Research Topics
Species | H JalankoSummaryAffiliation: Helsinki University Central Hospital Country: Finland Publications
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Detail Information
Publications
Genetic kidney diseases disclose the pathogenesis of proteinuriaH Jalanko
Hospital for Children and Adolescents and Biomedicum Helsinki, University of Helsinki, Finland
Ann Med 33:526-33. 2001..It seems that the slit diaphragm and its interplay with the podocyte cytoskeleton is critical for the normal sieving process, and defects in one of these components easily lead to proteinuria...- [Which organs will be transplanted in the future?]Hannu Jalanko
HYKS n lasten ja nuorten sairaala, HUS
Duodecim 120:1355-7. 2004 
Congenital nephrotic syndromeHannu Jalanko
Hospital for Children and Adolescents, University of Helsinki, Finland
Pediatr Nephrol 24:2121-8. 2009..The outcome of CNS patients without major extrarenal manifestations is comparable with other patient groups after kidney transplantation...- Graft function 5-7 years after renal transplantation in early childhoodE Qvist
Hospital for Children and Adolescents, Pediatric Nephrology and Transplantation, University of Helsinki, Finland
Transplantation 67:1043-9. 1999..Low recipient age is still a risk factor for graft failure after kidney transplantation (Tx). Detailed prospective reports on long-term graft function in small children after renal Tx are still lacking... - Impaired bone health in adolescents after liver transplantationH Valta
Department of Pediatric Nephrology and Transplantation, Hospital for Children and Adolescents, University of Helsinki, Finland
Am J Transplant 8:150-7. 2008..004) and higher LS Z-score (p = 0.005) than older patients. In conclusion, adolescent liver recipients are prone to osteoporosis and prevention should be targeted especially to this age group... - Sphingolipid activator proteins in a human hereditary renal disease with deposition of disialogangliosidesA Haltia
Department of Bacteriology and Immunology, University of Helsinki, Finland
Histochem J 28:681-7. 1996..Furthermore, these results suggest that saposins are not directly involved in the metabolism of the terminal sialic acids of disialogangliosides in the nephrotic syndrome kidneys... - Course of renal allograft histopathology after transplantation in early childhoodE Qvist
Hospital for Children and Adolescents, Pediatric Nephrology and Transplantation, University of Helsinki, Finland
Transplantation 70:480-7. 2000..We report a long-term prospective follow-up of renal allograft histology in children <5 years of age at transplantation (Tx)... - Glomerular sclerosis in kidneys with congenital nephrotic syndrome (NPHS1)A-M Kuusniemi
Hospital for Children and Adolescents and Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
Kidney Int 70:1423-31. 2006..Podocyte depletion, glomerular tuft adhesion, and misdirected filtration, however, seem to play a minor role in the nephron destruction... - Expression of nine developmental stage-specific genes in human kidney and cultured renal cellsA Haltia
Haartman Institute, Department of Bacteriology and Immunology, University of Helsinki, Finland
Exp Nephrol 5:457-64. 1997.... - Successful liver-kidney transplantation in two children with aHUS caused by a mutation in complement factor HH Jalanko
Hospital for Children and Adolescents, Helsinki, Finland
Am J Transplant 8:216-21. 2008..While more experience is needed, it seems that liver-kidney transplantation combined with pre- and perioperative PE is a rational option in the management of patients with aHUS caused by CFH mutation... - Scoliosis after solid organ transplantation in children and adolescentsI Helenius
Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland
Am J Transplant 6:324-30. 2006..The risk of scoliosis is increased in patients with solid organ transplantation. Pediatricians treating these patients should be aware of this increased risk to diagnose early curves and to refer these patients to an orthopedic surgeon... - Fine-needle aspiration biopsy allows early detection of acute rejection in children after renal transplantationM Their
Hospital for Children and Adolescents, University of Helsinki, Pediatric Nephrology and Transplantation, Finland
Transplantation 71:736-43. 2001..CONCLUSION: The results indicate that FNAB is a safe and sensitive method for the diagnosis and follow-up of acute cellular rejection in pediatric recipients of different ages... - Clinical outcome of pediatric patients on peritoneal dialysis under adequacy controlT Hölttä
Department of Pediatric Nephrology and Transplantation, Hospital for Children and Adolescents, University of Helsinki, Finland
