H Norppa

Summary

Affiliation: Finnish Institute of Occupational Health
Country: Finland

Publications

  1. ncbi request reprint Chromosomal aberrations and SCEs as biomarkers of cancer risk
    H Norppa
    New Technologies and Risks, Finnish Institute of Occupational Health, FI 00250 Helsinki, Finland
    Mutat Res 600:37-45. 2006
  2. ncbi request reprint Cytogenetic biomarkers and genetic polymorphisms
    Hannu Norppa
    Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, FIN 00250 Helsinki, Finland
    Toxicol Lett 149:309-34. 2004
  3. ncbi request reprint Genetic susceptibility, biomarker respones, and cancer
    Hannu Norppa
    Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 aA, FIN 00250 Helsinki, Finland
    Mutat Res 544:339-48. 2003
  4. ncbi request reprint What do human micronuclei contain?
    Hannu Norppa
    Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN 00250 Helsinki, Finland
    Mutagenesis 18:221-33. 2003
  5. doi request reprint Preparation of nanoparticle dispersions for in-vitro toxicity testing
    M Vippola
    Aerosols, Dusts, and Metals, Work Environment Development Centre, Finnish Institute of Occupational Health, Helsinki, Finland
    Hum Exp Toxicol 28:377-85. 2009
  6. ncbi request reprint Genetic polymorphisms and chromosome damage
    H Norppa
    Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN 00250 Helsinki, Finland
    Int J Hyg Environ Health 204:31-8. 2001
  7. pmc Cytogenetic markers of susceptibility: influence of polymorphic carcinogen-metabolizing enzymes
    H Norppa
    Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland
    Environ Health Perspect 105:829-35. 1997
  8. doi request reprint Genotoxic effects of nanosized and fine TiO2
    G C M Falck
    New Technologies and Risks, Work Environment Development Centre, Finnish Institute of Occupational Health, Helsinki, Finland
    Hum Exp Toxicol 28:339-52. 2009
  9. ncbi request reprint Trans-stilbene oxide-induced sister chromatid exchange in cultured human lymphocytes: influence of GSTM1 and GSTT1 genotypes
    S Bernardini
    Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 B, FIN-00250 Helsinki, Finland
    Mutagenesis 16:277-81. 2001
  10. ncbi request reprint Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: role in mutagen sensitivity
    Jarno Tuimala
    Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, FIN 00250 Helsinki, Finland
    Carcinogenesis 23:1003-8. 2002

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Chromosomal aberrations and SCEs as biomarkers of cancer risk
    H Norppa
    New Technologies and Risks, Finnish Institute of Occupational Health, FI 00250 Helsinki, Finland
    Mutat Res 600:37-45. 2006
    ..However, group level evidence should be enough to support the use of CA analysis as a tool in screening programs and prevention policies in occupational and environmental health...
  2. ncbi request reprint Cytogenetic biomarkers and genetic polymorphisms
    Hannu Norppa
    Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, FIN 00250 Helsinki, Finland
    Toxicol Lett 149:309-34. 2004
    ....
  3. ncbi request reprint Genetic susceptibility, biomarker respones, and cancer
    Hannu Norppa
    Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 aA, FIN 00250 Helsinki, Finland
    Mutat Res 544:339-48. 2003
    ..For instance, those concerning DNA repair proteins are presently being studied by many laboratories...
  4. ncbi request reprint What do human micronuclei contain?
    Hannu Norppa
    Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN 00250 Helsinki, Finland
    Mutagenesis 18:221-33. 2003
    ..Understanding the mechanistic origin and contents of MN is essential for the proper use of this cytogenetic end-point in biomarker studies, genotoxicity testing and risk assessment...
  5. doi request reprint Preparation of nanoparticle dispersions for in-vitro toxicity testing
    M Vippola
    Aerosols, Dusts, and Metals, Work Environment Development Centre, Finnish Institute of Occupational Health, Helsinki, Finland
    Hum Exp Toxicol 28:377-85. 2009
    ....
