D M Toivola

Summary

Affiliation: Abo Akademi University
Country: Finland

Publications

  1. pmc Shape engineering vs organic modification of inorganic nanoparticles as a tool for enhancing cellular internalization
    Didem Sen Karaman
    Centre for Functional Materials, Laboratory of Physical Chemistry, Department of Natural Sciences, Abo Akademi University, Porthansgatan 3 5, Turku, FI 20500, Finland
    Nanoscale Res Lett 7:358. 2012
  2. pmc Intermediate filaments take the heat as stress proteins
    D M Toivola
    Abo Akademi University, Department of Biosciences, Biology, Tykistokatu 6A, 20521 Turku, Finland
    Trends Cell Biol 20:79-91. 2010
  3. pmc Keratin overexpression levels correlate with the extent of spontaneous pancreatic injury
    Diana M Toivola
    Department of Medicine, Veterans Administration Palo Alto Health Care System, Palo Alto, CA, USA
    Am J Pathol 172:882-92. 2008
  4. ncbi request reprint Protein phosphatase inhibition in normal and keratin 8/18 assembly-incompetent mouse strains supports a functional role of keratin intermediate filaments in preserving hepatocyte integrity
    D M Toivola
    Department of Biology, Abo Akademi University, BioCity, Turku, Finland
    Hepatology 28:116-28. 1998
  5. ncbi request reprint Disturbances in hepatic cell-cycle regulation in mice with assembly-deficient keratins 8/18
    D M Toivola
    Department of Medicine, Palo Alto Veterans Affairs Medical Center and Stanford University, Palo Alto, CA, USA
    Hepatology 34:1174-83. 2001
  6. ncbi request reprint Effects of keratin filament disruption on exocrine pancreas-stimulated secretion and susceptibility to injury
    D M Toivola
    Department of Medicine, Palo Alto VA Medical Center, Stanford University Digestive Disease Center, 3801 Miranda Avenue, Palo Alto, California, 94304, USA
    Exp Cell Res 255:156-70. 2000
  7. doi request reprint Monitoring of epithelial cell caspase activation via detection of durable keratin fragment formation
    G Z Tao
    Department of Medicine, VA Palo Alto Health Care System, and the Digestive Disease Center, Stanford University, Palo Alto, CA, USA
    J Pathol 215:164-74. 2008
  8. doi request reprint Autophagy modulates keratin-containing inclusion formation and apoptosis in cell culture in a context-dependent fashion
    M Harada
    Department of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Exp Cell Res 314:1753-64. 2008
  9. ncbi request reprint Protein phosphatases maintain the organization and structural interactions of hepatic keratin intermediate filaments
    D M Toivola
    Department of Biology, Abo Akademi University, Turku, Finland
    J Cell Sci 110:23-33. 1997
  10. pmc Keratin 8 overexpression promotes mouse Mallory body formation
    Ikuo Nakamichi
    Department of Medicine, Stanford University, and Veterans Affairs Palo Alto Health Care System, CA 94305, USA
    J Cell Biol 171:931-7. 2005

Collaborators

  • P Strnad
  • Nam On Ku
  • ROBERT GLEN OSHIMA
  • J P Kukkonen
  • M Bishr Omary
  • M Harada
  • Shinichiro Hanada
  • David Nelson
  • J A Ursitti
  • K Zatloukal
  • T M Magin
  • E M Brunt
  • Guo Zhong Tao
  • Bihui Zhong
  • Qin Zhou
  • Aida Habtezion
  • Didem Sen Karaman
  • K Näreoja
  • G Z Tao
  • Michele R Stone
  • Ikuo Nakamichi
  • Harry B Greenberg
  • Sara A Michie
  • Evelyn Z Resurreccion
  • Magnus Odén
  • Natalie Råtts
  • John E Eriksson
  • Rajendran Senthilkumar
  • Cecilia Sahlgren
  • Diti Desai
  • Jessica M Rosenholm
  • Emma M Johansson
  • J Nasman
  • S Rondinelli
  • J Meriluoto
  • Jian Liao
  • Yuquan Wei
  • Kok Sun Looi
  • Q Zhou
  • N Sandesara
  • D H Li
  • A Hong
  • R C Cheung
  • Robert J Bloch
  • Xuhuai Ji
  • Andrea O'Neill
  • John Strong
  • Richard M Lovering
  • Wendy G Resneck
  • Patrick W Reed
  • Eugene C Butcher
  • Helene Baribault
  • Yoshitaka Tamai
  • Makoto M Taketo
  • Werner W Franke
  • Ningguo Feng

