H Jalanko

Summary

Affiliation: Helsinki University Central Hospital
Country: Finland

Publications

  1. ncbi request reprint [Which organs will be transplanted in the future?]
    Hannu Jalanko
    HYKS n lasten ja nuorten sairaala, HUS
    Duodecim 120:1355-7. 2004
  2. doi request reprint Combined liver and kidney transplantation in children
    Hannu Jalanko
    Department of Pediatric Nephrology and Transplantation, Children s Hospital, Helsinki University Central Hospital and University of Helsinki, Stenbackinkatu 11, 00290, Helsinki, Finland
    Pediatr Nephrol 29:805-14. 2014
  3. pmc Congenital nephrotic syndrome
    Hannu Jalanko
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Pediatr Nephrol 24:2121-8. 2009
  4. ncbi request reprint Genetic kidney diseases disclose the pathogenesis of proteinuria
    H Jalanko
    Hospital for Children and Adolescents and Biomedicum Helsinki, University of Helsinki, Finland
    Ann Med 33:526-33. 2001
  5. ncbi request reprint Graft function 5-7 years after renal transplantation in early childhood
    E Qvist
    Hospital for Children and Adolescents, Pediatric Nephrology and Transplantation, University of Helsinki, Finland
    Transplantation 67:1043-9. 1999
  6. ncbi request reprint Sphingolipid activator proteins in a human hereditary renal disease with deposition of disialogangliosides
    A Haltia
    Department of Bacteriology and Immunology, University of Helsinki, Finland
    Histochem J 28:681-7. 1996
  7. ncbi request reprint Impaired bone health in adolescents after liver transplantation
    H Valta
    Department of Pediatric Nephrology and Transplantation, Hospital for Children and Adolescents, University of Helsinki, Finland
    Am J Transplant 8:150-7. 2008
  8. doi request reprint Cholesterol metabolism altered and FGF21 levels high after pediatric liver transplantation despite normal serum lipids
    S Kosola
    Pediatric Surgery and Pediatric Transplantation Surgery, Children s Hospital, Helsinki University Central Hospital and University of Helsinki, Finland
    Am J Transplant 12:2815-24. 2012
  9. ncbi request reprint Course of renal allograft histopathology after transplantation in early childhood
    E Qvist
    Hospital for Children and Adolescents, Pediatric Nephrology and Transplantation, University of Helsinki, Finland
    Transplantation 70:480-7. 2000
  10. ncbi request reprint Congenital nephrosis of the Finnish type (CNF): matrix components of the glomerular basement membranes and of cultured mesangial cells
    P Ljungberg
    Department of Bacteriology and Immunology, University of Helsinki, Finland
    Histochem J 25:606-12. 1993

Collaborators

Detail Information

Publications54

  1. ncbi request reprint [Which organs will be transplanted in the future?]
    Hannu Jalanko
    HYKS n lasten ja nuorten sairaala, HUS
    Duodecim 120:1355-7. 2004
  2. doi request reprint Combined liver and kidney transplantation in children
    Hannu Jalanko
    Department of Pediatric Nephrology and Transplantation, Children s Hospital, Helsinki University Central Hospital and University of Helsinki, Stenbackinkatu 11, 00290, Helsinki, Finland
    Pediatr Nephrol 29:805-14. 2014
    ..The long-term outcome after CLKT is nowadays comparable to that of isolated liver and kidney transplantations. ..
  3. pmc Congenital nephrotic syndrome
    Hannu Jalanko
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Pediatr Nephrol 24:2121-8. 2009
    ..The outcome of CNS patients without major extrarenal manifestations is comparable with other patient groups after kidney transplantation...
  4. ncbi request reprint Genetic kidney diseases disclose the pathogenesis of proteinuria
    H Jalanko
    Hospital for Children and Adolescents and Biomedicum Helsinki, University of Helsinki, Finland
    Ann Med 33:526-33. 2001
    ..It seems that the slit diaphragm and its interplay with the podocyte cytoskeleton is critical for the normal sieving process, and defects in one of these components easily lead to proteinuria...
