T M Asikainen

Summary

Affiliation: Helsinki University Central Hospital
Country: Finland

Publications

  1. ncbi request reprint HIF stabilizing agents: shotgun or scalpel?
    Tiina M Asikainen
    Am J Physiol Lung Cell Mol Physiol 293:L555-6. 2007
  2. ncbi request reprint Cell-specific expression of manganese superoxide dismutase protein in the lungs of patients with respiratory distress syndrome, chronic lung disease, or persistent pulmonary hypertension
    T M Asikainen
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Pediatr Pulmonol 32:193-200. 2001
  3. ncbi request reprint Increased sensitivity of homozygous Sod2 mutant mice to oxygen toxicity
    Tiina M Asikainen
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Free Radic Biol Med 32:175-86. 2002
  4. ncbi request reprint Expression and developmental profile of antioxidant enzymes in human lung and liver
    T M Asikainen
    Hospital for Children and Adolescents, University of Helsinki, Helsinki and Department of Internal Medicine, University of Oulu, Oulu, Finland
    Am J Respir Cell Mol Biol 19:942-9. 1998
  5. pmc Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung
    Tiina M Asikainen
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 102:10212-7. 2005
  6. ncbi request reprint Antioxidant defenses in the preterm lung: role for hypoxia-inducible factors in BPD?
    Tiina M Asikainen
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Toxicol Appl Pharmacol 203:177-88. 2005
  7. ncbi request reprint Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells
    Tiina M Asikainen
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Free Radic Biol Med 38:1002-13. 2005
  8. ncbi request reprint Pulmonary antioxidant defenses in the preterm newborn with respiratory distress and bronchopulmonary dysplasia in evolution: implications for antioxidant therapy
    Tiina M Asikainen
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Antioxid Redox Signal 6:155-67. 2004
  9. ncbi request reprint Effect of preterm birth on hypoxia-inducible factors and vascular endothelial growth factor in primate lungs
    Tiina M Asikainen
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado, USA
    Pediatr Pulmonol 40:538-46. 2005
  10. ncbi request reprint Enhancement of angiogenic effectors through hypoxia-inducible factor in preterm primate lung in vivo
    Tiina M Asikainen
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Rm J 318, Denver, CO 80206, USA
    Am J Physiol Lung Cell Mol Physiol 291:L588-95. 2006

Detail Information

Publications12

  1. ncbi request reprint HIF stabilizing agents: shotgun or scalpel?
    Tiina M Asikainen
    Am J Physiol Lung Cell Mol Physiol 293:L555-6. 2007
  2. ncbi request reprint Cell-specific expression of manganese superoxide dismutase protein in the lungs of patients with respiratory distress syndrome, chronic lung disease, or persistent pulmonary hypertension
    T M Asikainen
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Pediatr Pulmonol 32:193-200. 2001
    ..However, the inability to induce MnSOD in response to oxygen treatment may result in a poor outcome...
  3. ncbi request reprint Increased sensitivity of homozygous Sod2 mutant mice to oxygen toxicity
    Tiina M Asikainen
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Free Radic Biol Med 32:175-86. 2002
    ..We conclude that MnSOD is required for normal O2 tolerance and that in the absence of MnSOD there is a compensatory increase in pulmonary glutathione-dependent antioxidant defense in hyperoxia...
  4. ncbi request reprint Expression and developmental profile of antioxidant enzymes in human lung and liver
    T M Asikainen
    Hospital for Children and Adolescents, University of Helsinki, Helsinki and Department of Internal Medicine, University of Oulu, Oulu, Finland
    Am J Respir Cell Mol Biol 19:942-9. 1998
    ..Activities of MnSOD and CuZnSOD correlated positively in the liver. We conclude that the regulation of AOEs differs between human lung and liver, and is not tightly coordinated in either tissue...
  5. pmc Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung
    Tiina M Asikainen
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 102:10212-7. 2005
    ..Through actions characterized above, FG-4095 could have desirable effects in enhancing lung growth in BPD...
  6. ncbi request reprint Antioxidant defenses in the preterm lung: role for hypoxia-inducible factors in BPD?
    Tiina M Asikainen
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Toxicol Appl Pharmacol 203:177-88. 2005
    ....
  7. ncbi request reprint Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells
    Tiina M Asikainen
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Free Radic Biol Med 38:1002-13. 2005
    ....
  8. ncbi request reprint Pulmonary antioxidant defenses in the preterm newborn with respiratory distress and bronchopulmonary dysplasia in evolution: implications for antioxidant therapy
    Tiina M Asikainen
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Antioxid Redox Signal 6:155-67. 2004
    ..An understanding of the processes involved in lung growth, especially in alveolarization and vascularization, as well as in repair of injured lung tissue, may facilitate development of strategies to enhance these processes...
  9. ncbi request reprint Effect of preterm birth on hypoxia-inducible factors and vascular endothelial growth factor in primate lungs
    Tiina M Asikainen
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado, USA
    Pediatr Pulmonol 40:538-46. 2005
    ..These results suggest that selective downregulation of HIFs in lungs of preterm neonates may contribute to the pathophysiology of BPD...
  10. ncbi request reprint Enhancement of angiogenic effectors through hypoxia-inducible factor in preterm primate lung in vivo
    Tiina M Asikainen
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Rm J 318, Denver, CO 80206, USA
    Am J Physiol Lung Cell Mol Physiol 291:L588-95. 2006
    ..These results indicate that HIF stimulation by PHD inhibition enhances lung angiogenesis in the primate model of BPD...
  11. ncbi request reprint Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity
    Tiina M Asikainen
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Rm J 318, Denver, Colorado 80206, USA
    FASEB J 20:1698-700. 2006
    ..These findings indicate that HIF stimulation by PHD inhibition ameliorates pathological and physiological consequences of BPD...
  12. ncbi request reprint Hypoxia-inducible factors HIF-1alpha and HIF-2alpha are decreased in an experimental model of severe respiratory distress syndrome in preterm lambs
    Theresa R Grover
    University of Colorado School of Medicine, Pediatric Heart Lung Center, Department of Pediatrics, and National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1345-51. 2007
    ..We speculate that early disruption of HIF and VEGF expression after preterm birth and RDS may contribute to long-term abnormalities in lung growth, leading to bronchopulmonary dysplasia...