Research Topics
Species | H J JärvinenSummaryAffiliation: Helsinki University Central Hospital Country: Finland Publications
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Detail Information
Publications
Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition lociIina Niittymäki
Department of Medical Genetics, Genome Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
BMC Med Genet 12:23. 2011....- EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposisAntti Kokko
Department of Medical Genetics, Molecular and Cancer Biology Research Program, P, O, Box 63, 00014 University of Helsinki, Finland
BMC Cancer 6:145. 2006..Inactivation of the gene has been shown to correlate with progression of colorectal tumorigenesis, and somatic mutations have been reported in both colorectal and prostate tumors... - Numbers of mutations to different types of colorectal cancerPeter Calabrese
Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
BMC Cancer 5:126. 2005..For example, a sporadic cancer should require at least one more somatic mutation relative to its hereditary counterpart... - Genetic testing for polyposis: practical and ethical aspectsH J Järvinen
Department of Surgery, Helsinki University Central Hospital, Finland
Gut 52:ii19-22. 2003.... 
The complex genotype-phenotype relationship in familial adenomatous polyposisHeikki J Jarvinen
Department of Gastroenterological Surgery, Helsinki University Central Hospital, Helsinki, Finland
Eur J Gastroenterol Hepatol 16:5-8. 2004..The clinical applications of genotype-phenotype correlation on the management of patients with familial adenomatous polyposis remain limited apart from predictive genetic testing...
Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family membersHeikki J Jarvinen
Department of Surgery, University of Helsinki, FI 00029 HUS, Helsinki, Finland
J Clin Oncol 27:4793-7. 2009..The long-term effectiveness of surveillance was evaluated in Lynch syndrome family members tested approximately 10 years ago...- DNA mismatch repair gene mutations in 55 kindreds with verified or putative hereditary non-polyposis colorectal cancerM Nystrom-Lahti
Department of Medical Genetics, Haartman Institute, University of Helsinki, Finland
Hum Mol Genet 5:763-9. 1996..Third, our results indicate that the successive application of RT-PCR and 2-D DNA electrophoresis is a sensitive and efficient method for mutation screening in typical HNPCC... - Hereditary cancer: guidelines in clinical practice. Colorectal cancer geneticsH J Järvinen
Helsinki University Central Hospital, Department of Surgery, Division of Gastroenterology, Finland
Ann Oncol 15:iv127-31. 2004 - Differential cancer predisposition in Lynch syndrome: insights from molecular analysis of brain and urinary tract tumorsA H S Gylling
Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Carcinogenesis 29:1351-9. 2008..Uroepithelial cancers of the ureter (and bladder to lesser extent) share many characteristics of MMR deficiency-driven tumorigenesis, whereas brain tumors and kidney adenocarcinomas follow separate pathways... - Female fertility and childbirth after ileal pouch-anal anastomosis for ulcerative colitisA Lepisto
Department of Surgery, Helsinki University Central Hospital, Finland
Br J Surg 94:478-82. 2007..The aim of this study was to calculate the probability of becoming pregnant after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis, and to evaluate complications during pregnancy and childbirth... - Surveillance and treatment of duodenal adenomatosis in familial adenomatous polyposisA Lepisto
Department of Surgery, Helsinki University Central Hospital, Finland
Endoscopy 41:504-9. 2009..We analyzed the results of endoscopic surveillance and different treatment modalities of duodenal adenomatosis in patients with FAP... - Founding mutations and Alu-mediated recombination in hereditary colon cancerM Nystrom-Lahti
Department of Medical Genetics, University of Helsinki, Finland
Nat Med 1:1203-6. 1995.... - Risk of cancer in patients with chronic pouchitis after restorative proctocolectomy for ulcerative colitisP Vento
Department of Surgery, Central Hospital of Kymenlaakso, Kotka, Finland
Colorectal Dis 13:58-66. 2011..The aim of this study was to evaluate the consequences of chronic pouchitis after restorative proctocolectomy for ulcerative colitis... - Familial cancer. A review on hereditary cancer traits with special regard to colorectal carcinomaH J Järvinen
Second Department of Surgery, Helsinki University Central Hospital, Finland
Acta Oncol 27:783-6. 1988..Identification of CFS patients remains a problem even when careful family history is taken, and a specific biomarker for CFS is urgently needed... - Survival of patients with pseudomyxoma peritonei treated by serial debulkingP Jarvinen
Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
Colorectal Dis 12:868-72. 2010..Patients with PMP have traditionally been treated by serial debulking, but aggressive cytoreduction followed by hyperthermic intraperitoneal chemotherapy is now advocated as standard treatment in PMP... - Serum, biliary, and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarineT A Miettinen
Departments of Medicine and Surgery, the University of Helsinki, Helsinki, Finland
Am J Clin Nutr 71:1095-102. 2000..Cholesterol metabolic studies are simplified in colectomized patients because of rapid intestinal passage and reduced bacterial action... - Fate of the rectum after colectomy with ileorectal anastomosis in ulcerative colitisA Lepisto
Helsinki University Central Hospital, Department of Surgery, Helsinki, Finland
Scand J Surg 94:40-2. 2005..Aim of the study was to evaluate the cumulative success of colectomy and ileorectal anastomosis in 20 patients with ulcerative colitis...