T Erkinjuntti

Summary

Affiliation: Helsinki University Central Hospital
Country: Finland

Publications

  1. ncbi request reprint Βeta-fibrinogen gene promoter A -455 allele associated with poor longterm survival among 55-71 years old Caucasian women in Finnish stroke cohort
    Mika Martiskainen
    Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
    BMC Neurol 14:137. 2014
  2. ncbi request reprint Treatment options: the latest evidence with galantamine (Reminyl)
    Timo Erkinjuntti
    Memory Research Unit, Department of Clinical Neurosciences, Helsinki University Central Hospital, P O Box 300, 00029 HYKS, Finland
    J Neurol Sci 203:125-30. 2002
  3. doi request reprint The concept of vascular cognitive impairment
    Timo Erkinjuntti
    Memory Research Unit, Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
    Front Neurol Neurosci 24:79-85. 2009
  4. ncbi request reprint Cognitive decline and treatment options for patients with vascular dementia
    T Erkinjuntti
    Memory Research Unit, Department of Clinical Neurology, Helsinki University Central Hospital, Helsinki, Finland
    Acta Neurol Scand Suppl 178:15-8. 2002
  5. ncbi request reprint Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial
    Timo Erkinjuntti
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland
    Lancet 359:1283-90. 2002
  6. ncbi request reprint Treatment of vascular dementia--evidence from clinical trials with cholinesterase inhibitors
    Timo Erkinjuntti
    Helsinki University Central Hospital, Helsinki, Finland
    J Neurol Sci 226:63-6. 2004
  7. ncbi request reprint An open-label extension trial of galantamine in patients with probable vascular dementia and mixed dementia
    Timo Erkinjuntti
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland
    Clin Ther 25:1765-82. 2003
  8. ncbi request reprint Vascular cognitive deterioration and stroke
    Timo Erkinjuntti
    Department of Neurology, University of Helsinki, Helsinki, Finland
    Cerebrovasc Dis 24:189-94. 2007
  9. ncbi request reprint Cognitive functions and depression as predictors of poor outcome 15 months after stroke
    T Pohjasvaara
    Stroke Unit, Department of Clinical Neuroscience, Helsinki University Central Hospital, Helsinki, Finland
    Cerebrovasc Dis 14:228-33. 2002
  10. pmc Cognitive profile of subcortical ischaemic vascular disease
    H Jokinen
    Department of Psychology, University of Helsinki, Helsinki, Finland
    J Neurol Neurosurg Psychiatry 77:28-33. 2006

Collaborators

Detail Information

Publications80

  1. ncbi request reprint Βeta-fibrinogen gene promoter A -455 allele associated with poor longterm survival among 55-71 years old Caucasian women in Finnish stroke cohort
    Mika Martiskainen
    Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
    BMC Neurol 14:137. 2014
    ..We investigated whether the FGB -455 G/A polymorphism and smoking might interact with sex on longterm survival of acute stroke sufferers...
  2. ncbi request reprint Treatment options: the latest evidence with galantamine (Reminyl)
    Timo Erkinjuntti
    Memory Research Unit, Department of Clinical Neurosciences, Helsinki University Central Hospital, P O Box 300, 00029 HYKS, Finland
    J Neurol Sci 203:125-30. 2002
    ..Galantamine therefore has potential to benefit a wide range of patients with dementia in the clinic...
  3. doi request reprint The concept of vascular cognitive impairment
    Timo Erkinjuntti
    Memory Research Unit, Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
    Front Neurol Neurosci 24:79-85. 2009
    ..Whilst CVD is preventable and treatable, it clearly is a major factor in the prevalence of cognitive impairment in the elderly worldwide...
  4. ncbi request reprint Cognitive decline and treatment options for patients with vascular dementia
    T Erkinjuntti
    Memory Research Unit, Department of Clinical Neurology, Helsinki University Central Hospital, Helsinki, Finland
    Acta Neurol Scand Suppl 178:15-8. 2002
    ..Additionally, functional and behavioral benefits have been reported with the dual-mechanism AChEI galantamine. These studies suggest a potential role for AChEIs in the management of cognitive impairment associated with VaD...