  5. ncbi request reprint Graft function 5-7 years after renal transplantation in early childhood
    E Qvist
    Hospital for Children and Adolescents, Pediatric Nephrology and Transplantation, University of Helsinki, Finland
    Transplantation 67:1043-9. 1999
    ..Low recipient age is still a risk factor for graft failure after kidney transplantation (Tx). Detailed prospective reports on long-term graft function in small children after renal Tx are still lacking...
  6. ncbi request reprint Sphingolipid activator proteins in a human hereditary renal disease with deposition of disialogangliosides
    A Haltia
    Department of Bacteriology and Immunology, University of Helsinki, Finland
    Histochem J 28:681-7. 1996
    ..Furthermore, these results suggest that saposins are not directly involved in the metabolism of the terminal sialic acids of disialogangliosides in the nephrotic syndrome kidneys...
  7. ncbi request reprint Impaired bone health in adolescents after liver transplantation
    H Valta
    Department of Pediatric Nephrology and Transplantation, Hospital for Children and Adolescents, University of Helsinki, Finland
    Am J Transplant 8:150-7. 2008
    ..004) and higher LS Z-score (p = 0.005) than older patients. In conclusion, adolescent liver recipients are prone to osteoporosis and prevention should be targeted especially to this age group...
  8. doi request reprint Cholesterol metabolism altered and FGF21 levels high after pediatric liver transplantation despite normal serum lipids
    S Kosola
    Pediatric Surgery and Pediatric Transplantation Surgery, Children s Hospital, Helsinki University Central Hospital and University of Helsinki, Finland
    Am J Transplant 12:2815-24. 2012
    ..Normal serum lipids are achievable in long-term survivors of pediatric LT, but changes in cholesterol metabolism and increased FGF21 levels may explicate later cardiovascular risk...
  9. ncbi request reprint Course of renal allograft histopathology after transplantation in early childhood
    E Qvist
    Hospital for Children and Adolescents, Pediatric Nephrology and Transplantation, University of Helsinki, Finland
    Transplantation 70:480-7. 2000
    ..We report a long-term prospective follow-up of renal allograft histology in children <5 years of age at transplantation (Tx)...
  10. ncbi request reprint Congenital nephrosis of the Finnish type (CNF): matrix components of the glomerular basement membranes and of cultured mesangial cells
    P Ljungberg
    Department of Bacteriology and Immunology, University of Helsinki, Finland
    Histochem J 25:606-12. 1993
    ..Cultured mesangial cells of CNF glomeruli also showed continued in vitro production of the matrix components and their incorporation into the matrix underneath the cell layer...
  11. ncbi request reprint Glomerular sclerosis in kidneys with congenital nephrotic syndrome (NPHS1)
    A M Kuusniemi
    Hospital for Children and Adolescents and Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Kidney Int 70:1423-31. 2006
    ..Podocyte depletion, glomerular tuft adhesion, and misdirected filtration, however, seem to play a minor role in the nephron destruction...
  12. ncbi request reprint Successful liver-kidney transplantation in two children with aHUS caused by a mutation in complement factor H
    H Jalanko
    Hospital for Children and Adolescents, Helsinki, Finland
    Am J Transplant 8:216-21. 2008
    ..While more experience is needed, it seems that liver-kidney transplantation combined with pre- and perioperative PE is a rational option in the management of patients with aHUS caused by CFH mutation...
  13. ncbi request reprint Expression of nine developmental stage-specific genes in human kidney and cultured renal cells
    A Haltia
    Haartman Institute, Department of Bacteriology and Immunology, University of Helsinki, Finland
    Exp Nephrol 5:457-64. 1997
    ....
  14. doi request reprint General health, health-related quality of life and sexual health after pediatric liver transplantation: a nationwide study
    S Kosola
    Pediatric Surgery, Children s Hospital, and University of Helsinki, Helsinki, Finland
    Am J Transplant 12:420-7. 2012
    ..050) and condom-based contraception was more common after LT than among controls (58% and 12%, p < 0.001). In conclusion, normal HRQoL and sexual health are achievable post-LT...
