H J Järvinen

Summary

Affiliation: Helsinki University Central Hospital
Country: Finland

Publications

  1. pmc Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases
    Johanna E Lotsari
    Department of Medical Genetics, Biomedicum Helsinki, P, O, Box 63 Haartmaninkatu 8, University of Helsinki, Helsinki, Finland, FIN 00014
    Breast Cancer Res 14:R90. 2012
  2. pmc Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci
    Iina Niittymäki
    Department of Medical Genetics, Genome Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    BMC Med Genet 12:23. 2011
  3. pmc EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis
    Antti Kokko
    Department of Medical Genetics, Molecular and Cancer Biology Research Program, P, O, Box 63, 00014 University of Helsinki, Finland
    BMC Cancer 6:145. 2006
  4. pmc Numbers of mutations to different types of colorectal cancer
    Peter Calabrese
    Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    BMC Cancer 5:126. 2005
  5. pmc Genetic testing for polyposis: practical and ethical aspects
    H J Järvinen
    Department of Surgery, Helsinki University Central Hospital, Finland
    Gut 52:ii19-22. 2003
  6. ncbi request reprint The complex genotype-phenotype relationship in familial adenomatous polyposis
    Heikki J Jarvinen
    Department of Gastroenterological Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Gastroenterol Hepatol 16:5-8. 2004
  7. doi request reprint Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members
    Heikki J Jarvinen
    Department of Surgery, University of Helsinki, FI 00029 HUS, Helsinki, Finland
    J Clin Oncol 27:4793-7. 2009
  8. ncbi request reprint DNA mismatch repair gene mutations in 55 kindreds with verified or putative hereditary non-polyposis colorectal cancer
    M Nystrom-Lahti
    Department of Medical Genetics, Haartman Institute, University of Helsinki, Finland
    Hum Mol Genet 5:763-9. 1996
  9. ncbi request reprint Hereditary cancer: guidelines in clinical practice. Colorectal cancer genetics
    H J Järvinen
    Helsinki University Central Hospital, Department of Surgery, Division of Gastroenterology, Finland
    Ann Oncol 15:iv127-31. 2004
  10. doi request reprint Differential cancer predisposition in Lynch syndrome: insights from molecular analysis of brain and urinary tract tumors
    A H S Gylling
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Carcinogenesis 29:1351-9. 2008

