Research Topics
| Iiro P JaaskelainenSummaryAffiliation: Helsinki University of Technology Country: Finland Publications
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Detail Information
Publications
Short-term plasticity in auditory cognitionIiro P Jaaskelainen
Laboratory of Computational Engineering, Helsinki University of Technology, FIN 02015 TKK, Espoo, Finland
Trends Neurosci 30:653-61. 2007....
Formant transition-specific adaptation by lipreading of left auditory cortex N1mIiro P Jaaskelainen
Laboratory of Computational Engineering, Helsinki University of Technology, Espoo, Finland
Neuroreport 19:93-7. 2008..This suggests that visual speech activates and adapts auditory cortex neural populations tuned to formant transitions, the basic sound-sweep constituents of phonemes, potentially explaining enhanced speech perception during lipreading...
Lipreading and covert speech production similarly modulate human auditory-cortex responses to pure tonesJaakko Kauramäki
Department of Biomedical Engineering and Computational Science, Brain Research Unit, Low Temperature Laboratory, and Advanced Magnetic Imaging Centre, Helsinki University of Technology, FI 02015 TKK, Espoo, Finland
J Neurosci 30:1314-21. 2010..These findings suggest that the lipreading-related suppression in the auditory cortex is caused by top-down influences, possibly by an efference copy from the speech-production system, generated during both own speech and lipreading...- Bayesian inverse analysis of neuromagnetic data using cortically constrained multiple dipolesToni Auranen
Laboratory of Computational Engineering, Helsinki University of Technology, Espoo, Finland
Hum Brain Mapp 28:979-94. 2007..To overcome the difficulties with the present model, we propose the use of loose orientation constraints and combined model of prelocalization utilizing the hierarchical minimum-norm estimate and multiple dipole sampling scheme... - Automatic fMRI-guided MEG multidipole localization for visual responsesToni Auranen
Department of Biomedical Engineering and Computational Science, Helsinki University of Technology, Espoo, Finland
Hum Brain Mapp 30:1087-99. 2009..On this account, the algorithm acts perhaps more as a stochastic optimizer than enables a full Bayesian posterior analysis... - Synchrony of audio-visual speech stimuli modulates left superior temporal sulcusMarja H Balk
Department of Biomedical Engineering and Computational Science, Aalto University School of Science and Engineering, Espoo, Finland
Neuroreport 21:822-6. 2010..It is possible that this reflects sensitivity of the left middle superior temporal sulcus to temporal synchrony of audio-visual speech stimuli... - Perception of matching and conflicting audiovisual speech in dyslexic and fluent readers: an fMRI study at 3 TJohanna Pekkola
Laboratory of Computational Engineering, Helsinki University of Technology, Espoo, Finland
Neuroimage 29:797-807. 2006.... - Hierarchical Bayesian estimates of distributed MEG sources: theoretical aspects and comparison of variational and MCMC methodsAapo Nummenmaa
Laboratory of Computational Engineering, Helsinki University of Technology, PO Box 9203, 02015, HUT, Espoo, Finland
Neuroimage 35:669-85. 2007..The difficulties in using a unimodal variational distribution as a proxy for a truly multimodal distribution are also discussed. Simulated MEG data with realistic sensor and source geometries are used in performing the analyses... - Automatic relevance determination based hierarchical Bayesian MEG inversion in practiceAapo Nummenmaa
Laboratory of Computational Engineering, Helsinki University of Technology, Espoo, Finland Advanced Magnetic Imaging Centre, Helsinki University of Technology, Espoo, Finland
Neuroimage 37:876-89. 2007..Our results show, with a comparison to the basic MNE, that the hierarchical VB approach yields robust and physiologically plausible estimates of distributed sources underlying MEG measurements, in a rather automated fashion... - Attention to visual speech gestures enhances hemodynamic activity in the left planum temporaleJohanna Pekkola
Laboratory of Computational Engineering, Helsinki University of Technology, Espoo, Finland
Hum Brain Mapp 27:471-7. 2006..These findings suggest that attention to visually perceived speech gestures modulates auditory cortex function and that this modulation takes place at a hierarchically relatively early processing level... - Nonlinear relationship between emotional valence and brain activity: evidence of separate negative and positive valence dimensionsMikko Viinikainen