  15. ncbi request reprint Fine-needle aspiration biopsy allows early detection of acute rejection in children after renal transplantation
    M Their
    Hospital for Children and Adolescents, University of Helsinki, Pediatric Nephrology and Transplantation, Finland
    Transplantation 71:736-43. 2001
    ..CONCLUSION: The results indicate that FNAB is a safe and sensitive method for the diagnosis and follow-up of acute cellular rejection in pediatric recipients of different ages...
  16. ncbi request reprint Scoliosis after solid organ transplantation in children and adolescents
    I Helenius
    Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland
    Am J Transplant 6:324-30. 2006
    ..The risk of scoliosis is increased in patients with solid organ transplantation. Pediatricians treating these patients should be aware of this increased risk to diagnose early curves and to refer these patients to an orthopedic surgeon...
  17. ncbi request reprint Studies on the elevated amniotic fluid SP1 in Meckel's syndrome: modified glycosylation of SP1
    M Heikinheimo
    Department of Bacteriology and Immunology, Children s Hospital, Helsinki, Finland
    Placenta 8:427-32. 1987
    ..An especially low percentage of SP1 not bound to Con A was found in Meckel's syndrome, suggesting an altered carbohydrate structure of SP1 in these amniotic fluids...
  18. ncbi request reprint Clinical outcome of pediatric patients on peritoneal dialysis under adequacy control
    T Hölttä
    Department of Pediatric Nephrology and Transplantation, Hospital for Children and Adolescents, University of Helsinki, Finland
    Pediatr Nephrol 14:889-97. 2000
    ..The clinical outcome in patients under 5 years of age improved under adequacy control, when compared with our previous results in patients of the same age. This suggests a positive effect of adequacy control on clinical outcome...
  19. ncbi request reprint Bone health and growth in glucocorticoid-treated patients with juvenile idiopathic arthritis
    Helena Valta
    Hospital for Children and Adolescents, Metabolic Bone Clinic, University of Helsinki, Helsinki, Finland
    J Rheumatol 34:831-6. 2007
    ..To evaluate bone health and growth and their correlates in glucocorticoid (GC)-treated pediatric patients with juvenile idiopathic arthritis (JIA)...
  20. ncbi request reprint Proteinuria and prenatal diagnosis of congenital nephrosis in fetal carriers of nephrin gene mutations
    Jaakko Patrakka
    Hospital for Children and Adolescents and Biomedicum Helsinki, Electron Microscopy Unit, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    Lancet 359:1575-7. 2002
    ..We strongly recommend the use of mutation analysis of the NPHS1 gene to confirm the AFP results in prenatal diagnosis of NPHS1...
  21. ncbi request reprint Serum C-reactive protein in pediatric kidney and liver transplant patients
    Maria Their
    Hospital for Children and Adolescents, Pediatric Nephrology and Transplantation, University of Helsinki, Finland
    Pediatr Transplant 6:153-60. 2002
    ..We conclude that the daily measurement of serum CRP is a simple and fairly sensitive, but non-specific, method for detecting rejection and infectious complications after pediatric liver and kidney Tx...
  22. ncbi request reprint Glomerular endothelium in kidneys with congenital nephrotic syndrome of the Finnish type (NPHS1)
    Anne Kaukinen
    Hospital for Children and Adolescents, University of Helsinki, 00029 Helsinki, Finland
    Nephrol Dial Transplant 23:1224-32. 2008
    ..The disorder is caused by a genetic defect in a major podocyte slit diaphragm protein, nephrin. It manifests as nephrotic syndrome soon after birth and leads to glomerular sclerosis in early childhood...
  23. pmc Surgical correction of spinal deformities after solid organ transplantation in childhood
    Jari Peltonen
    Hospital for Children and Adolescents, Helsinki University Central Hospital, P O Box 281, 00029 HUS, Helsinki, Finland
    Eur Spine J 15:1230-8. 2006
    ..Primary correction of these deformities was satisfactory, but during follow-up, a certain amount of recurrence of the curves was evident. Poor bone quality may explain some of the loss of correction...
