T Erkinjuntti

Summary

Affiliation: Helsinki University Central Hospital
Country: Finland

Publications

  1. ncbi request reprint Management of patients with Alzheimer's disease plus cerebrovascular disease: 12-month treatment with galantamine
    Roger Bullock
    Kingshill Research Centre, Victoria Hospital, Swindon, UK
    Dement Geriatr Cogn Disord 17:29-34. 2004
  2. ncbi request reprint Limitations of clinical criteria for the diagnosis of vascular dementia in clinical trials. Is a focus on subcortical vascular dementia a solution?
    T Erkinjuntti
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Finland
    Ann N Y Acad Sci 903:262-72. 2000
  3. ncbi request reprint Subcortical vascular dementia
    Timo Erkinjuntti
    Memory Research Unit, Department of Clinical Neurosciences, University of Helsinki, Finland
    Cerebrovasc Dis 13:58-60. 2002
  4. pmc Cognitive profile of subcortical ischaemic vascular disease
    H Jokinen
    Department of Psychology, University of Helsinki, Helsinki, Finland
    J Neurol Neurosurg Psychiatry 77:28-33. 2006
  5. ncbi request reprint Magnetic resonance imaging correlates of depression after ischemic stroke
    R Vataja
    Department of Clinical Neurosciences, Memory Research Unit, Helsinki University Central Hospital, PO Box 300, FIN-00029 HUS, Finland
    Arch Gen Psychiatry 58:925-31. 2001
  6. ncbi request reprint Medial temporal lobe atrophy and memory deficits in elderly stroke patients
    H Jokinen
    Department of Psychology, University of Helsinki, Helsinki, Finland
    Eur J Neurol 11:825-32. 2004
  7. pmc White matter hyperintensities as a predictor of neuropsychological deficits post-stroke
    H Jokinen
    Department of Neurology, Helsinki University Central Hospital, P O Box 302, FIN 00029 HUS, Helsinki, Finland
    J Neurol Neurosurg Psychiatry 76:1229-33. 2005
  8. doi request reprint Brain atrophy accelerates cognitive decline in cerebral small vessel disease: the LADIS study
    H Jokinen
    Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
    Neurology 78:1785-92. 2012
  9. ncbi request reprint MRI pontine hyperintensity after supratentorial ischemic stroke relates to poor clinical outcome
    R Mäntyla
    Departments of Radiology, Helsinki University Central Hospital, Helsinki, Finland
    Stroke 31:695-700. 2000
  10. ncbi request reprint The prevalence and distribution of white-matter changes on different MRI pulse sequences in a post-stroke cohort
    R Mäntyla
    Department of Radiology, University of Helsinki, Haartmaninkatu 4, FIN 00290 Helsinki, Finland
    Neuroradiology 41:657-65. 1999

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Management of patients with Alzheimer's disease plus cerebrovascular disease: 12-month treatment with galantamine
    Roger Bullock
    Kingshill Research Centre, Victoria Hospital, Swindon, UK
    Dement Geriatr Cogn Disord 17:29-34. 2004
    ..Subgroup analysis was performed of patients with AD + CVD who participated in a 6-month, multicenter, randomized, double-blind, parallel-group study and a 6-month, open-label, active-treatment extension...
  2. ncbi request reprint Limitations of clinical criteria for the diagnosis of vascular dementia in clinical trials. Is a focus on subcortical vascular dementia a solution?
    T Erkinjuntti
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Finland
    Ann N Y Acad Sci 903:262-72. 2000
    ..Subcortical VaD is expected to show a more predictable clinical picture, natural history, outcomes, and treatment responses...
  3. ncbi request reprint Subcortical vascular dementia
    Timo Erkinjuntti
    Memory Research Unit, Department of Clinical Neurosciences, University of Helsinki, Finland
    Cerebrovasc Dis 13:58-60. 2002
    ..Subcortical VaD is expected to show a more predictable clinical picture, natural history, outcome and treatment responses...
  4. pmc Cognitive profile of subcortical ischaemic vascular disease
    H Jokinen
    Department of Psychology, University of Helsinki, Helsinki, Finland
    J Neurol Neurosurg Psychiatry 77:28-33. 2006
    ..The aim of this study is to describe in detail the neuropsychological characteristics of patients with SIVD from a large well defined stroke cohort...