  6. ncbi request reprint Genetic polymorphisms and chromosome damage
    H Norppa
    Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN 00250 Helsinki, Finland
    Int J Hyg Environ Health 204:31-8. 2001
    ..Both GSTM1 and GSTT1 genotypes may shape the in vitro genotoxic response of human lymphocytes. The significance of DNA repair polymorphisms is presently unclear...
  7. pmc Cytogenetic markers of susceptibility: influence of polymorphic carcinogen-metabolizing enzymes
    H Norppa
    Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland
    Environ Health Perspect 105:829-35. 1997
    ....
  8. doi request reprint Genotoxic effects of nanosized and fine TiO2
    G C M Falck
    New Technologies and Risks, Work Environment Development Centre, Finnish Institute of Occupational Health, Helsinki, Finland
    Hum Exp Toxicol 28:339-52. 2009
    ....
  9. ncbi request reprint Trans-stilbene oxide-induced sister chromatid exchange in cultured human lymphocytes: influence of GSTM1 and GSTT1 genotypes
    S Bernardini
    Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 B, FIN-00250 Helsinki, Finland
    Mutagenesis 16:277-81. 2001
    ..GSTT1 genotype did not have an unequivocal effect. Our findings suggest that the lack of the GSTM1 gene, resulting in reduced detoxification capacity, increases individual sensitivity to the genotoxic effects of TSO...
  10. ncbi request reprint Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: role in mutagen sensitivity
    Jarno Tuimala
    Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, FIN 00250 Helsinki, Finland
    Carcinogenesis 23:1003-8. 2002
    ..Although based on relatively few individuals, our results suggest that bleomycin sensitivity is partially explained by genetic polymorphisms affecting DNA repair (XRCC1) and in vitro metabolism of bleomycin (BLHX)...
  11. ncbi request reprint The effects of GSTM1 and GSTT1 polymorphisms on micronucleus frequencies in human lymphocytes in vivo
    Micheline Kirsch-Volders
    Laboratory of Cell Genetics, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussels, Belgium
    Cancer Epidemiol Biomarkers Prev 15:1038-42. 2006
    ..79). This study confirms that pooled analyses, by increasing the statistical power, are adequate for assessing the involvement of genetic variants on genome stability and for resolving discrepancies among individual studies...
  12. ncbi request reprint Copy number gains on 5p15, 6p11-q11, 7p12, and 8q24 are rare in sputum cells of individuals at high risk of lung cancer
    Eeva Kettunen
    Finnish Institute of Occupational Health, Centre of Expertise for Health and Work Ability, Topeliuksenkatu 41 a A, FI 00250 Helsinki, Finland
    Lung Cancer 54:169-76. 2006
    ..One of such probe sets, LAVysion, detects copy number changes in the centromeric region of chromosome 6 (CEP6), and regions 5p15, 8q24, and 7p12, often gained in lung cancer...
  13. ncbi request reprint An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans
    Stefano Bonassi
    Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy
    Carcinogenesis 28:625-31. 2007
    ..The current wide-spread use of the MN assay provides a valuable opportunity to apply this assay in the planning and validation of cancer surveillance and prevention programs...
  14. ncbi request reprint Chromosomal aberrations and cancer risk: results of a cohort study from Central Europe
    Paolo Boffetta
    International Agency for Research on Cancer, Lyon, France
    Am J Epidemiol 165:36-43. 2007
    ....
  15. ncbi request reprint Origin of nuclear buds and micronuclei in normal and folate-deprived human lymphocytes
    Hanna K Lindberg
    New Technologies and Risks, Work Environment Development, Finnish Institute of Occupational Health, Topeliuksenkatu 41aA, FI 00250 Helsinki, Finland
    Mutat Res 617:33-45. 2007
    ....
  16. ncbi request reprint Chromosome damage and cancer risk in the workplace: the example of cytogenetic surveillance in Croatia
    Aleksandra Fucic
    Institute for Medical Research and Occupational Health, Ksaverska c 2, Zagreb, Croatia
    Toxicol Lett 172:4-11. 2007
    ..61-4.72). Recommendations for future strategies comprise the inclusion of predictive biomarkers in surveillance programs, the definition of a regulatory framework, and their possible use for the identification of individual risk profiles...