  24. ncbi request reprint Nephrin gene (NPHS1) in patients with minimal change nephrotic syndrome (MCNS)
    Anne Tiina Lahdenkari
    Hospital for Children and Adolescents and Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Kidney Int 65:1856-63. 2004
    ..Because nephrin is known to be a major component of the slit diaphragm, we analyzed the structure of nephrin gene (NPHS1) in patients with MCNS of different severity...
  25. ncbi request reprint Recurrence of nephrotic syndrome in kidney grafts of patients with congenital nephrotic syndrome of the Finnish type: role of nephrin
    Jaakko Patrakka
    Hospital for Children and Adolescents, Biomedicum Helsinki, University of Helsinki, 00290 Helsinki, Finland
    Transplantation 73:394-403. 2002
    ..We have previously described recurrence of severe proteinuria in grafts transplanted to children with NPHS1. Here we studied the pathophysiology of this proteinuria...
  26. ncbi request reprint Therapy insight: orthopedic complications after solid organ transplantation in childhood
    Ilkka Helenius
    Hospital for Children and Adolescents, Helsinki University Central Hospital, PO Box 281, 00029 HUS, Helsinki, Finland
    Nat Clin Pract Nephrol 3:96-105. 2007
    ..By contrast, routine MRI of the joints seems unnecessary...
  27. ncbi request reprint [Primary hyperoxaluria]
    Jussi Merenmies
    HUS n lasten ja nuorten sairaala PL 281, 00029 HUS
    Duodecim 119:1836-41. 2003
  28. ncbi request reprint [Selection of organ transplant drugs is increasing]
    Helena Isoniemi
    HYKS, Kirurginen sairaala, elinsiirto ja maksakirurgian klinikka, HUS
    Duodecim 120:1371-8. 2004
  29. ncbi request reprint Muscular dystonia and athetosis in six patients with congenital nephrotic syndrome of the Finnish type (NPHS1)
    Hanne Laakkonen
    Department of Pediatric Nephrology and Transplantation, Hospital for Children and Adolescents, University of Helsinki, Stenbackinkatu 11, 00290 Helsinki, Finland
    Pediatr Nephrol 21:182-9. 2006
    ..Four children died at an early age: two during dialysis and two shortly after renal transplantation. Two are still alive with a functioning graft. Both have severe motor defects, but are mentally active and social...
  30. ncbi request reprint Better renal function with enhanced immunosuppression and protocol biopsies after kidney transplantation in children
    Paula Seikku
    Department of Pediatrics, University of Helsinki, Helsinki, Finland
    Pediatr Transplant 9:754-62. 2005
    ..68 mL/min/1.73 m(2)). Detection of subclinical rejection and slightly enhanced and individualized immunosuppression improved GFR 18 months after renal Tx, especially in the youngest patients...
  31. ncbi request reprint Neuroradiologic findings in children with renal transplantation under 5 years of age
    Leena Valanne
    Department of Radiology, Helsinki University, Haartmaninkatu 4, Box 340, 00029 Helsinki, Finland
    Pediatr Transplant 8:44-51. 2004
    ..The good correlation to pre-TX hemodynamic crises seems, however, to indicate that most of these lesions could be prevented by careful clinical monitoring and early TX...
  32. ncbi request reprint Clinical features and outcome of childhood minimal change nephrotic syndrome: is genetics involved?
    Anne Tiina Lahdenkari
    Hospital for Children and Adolescents and Biomedicum Helsinki, University of Helsinki, Finland
    Pediatr Nephrol 20:1073-80. 2005
    ..In conclusion, MCNS is a multifactorial disease, in which genetics play a minor role. Allelic variants of the podocyte proteins may, however, modify the phenotype in occasional individuals...
  33. ncbi request reprint Recurrence of proteinuria following renal transplantation in congenital nephrotic syndrome of the Finnish type
    Tarak Srivastava
    Section of Nephrology, The Children s Mercy Hospital, 2401 Gillham Road, Kansas City, Missouri 64108, USA, and Department of Biochemistry, University of Oulu, Finland
    Pediatr Nephrol 21:711-8. 2006
    ..This is the first report of increased Palb activity in recurrence of proteinuria following transplantation in NPHS1. We speculate the role of increased Palb activity in the recurrence of proteinuria following transplantation in NPHS1...