  5. ncbi request reprint Magnetic resonance imaging correlates of depression after ischemic stroke
    R Vataja
    Department of Clinical Neurosciences, Memory Research Unit, Helsinki University Central Hospital, PO Box 300, FIN-00029 HUS, Finland
    Arch Gen Psychiatry 58:925-31. 2001
    ..3), and mean volume of infarcts in the right occipital lobe (OR, 0.98; 95% CI, 0.96-0.99). CONCLUSION: Lesions affecting the prefrontosubcortical circuits, especially on the left side, are correlates of depression after ischemic stroke...
  6. ncbi request reprint Medial temporal lobe atrophy and memory deficits in elderly stroke patients
    H Jokinen
    Department of Psychology, University of Helsinki, Helsinki, Finland
    Eur J Neurol 11:825-32. 2004
    ..The most vulnerable domains are memory and visuospatial functions, whereas verbal and executive functions seem to be unrelated to MTA...
  7. pmc White matter hyperintensities as a predictor of neuropsychological deficits post-stroke
    H Jokinen
    Department of Neurology, Helsinki University Central Hospital, P O Box 302, FIN 00029 HUS, Helsinki, Finland
    J Neurol Neurosurg Psychiatry 76:1229-33. 2005
    ..The purpose of this study was to explore how the severity and location of WMHs predict neuropsychological test performance in the context of other brain lesions in elderly stroke patients...
  8. doi request reprint Brain atrophy accelerates cognitive decline in cerebral small vessel disease: the LADIS study
    H Jokinen
    Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
    Neurology 78:1785-92. 2012
    ..To examine the independent contributions and combined interactions of medial temporal lobe atrophy (MTA), cortical and subcortical atrophy, and white matter lesion (WML) volume in longitudinal cognitive performance...
  9. ncbi request reprint MRI pontine hyperintensity after supratentorial ischemic stroke relates to poor clinical outcome
    R Mäntyla
    Departments of Radiology, Helsinki University Central Hospital, Helsinki, Finland
    Stroke 31:695-700. 2000
    ..We examined the frequency, as well as the radiological and clinical correlates, of PHI in poststroke patients...
  10. ncbi request reprint The prevalence and distribution of white-matter changes on different MRI pulse sequences in a post-stroke cohort
    R Mäntyla
    Department of Radiology, University of Helsinki, Haartmaninkatu 4, FIN 00290 Helsinki, Finland
    Neuroradiology 41:657-65. 1999
    ..The prevalence of WM high-signal foci was greatest in the watershed zone and smallest in the subcortical area. There was a significant correlation between foci in different areas...
  11. ncbi request reprint Heterogeneity of cognitive profiles in aging: successful aging, normal aging, and individuals at risk for cognitive decline
    R Ylikoski
    Neuropsychological Unit, Department of Clinical Neurosciences, P O Box 300, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Neurol 6:645-52. 1999
    ..Age, activity and intellectual levels, and to a lesser degree education, were significantly related to the cluster solution. The present findings caution against treating samples of elderly individuals as homogeneous...
  12. ncbi request reprint Impaired preconscious auditory processing and cognitive functions in Alzheimer's disease
    E Pekkonen
    Department of Neurology, Helsinki University Central Hospital, Finland
    Clin Neurophysiol 110:1942-7. 1999
    ..To investigate whether auditory processing correlates with the impairment of the higher cortical functions...
  13. ncbi request reprint Variable agreement between visual rating scales for white matter hyperintensities on MRI. Comparison of 13 rating scales in a poststroke cohort
    R Mäntyla
    Department of Radiology, University of Helsinki, Finland
    Stroke 28:1614-23. 1997
    ..The purpose of this study was to test whether part of this variation could be explained by the different properties of the visual WMHI rating scales used...
  14. ncbi request reprint Magnetic resonance imaging white matter hyperintensities and mechanism of ischemic stroke
    R Mäntyla
    Department of Radiology, Memory Research Unit, Helsinki University Central Hospital, Finland
    Stroke 30:2053-8. 1999
    ..We sought to determine the relations between infarct subtype and white matter hyperintensities (WMHIs) on MRI...
  15. doi request reprint Extensive white matter changes predict stroke recurrence up to 5 years after a first-ever ischemic stroke
    S Melkas
    Department of Neurological Sciences, University of Helsinki, and Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
    Cerebrovasc Dis 34:191-8. 2012
    ..We aimed to investigate whether severe WMCs are a risk factor for recurrent ischemic stroke in a long-term follow-up...