Pediatr Nephrol 14:889-97. 2000..The clinical outcome in patients under 5 years of age improved under adequacy control, when compared with our previous results in patients of the same age. This suggests a positive effect of adequacy control on clinical outcome... - Better renal function with enhanced immunosuppression and protocol biopsies after kidney transplantation in childrenPaula Seikku
Department of Pediatrics, University of Helsinki, Helsinki, Finland
Pediatr Transplant 9:754-62. 2005..68 mL/min/1.73 m(2)). Detection of subclinical rejection and slightly enhanced and individualized immunosuppression improved GFR 18 months after renal Tx, especially in the youngest patients... - Muscular dystonia and athetosis in six patients with congenital nephrotic syndrome of the Finnish type (NPHS1)Hanne Laakkonen
Department of Pediatric Nephrology and Transplantation, Hospital for Children and Adolescents, University of Helsinki, Stenbackinkatu 11, 00290 Helsinki, Finland
Pediatr Nephrol 21:182-9. 2006..Four children died at an early age: two during dialysis and two shortly after renal transplantation. Two are still alive with a functioning graft. Both have severe motor defects, but are mentally active and social... - Surgical correction of spinal deformities after solid organ transplantation in childhoodJari Peltonen
Hospital for Children and Adolescents, Helsinki University Central Hospital, P.O. Box 281, 00029 HUS, Helsinki, Finland
Eur Spine J 15:1230-8. 2006..Primary correction of these deformities was satisfactory, but during follow-up, a certain amount of recurrence of the curves was evident. Poor bone quality may explain some of the loss of correction... - Clinical features and outcome of childhood minimal change nephrotic syndrome: is genetics involved?Anne Tiina Lahdenkari
Hospital for Children and Adolescents and Biomedicum Helsinki, University of Helsinki, Finland
Pediatr Nephrol 20:1073-80. 2005..In conclusion, MCNS is a multifactorial disease, in which genetics play a minor role. Allelic variants of the podocyte proteins may, however, modify the phenotype in occasional individuals... - Recurrence of proteinuria following renal transplantation in congenital nephrotic syndrome of the Finnish typeTarak Srivastava
Section of Nephrology, The Children s Mercy Hospital, 2401 Gillham Road, Kansas City, Missouri 64108, USA, and Department of Biochemistry, University of Oulu, Finland
Pediatr Nephrol 21:711-8. 2006..This is the first report of increased Palb activity in recurrence of proteinuria following transplantation in NPHS1. We speculate the role of increased Palb activity in the recurrence of proteinuria following transplantation in NPHS1... - Glomerular endothelium in kidneys with congenital nephrotic syndrome of the Finnish type (NPHS1)Anne Kaukinen
Hospital for Children and Adolescents, University of Helsinki, 00029 Helsinki, Finland
Nephrol Dial Transplant 23:1224-32. 2008..The disorder is caused by a genetic defect in a major podocyte slit diaphragm protein, nephrin. It manifests as nephrotic syndrome soon after birth and leads to glomerular sclerosis in early childhood... - Spine after solid organ transplantation in childhood: a clinical, radiographic, and magnetic resonance imaging analysis of 40 patientsIlkka Helenius
Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland
Spine (Phila Pa 1976) 31:2130-6. 2006..A cross-sectional study of the spine in 40 young adults after solid organ transplantation in childhood... - Therapy insight: orthopedic complications after solid organ transplantation in childhoodIlkka Helenius
Hospital for Children and Adolescents, Helsinki University Central Hospital, PO Box 281, 00029 HUS, Helsinki, Finland
Nat Clin Pract Nephrol 3:96-105. 2007..By contrast, routine MRI of the joints seems unnecessary... - Plasma exchange and retransplantation in recurrent nephrosis of patients with congenital nephrotic syndrome of the Finnish type (NPHS1)Arvi Matti Kuusniemi
Hospital for Children and Adolescents and Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
Transplantation 83:1316-23. 2007..We evaluated here the use of plasma exchange (PE) therapy and kidney retransplantation in NPHS1 patients with recurrent NS and extended our studies on the pathogenesis of the recurrence... - Early treatment of acute rejections gives favorable long-term function after renal transplantation in small childrenErik Qvist
Hospital for Children and Adolescents, Pediatric Nephrology and Transplantation, University of Helsinki, Helsinki, Finland
Pediatr Transplant 11:895-900. 2007..Prompt and early treatment of post-operative AR gives favorable long-term graft function compared with children without AR. Late AR is a risk factor for inferior long-term graft function... - Bone health and growth in glucocorticoid-treated patients with juvenile idiopathic arthritisHelena Valta