  34. ncbi request reprint Spine after solid organ transplantation in childhood: a clinical, radiographic, and magnetic resonance imaging analysis of 40 patients
    Ilkka Helenius
    Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland
    Spine (Phila Pa 1976) 31:2130-6. 2006
    ..A cross-sectional study of the spine in 40 young adults after solid organ transplantation in childhood...
  35. ncbi request reprint Plasma exchange and retransplantation in recurrent nephrosis of patients with congenital nephrotic syndrome of the Finnish type (NPHS1)
    Arvi Matti Kuusniemi
    Hospital for Children and Adolescents and Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Transplantation 83:1316-23. 2007
    ..We evaluated here the use of plasma exchange (PE) therapy and kidney retransplantation in NPHS1 patients with recurrent NS and extended our studies on the pathogenesis of the recurrence...
  36. ncbi request reprint Tissue expression of nephrin in human and pig
    Arvi Matti Kuusniemi
    Hospital for Children and Adolescents and Biomedicum Helsinki, University of Helsinki, 00290 Helsinki, Finland
    Pediatr Res 55:774-81. 2004
    ..The studies suggest that nephrin has no major clinical significance outside the kidney...
  37. ncbi request reprint Psychosocial adaptation after solid organ transplantation in children
    Erik Qvist
    Hospital for Children and Adolescents, Pediatric Nephrology and Transplantation, University of Helsinki, Stenbackinkatu 11, FIN 00290, Finland
    Pediatr Clin North Am 50:1505-19. 2003
    ..A continuing effort must be made to improve psychosocial adjustment and QOL after transplantation to achieve the ultimate goal in medicine: the overall well-being of our patients...
  38. ncbi request reprint Early treatment of acute rejections gives favorable long-term function after renal transplantation in small children
    Erik Qvist
    Hospital for Children and Adolescents, Pediatric Nephrology and Transplantation, University of Helsinki, Helsinki, Finland
    Pediatr Transplant 11:895-900. 2007
    ..Prompt and early treatment of post-operative AR gives favorable long-term graft function compared with children without AR. Late AR is a risk factor for inferior long-term graft function...
  39. ncbi request reprint Predictive value of pretransplantation cyclosporine pharmacokinetic studies on initial post-transplantation dosing in pediatric kidney allograft recipients
    Paula Seikku
    Hospital for Children and Adolescents, University of Helsinki, Pediatric Nephrology and Transplantation, Helsinki, Finland
    Pediatr Transplant 7:102-10. 2003
    ..Individual dosing led to relatively high initial CsA doses, which could be significant for the long-term survival of the graft...
  40. ncbi request reprint Pathogenesis of proteinuria: lessons learned from nephrin and podocin
    Hannu Jalanko
    Pediatr Nephrol 18:487-91. 2003
  41. pmc Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography
    Jorma Wartiovaara
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    J Clin Invest 114:1475-83. 2004
    ..The results suggest the direct involvement of nephrin molecules in constituting the macromolecule-retaining slit diaphragm and its pores...
  42. ncbi request reprint Kidneys with heavy proteinuria show fibrosis, inflammation, and oxidative stress, but no tubular phenotypic change
    Arvi Matti Kuusniemi
    Hospital for Children and Adolescents and Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Kidney Int 68:121-32. 2005
    ..In this work we studied the tubulointerstitial changes that occur in NPHS1 kidneys during infancy...
  43. ncbi request reprint Growth after renal transplantation in infancy or early childhood
    Erik Qvist
    Pediatric Nephrology and Transplantation, Hospital for Children and Adolescents, University of Helsinki, Stenbackinkatu 11, 00290 Finland
    Pediatr Nephrol 17:438-43. 2002
    ..In children <5 years of age at TX, growth is predicted better by the degree of stunting than by age...