  16. ncbi request reprint Potential long-term effects of rivastigmine on disease progression may be linked to drug effects on vascular changes in Alzheimer brains
    T Erkinjuntti
    Department of Neurology, Helsinki University Central Hospital, HYKS, Finland
    Int J Clin Pract 57:756-60. 2003
    ..These findings may have an important influence on the way cholinesterase inhibitors are prescribed...
  17. doi request reprint Small-vessel disease relates to poor poststroke survival in a 12-year follow-up
    S Melkas
    Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
    Neurology 76:734-9. 2011
    ..We sought to compare ultra-long-term poststroke survival in small-vessel disease (SVD) vs non-SVD subtype of stroke...
  18. ncbi request reprint Evaluation of various methods of assessing symptoms of cognitive impairment and dementia
    T Pohjasvaara
    Memory Research and Stroke Unit, Department of Clinical Neuroscience, Helsinki University Central Hospital, Helsinki, Finland
    Alzheimer Dis Assoc Disord 15:184-93. 2001
    ..This may have serious influences on investigation and treatment of patients. We underline the importance of further debate and studies to refine the categories of cognitive impairment used in the setting of CVD...
  19. doi request reprint Galantamine treatment in Alzheimer's disease with cerebrovascular disease: responder analyses from a randomized, controlled trial (GAL-INT-6)
    T Erkinjuntti
    Memory Research Unit, Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
    J Psychopharmacol 22:761-8. 2008
    ..These findings are consistent with a broad range of cognitive, functional and behavioural benefits with galantamine across the spectrum of AD and AD with CVD...
  20. ncbi request reprint Poststroke depression and lesion location revisited
    R Vataja
    Department of Neurology, Memory Research Unit, Stroke Unit, Psychiatry, Psychiatric Consultation Unit, Helsinki University Central Hospital, Helsinki, Finland
    J Neuropsychiatry Clin Neurosci 16:156-62. 2004
    ..Using a logistic regression analysis, the authors found that a brain infarct that affected pallidum was a strong independent MRI correlate for poststroke depression (odds ratio = 7.2)...
  21. doi request reprint Poststroke dementia predicts poor survival in long-term follow-up: influence of prestroke cognitive decline and previous stroke
    S Melkas
    Department of Neurology, Helsinki University Central Hospital, POB 300, 00029 HUS, Finland
    J Neurol Neurosurg Psychiatry 80:865-70. 2009
    ..The aim of this study was to investigate the influence of poststroke dementia on long-term survival after acute stroke and also to assess the possible influence of prestroke cognitive decline and previous stroke on this relationship...
  22. ncbi request reprint Depression is an independent predictor of poor long-term functional outcome post-stroke
    T Pohjasvaara
    Memory Research Unit, Department of Clinical Neuroscience, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Neurol 8:315-9. 2001
    ..5, 95% CI 1.6-3.8). More careful examination and treatment of depression in stroke patients is emphasized...
  23. doi request reprint Incident lacunes influence cognitive decline: the LADIS study
    H Jokinen
    Memory Research Unit, Department of Neurology, University of Helsinki, Helsinki, Finland
    Neurology 76:1872-8. 2011
    ..This study investigated whether incident lacunes on MRI determine longitudinal cognitive change in elderly subjects with WML...
  24. ncbi request reprint Perseveration in Alzheimer's disease
    S Pekkala
    Department of Speech Sciences, University of Helsinki, Helsinki, Finland
    Dement Geriatr Cogn Disord 25:109-14. 2008
    ..We document the type and quantitative burden of perseveration as cognitive decline progresses from normal aging (n = 30) through mild AD (n = 20) to moderate AD (n = 20) by administering a semantic verbal fluency task...
  25. ncbi request reprint Suicidal ideas in stroke patients 3 and 15 months after stroke
    T Pohjasvaara
    Department of Clinical Neuroscience, Psychiatric Consultation Unit, Helsinki University Central Hospital, Helsinki, Finland
    Cerebrovasc Dis 12:21-6. 2001
    ..Recurrent strokes, depressive symptoms, more disabling stroke and right-sided stroke correlated to suicidal ideas at 15 months after stroke. Early identification of these risk factors may lead to effective therapeutic intervention...
  26. ncbi request reprint No antibodies to HTLV-I and HIV in patients with dementia in Finland
    R Sulkava
    Department of Neurology, University of Helsinki, Finland
    Acta Neurol Scand 76:155-6. 1987
    ..No antibodies to HTLV-I and HIV were detected in patients with the clinical diagnosis of Alzheimer's disease, vascular dementia, secondary dementia due to a specific cause, or in cases of atypical dementia...