Detail Information

Publications28

  1. pmc Shape engineering vs organic modification of inorganic nanoparticles as a tool for enhancing cellular internalization
    Didem Sen Karaman
    Centre for Functional Materials, Laboratory of Physical Chemistry, Department of Natural Sciences, Abo Akademi University, Porthansgatan 3 5, Turku, FI 20500, Finland
    Nanoscale Res Lett 7:358. 2012
    ....
  2. pmc Intermediate filaments take the heat as stress proteins
    D M Toivola
    Abo Akademi University, Department of Biosciences, Biology, Tykistokatu 6A, 20521 Turku, Finland
    Trends Cell Biol 20:79-91. 2010
    ..In this report, we review data that corroborate the view that IFs function as highly specialized cytoskeletal stress proteins that promote cellular organization and homeostasis...
  3. pmc Keratin overexpression levels correlate with the extent of spontaneous pancreatic injury
    Diana M Toivola
    Department of Medicine, Veterans Administration Palo Alto Health Care System, Palo Alto, CA, USA
    Am J Pathol 172:882-92. 2008
    ..Keratin absence or mutation is well tolerated after pancreatic but not liver injury, whereas excessive overexpression is toxic to the pancreas but not the liver when induced under basal conditions...
  4. ncbi request reprint Protein phosphatase inhibition in normal and keratin 8/18 assembly-incompetent mouse strains supports a functional role of keratin intermediate filaments in preserving hepatocyte integrity
    D M Toivola
    Department of Biology, Abo Akademi University, BioCity, Turku, Finland
    Hepatology 28:116-28. 1998
    ..The absence or occurrence of defective K8/K18 filaments render animals more prone to liver damage, which supports the previously suggested roles of keratin IFs in maintenance of structural integrity...
  5. ncbi request reprint Disturbances in hepatic cell-cycle regulation in mice with assembly-deficient keratins 8/18
    D M Toivola
    Department of Medicine, Palo Alto Veterans Affairs Medical Center and Stanford University, Palo Alto, CA, USA
    Hepatology 34:1174-83. 2001
    ..These effects could stem from disturbed functions of K8/18-dependent cell-cycle regulators, such as the signaling integrator, 14-3-3...
  6. ncbi request reprint Effects of keratin filament disruption on exocrine pancreas-stimulated secretion and susceptibility to injury
    D M Toivola
    Department of Medicine, Palo Alto VA Medical Center, Stanford University Digestive Disease Center, 3801 Miranda Avenue, Palo Alto, California, 94304, USA
    Exp Cell Res 255:156-70. 2000
    ..Alternatively, identical keratins may function differently in different tissues...
  7. doi request reprint Monitoring of epithelial cell caspase activation via detection of durable keratin fragment formation
    G Z Tao
    Department of Medicine, VA Palo Alto Health Care System, and the Digestive Disease Center, Stanford University, Palo Alto, CA, USA
    J Pathol 215:164-74. 2008
    ..The Asp237-directed antibodies provide a powerful tool to study apoptosis in human and mouse tissues, cells and serum, using a broad range of detection modalities...
  8. doi request reprint Autophagy modulates keratin-containing inclusion formation and apoptosis in cell culture in a context-dependent fashion
    M Harada
    Department of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Exp Cell Res 314:1753-64. 2008
    ..Manipulation of autophagy may offer a strategy to address the importance of inclusion formation and its significance in inclusion-associated diseases...
  9. ncbi request reprint Protein phosphatases maintain the organization and structural interactions of hepatic keratin intermediate filaments
    D M Toivola
    Department of Biology, Abo Akademi University, Turku, Finland
    J Cell Sci 110:23-33. 1997
    ....
  10. pmc Keratin 8 overexpression promotes mouse Mallory body formation