  5. ncbi request reprint Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial
    Timo Erkinjuntti
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland
    Lancet 359:1283-90. 2002
    ..We investigated the effects of galantamine in patients with a diagnosis of probable vascular dementia or Alzheimer's disease combined with cerebrovascular disease...
  6. ncbi request reprint Treatment of vascular dementia--evidence from clinical trials with cholinesterase inhibitors
    Timo Erkinjuntti
    Helsinki University Central Hospital, Helsinki, Finland
    J Neurol Sci 226:63-6. 2004
    ..Controlled clinical trials with donepezil, galantamine and rivastigmine in VaD, as well as in patients with AD plus CVD, have demonstrated improvements in cognition, behavior and activities of daily living...
  7. ncbi request reprint An open-label extension trial of galantamine in patients with probable vascular dementia and mixed dementia
    Timo Erkinjuntti
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland
    Clin Ther 25:1765-82. 2003
    ....
  8. ncbi request reprint Vascular cognitive deterioration and stroke
    Timo Erkinjuntti
    Department of Neurology, University of Helsinki, Helsinki, Finland
    Cerebrovasc Dis 24:189-94. 2007
    ..Whilst CVD is preventable and treatable, it is clearly a major factor in the prevalence of cognitive impairment in the elderly worldwide...
  9. ncbi request reprint Cognitive functions and depression as predictors of poor outcome 15 months after stroke
    T Pohjasvaara
    Stroke Unit, Department of Clinical Neuroscience, Helsinki University Central Hospital, Helsinki, Finland
    Cerebrovasc Dis 14:228-33. 2002
    ..1, 95% CI 1.02-1.12), between 3 and 15 months follow-up, had an independent effect on dependent living 15 months after ischemic stroke. This challenges the care and rehabilitation of these items even at the stable period after stroke...
  10. pmc Cognitive profile of subcortical ischaemic vascular disease
    H Jokinen
    Department of Psychology, University of Helsinki, Helsinki, Finland
    J Neurol Neurosurg Psychiatry 77:28-33. 2006
    ..The aim of this study is to describe in detail the neuropsychological characteristics of patients with SIVD from a large well defined stroke cohort...
  11. ncbi request reprint Executive functions and speed of mental processing in elderly patients with frontal or nonfrontal ischemic stroke
    M Leskelä
    Unit of Neuropsychology, Department of Clinical Neuroscience, University of Helsinki, Helsinki, Sweden
    Eur J Neurol 6:653-61. 1999
    ..Frontal stroke related mainly to the slowing of mental processing...
  12. ncbi request reprint Medial temporal lobe atrophy and memory deficits in elderly stroke patients
    H Jokinen
    Department of Psychology, University of Helsinki, Helsinki, Finland
    Eur J Neurol 11:825-32. 2004
    ..The most vulnerable domains are memory and visuospatial functions, whereas verbal and executive functions seem to be unrelated to MTA...
  13. pmc White matter hyperintensities as a predictor of neuropsychological deficits post-stroke
    H Jokinen
    Department of Neurology, Helsinki University Central Hospital, P O Box 302, FIN 00029 HUS, Helsinki, Finland
    J Neurol Neurosurg Psychiatry 76:1229-33. 2005
    ..The purpose of this study was to explore how the severity and location of WMHs predict neuropsychological test performance in the context of other brain lesions in elderly stroke patients...
  14. doi request reprint Brain atrophy accelerates cognitive decline in cerebral small vessel disease: the LADIS study
    H Jokinen
    Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
    Neurology 78:1785-92. 2012
    ..To examine the independent contributions and combined interactions of medial temporal lobe atrophy (MTA), cortical and subcortical atrophy, and white matter lesion (WML) volume in longitudinal cognitive performance...
  15. ncbi request reprint MRI correlates of executive dysfunction in patients with ischaemic stroke
    R Vataja
    Memory Research Unit, Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Neurol 10:625-31. 2003
    ..Brain infarcts and WML affecting the frontal-subcortical circuits or the pons may increase risk for ED in stroke patients...