  27. ncbi request reprint Is determination of plasma lipids useful in the differentiation of multi-infarct dementia from Alzheimer's disease?
    T Erkinjuntti
    Department of Neurology, University of Helsinki, Finland
    Compr Gerontol A 2:1-6. 1988
    ....
  28. ncbi request reprint Sleep apnea in multiinfarct dementia and Alzheimer's disease
    T Erkinjuntti
    Department of Neurology, University of Helsinki, Finland
    Sleep 10:419-25. 1987
    ..Age had no effect on the proportion of apneas and hypopneas among demented patients or control subjects, but male controls had more apneas and hypopneas than did female controls...
  29. ncbi request reprint Preserved stimulus deviance detection in Alzheimer's disease
    E Pekkonen
    Department of Neurology, University of Helsinki, and Medical Engineering Centre, Helsinki University Central Hospital, Finland
    Neuroreport 12:1649-52. 2001
    ..This suggests that although MMNm is delayed in the left hemisphere, the automatic discrimination to duration change in the auditory cortex is not attenuated in the early stages of AD...
  30. ncbi request reprint MRI correlates of executive dysfunction in patients with ischaemic stroke
    R Vataja
    Memory Research Unit, Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Neurol 10:625-31. 2003
    ..Brain infarcts and WML affecting the frontal-subcortical circuits or the pons may increase risk for ED in stroke patients...
  31. ncbi request reprint Rivastigmine in patients with Alzheimer's disease and concurrent hypertension
    T Erkinjuntti
    Department of Neurology, Helsinki University Central Hospital, HYKS, Finland
    Int J Clin Pract 56:791-6. 2002
    ..Our data support the hypothesis that rivastigmine provides benefits to patients with or without hypertension, and contribute to the evidence that particular benefits may be observed in those with vascular risk factors...
  32. ncbi request reprint Cognitive decline and treatment options for patients with vascular dementia
    T Erkinjuntti
    Memory Research Unit, Department of Clinical Neurology, Helsinki University Central Hospital, Helsinki, Finland
    Acta Neurol Scand Suppl 178:15-8. 2002
    ..Additionally, functional and behavioral benefits have been reported with the dual-mechanism AChEI galantamine. These studies suggest a potential role for AChEIs in the management of cognitive impairment associated with VaD...
  33. ncbi request reprint Post-stroke depression, executive dysfunction and functional outcome
    T Pohjasvaara
    Memory Research Unit, Department of Clinical Neuroscience, Helsinki University Central Hospital, Finland
    Eur J Neurol 9:269-75. 2002
    ..Executive measures may detect patients at risk of dementia and disability post-stroke...
  34. ncbi request reprint Cognitive functions and depression as predictors of poor outcome 15 months after stroke
    T Pohjasvaara
    Stroke Unit, Department of Clinical Neuroscience, Helsinki University Central Hospital, Helsinki, Finland
    Cerebrovasc Dis 14:228-33. 2002
    ..1, 95% CI 1.02-1.12), between 3 and 15 months follow-up, had an independent effect on dependent living 15 months after ischemic stroke. This challenges the care and rehabilitation of these items even at the stable period after stroke...
  35. ncbi request reprint An open-label extension trial of galantamine in patients with probable vascular dementia and mixed dementia
    Timo Erkinjuntti
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland
    Clin Ther 25:1765-82. 2003
    ....
  36. ncbi request reprint Vascular cognitive deterioration and stroke
    Timo Erkinjuntti
    Department of Neurology, University of Helsinki, Helsinki, Finland
    Cerebrovasc Dis 24:189-94. 2007
    ..Whilst CVD is preventable and treatable, it is clearly a major factor in the prevalence of cognitive impairment in the elderly worldwide...
  37. ncbi request reprint Comparison of the Alzheimer's Disease Assessment Scale Cognitive Subscale and the Vascular Dementia Assessment Scale in differentiating elderly individuals with different degrees of white matter changes. The LADIS Study
    Raija Ylikoski
    Memory Research Unit, Department of Neurology, University of Helsinki, Helsinki, Finland
    Dement Geriatr Cogn Disord 24:73-81. 2007
    ..The objective of this study was to compare the results of the two scales among subjects with various degrees of white matter hyperintensities (WMHs)...
