver necrosis in patient with antiphospholipid syndrome
    V M Ulander
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Lupus 15:889-91. 2006
    ..We describe a rare case of recurrent liver necrosis postpartum in two consecutive pregnancies of woman with systemic lupus erythematosus (SLE) and positive antiphospholipid antibodies (aPL) who underwent complete recovery...
  21. doi Vascular complications in diabetic pregnancy
    R Kaaja
    Obstetric physician, Associate Professor, Helsinki University Hospital, Helsinki, Finland
    Thromb Res 123:S1-3. 2009
    ..Women with Type 1 diabetes should be evaluated before pregnancy for microangiopathies, treated and followed closely during pregnancy by obstetrician and internist/diabetologue...
  22. ncbi Predictors and risk factors of pre-eclampsia
    R Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland
    Minerva Ginecol 60:421-9. 2008
    ..Large-scale prospective studies, assessing these markers, are important to advance progress in reducing maternal and perinatal morbidity and relieving the heavy burden of pre-eclampsia...
  23. ncbi Reduced pain tolerance during and after pregnancy in women suffering from fear of labor
    T Saisto
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, P O Box 140, Haartmaninkatu 2, FIN 00029 HUS, Finland
    Pain 93:123-7. 2001
    ..6.60+/-2.6, P=0.001). Patients with fear of labor were characterized by pain intolerance also in circumstances other than labor. This fact may indicate enhanced sensitivity to pain-causing mechanisms in women who develop fear of labor...
  24. ncbi Peripartum cardiomyopathy
    R Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland
    Minerva Cardioangiol 54:331-6. 2006
    ..In less than 50% of PPCM patients, left ventricular function normalizes with pharmacologic therapy. However, subsequent pregnancies are often associated with recurrence of left ventricular systolic dysfunction...
  25. doi A relationship between insulin sensitivity and vasodilation in women with a history of preeclamptic pregnancy
    Katja H Lampinen
    Department of Obstetrics and Gynecology, Helsinki University Hospital, Department of Obstetrics and Gynecology, Haartmaninkatu 2, 00290 Helsinki, Finland
    Hypertension 52:394-401. 2008
    ..The present study indicates a relation between insulin sensitivity with vascular dilatory function in women with previous preeclampsia. Furthermore, early onset preeclampsia correlates with impaired insulin sensitivity later in life...
  26. ncbi [Hypertension in postmenopausal women]
    Risto J Kaaja
    HYKS n naistentautien klinikka PL 140, 00029 HUS
    Duodecim 118:25-30. 2002
  27. ncbi Manifestations of chronic disease during pregnancy
    Risto J Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland
    JAMA 294:2751-7. 2005
    ..Physiologic changes of pregnancy include insulin resistance, thrombophilia, immunosuppression, and hypervolemia. These changes may herald the development of disease in later life...
  28. ncbi Vasoactive mediators and retinopathy during type 1 diabetic pregnancy
    Sirpa Loukovaara
    Department of Ophthalmology, Helsinki University Central Hospital, Haartmaninkatu 4C, FIN 00290 Helsinki, Finland
    Acta Ophthalmol Scand 83:57-62. 2005
    ..To evaluate the role of various vasoactive hormones in the evolution of diabetic retinopathy during pregnancy and postpartum...
  29. ncbi N-terminal pro-C-type natriuretic peptide, but not C-type natriuretic peptide, is greatly elevated in the fetal circulation
    Timothy C R Prickett
    Department of Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Clin Sci (Lond) 106:535-40. 2004
    ..In conclusion, the greatly elevated ratio of NT-proCNP/CNP in fetal compared with maternal plasma suggests that synthesis, as well as clearance, of CNP (but not NT-proCNP clearance) are markedly increased in fetal tissues...
  30. ncbi Impaired vascular dilatation in women with a history of pre-eclampsia
    Katja H Lampinen
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    J Hypertens 24:751-6. 2006
    ..We studied endothelial function and arterial compliance in non-pregnant, previously pre-eclamptic women...