  16. ncbi request reprint The prevalence and distribution of white-matter changes on different MRI pulse sequences in a post-stroke cohort
    R Mäntyla
    Department of Radiology, University of Helsinki, Haartmaninkatu 4, FIN 00290 Helsinki, Finland
    Neuroradiology 41:657-65. 1999
    ..The prevalence of WM high-signal foci was greatest in the watershed zone and smallest in the subcortical area. There was a significant correlation between foci in different areas...
  17. ncbi request reprint MRI pontine hyperintensity after supratentorial ischemic stroke relates to poor clinical outcome
    R Mäntyla
    Departments of Radiology, Helsinki University Central Hospital, Helsinki, Finland
    Stroke 31:695-700. 2000
    ..We examined the frequency, as well as the radiological and clinical correlates, of PHI in poststroke patients...
  18. ncbi request reprint Magnetic resonance imaging correlates of depression after ischemic stroke
    R Vataja
    Department of Clinical Neurosciences, Memory Research Unit, Helsinki University Central Hospital, PO Box 300, FIN-00029 HUS, Finland
    Arch Gen Psychiatry 58:925-31. 2001
    ..3), and mean volume of infarcts in the right occipital lobe (OR, 0.98; 95% CI, 0.96-0.99). CONCLUSION: Lesions affecting the prefrontosubcortical circuits, especially on the left side, are correlates of depression after ischemic stroke...
  19. ncbi request reprint Post-stroke depression, executive dysfunction and functional outcome
    T Pohjasvaara
    Memory Research Unit, Department of Clinical Neuroscience, Helsinki University Central Hospital, Finland
    Eur J Neurol 9:269-75. 2002
    ..Executive measures may detect patients at risk of dementia and disability post-stroke...
  20. ncbi request reprint Heterogeneity of cognitive profiles in aging: successful aging, normal aging, and individuals at risk for cognitive decline
    R Ylikoski
    Neuropsychological Unit, Department of Clinical Neurosciences, P O Box 300, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Neurol 6:645-52. 1999
    ..Age, activity and intellectual levels, and to a lesser degree education, were significantly related to the cluster solution. The present findings caution against treating samples of elderly individuals as homogeneous...
  21. ncbi request reprint Impaired preconscious auditory processing and cognitive functions in Alzheimer's disease
    E Pekkonen
    Department of Neurology, Helsinki University Central Hospital, Finland
    Clin Neurophysiol 110:1942-7. 1999
    ..To investigate whether auditory processing correlates with the impairment of the higher cortical functions...
  22. ncbi request reprint Poststroke depression and lesion location revisited
    R Vataja
    Department of Neurology, Memory Research Unit, Stroke Unit, Psychiatry, Psychiatric Consultation Unit, Helsinki University Central Hospital, Helsinki, Finland
    J Neuropsychiatry Clin Neurosci 16:156-62. 2004
    ..Using a logistic regression analysis, the authors found that a brain infarct that affected pallidum was a strong independent MRI correlate for poststroke depression (odds ratio = 7.2)...
  23. ncbi request reprint Variable agreement between visual rating scales for white matter hyperintensities on MRI. Comparison of 13 rating scales in a poststroke cohort
    R Mäntyla
    Department of Radiology, University of Helsinki, Finland
    Stroke 28:1614-23. 1997
    ..The purpose of this study was to test whether part of this variation could be explained by the different properties of the visual WMHI rating scales used...
  24. ncbi request reprint Galantamine treatment in Alzheimer's disease with cerebrovascular disease: responder analyses from a randomized, controlled trial (GAL-INT-6)
    T Erkinjuntti
    Memory Research Unit, Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
    J Psychopharmacol 22:761-8. 2008
    ..These findings are consistent with a broad range of cognitive, functional and behavioural benefits with galantamine across the spectrum of AD and AD with CVD...
  25. ncbi request reprint Magnetic resonance imaging white matter hyperintensities and mechanism of ischemic stroke
    R Mäntyla
    Department of Radiology, Memory Research Unit, Helsinki University Central Hospital, Finland
    Stroke 30:2053-8. 1999
    ..We sought to determine the relations between infarct subtype and white matter hyperintensities (WMHIs) on MRI...