  38. ncbi request reprint Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial
    Timo Erkinjuntti
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland
    Lancet 359:1283-90. 2002
    ..We investigated the effects of galantamine in patients with a diagnosis of probable vascular dementia or Alzheimer's disease combined with cerebrovascular disease...
  39. ncbi request reprint Classification and subtypes of vascular dementia
    Anders Wallin
    Goteborg University, Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Molndal, Sweden
    Int Psychogeriatr 15:27-37. 2003
    ..Subcortical VaD has a relatively homogeneous clinical picture for which detailed criteria are suggested. AD + VaD is more difficult to identify but is possible, sometimes with the aid of neuroimaging and/or biological markers...
  40. ncbi request reprint Vascular burden of the brain
    JOHN O'BRIEN
    Int Psychogeriatr 15:7-10. 2003
  41. ncbi request reprint Vascular dementia
    Timo Erkinjuntti
    Department of Neurology, University of Helsinki, Helsinki, Finland
    Semin Clin Neuropsychiatry 8:37-45. 2003
    ..Attempts to treat VaD had varying degrees of success, but it now appears that many forms of VCI might be preventable, especially with good control of vascular risk factors in middle age...
  42. ncbi request reprint Galantamine in the treatment of cognitive decline in patients with vascular dementia or Alzheimer's disease with cerebrovascular disease
    Gary Small
    Department of Psychiatry and Biobehavioral Sciences and Neuropsychiatric Institute, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90024, USA
    CNS Drugs 17:905-14. 2003
    ....
  43. ncbi request reprint Clinical features of MRI-defined subcortical vascular disease
    Tarja Pohjasvaara
    Department of Neurology, Memory Research Unit, Helsinki University Central Hospital, Helsinki, Finland
    Alzheimer Dis Assoc Disord 17:236-42. 2003
    ..We applied magnetic resonance imaging (MRI) criteria based on research criteria for SIVD in a large cohort of patients with ischemic stroke. We compared clinical features of patients with SIVD and patients with other stroke type...
  44. ncbi request reprint Emerging therapies for vascular dementia and vascular cognitive impairment
    Timo Erkinjuntti
    Helsinki University Central Hospital, Helsinki, Finland
    Stroke 35:1010-7. 2004
    ..Cerebrovascular disease (CVD) and ischemic brain injury secondary to cardiovascular disease are common causes of dementia and cognitive decline in the elderly. CVD also contributes to cognitive loss in Alzheimer disease (AD)...
  45. ncbi request reprint Treatment of vascular dementia-evidence from clinical trials with cholinesterase inhibitors
    Timo Erkinjuntti
    Helsinki University Central Hospital, Finland
    Neurol Res 26:603-5. 2004
    ..Controlled clinical trials with donepezil, galantamine, and rivastigmine in VaD, as well as in patients with AD plus CVD, have demonstrated improvement in cognition, behavior and activities of daily living...
  46. ncbi request reprint Treatment of vascular dementia--evidence from clinical trials with cholinesterase inhibitors
    Timo Erkinjuntti
    Helsinki University Central Hospital, Helsinki, Finland
    J Neurol Sci 226:63-6. 2004
    ..Controlled clinical trials with donepezil, galantamine and rivastigmine in VaD, as well as in patients with AD plus CVD, have demonstrated improvements in cognition, behavior and activities of daily living...
  47. ncbi request reprint Treatment options: the latest evidence with galantamine (Reminyl)
    Timo Erkinjuntti
    Memory Research Unit, Department of Clinical Neurosciences, Helsinki University Central Hospital, P O Box 300, 00029 HYKS, Finland
    J Neurol Sci 203:125-30. 2002
    ..Galantamine therefore has potential to benefit a wide range of patients with dementia in the clinic...
  48. ncbi request reprint Subcortical ischaemic vascular dementia
    Gustavo C Roman
    University of Texas at San Antonio and the Audie L Murphy Memorial Veterans Hospital, San Antonio, Texas 78284 7883, USA
    Lancet Neurol 1:426-36. 2002
    ..Treatment is symptomatic and prevention requires control of treatable risk factors...
  49. ncbi request reprint Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study
    Wiesje M van der Flier
    Alzheimer Center, Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Stroke 36:2116-20. 2005
    ..We investigated the independent contribution of WMH and lacunes to general cognitive function in a group of independently living elderly with varying degrees of small vessel disease...