  17. doi request reprint Aberrations of chromosome 19 in asbestos-associated lung cancer and in asbestos-induced micronuclei of bronchial epithelial cells in vitro
    Salla T Ruosaari
    Biological Mechanisms and Prevention of Work related Diseases, Health and Work Ability, Finnish Institute of Occupational Health, Topeliuksenkatu 41 aA, FI 00250 Helsinki, Finland
    Carcinogenesis 29:913-7. 2008
    ..01). The results suggest that 19p has significance in asbestos-associated carcinogenesis and that asbestos may be capable of inducing specific chromosome aberrations...
  18. pmc Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries
    Stefano Bonassi
    Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy
    Carcinogenesis 29:1178-83. 2008
    ..These results reinforce the evidence of a link between CA frequency and cancer risk and provide novel information on the role of aberration subclass and cancer type...
  19. doi request reprint Genotoxic effects of fumes from asphalt modified with waste plastic and tall oil pitch
    Hanna K Lindberg
    New Technologies and Risks, Work Environment Development, Finnish Institute of Occupational Health, FI 00250 Helsinki, Finland
    Mutat Res 653:82-90. 2008
    ..Our results indicate that fumes from SMA and SMA-WPT contain direct-acting genotoxic components...
  20. doi request reprint Characterization of chromosomes and chromosomal fragments in human lymphocyte micronuclei by telomeric and centromeric FISH
    Hanna K Lindberg
    New Technologies and Risks, Work Environment Development, Finnish Institute of Occupational Health, Topeliuksenkatu 41aA, FI 00250 Helsinki, Finland
    Mutagenesis 23:371-6. 2008
    ..This approach could particularly have use in discriminating between MN harbouring chromatid- and chromosome-type fragments in studies of human exposure to chemical clastogens and ionizing radiation...
  21. ncbi request reprint In vivo micronuclei in uncultured T-lymphocytes of male railroad transit workers and referents
    Julia Catalán
    Finnish Institute of Occupational Health, Helsinki and Lappeenranta, Finland
    Environ Mol Mutagen 47:345-51. 2006
    ..5- and 3.8-times greater than would be expected assuming an equal contribution by all chromosomes. Thus, sex chromosomes appear to be over-represented in lymphocyte MN of men in vivo, confirming previous results obtained in vitro...
  22. ncbi request reprint Influence of DNA repair gene polymorphisms on the yield of chromosomal aberrations
    Anne Kiuru
    Department of Research and Environmental Surveillance, STUK Radiation and Nuclear Safety Authority, FIN 00881 Helsinki, Finland
    Environ Mol Mutagen 46:198-205. 2005
    ..74; P = 0.028) in two-way translocations when age was taken into account in the analysis. Our data suggest that the XRCC1 280His and XRCC3 241Met alleles affect individual CA levels, most probably via influencing the DNA repair phenotype...
  23. ncbi request reprint Nasal cell micronuclei, cytology and clinical symptoms in stainless steel production workers exposed to chromium
    Markku Huvinen
    Outokumpu Oyj, PO Box 27, FIN 02201 Espoo, Finland
    Mutagenesis 17:425-9. 2002
    ....
  24. pmc Sister chromatid exchanges and micronuclei in peripheral lymphocytes of shoe factory workers exposed to solvents
    Mariá Pitarque
    Grup de Mutagenesi, Departament de Genetica i de Microbiologia, Edifici Cn, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Environ Health Perspect 110:399-404. 2002
    ..The exposures responsible for the MN induction could not be identified with certainty, but exposure to benzene in gasoline and methylenediphenyl diisocyanate may explain some of the findings...
  25. ncbi request reprint Genetic polymorphisms in DNA repair genes and possible links with DNA repair rates, chromosomal aberrations and single-strand breaks in DNA
    Pavel Vodicka
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 14200 Prague 4, Czech Republic
    Carcinogenesis 25:757-63. 2004
    ..9, P = 0.010) and XPC polymorphisms (F = 4.2, P = 0.046, MANOVA). Our results from this study suggest that markers of genotoxicity are associated with polymorphisms in genes encoding DNA repair enzymes...