  26. ncbi request reprint Evaluation of various methods of assessing symptoms of cognitive impairment and dementia
    T Pohjasvaara
    Memory Research and Stroke Unit, Department of Clinical Neuroscience, Helsinki University Central Hospital, Helsinki, Finland
    Alzheimer Dis Assoc Disord 15:184-93. 2001
    ..This may have serious influences on investigation and treatment of patients. We underline the importance of further debate and studies to refine the categories of cognitive impairment used in the setting of CVD...
  27. doi request reprint Extensive white matter changes predict stroke recurrence up to 5 years after a first-ever ischemic stroke
    S Melkas
    Department of Neurological Sciences, University of Helsinki, and Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
    Cerebrovasc Dis 34:191-8. 2012
    ..We aimed to investigate whether severe WMCs are a risk factor for recurrent ischemic stroke in a long-term follow-up...
  28. ncbi request reprint Potential long-term effects of rivastigmine on disease progression may be linked to drug effects on vascular changes in Alzheimer brains
    T Erkinjuntti
    Department of Neurology, Helsinki University Central Hospital, HYKS, Finland
    Int J Clin Pract 57:756-60. 2003
    ..These findings may have an important influence on the way cholinesterase inhibitors are prescribed...
  29. doi request reprint Poststroke dementia predicts poor survival in long-term follow-up: influence of prestroke cognitive decline and previous stroke
    S Melkas
    Department of Neurology, Helsinki University Central Hospital, POB 300, 00029 HUS, Finland
    J Neurol Neurosurg Psychiatry 80:865-70. 2009
    ..The aim of this study was to investigate the influence of poststroke dementia on long-term survival after acute stroke and also to assess the possible influence of prestroke cognitive decline and previous stroke on this relationship...
  30. ncbi request reprint Insomnia in ischemic stroke patients
    A Leppävuori
    Department of Psychiatry, Psychiatric Consultation Unit, Helsinki University Central Hospital, Helsinki, Finland
    Cerebrovasc Dis 14:90-7. 2002
    ..Insomnia should be taken into consideration in treating and rehabilitating stroke patients...
  31. doi request reprint Small-vessel disease relates to poor poststroke survival in a 12-year follow-up
    S Melkas
    Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
    Neurology 76:734-9. 2011
    ..We sought to compare ultra-long-term poststroke survival in small-vessel disease (SVD) vs non-SVD subtype of stroke...
  32. ncbi request reprint Emerging therapies for vascular dementia and vascular cognitive impairment
    Timo Erkinjuntti
    Helsinki University Central Hospital, Helsinki, Finland
    Stroke 35:1010-7. 2004
    ..Cerebrovascular disease (CVD) and ischemic brain injury secondary to cardiovascular disease are common causes of dementia and cognitive decline in the elderly. CVD also contributes to cognitive loss in Alzheimer disease (AD)...
  33. ncbi request reprint Alcohol misuse: a risk factor for putaminal damage by ischemic brain infarct?
    A Leppävuori
    Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
    Eur Neurol 50:69-72. 2003
    ..The misuse of alcohol seemed to be associated with cerebral infarct localization in the putamen and superior anterior cerebral artery area. Prospective studies are needed to verify our preliminary finding...
  34. ncbi request reprint Depression is an independent predictor of poor long-term functional outcome post-stroke
    T Pohjasvaara
    Memory Research Unit, Department of Clinical Neuroscience, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Neurol 8:315-9. 2001
    ..5, 95% CI 1.6-3.8). More careful examination and treatment of depression in stroke patients is emphasized...
  35. ncbi request reprint Treatment of vascular dementia-evidence from clinical trials with cholinesterase inhibitors
    Timo Erkinjuntti
    Helsinki University Central Hospital, Finland
    Neurol Res 26:603-5. 2004
    ..Controlled clinical trials with donepezil, galantamine, and rivastigmine in VaD, as well as in patients with AD plus CVD, have demonstrated improvement in cognition, behavior and activities of daily living...
  36. ncbi request reprint Suicidal ideas in stroke patients 3 and 15 months after stroke
    T Pohjasvaara
    Department of Clinical Neuroscience, Psychiatric Consultation Unit, Helsinki University Central Hospital, Helsinki, Finland
    Cerebrovasc Dis 12:21-6. 2001
    ..Recurrent strokes, depressive symptoms, more disabling stroke and right-sided stroke correlated to suicidal ideas at 15 months after stroke. Early identification of these risk factors may lead to effective therapeutic intervention...