Hospital for Children and Adolescents, Metabolic Bone Clinic, University of Helsinki, Helsinki, Finland
J Rheumatol 34:831-6. 2007..To evaluate bone health and growth and their correlates in glucocorticoid (GC)-treated pediatric patients with juvenile idiopathic arthritis (JIA)... - [Selection of organ transplant drugs is increasing]Helena Isoniemi
HYKS, Kirurginen sairaala, elinsiirto- ja maksakirurgian klinikka, HUS
Duodecim 120:1371-8. 2004 - Predictive value of pretransplantation cyclosporine pharmacokinetic studies on initial post-transplantation dosing in pediatric kidney allograft recipientsPaula Seikku
Hospital for Children and Adolescents, University of Helsinki, Pediatric Nephrology and Transplantation, Helsinki, Finland
Pediatr Transplant 7:102-10. 2003..Individual dosing led to relatively high initial CsA doses, which could be significant for the long-term survival of the graft... - Pathogenesis of proteinuria: lessons learned from nephrin and podocinHannu Jalanko
Pediatr Nephrol 18:487-91. 2003 - [Primary hyperoxaluria]Jussi Merenmies
HUS:n lasten ja nuorten sairaala PL 281, 00029 HUS
Duodecim 119:1836-41. 2003 - Proteinuria and prenatal diagnosis of congenital nephrosis in fetal carriers of nephrin gene mutationsJaakko Patrakka
Hospital for Children and Adolescents and Biomedicum Helsinki, Electron Microscopy Unit, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
Lancet 359:1575-7. 2002..We strongly recommend the use of mutation analysis of the NPHS1 gene to confirm the AFP results in prenatal diagnosis of NPHS1... - Psychosocial adaptation after solid organ transplantation in childrenErik Qvist
Hospital for Children and Adolescents, Pediatric Nephrology and Transplantation, University of Helsinki, Stenbackinkatu 11, FIN 00290, Finland
Pediatr Clin North Am 50:1505-19. 2003..A continuing effort must be made to improve psychosocial adjustment and QOL after transplantation to achieve the ultimate goal in medicine: the overall well-being of our patients... - Tissue expression of nephrin in human and pigArvi-Matti Kuusniemi
Hospital for Children and Adolescents and Biomedicum Helsinki, University of Helsinki, 00290 Helsinki, Finland
Pediatr Res 55:774-81. 2004..The studies suggest that nephrin has no major clinical significance outside the kidney... - Neuroradiologic findings in children with renal transplantation under 5 years of ageLeena Valanne
Department of Radiology, Helsinki University, Haartmaninkatu 4, Box 340, 00029 Helsinki, Finland
Pediatr Transplant 8:44-51. 2004..The good correlation to pre-TX hemodynamic crises seems, however, to indicate that most of these lesions could be prevented by careful clinical monitoring and early TX... - Nephrin gene (NPHS1) in patients with minimal change nephrotic syndrome (MCNS)Anne Tiina Lahdenkari
Hospital for Children and Adolescents and Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
Kidney Int 65:1856-63. 2004..Because nephrin is known to be a major component of the slit diaphragm, we analyzed the structure of nephrin gene (NPHS1) in patients with MCNS of different severity... - Serum C-reactive protein in pediatric kidney and liver transplant patientsMaria Their
Hospital for Children and Adolescents, Pediatric Nephrology and Transplantation, University of Helsinki, Finland
Pediatr Transplant 6:153-60. 2002..We conclude that the daily measurement of serum CRP is a simple and fairly sensitive, but non-specific, method for detecting rejection and infectious complications after pediatric liver and kidney Tx... - Recurrence of nephrotic syndrome in kidney grafts of patients with congenital nephrotic syndrome of the Finnish type: role of nephrinJaakko Patrakka
Hospital for Children and Adolescents, Biomedicum Helsinki, University of Helsinki, 00290 Helsinki, Finland
Transplantation 73:394-403. 2002..CONCLUSIONS: Circulating anti-nephrin antibodies seem to have a pathogenic role in the development of heavy proteinuria in kidney grafts of NPHS1 patients with Fin-major/Fin-major genotype... - The use of fine-needle aspiration biopsy in detection of acute rejection in children after liver transplantationMaria Their
Pediatric Nephrology and Transplantation, Hospital for Children and Adolescents, University of Helsinki, PL 281, 00029 HUS, Finland
Transpl Int 15:240-7. 2002..The results indicate that FNAB is a safe and sensitive method for the diagnosis and follow up of acute cellular rejection in pediatric liver recipients... - Neurodevelopmental outcome in high-risk patients after renal transplantation in early childhoodErik Qvist