    Ikuo Nakamichi
    Department of Medicine, Stanford University, and Veterans Affairs Palo Alto Health Care System, CA 94305, USA
    J Cell Biol 171:931-7. 2005
    ..K8 overexpression is sufficient to form pre-MB and primes animals to accumulate MBs upon DDC challenge, which may help explain MB formation in human liver diseases...
  11. ncbi request reprint Keratin-8 null mice have different gallbladder and liver susceptibility to lithogenic diet-induced injury
    Guo Zhong Tao
    Palo Alto VA Medical Center, Palo Alto, Mail code 154J, 3801 Miranda Avenue, Palo Alto, CA 94304 and Stanford University School of Medicine Digestive Disease Center, Stanford, CA 94305, USA
    J Cell Sci 116:4629-38. 2003
    ..Differences between K8-null mouse gallbladder and hepatocyte susceptibility to injury may be related to their minimal versus absent keratin expression, respectively...
  12. pmc Keratins modulate the shape and function of hepatocyte mitochondria: a mechanism for protection from apoptosis
    Guo Zhong Tao
    Department of Surgery, Stanford University, Palo Alto, CA 94305, USA
    J Cell Sci 122:3851-5. 2009
    ..The effects of keratin mutation on mitochondria are likely to contribute to hepatocyte predisposition to apoptosis and oxidative injury, and to play a pathogenic role in keratin-mutation-related human liver disease...
  13. pmc Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models
    Pavel Strnad
    Department of Medicine, Palo Alto VA Medical Center, Palo Alto, California, USA
    Gastroenterology 134:1169-79. 2008
    ..We sought direct evidence for a keratin mutation-related predisposition to liver fibrosis using transgenic mouse models because the relationship between keratin mutations and cirrhosis is based primarily on human association studies...
  14. pmc Keratin 20 helps maintain intermediate filament organization in intestinal epithelia
    Qin Zhou
    Department of Medicine, VA Palo Alto Health Care System, Palo Alto, California 94304, USA
    Mol Biol Cell 14:2959-71. 2003
    ..Our data suggest the presence of unique regulatory domains for pancreatic and gastric K20 expression and support a significant role for K20 in maintaining keratin filaments in intestinal epithelia...
  15. ncbi request reprint "Heads and tails" of intermediate filament phosphorylation: multiple sites and functional insights
    M Bishr Omary
    Department of Medicine, Palo Alto VA Medical Center and Stanford University School of Medicine, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    Trends Biochem Sci 31:383-94. 2006
    ....
  16. pmc Adrenoceptor activity of muscarinic toxins identified from mamba venoms
    K Näreoja
    Department of Biosciences, Biochemistry, Abo Akademi University, Turku, Finland
    Br J Pharmacol 164:538-50. 2011
    ..Recent data infer that these toxins may have other G-protein-coupled receptor targets than the mAChRs. The purpose of this study was to systematically investigate the interactions of MTs with the adrenoceptor family members...
  17. ncbi request reprint Organ-specific stress induces mouse pancreatic keratin overexpression in association with NF-kappaB activation
    Bihui Zhong
    VA Palo Alto Health Care System, Department of Medicine, 3801 Miranda Avenue, 154J, Palo Alto, CA 94304, USA
    J Cell Sci 117:1709-19. 2004
    ..Pancreatic keratin overexpression is associated with NF-kappaB activation and may serve unique functions in acinar or ductal cell response to injury...
  18. pmc Reg-II is an exocrine pancreas injury-response product that is up-regulated by keratin absence or mutation
    Bihui Zhong
    Department of Medicine, Palo Alto Veterans Affairs Medical Center, Palo Alto, CA 94304, USA
    Mol Biol Cell 18:4969-78. 2007
