- Site dependent bioavailability and metabolism of levosimendan in dogsS Antila
Orion Pharma, PO Box 65, 02101, Espoo, Finland
Eur J Pharm Sci 9:85-91. 1999..The bacteria or enzymes responsible for the metabolism of levosimendan are located in the lower parts of the gastrointestinal tract...
- Pharmacokinetic and pharmacodynamic interactions between the novel calcium sensitiser levosimendan and warfarinS Antila
Orion Pharma, Research Centre, Espoo, Finland
Eur J Clin Pharmacol 56:705-10. 2000..To study the effects of possible interactions between levosimendan and warfarin on pharmacokinetics and pharmacodynamics. Furthermore, the effects of levosimendan on blood coagulation were investigated...
- Pharmacokinetic-pharmacodynamic interrelationships of intravenous and oral levosimendan in patients with severe congestive heart failureP Poder
Cardiovascular Projects, Research Centre, Orion Pharma, Espoo, Finland
Int J Clin Pharmacol Ther 41:365-73. 2003..To assess the pharmacokinetic-pharmacodynamic (PK-PD) interrelations after a 6-hour continuous infusion and a 2 mg single oral dose of levosimendan in patients with congestive heart failure (CHF)...
- Pharmacokinetics of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, in man. A study using a stable isotope techiqueH Heikkinen
Research Centre, Orion Corporation Orion Pharma, Espoo, Finland
Eur J Clin Pharmacol 56:821-6. 2001..In comparison with a crossover design, the simultaneous i.v. and oral administration made it possible to minimise intra-individual variation, sample size and the duration of the study and still obtain accurate pharmacokinetic data...
- Pharmacokinetics of levosimendan and its metabolites during and after a 24-hour continuous infusion in patients with severe heart failureM Kivikko
Orion Pharma, Cardiovascular Projects, Espoo, Finland
Int J Clin Pharmacol Ther 40:465-71. 2002..The aims of the present study were to determine the pharmacokinetics and hemodynamic effects of levosimendan and its metabolites during and after a 24-hour levosimendan infusion...
- Development of level A, B and C in vitro-in vivo correlations for modified-release levosimendan capsulesH Kortejärvi
Orion Pharma, PO Box 65, FIN 02101, Espoo, Finland
Int J Pharm 241:87-95. 2002....