Collaborators

Detail Information

Publications18

  1. pmc Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases
    Johanna E Lotsari
    Department of Medical Genetics, Biomedicum Helsinki, P, O, Box 63 Haartmaninkatu 8, University of Helsinki, Helsinki, Finland, FIN 00014
    Breast Cancer Res 14:R90. 2012
    ..This study aimed to settle the question as to whether breast carcinoma belongs to the LS tumor spectrum...
  2. pmc Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci
    Iina Niittymäki
    Department of Medical Genetics, Genome Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    BMC Med Genet 12:23. 2011
    ....
  3. pmc EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis
    Antti Kokko
    Department of Medical Genetics, Molecular and Cancer Biology Research Program, P, O, Box 63, 00014 University of Helsinki, Finland
    BMC Cancer 6:145. 2006
    ..Inactivation of the gene has been shown to correlate with progression of colorectal tumorigenesis, and somatic mutations have been reported in both colorectal and prostate tumors...
  4. pmc Numbers of mutations to different types of colorectal cancer
    Peter Calabrese
    Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    BMC Cancer 5:126. 2005
    ..For example, a sporadic cancer should require at least one more somatic mutation relative to its hereditary counterpart...
  5. pmc Genetic testing for polyposis: practical and ethical aspects
    H J Järvinen
    Department of Surgery, Helsinki University Central Hospital, Finland
    Gut 52:ii19-22. 2003
    ....
  6. ncbi request reprint The complex genotype-phenotype relationship in familial adenomatous polyposis
    Heikki J Jarvinen
    Department of Gastroenterological Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Gastroenterol Hepatol 16:5-8. 2004
    ..The clinical applications of genotype-phenotype correlation on the management of patients with familial adenomatous polyposis remain limited apart from predictive genetic testing...
  7. doi request reprint Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members
    Heikki J Jarvinen
    Department of Surgery, University of Helsinki, FI 00029 HUS, Helsinki, Finland
    J Clin Oncol 27:4793-7. 2009
    ..The long-term effectiveness of surveillance was evaluated in Lynch syndrome family members tested approximately 10 years ago...
  8. ncbi request reprint DNA mismatch repair gene mutations in 55 kindreds with verified or putative hereditary non-polyposis colorectal cancer
    M Nystrom-Lahti
    Department of Medical Genetics, Haartman Institute, University of Helsinki, Finland
    Hum Mol Genet 5:763-9. 1996
    ..Third, our results indicate that the successive application of RT-PCR and 2-D DNA electrophoresis is a sensitive and efficient method for mutation screening in typical HNPCC...
  9. ncbi request reprint Hereditary cancer: guidelines in clinical practice. Colorectal cancer genetics
    H J Järvinen
    Helsinki University Central Hospital, Department of Surgery, Division of Gastroenterology, Finland
    Ann Oncol 15:iv127-31. 2004
  10. doi request reprint Differential cancer predisposition in Lynch syndrome: insights from molecular analysis of brain and urinary tract tumors
    A H S Gylling
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Carcinogenesis 29:1351-9. 2008
    ..Uroepithelial cancers of the ureter (and bladder to lesser extent) share many characteristics of MMR deficiency-driven tumorigenesis, whereas brain tumors and kidney adenocarcinomas follow separate pathways...
  11. ncbi request reprint Female fertility and childbirth after ileal pouch-anal anastomosis for ulcerative colitis
    A Lepisto
    Department of Surgery, Helsinki University Central Hospital, Finland
    Br J Surg 94:478-82. 2007
    ..The aim of this study was to calculate the probability of becoming pregnant after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis, and to evaluate complications during pregnancy and childbirth...
  12. doi request reprint Surveillance and treatment of duodenal adenomatosis in familial adenomatous polyposis
    A Lepisto
    Department of Surgery, Helsinki University Central Hospital, Finland
    Endoscopy 41:504-9. 2009
    ..We analyzed the results of endoscopic surveillance and different treatment modalities of duodenal adenomatosis in patients with FAP...
  13. doi request reprint Risk of cancer in patients with chronic pouchitis after restorative proctocolectomy for ulcerative colitis
    P Vento
    Department of Surgery, Central Hospital of Kymenlaakso, Kotka, Finland
    Colorectal Dis 13:58-66. 2011
    ..The aim of this study was to evaluate the consequences of chronic pouchitis after restorative proctocolectomy for ulcerative colitis...
  14. ncbi request reprint Founding mutations and Alu-mediated recombination in hereditary colon cancer
    M Nystrom-Lahti
    Department of Medical Genetics, University of Helsinki, Finland
    Nat Med 1:1203-6. 1995
    ....
  15. ncbi request reprint Familial cancer. A review on hereditary cancer traits with special regard to colorectal carcinoma
    H J Järvinen
    Second Department of Surgery, Helsinki University Central Hospital, Finland
    Acta Oncol 27:783-6. 1988
    ..Identification of CFS patients remains a problem even when careful family history is taken, and a specific biomarker for CFS is urgently needed...
  16. doi request reprint Survival of patients with pseudomyxoma peritonei treated by serial debulking
    P Jarvinen
    Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Colorectal Dis 12:868-72. 2010
    ..Patients with PMP have traditionally been treated by serial debulking, but aggressive cytoreduction followed by hyperthermic intraperitoneal chemotherapy is now advocated as standard treatment in PMP...
  17. ncbi request reprint Serum, biliary, and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine
    T A Miettinen
    Departments of Medicine and Surgery, the University of Helsinki, Helsinki, Finland
    Am J Clin Nutr 71:1095-102. 2000
    ..Cholesterol metabolic studies are simplified in colectomized patients because of rapid intestinal passage and reduced bacterial action...
  18. ncbi request reprint Fate of the rectum after colectomy with ileorectal anastomosis in ulcerative colitis
    A Lepisto
    Helsinki University Central Hospital, Department of Surgery, Helsinki, Finland
    Scand J Surg 94:40-2. 2005
    ..Aim of the study was to evaluate the cumulative success of colectomy and ileorectal anastomosis in 20 patients with ulcerative colitis...