Department of Biomedical Engineering and Computational Science, Helsinki University of Technology, Helsinki, Finland
Hum Brain Mapp 31:1030-40. 2010..This is consistent with the basic division of behavior to approach and withdrawal, where differentiation of hostile and hospitable stimuli is crucial... - Processing of audiovisual speech in Broca's areaVille Ojanen
Laboratory of Computational Engineering, Helsinki University of Technology, P O Box 3000, FIN 02015 HUT, Helsinki, Finland
Neuroimage 25:333-8. 2005..On the other hand, matching acoustic and visual inputs would converge on the same neurons... - Primary auditory cortex activation by visual speech: an fMRI study at 3 TJohanna Pekkola
Laboratory of Computational Engineering, Helsinki University Central Hospital, Helsinki, Finland
Neuroreport 16:125-8. 2005..Further, a significant hemisphere by stimulus interaction occurred, suggesting left Heschl's gyrus specialization for visual speech processing... - Adaptation of neuromagnetic N1 responses to phonetic stimuli by visual speech in humansIiro P Jaaskelainen
Laboratory of Computational Engineering, Helsinki University of Technology, Espoo, P O Box 9203, Innopoli 2, Tekniikant 14, FIN 02015 HUT Finland
Neuroreport 15:2741-4. 2004..This suggests that seeing articulatory gestures of a speaker influences auditory speech perception by modulating the responsiveness of auditory-cortex neurons... - Stimulus-related independent component and voxel-wise analysis of human brain activity during free viewing of a feature filmJuha M Lahnakoski
Brain and Mind Laboratory, Department of Biomedical Engineering and Computational Science, School of Science, Aalto University, Espoo, Finland
PLoS ONE 7:e35215. 2012..Our results encourage the use of naturalistic stimuli and tasks in cognitive neuroimaging to study how the brain processes stimuli in rich natural environments... - Short-term plasticity as a neural mechanism supporting memory and attentional functionsIiro P Jaaskelainen
Brain and Mind Laboratory, Department of Biomedical Engineering and Computational Science, Aalto University, School of Science, Espoo, Finland
Brain Res 1422:66-81. 2011.... - Perceiving identical sounds as speech or non-speech modulates activity in the left posterior superior temporal sulcusRiikka Möttönen
Laboratory of Computational Engineering, Helsinki University of Technology, Finland
Neuroimage 30:563-9. 2006..Altogether, the present findings suggest that activation of the neural speech representations in the left STSp might be a pre-requisite for hearing sounds as speech... - Two-stage processing of sounds explains behavioral performance variations due to changes in stimulus contrast and selective attention: an MEG studyJaakko Kauramäki
Department of Biomedical Engineering and Computational Science BECS, Brain and Mind Laboratory, Aalto University School of Science, Espoo, Finland
PLoS ONE 7:e46872. 2012.... - Selective attention increases both gain and feature selectivity of the human auditory cortexJaakko Kauramäki
Laboratory of Computational Engineering, Helsinki University of Technology, Espoo, Finland
PLoS ONE 2:e909. 2007..While most of the literature explains the neural basis of selective attention by means of an increase in neural gain, a number of papers propose enhancement in neural selectivity as an alternative or a complementary mechanism... - Functional magnetic resonance imaging phase synchronization as a measure of dynamic functional connectivityEnrico Glerean
Brain and Mind Laboratory, Department of Biomedical Engineering and Computational Science BECS, School of Science, Aalto University, Espoo, Finland
Brain Connect 2:91-101. 2012..g., event-related or blocked design) paradigms. A MATLAB toolbox FUNPSY ( http://becs.aalto.fi/bml/software.html ) is openly available for using these metrics in fMRI data analysis... - Inter-subject synchronization of prefrontal cortex hemodynamic activity during natural viewingIiro P Jaaskelainen
Department of Biomedical Engineering and Computational Science, Helsinki University of Technology, FIN 02015 TKK, Espoo, Finland
Open Neuroimag J 2:14-9. 2008..We further show that probabilistic independent component analysis (ICA) reveals meaningful activations in individual subjects during natural viewing... - Bayesian analysis of the neuromagnetic inverse problem with l(p)-norm priorsToni Auranen
Laboratory of Computational Engineering, Helsinki University of Technology, P O Box 9203, 02015 HUT, Espoo, Finland