  37. ncbi request reprint Perseveration in Alzheimer's disease
    S Pekkala
    Department of Speech Sciences, University of Helsinki, Helsinki, Finland
    Dement Geriatr Cogn Disord 25:109-14. 2008
    ..We document the type and quantitative burden of perseveration as cognitive decline progresses from normal aging (n = 30) through mild AD (n = 20) to moderate AD (n = 20) by administering a semantic verbal fluency task...
  38. doi request reprint Incident lacunes influence cognitive decline: the LADIS study
    H Jokinen
    Memory Research Unit, Department of Neurology, University of Helsinki, Helsinki, Finland
    Neurology 76:1872-8. 2011
    ..This study investigated whether incident lacunes on MRI determine longitudinal cognitive change in elderly subjects with WML...
  39. ncbi request reprint Rivastigmine in patients with Alzheimer's disease and concurrent hypertension
    T Erkinjuntti
    Department of Neurology, Helsinki University Central Hospital, HYKS, Finland
    Int J Clin Pract 56:791-6. 2002
    ..Our data support the hypothesis that rivastigmine provides benefits to patients with or without hypertension, and contribute to the evidence that particular benefits may be observed in those with vascular risk factors...
  40. ncbi request reprint Limitations of clinical criteria for the diagnosis of vascular dementia in clinical trials. Is a focus on subcortical vascular dementia a solution?
    T Erkinjuntti
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Finland
    Ann N Y Acad Sci 903:262-72. 2000
    ..Subcortical VaD is expected to show a more predictable clinical picture, natural history, outcomes, and treatment responses...
  41. ncbi request reprint No antibodies to HTLV-I and HIV in patients with dementia in Finland
    R Sulkava
    Department of Neurology, University of Helsinki, Finland
    Acta Neurol Scand 76:155-6. 1987
    ..No antibodies to HTLV-I and HIV were detected in patients with the clinical diagnosis of Alzheimer's disease, vascular dementia, secondary dementia due to a specific cause, or in cases of atypical dementia...
  42. doi request reprint MRI-defined subcortical ischemic vascular disease: baseline clinical and neuropsychological findings. The LADIS Study
    Hanna Jokinen
    Department of Psychology, University of Helsinki, Helsinki, Finland
    Cerebrovasc Dis 27:336-44. 2009
    ..The purpose of the study was to describe the clinical and cognitive characteristics of the MRI-defined SIVD in a mixed sample of functionally independent elderly subjects with WML...
  43. ncbi request reprint Comparison of the Alzheimer's Disease Assessment Scale Cognitive Subscale and the Vascular Dementia Assessment Scale in differentiating elderly individuals with different degrees of white matter changes. The LADIS Study
    Raija Ylikoski
    Memory Research Unit, Department of Neurology, University of Helsinki, Helsinki, Finland
    Dement Geriatr Cogn Disord 24:73-81. 2007
    ..The objective of this study was to compare the results of the two scales among subjects with various degrees of white matter hyperintensities (WMHs)...
  44. doi request reprint Depression-executive dysfunction syndrome relates to poor poststroke survival
    Susanna Melkas
    Department of Neurology, Helsinki University Central Hospital, Finland
    Am J Geriatr Psychiatry 18:1007-16. 2010
    ..The aim of this study was to investigate the influence of poststroke depression and executive dysfunction on long-term survival after acute stroke...
  45. ncbi request reprint White matter lesions are related to impaired instrumental activities of daily living poststroke
    Tarja Ilona Pohjasvaara
    Department of Neurology, Helsinki Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland
    J Stroke Cerebrovasc Dis 16:251-8. 2007
    ..We sought to examine the role of WMLs and their extent, in regard to basic ADL, instrumental ADL (IADL), and cognitive functions, in a large well-defined cohort examined 3 months after an ischemic stroke...