    ..Thus, Reg-II is a likely mouse exocrine pancreas cytoprotective candidate protein whose expression is regulated by keratin filament organization and phosphorylation...
  19. ncbi request reprint Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment
    Aida Habtezion
    Department of Medicine, Palo Alto VA Medical Center, 3801 Miranda Avenue, 154J, Palo Alto, CA 94304, USA
    J Cell Sci 118:1971-80. 2005
    ..These mice provide a model to investigate epithelial-leukocyte and epithelial-microbial cross-talk...
  20. ncbi request reprint Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease
    Diana M Toivola
    Department of Medicine, Palo Alto VA Medical Center, Stanford University School of Medicine Digestive Disease Center, Palo Alto, CA 94304, USA
    Hepatology 40:459-66. 2004
    ..In conclusion, site-specific keratin phosphorylation in liver disease is a progression marker when increased and a likely regression marker when decreased...
  21. ncbi request reprint Studying simple epithelial keratins in cells and tissues
    Nam On Ku
    Department of Medicine, Palo Alto VA Medical Center and Stanford University, Palo Alto, California 94304, USA
    Methods Cell Biol 78:489-517. 2004
  22. doi request reprint Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation
    Masaru Harada
    Department of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Hepatology 47:2026-35. 2008
    ..Rap also led to resorption of spontaneously formed MDBs in aging K8-overexpressing mice. Immune EM demonstrated K8-positive and ubiquitin-positive structures in autophagic vacuoles in the mouse liver...
  23. pmc Keratins modulate colonocyte electrolyte transport via protein mistargeting
    Diana M Toivola
    Palo Alto VA Medical Center, 3801 Miranda Ave, Mail code 154J, Palo Alto, CA 94304, USA
    J Cell Biol 164:911-21. 2004
    ..Therefore, colonic keratins have a novel function in regulating electrolyte transport, likely by targeting ion transporters to their cellular compartments...
  24. ncbi request reprint Cellular integrity plus: organelle-related and protein-targeting functions of intermediate filaments
    Diana M Toivola
    Palo Alto VA Medical Center, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    Trends Cell Biol 15:608-17. 2005
    ..The IF-related organelle-specific and protein-targeting roles, which are likely interrelated, provide functions beyond cell scaffolding and integrity and contribute to the cytoprotective and tissue-specific functions of IF proteins...
  25. pmc Type II keratins are phosphorylated on a unique motif during stress and mitosis in tissues and cultured cells
    Diana M Toivola
    Department of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    Mol Biol Cell 13:1857-70. 2002
    ..In conclusion, type II keratins of proliferating epithelia undergo phosphorylation at a unique and conserved motif as part of physiological mitotic and stress-related signals...
  26. ncbi request reprint Keratins: guardians of the liver
    M Bishr Omary
    Department of Medicine, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Hepatology 35:251-7. 2002
  27. ncbi request reprint From Mallory to Mallory-Denk bodies: what, how and why?
    Kurt Zatloukal
    Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
    Exp Cell Res 313:2033-49. 2007
    ..Although it remains unclear whether MDBs serve a bystander, protective or injury promoting function, they do serve an important role as histological and potential progression markers in several liver diseases...
  28. ncbi request reprint Absence of keratin 19 in mice causes skeletal myopathy with mitochondrial and sarcolemmal reorganization
    Michele R Stone
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Cell Sci 120:3999-4008. 2007
    ..This is the first demonstration of a mammalian phenotype associated with a genetic perturbation of keratin 19...