Neuroimage 26:870-84. 2005.... - Task-modulated "what" and "where" pathways in human auditory cortexJyrki Ahveninen
Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, CNY 149 13th Street, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 103:14608-13. 2006..This finding suggests that selective-attention effects are feature-specific in the human nonprimary auditory cortex and that they arise from enhanced tuning of receptive fields of task-relevant neuronal populations... - Enhanced magnetic auditory steady-state response in early Alzheimer's diseaseDaria Osipova
Cognitive Brain Research Unit, Department of Psychology, University of Helsinki, Finland
Clin Neurophysiol 117:1990-5. 2006..We studied the auditory steady-state response (SSR) which represents the net effect of entrained background activity and superimposed cortical evoked responses, in AD patients and healthy controls... - Inherited auditory-cortical dysfunction in twin pairs discordant for schizophreniaJyrki Ahveninen
Department of Radiology, Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Biol Psychiatry 60:612-20. 2006..We used magnetoencephalography (MEG) and electroencephalography (EEG) to investigate the inheritance of auditory-cortical deficiencies in twin pairs discordant for schizophrenia... - Auditory selective attention modulated by tryptophan depletion in humansJyrki Ahveninen
Department of Psychology, PO Box 9, FIN 00014 University of Helsinki, Helsinki, Finland
Neurosci Lett 340:181-4. 2003..The P50 latencies were increased after ATD, irrespective of attention. In conclusion, serotonin may regulate attentional modulation of early cortical stimulus processing... - Serotonergic modulation of mismatch negativitySeppo Kahkonen
Cognitive Brain Research Unit, University of Helsinki, Finland
Psychiatry Res 138:61-74. 2005..No effects on P50 were observed. The present results suggest serotonergic modulation of preattentive auditory change detection, suggested to initiate involuntary attention shifting in the human brain... - Cholinergic modulation of preattentive auditory processing in agingEero Pekkonen
Department of Neurology, University of Helsinki, PO Box 340, FIN 00029 HUS, Finland
Neuroimage 27:387-92. 2005..The combined MEG/EEG measurements using particularly auditory N100 response might offer an objective tool to monitor cholinergic activity in aging and Alzheimer's disease (AD)... - Serotonin modulates early cortical auditory processing in healthy subjects: evidence from MEG with acute tryptophan depletionSeppo Kahkonen
BioMag Laboratory, Engineering Centre, Helsinki University Central Hospital, Helsinki, Finland
Neuropsychopharmacology 27:862-8. 2002..The results suggest that the neurotransmitter serotonin is involved in early auditory cortical processing. Further, the serotonin modulation may be different in males and females... - Tryptophan depletion effects on EEG and MEG responses suggest serotonergic modulation of auditory involuntary attention in humansJyrki Ahveninen
Cognitive Brain Research Unit, Department of Psychology, P.O. Box 13, University of Helsinki, Helsinki, FIN-00014, Finland
Neuroimage 16:1052-61. 2002..In conclusion, the results suggest that decreased level of central 5-HT function after ATD may decrease involuntary attention shifting to task-irrelevant sound changes and thus modulate resource allocation to the task-relevant activity... - Memory-based comparison process not attenuated by haloperidol: a combined MEG and EEG studyEero Pekkone
Department of Neurology, Medical Engineering Centre, Helsinki University Central Hospital, Finland
Neuroreport 13:177-81. 2002..Our results indicate that memory-based sound comparison and preceding cortical processing underlying stimulus detection are not attenuated by haloperidol, whereas haloperidol appears to accelerate preattentive sound comparison... - Acute tryptophan depletion decreases intensity dependence of auditory evoked magnetic N1/P2 dipole source activitySeppo Kahkonen
BioMag Laboratory, Engineering Centre, Helsinki University Central Hospital, P O Box 340, 00029 HUS, Finland
Psychopharmacology (Berl) 164:221-7. 2002..Depletion of tryptophan (TRP), a precursor for serotonin has been described to reduce serotonin content in brain of animals and humans... - Dopamine modulates involuntary attention shifting and reorienting: an electromagnetic studySeppo Kahkonen
Cognitive Brain Research Unit, Department of Psychology, University of Helsinki, Helsinki, Finland