  46. ncbi request reprint Sleep apnea in multiinfarct dementia and Alzheimer's disease
    T Erkinjuntti
    Department of Neurology, University of Helsinki, Finland
    Sleep 10:419-25. 1987
    ..Age had no effect on the proportion of apneas and hypopneas among demented patients or control subjects, but male controls had more apneas and hypopneas than did female controls...
  47. ncbi request reprint Preserved stimulus deviance detection in Alzheimer's disease
    E Pekkonen
    Department of Neurology, University of Helsinki, and Medical Engineering Centre, Helsinki University Central Hospital, Finland
    Neuroreport 12:1649-52. 2001
    ..This suggests that although MMNm is delayed in the left hemisphere, the automatic discrimination to duration change in the auditory cortex is not attenuated in the early stages of AD...
  48. ncbi request reprint Clinical features of MRI-defined subcortical vascular disease
    Tarja Pohjasvaara
    Department of Neurology, Memory Research Unit, Helsinki University Central Hospital, Helsinki, Finland
    Alzheimer Dis Assoc Disord 17:236-42. 2003
    ..We applied magnetic resonance imaging (MRI) criteria based on research criteria for SIVD in a large cohort of patients with ischemic stroke. We compared clinical features of patients with SIVD and patients with other stroke type...
  49. ncbi request reprint Depression-executive dysfunction syndrome in stroke patients
    Risto Vataja
    Memory Research Unit, Department of Neurology, Helsinki University Central Hospital, P O Box 300, FIN 00029 HUS, Finland
    Am J Geriatr Psychiatry 13:99-107. 2005
    ....
  50. ncbi request reprint Is determination of plasma lipids useful in the differentiation of multi-infarct dementia from Alzheimer's disease?
    T Erkinjuntti
    Department of Neurology, University of Helsinki, Finland
    Compr Gerontol A 2:1-6. 1988
    ....
  51. ncbi request reprint Vascular dementia
    Timo Erkinjuntti
    Department of Neurology, University of Helsinki, Helsinki, Finland
    Semin Clin Neuropsychiatry 8:37-45. 2003
    ..Attempts to treat VaD had varying degrees of success, but it now appears that many forms of VCI might be preventable, especially with good control of vascular risk factors in middle age...
  52. doi request reprint Longitudinal cognitive decline in subcortical ischemic vascular disease--the LADIS Study
    Hanna Jokinen
    Department of Psychology, University of Helsinki, Helsinki, Finland
    Cerebrovasc Dis 27:384-91. 2009
    ..The aim of the study was to investigate the longitudinal cognitive performance and incident dementia in subjects with and without SIVD in a sample of older adults with white matter lesions...
  53. ncbi request reprint Subcortical ischemic vascular disease and dementia
    Timo Erkinjuntti
    Department of Neurology, University of Helsinki, Helsinki, Finland
    Int Psychogeriatr 15:23-6. 2003
    ..Further empirical research is needed to refine the syndrome and stages and validate the brain imaging criteria, as well as to detail the natural history and outcomes of SIVD...
  54. pmc Semantic verbal fluency in two contrasting languages
    Seija Pekkala
    Department of Speech Sciences, University of Helsinki, Helsinki, Finland
    Clin Linguist Phon 23:431-45. 2009
    ..It was concluded that culture and language differences do not contribute significantly to variability in SVF performance in healthy elderly people...
  55. ncbi request reprint Generalized anxiety disorders three to four months after ischemic stroke
    Antero Leppävuori
    Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
    Cerebrovasc Dis 16:257-64. 2003
    ..The main objective of our study was to detail the frequency and clinical determinants of poststroke generalized anxiety disorders in a large, well-defined stroke cohort...
  56. ncbi request reprint Neuropsychological functions in variant Alzheimer's disease with spastic paraparesis
    Auli Verkkoniemi
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki FIN 00290, Finland
    J Neurol Sci 218:29-37. 2004
    ..However, all these early-onset patients (age range 43-63 years) with a deletion mutation of PS-1 gene showed prominent memory impairment and deficits in visuoconstructive and intellectual functions...