  26. ncbi request reprint Impact of types of lymphocyte chromosomal aberrations on human cancer risk: results from Nordic and Italian cohorts
    Lars Hagmar
    Department of Occupational and Environmental Medicine, Lund University Hospital, SE 221 85 Lund, Sweden
    Cancer Res 64:2258-63. 2004
    ..The results suggest that both DNA double-strand breaks and other initial DNA lesions responsible for CSAs and CTAs are associated with cancer risk...
  27. pmc Cytogenetic markers, DNA single-strand breaks, urinary metabolites, and DNA repair rates in styrene-exposed lamination workers
    Pavel Vodicka
    Institute of Experimental Medicine, Academy of Science of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Environ Health Perspect 112:867-71. 2004
    ..The positive correlation between exposure parameters and DNA repair rates suggests that particular DNA repair pathways may be induced by styrene exposure...
  28. ncbi request reprint Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: effects on levels of sister chromatid exchanges and chromosomal aberrations
    Jarno Tuimala
    Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 aA, FIN 00250 Helsinki
    Mutat Res 554:319-33. 2004
    ..It remains to be examined whether these or other genetic polymorphisms could explain the observed cancer risk predictivity of high CA frequency...
  29. ncbi request reprint Markers of individual susceptibility and DNA repair rate in workers exposed to xenobiotics in a tire plant
    Pavel Vodicka
    Institute of Experimental Medicine, Academy of Science of Czech Republic, 14200 Prague, Czech Republic
    Environ Mol Mutagen 44:283-92. 2004
    ..097). The results from this study suggest the importance of evaluating markers of individual susceptibility, since they may modulate genotoxic effects induced by occupational exposure to xenobiotics...
  30. ncbi request reprint Nature of anaphase laggards and micronuclei in female cytokinesis-blocked lymphocytes
    Ghita C M Falck
    Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN 00250 Helsinki, Finland
    Mutagenesis 17:111-7. 2002
    ..X laggards are particularly efficiently micronucleated in Cyt-B-treated cells, perhaps because they stay further away from the poles in round cytokinesis-blocked anaphases than in normally elongated non-blocked anaphases...
  31. ncbi request reprint Cytogenetic biomarkers, urinary metabolites and metabolic gene polymorphisms in workers exposed to styrene
    Lucia Migliore
    Department of Human and Environmental Sciences, University of Pisa, Italy
    Pharmacogenet Genomics 16:87-99. 2006
    ..These observations may have relevance considering the risk of lymphatic and haematopoietic malignancies tentatively associated with styrene exposure...
  32. ncbi request reprint N-Acetyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma risk
    Harriet Wikman
    Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland
    Pharmacogenetics 12:227-33. 2002
    ..20, 95% CI 1.51 to 11.6). The results suggest for the first time that in addition to GSTs, the NATs play an important role in inception of asthmatic reactions related to occupational exposure to diisocyanates...
  33. ncbi request reprint Micronuclei frequency induced by bleomycin in human peripheral lymphocytes: correlating BLHX polymorphism with mutagen sensitivity
    Francesca Maffei
    Department of Pharmacology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Mutat Res 639:20-6. 2008
    ..01), whereas age correlated only with the spontaneous MN frequency...
  34. ncbi request reprint Report from the in vitro micronucleus assay working group
    Micheline Kirsch-Volders
    Laboratorium voor Cellulaire Genetica, Vrije Universiteit Brussel, Pleinlaan 2, Brussels 1050, Belgium
    Mutat Res 540:153-63. 2003
    ..7. Statistics: statistical significance should not be the sole factor for determining positive results. Biological meaning should serve as a guideline. Examples of statistical analyses are given...
  35. ncbi request reprint Influence of GSTM1 and GSTT1 genotypes on sister chromatid exchange induction by styrene in cultured human lymphocytes
    Sabrina Bernardini
    Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN 00250 Helsinki, Finland
    Carcinogenesis 23:893-7. 2002
    ....
  36. ncbi request reprint Biomarkers of exposure, effect, and susceptibility in workers exposed to nitrotoluenes
    Gabriele Sabbioni
    Institute of Environmental and Occupational Toxicology, Casella Postale 108, 6780 Airolo, Switzerland
    Cancer Epidemiol Biomarkers Prev 15:559-66. 2006
    ....