Clin Neurophysiol 113:1894-902. 2002..Dopaminergic function has been closely associated with attentional performance, but its precise role has remained elusive... - Impaired temporal lobe processing of preattentive auditory discrimination in schizophreniaEero Pekkonen
Department of Neurology, University of Helsinki, Finland
Schizophr Bull 28:467-74. 2002..These results suggest that patients with schizophrenia have impaired auditory processing in the temporal lobes underlying preattentive stimulus discrimination that is also selectively delayed in the left hemisphere... - Acute tryptophan depletion does not change somatosensory evoked magnetic fieldsSeppo Kahkonen
Cognitive Brain Research Unit, University of Helsinki, Helsinki, Finland
Psychopharmacology (Berl) 170:332-3. 2003..Serotonin is shown to regulate the activity of primary auditory cortex, but little is known about serotonin modulation of other sensory cortices... - Parallel input makes the brain run fasterTommi Raij
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
Neuroimage 40:1792-7. 2008..This arrangement could also allow very early top-down modulation of the bottom-up stream of sensory information... - Effects of scopolamine on MEG spectral power and coherence in elderly subjectsDaria Osipova
Cognitive Brain Research Unit, Department of Psychology, University of Helsinki, P O Box 9 00014, Helsinki, Finland
Clin Neurophysiol 114:1902-7. 2003..In order to test the sensitivity of spectral power and hemispheric coherence to changes in cholinergic transmission, we evaluated quantitative magnetoencephalogram (MEG) after intravenous injection of scopolamine... - Human posterior auditory cortex gates novel sounds to consciousnessIiro P Jaaskelainen
Massachusetts General Hospital, Massachusetts Institute of Technology, Harvard Medical School, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 101:6809-14. 2004..Our converging findings suggest that transient adaptation of feature-specific neurons within human posterior auditory cortex filters superfluous sounds from entering one's awareness... - Dysfunction in early auditory processing in major depressive disorder revealed by combined MEG and EEGSeppo Kahkonen
BioMag Laboratory, Helsinki University Central Hospital and the Cognitive Brain Research Unit, University of Helsinki, Helsinky, Finland
J Psychiatry Neurosci 32:316-22. 2007..We investigated whether MDD affects neural mechanisms of involuntary attention studied by auditory evoked potentials (AEPs) and auditory evoked magnetic fields (AEFs)... - Impaired pre-attentive auditory processing in opioid dependence with and without benzodiazepine co-dependence revealed by combined magnetoencephalography and electroencephalographyReetta Kivisaari
Medical Imaging Centre, Box 281, Helsinki University Central Hospital, 00029 HUS, Finland
Prog Neuropsychopharmacol Biol Psychiatry 31:1378-86. 2007..There were no group differences in EEG amplitude measures. In conclusion, our results suggest delayed pre-attentive auditory processing of novel information in opioid dependence. Benzodiazepine co-dependence modulated N1m response... - Altered generation of spontaneous oscillations in Alzheimer's diseaseDaria Osipova
Cognitive Brain Research Unit, Department of Psychology, University of Helsinki, Finland
Neuroimage 27:835-41. 2005.... - MRI-constrained spectral imaging of benzodiazepine modulation of spontaneous neuromagnetic activity in human cortexJyrki Ahveninen
Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, CNY149 13th Street, Charlestown, MA 02129, USA
Neuroimage 35:577-82. 2007..Anatomically constrained spectral imaging displays the cortical loci of drug effects on oscillatory brain activity, providing a novel tool for human pharmacological neuroimaging... - Source estimation of spontaneous MEG oscillations in mild cognitive impairmentDaria Osipova
Cognitive Brain Research Unit, Department of Psychology, University of Helsinki, Helsinki, Finland
Neurosci Lett 405:57-61. 2006..Deficits in the distribution of oscillatory sources in the resting state are thus likely to occur at later stages of cognitive impairment than MCI... - Aging and cholinergic modulation of the transient magnetic 40-Hz auditory responseJyrki Ahveninen
Cognitive Brain Research Unit, Department of Neurology, University of Helsinki, FIN 00014 Helsinki, Finland
Neuroimage 15:153-8. 2002..In sum, the transient magnetic 40-Hz auditory response may be useful in studies on brain cholinergic deficits in elderly subjects...