  57. pmc Corpus callosum atrophy is associated with mental slowing and executive deficits in subjects with age-related white matter hyperintensities: the LADIS Study
    Hanna Jokinen
    Department of Psychology, University of Helsinki, Helsinki, Finland
    J Neurol Neurosurg Psychiatry 78:491-6. 2007
    ..Previous research has indicated that corpus callosum atrophy is associated with global cognitive decline in neurodegenerative diseases, but few studies have investigated specific cognitive functions...
  58. ncbi request reprint Subcortical vascular dementia
    Timo Erkinjuntti
    Memory Research Unit, Department of Clinical Neurosciences, University of Helsinki, Finland
    Cerebrovasc Dis 13:58-60. 2002
    ..Subcortical VaD is expected to show a more predictable clinical picture, natural history, outcome and treatment responses...
  59. ncbi request reprint Management of patients with Alzheimer's disease plus cerebrovascular disease: 12-month treatment with galantamine
    Roger Bullock
    Kingshill Research Centre, Victoria Hospital, Swindon, UK
    Dement Geriatr Cogn Disord 17:29-34. 2004
    ..Subgroup analysis was performed of patients with AD + CVD who participated in a 6-month, multicenter, randomized, double-blind, parallel-group study and a 6-month, open-label, active-treatment extension...
  60. ncbi request reprint Risk of rapid global functional decline in elderly patients with severe cerebral age-related white matter changes: the LADIS study
    Domenico Inzitari
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Arch Intern Med 167:81-8. 2007
    ..The LADIS (LeukoAraiosis and DISability) Study primarily aims to assess ARWMCs as a determinant of global functional decline in the elderly population...
  61. ncbi request reprint Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study
    Elisabeth C W van Straaten
    Department of Neurology and Alzheimer Center, VU Medical Center, Amsterdam, The Netherlands
    Stroke 37:836-40. 2006
    ..Associations may depend on the method used for measuring WMH. We investigated the ability of different WMH scoring methods to detect differences in WMH load between groups with and without symptoms...
  62. pmc Differential impact of cerebral white matter changes, diabetes, hypertension and stroke on cognitive performance among non-disabled elderly. The LADIS study
    Ana Verdelho
    Neurology Department, Centro de Estudos Egas Moniz, Santa Maria Hospital, Lisbon, Portugal
    J Neurol Neurosurg Psychiatry 78:1325-30. 2007
    ..Our aim was to study the influence of vascular risk factors and ARWMC on the neuropsychological performance of an independent elderly population, to see if vascular risk factors impair cognition in addition to the effects of ARWMC...
  63. ncbi request reprint Vascular cognitive impairment
    John T O'Brien
    Institute for Aging and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Lancet Neurol 2:89-98. 2003
    ..Clinical trials in vascular cognitive impairment are in their infancy but support the value of therapeutic interventions for symptomatic treatment...
  64. ncbi request reprint Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study
    Wiesje M van der Flier
    Alzheimer Center, Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Stroke 36:2116-20. 2005
    ..We investigated the independent contribution of WMH and lacunes to general cognitive function in a group of independently living elderly with varying degrees of small vessel disease...
  65. ncbi request reprint Vascular burden of the brain
    JOHN O'BRIEN
    Int Psychogeriatr 15:7-10. 2003
  66. ncbi request reprint Impact of age-related cerebral white matter changes on the transition to disability -- the LADIS study: rationale, design and methodology
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Neuroepidemiology 24:51-62. 2005
    ..The study results may also help to standardize, on an international basis, tools and criteria to identify early stages of disability...
  67. ncbi request reprint Age, hypertension, and lacunar stroke are the major determinants of the severity of age-related white matter changes. The LADIS (Leukoaraiosis and Disability in the Elderly) Study
    Anna Maria Basile
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy, and Department of Neurology, Hopital Lariboisiere, Paris, France
    Cerebrovasc Dis 21:315-22. 2006
    ..We sought whether such a trend existed in the association of vascular risk factors or comorbidities with the severity of ARWMC aiming particularly at further elucidating the relative roles of hypertension and stroke in this regard...
  68. ncbi request reprint Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: the LADIS (Leukoaraiosis and Disability in the Elderly) Study
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    J Am Geriatr Soc 54:1095-101. 2006
    ..To determine whether leukoaraiosis severity is independently associated with differences in global functioning in nondisabled elderly patients...