Pediatric Nephrology and Transplantation, Hospital for Children and Adolescents, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
Pediatr Transplant 6:53-62. 2002..In these previously lethal diseases, the overall neurodevelopmental outcome is reassuring. However, it is of crucial importance to further minimize the risk factors prior to Tx... - Misleading findings of homozygosity mapping resulting from three novel mutations in NPHS1 encoding nephrin in a highly inbred communityYaacov Frishberg
Division of Pediatric Nephrology, Shaare Zedek Medical Center, Jerusalem, Israel
Genet Med 9:180-4. 2007..The aim of this study was to confirm that the NPHS1 gene is responsible for congenital nephrotic syndrome in our population, applying homozygosity mapping... - Growth after renal transplantation in infancy or early childhoodErik Qvist
Pediatric Nephrology and Transplantation, Hospital for Children and Adolescents, University of Helsinki, Stenbackinkatu 11, 00290 Finland
Pediatr Nephrol 17:438-43. 2002..In children <5 years of age at TX, growth is predicted better by the degree of stunting than by age... - The number of podocyte slit diaphragms is decreased in minimal change nephrotic syndromeJaakko Patrakka
Hospital for Children and Adolescents and Biomedicum Helsinki, University of Helsinki, 00290 Helsinki, Finland
Pediatr Res 52:349-55. 2002..0003). In contrast to findings in MCNS, no significant reduction of the slit diaphragms were seen in MN kidneys compared with the controls. The results suggest that MCNS is associated with disruption of glomerular slit diaphragms... - Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14RikJaakko Patrakka
Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden
J Am Soc Nephrol 18:689-97. 2007..This study provides fresh insights into glomerular biology and uncovers new possibilities to explore the role of these novel proteins in the glomerular physiology and pathology... - Farber disease diagnosed after liver transplantationMatti K Salo
Department of Pediatrics, Tampere University Hospital, PO Box 2000, 33521 Tampere, Finland
J Pediatr Gastroenterol Nutr 36:274-7. 2003 - Podocytes are firmly attached to glomerular basement membrane in kidneys with heavy proteinuriaAnne-Tiina Lahdenkari
Hospital for Children and Adolescents, University of Helsinki, 00290, Finland
J Am Soc Nephrol 15:2611-8. 2004.... - Incidence and predictors of fractures in children after solid organ transplantation: a 5-year prospective, population-based studyIlkka Helenius
Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland
J Bone Miner Res 21:380-7. 2006..35 fractures/1000 persons/year; p < 0.001) in the study group compared with the control population. Thus, screening of vertebral fractures at regular intervals is recommended, and preventive strategies should be studied... - Psychosocial adjustment and quality of life after renal transplantation in early childhoodErik Qvist
Pediatric Nephrology and Transplantation, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
Pediatr Transplant 8:120-5. 2004..HRQOL assessment by the children themselves can be used to direct interventions and support the children's psychosocial adjustment... - Kidneys with heavy proteinuria show fibrosis, inflammation, and oxidative stress, but no tubular phenotypic changeArvi-Matti Kuusniemi
Hospital for Children and Adolescents and Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
Kidney Int 68:121-32. 2005..The tubular epithelial cells, however, were resistant to proteinuria and did not show epithelial-mesenchymal transition... - Recombinant human growth hormone treatment after liver transplantation in childhood: the 5-year outcomeLauri Puustinen
The Hospital for Children and Adolescents, Pediatric Nephrology and Transplantation, Helsinki University Central Hospital, Helsinki, Finland
Transplantation 79:1241-6. 2005..Because of a potential risk of side effects, close monitoring of these patients is required... - Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomographyJorma Wartiovaara
Institute of Biotechnology, University of Helsinki, Helsinki, Finland
J Clin Invest 114:1475-83. 2004..The results suggest the direct involvement of nephrin molecules in constituting the macromolecule-retaining slit diaphragm and its pores... - Avascular bone necrosis of the hip joint after solid organ transplantation in childhood: a clinical and MRI analysisIlkka Helenius
Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland
Transplantation 81:1621-7. 2006..The occurrence of osteonecrosis in growing age has been studied after kidney transplantation, but no systematic evaluation of the joints has been reported after heart or liver transplantation in childhood...