  44. ncbi request reprint The number of podocyte slit diaphragms is decreased in minimal change nephrotic syndrome
    Jaakko Patrakka
    Hospital for Children and Adolescents and Biomedicum Helsinki, University of Helsinki, 00290 Helsinki, Finland
    Pediatr Res 52:349-55. 2002
    ..0003). In contrast to findings in MCNS, no significant reduction of the slit diaphragms were seen in MN kidneys compared with the controls. The results suggest that MCNS is associated with disruption of glomerular slit diaphragms...
  45. ncbi request reprint Avascular bone necrosis of the hip joint after solid organ transplantation in childhood: a clinical and MRI analysis
    Ilkka Helenius
    Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland
    Transplantation 81:1621-7. 2006
    ..The occurrence of osteonecrosis in growing age has been studied after kidney transplantation, but no systematic evaluation of the joints has been reported after heart or liver transplantation in childhood...
  46. ncbi request reprint Recombinant human growth hormone treatment after liver transplantation in childhood: the 5-year outcome
    Lauri Puustinen
    The Hospital for Children and Adolescents, Pediatric Nephrology and Transplantation, Helsinki University Central Hospital, Helsinki, Finland
    Transplantation 79:1241-6. 2005
    ....
  47. ncbi request reprint The use of fine-needle aspiration biopsy in detection of acute rejection in children after liver transplantation
    Maria Their
    Pediatric Nephrology and Transplantation, Hospital for Children and Adolescents, University of Helsinki, PL 281, 00029 HUS, Finland
    Transpl Int 15:240-7. 2002
    ..The results indicate that FNAB is a safe and sensitive method for the diagnosis and follow up of acute cellular rejection in pediatric liver recipients...
  48. ncbi request reprint Misleading findings of homozygosity mapping resulting from three novel mutations in NPHS1 encoding nephrin in a highly inbred community
    Yaacov Frishberg
    Division of Pediatric Nephrology, Shaare Zedek Medical Center, Jerusalem, Israel
    Genet Med 9:180-4. 2007
    ..The aim of this study was to confirm that the NPHS1 gene is responsible for congenital nephrotic syndrome in our population, applying homozygosity mapping...
  49. ncbi request reprint Neurodevelopmental outcome in high-risk patients after renal transplantation in early childhood
    Erik Qvist
    Pediatric Nephrology and Transplantation, Hospital for Children and Adolescents, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    Pediatr Transplant 6:53-62. 2002
    ..In these previously lethal diseases, the overall neurodevelopmental outcome is reassuring. However, it is of crucial importance to further minimize the risk factors prior to Tx...
  50. ncbi request reprint Incidence and predictors of fractures in children after solid organ transplantation: a 5-year prospective, population-based study
    Ilkka Helenius
    Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland
    J Bone Miner Res 21:380-7. 2006
    ..35 fractures/1000 persons/year; p < 0.001) in the study group compared with the control population. Thus, screening of vertebral fractures at regular intervals is recommended, and preventive strategies should be studied...
  51. ncbi request reprint Farber disease diagnosed after liver transplantation
    Matti K Salo
    Department of Pediatrics, Tampere University Hospital, PO Box 2000, 33521 Tampere, Finland
    J Pediatr Gastroenterol Nutr 36:274-7. 2003
  52. ncbi request reprint Podocytes are firmly attached to glomerular basement membrane in kidneys with heavy proteinuria
    Anne Tiina Lahdenkari
    Hospital for Children and Adolescents, University of Helsinki, 00290, Finland
    J Am Soc Nephrol 15:2611-8. 2004
    ....
  53. ncbi request reprint Psychosocial adjustment and quality of life after renal transplantation in early childhood
    Erik Qvist
    Pediatric Nephrology and Transplantation, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Pediatr Transplant 8:120-5. 2004
    ..HRQOL assessment by the children themselves can be used to direct interventions and support the children's psychosocial adjustment...
  54. ncbi request reprint Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik
    Jaakko Patrakka
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden
    J Am Soc Nephrol 18:689-97. 2007
    ..This study provides fresh insights into glomerular biology and uncovers new possibilities to explore the role of these novel proteins in the glomerular physiology and pathology...