S Anttila

Summary

Affiliation: Finnish Institute of Occupational Health
Country: Finland

Publications

  1. ncbi request reprint CYP1A1 levels in lung tissue of tobacco smokers and polymorphisms of CYP1A1 and aromatic hydrocarbon receptor
    S Anttila
    Finnish Institute of Occupational Health, Helsinki, Finland
    Pharmacogenetics 11:501-9. 2001
  2. pmc DNA copy number loss and allelic imbalance at 2p16 in lung cancer associated with asbestos exposure
    E Kettunen
    Health and Work Ability, Finnish Institute of Occupational Health, Helsinki, Finland
    Br J Cancer 100:1336-42. 2009
  3. ncbi request reprint Lung cancer and past occupational exposure to asbestos. Role of p53 and K-ras mutations
    K Husgafvel-Pursiainen
    Departments of Industrial Hygiene and Toxicology, Epidemiology and Biostatistics, and Occupational Medicine, Finnish Institute of Occupational Health, Helsinki, Finland
    Am J Respir Cell Mol Biol 20:667-74. 1999
  4. ncbi request reprint Expression of CYP1A1, CYP1B1 and CYP3A, and polycyclic aromatic hydrocarbon-DNA adduct formation in bronchoalveolar macrophages of smokers and non-smokers
    R Piipari
    Departments of Occupational Medicine, Industrial Hygiene and Toxicology, and Epidemiology and Biostatistics, Finnish Institute of Occupational Health, Helsinki, Finland
    Int J Cancer 86:610-6. 2000
  5. ncbi request reprint Increased expression of high mobility group A proteins in lung cancer
    V K Sarhadi
    Department of Occupational Medicine, Finnish Institute of Occupational Health, Helsinki, Finland
    J Pathol 209:206-12. 2006
  6. ncbi request reprint Gene expression and copy number profiling suggests the importance of allelic imbalance in 19p in asbestos-associated lung cancer
    H Wikman
    Finnish Institute of Occupational Health, Helsinki, Finland
    Oncogene 26:4730-7. 2007
  7. ncbi request reprint Expression and localization of CYP3A4 and CYP3A5 in human lung
    S Anttila
    Finnish Institute of Occupational Health, Helsinki
    Am J Respir Cell Mol Biol 16:242-9. 1997
  8. ncbi request reprint L1CAM, INP10, P-cadherin, tPA and ITGB4 over-expression in malignant pleural mesotheliomas revealed by combined use of cDNA and tissue microarray
    E Kettunen
    Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
    Carcinogenesis 26:17-25. 2005
  9. ncbi request reprint Immunohistochemical localization of glutathione S-transferases in human lung
    S Anttila
    Institute of Occupational Health, Helsinki, Finland
    Cancer Res 53:5643-8. 1993
  10. ncbi request reprint Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes
    J Hukkanen
    Department of Pharmacology and Toxicology, University of Oulu, Finland
    Mol Carcinog 20:224-30. 1997