  69. ncbi request reprint Galantamine in the treatment of cognitive decline in patients with vascular dementia or Alzheimer's disease with cerebrovascular disease
    Gary Small
    Department of Psychiatry and Biobehavioral Sciences and Neuropsychiatric Institute, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90024, USA
    CNS Drugs 17:905-14. 2003
    ....
  70. ncbi request reprint White matter hyperintensities rather than lacunar infarcts are associated with depressive symptoms in older people: the LADIS study
    John T O'Brien
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Am J Geriatr Psychiatry 14:834-41. 2006
    ..This study investigates the relationship between location and burden of WMH and lacunes on depressive features in older people...
  71. ncbi request reprint Development of a neuropsychological battery for the Leukoaraiosis and Disability in the Elderly Study (LADIS): experience and baseline data
    Sofia Madureira
    Servico de Neurologia, Centro de Estudos Egas Moniz, Hospital de Santa Maria, Lisboa, Portugal
    Neuroepidemiology 27:101-16. 2006
    ..In the LADIS population baseline data, older age and lower educational levels negatively influence neuropsychological performance...
  72. doi request reprint Reliability and sensitivity of visual scales versus volumetry for evaluating white matter hyperintensity progression
    A A Gouw
    Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Cerebrovasc Dis 25:247-53. 2008
    ..However, the most suitable method for measuring WMH progression has not been established yet. We compared the reliability and sensitivity of cross-sectional and longitudinal visual scales with volumetry for measuring WMH progression...
  73. ncbi request reprint Classification and subtypes of vascular dementia
    Anders Wallin
    Goteborg University, Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Molndal, Sweden
    Int Psychogeriatr 15:27-37. 2003
    ..Subcortical VaD has a relatively homogeneous clinical picture for which detailed criteria are suggested. AD + VaD is more difficult to identify but is possible, sometimes with the aid of neuroimaging and/or biological markers...
  74. ncbi request reprint Relationship between periventricular and deep white matter lesions and depressive symptoms in older people. The LADIS Study
    Mani S Krishnan
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 21:983-9. 2006
    ..However, it remains controversial as to whether PVL, DWML, or both are most strongly associated with depression and this was the aim of the current study...
  75. ncbi request reprint Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: the Leukoaraiosis and Disability study
    Alida A Gouw
    Department of Neurology, Alzheimer Center and Image Analysis Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Stroke 39:1414-20. 2008
    ..We studied the natural course of white matter hyperintensities (WMH) and lacunes, the main MRI representatives of small vessel disease, over time and evaluated possible predictors for their development...
  76. ncbi request reprint [Cognition disorders after cerebrovascular accidents]
    Tarja Pohjasvaara
    HUS, HYKS Neuroklinikka 00029 HUS, Lohjan aluesairaala 08100 Lohja
    Duodecim 118:593-9. 2002
  77. ncbi request reprint White matter hyperintensities and depression--preliminary results from the LADIS study
    Michael J Firbank
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 20:674-9. 2005
    ..White matter hyperintensities have been associated with the development of depression in older subjects, though the details of this relationship are not fully understood...
  78. ncbi request reprint Subcortical ischaemic vascular dementia
    Gustavo C Roman
    University of Texas at San Antonio and the Audie L Murphy Memorial Veterans Hospital, San Antonio, Texas 78284 7883, USA
    Lancet Neurol 1:426-36. 2002
    ..Treatment is symptomatic and prevention requires control of treatable risk factors...
  79. ncbi request reprint Smoking and the platelet fibrinogen receptor glycoprotein IIb/IIIA PlA1/A2 polymorphism interact in the risk of lacunar stroke and midterm survival
    Niku K J Oksala
    Division of Vascular Surgery, Department of Surgery, Tampere University Hospital, Tampere, Finland
    Stroke 38:50-5. 2007
    ..The platelet fibrinogen receptor glycoprotein (Gp) IIb/IIIa Pl(A1/A2) polymorphism affects the binding of platelets to fibrinogen and is suggested to interact with smoking...
  80. ncbi request reprint On the etiology of incident brain lacunes: longitudinal observations from the LADIS study
    Alida A Gouw
    Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Stroke 39:3083-5. 2008
    ..We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period...