Collaborators

Detail Information

Publications14

  1. ncbi request reprint CYP1A1 levels in lung tissue of tobacco smokers and polymorphisms of CYP1A1 and aromatic hydrocarbon receptor
    S Anttila
    Finnish Institute of Occupational Health, Helsinki, Finland
    Pharmacogenetics 11:501-9. 2001
    ..Our results thus indicate that the interindividual variation of CYP1A1 levels in smokers' lung tissue is not attributable to genetic polymorphisms of CYP1A1 or AHR tested in this study...
  2. pmc DNA copy number loss and allelic imbalance at 2p16 in lung cancer associated with asbestos exposure
    E Kettunen
    Health and Work Ability, Finnish Institute of Occupational Health, Helsinki, Finland
    Br J Cancer 100:1336-42. 2009
    ..1-p16.1 using 14 microsatellite markers and also AI at 2p16 was related to asbestos exposure (P=0.003). Our results suggest that alterations at 2p16 combined with other markers could be useful in diagnosing asbestos-related lung cancer...
  3. ncbi request reprint Lung cancer and past occupational exposure to asbestos. Role of p53 and K-ras mutations
    K Husgafvel-Pursiainen
    Departments of Industrial Hygiene and Toxicology, Epidemiology and Biostatistics, and Occupational Medicine, Finnish Institute of Occupational Health, Helsinki, Finland
    Am J Respir Cell Mol Biol 20:667-74. 1999
    ..In conclusion, the results may primarily reflect the observed excess of adenocarcinoma in the asbestos- exposed patients, and hence the decrease in p53 mutations and increase in K-ras mutations...
  4. ncbi request reprint Expression of CYP1A1, CYP1B1 and CYP3A, and polycyclic aromatic hydrocarbon-DNA adduct formation in bronchoalveolar macrophages of smokers and non-smokers
    R Piipari
    Departments of Occupational Medicine, Industrial Hygiene and Toxicology, and Epidemiology and Biostatistics, Finnish Institute of Occupational Health, Helsinki, Finland
    Int J Cancer 86:610-6. 2000
    ..002). As CYP3A5 is abundant in both lung epithelial cells and BAM, its association with adduct formation suggests that this CYP form may be important in the activation of cigarette smoke procarcinogens...
  5. ncbi request reprint Increased expression of high mobility group A proteins in lung cancer
    V K Sarhadi
    Department of Occupational Medicine, Finnish Institute of Occupational Health, Helsinki, Finland
    J Pathol 209:206-12. 2006
    ..As HMGA proteins were expressed in about 90% of lung carcinomas and their expression was inversely associated with survival, they may provide useful markers for lung cancer diagnosis and prognosis...
  6. ncbi request reprint Gene expression and copy number profiling suggests the importance of allelic imbalance in 19p in asbestos-associated lung cancer
    H Wikman
    Finnish Institute of Occupational Health, Helsinki, Finland
    Oncogene 26:4730-7. 2007
    ..008) were found to be carriers of AI in their lung tumors. In the exposed group, AI in 19p was prevalent regardless of the histological tumor type. In adenocarcinomas, AI in 19p appeared to occur independently of the asbestos exposure...
  7. ncbi request reprint Expression and localization of CYP3A4 and CYP3A5 in human lung
    S Anttila
    Finnish Institute of Occupational Health, Helsinki
    Am J Respir Cell Mol Biol 16:242-9. 1997
    ..These data establish that CYP3A5 is the predominant CYP3A form in human lung, that CYP3A4 is expressed in about 20% of individuals, and considerable variation of pulmonary expression occurs in both CYPs between individuals...
  8. ncbi request reprint L1CAM, INP10, P-cadherin, tPA and ITGB4 over-expression in malignant pleural mesotheliomas revealed by combined use of cDNA and tissue microarray
    E Kettunen
    Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
    Carcinogenesis 26:17-25. 2005
    ..In particular, INP10, ITGB4 and COL1A2 were up-regulated in MM compared with both reference sample types, suggesting a relationship with development of these tumours...
  9. ncbi request reprint Immunohistochemical localization of glutathione S-transferases in human lung
    S Anttila
    Institute of Occupational Health, Helsinki, Finland
    Cancer Res 53:5643-8. 1993
    ..The localization of GSTs in the bronchial wall suggests that GST polymorphisms may contribute to susceptibility, especially to bronchial tumors of tobacco smokers...
  10. ncbi request reprint Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes
    J Hukkanen
    Department of Pharmacology and Toxicology, University of Oulu, Finland
    Mol Carcinog 20:224-30. 1997
    ..The differences in the CYP gene expression patterns between lung and lymphocytes cast additional doubt on the use of lymphocytes as a surrogate for the lung...
  11. ncbi request reprint Expression of CYP2A genes in human liver and extrahepatic tissues
    S Koskela
    Department of Pharmacology and Toxicology, University of Oulu, Finland
    Biochem Pharmacol 57:1407-13. 1999
    ....
  12. ncbi request reprint RGS4 genotype is not associated with antipsychotic medication response in schizophrenia
    O Kampman
    Medical School, University of Tampere, Tampere, Finland
    J Neural Transm 113:1563-8. 2006
    ..The RGS4 (T > G, Rs 951436) genotype was not associated with incidence or age at onset in schizophrenia. Neither was the RGS4 genotype associated with medication response with two different subpopulations with schizophrenia...
  13. ncbi request reprint Interaction between TPH1 and GNB3 genotypes and electroconvulsive therapy in major depression
    S Anttila
    Medical School, University of Tampere, Tampere, Finland
    J Neural Transm 114:461-8. 2007
    ..Moreover, in females the combination of TPH1 CC and GNB3 CT + TT genotype is associated with an increased risk of belonging to the patient group...
  14. ncbi request reprint Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression
    S Anttila
    Medical School, University of Tampere, Tampere, Finland
    J Neural Transm 114:1065-8. 2007
    ..5-HT1A C1019G and BDNF G196A (Val66Met) polymorphisms were studied. The combination of 5-HT1A GG and BDNF GA + AA genotypes is associated with an increased risk of depression...