D M Toivola
Affiliation: Abo Akademi University
- Keratins in health and diseaseDiana M Toivola
Department of Biosciences, Cell Biology, Åbo Akademi University and Turku Center for Disease Modeling, University of Turku, Turku, Finland Electronic address
Curr Opin Cell Biol 32:73-81. 2015..Therefore, our understanding of keratins is shifting from diagnostic markers to active disease modifiers. ..
- Shape engineering vs organic modification of inorganic nanoparticles as a tool for enhancing cellular internalizationDidem Sen Karaman
Centre for Functional Materials, Laboratory of Physical Chemistry, Department of Natural Sciences, Abo Akademi University, Porthansgatan 3 5, Turku, FI 20500, Finland
Nanoscale Res Lett 7:358. 2012....
- Keratin overexpression levels correlate with the extent of spontaneous pancreatic injuryDiana M Toivola
Department of Medicine, Veterans Administration Palo Alto Health Care System, Palo Alto, CA, USA
Am J Pathol 172:882-92. 2008..Keratin absence or mutation is well tolerated after pancreatic but not liver injury, whereas excessive overexpression is toxic to the pancreas but not the liver when induced under basal conditions...
- Intermediate filaments take the heat as stress proteinsD M Toivola
Abo Akademi University, Department of Biosciences, Biology, Tykistokatu 6A, 20521 Turku, Finland
Trends Cell Biol 20:79-91. 2010..In this report, we review data that corroborate the view that IFs function as highly specialized cytoskeletal stress proteins that promote cellular organization and homeostasis...
- Protein phosphatase inhibition in normal and keratin 8/18 assembly-incompetent mouse strains supports a functional role of keratin intermediate filaments in preserving hepatocyte integrityD M Toivola
Department of Biology, Abo Akademi University, BioCity, Turku, Finland
Hepatology 28:116-28. 1998..The absence or occurrence of defective K8/K18 filaments render animals more prone to liver damage, which supports the previously suggested roles of keratin IFs in maintenance of structural integrity...
- Disturbances in hepatic cell-cycle regulation in mice with assembly-deficient keratins 8/18D M Toivola
Department of Medicine, Palo Alto Veterans Affairs Medical Center and Stanford University, Palo Alto, CA, USA
Hepatology 34:1174-83. 2001..These effects could stem from disturbed functions of K8/18-dependent cell-cycle regulators, such as the signaling integrator, 14-3-3...
- Effects of keratin filament disruption on exocrine pancreas-stimulated secretion and susceptibility to injuryD M Toivola
Department of Medicine, Palo Alto VA Medical Center, Stanford University Digestive Disease Center, 3801 Miranda Avenue, Palo Alto, California, 94304, USA
Exp Cell Res 255:156-70. 2000..Alternatively, identical keratins may function differently in different tissues...
- Monitoring of epithelial cell caspase activation via detection of durable keratin fragment formationG Z Tao
Department of Medicine, VA Palo Alto Health Care System, and the Digestive Disease Center, Stanford University, Palo Alto, CA, USA
J Pathol 215:164-74. 2008..The Asp237-directed antibodies provide a powerful tool to study apoptosis in human and mouse tissues, cells and serum, using a broad range of detection modalities...
- Autophagy modulates keratin-containing inclusion formation and apoptosis in cell culture in a context-dependent fashionM Harada
Department of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
Exp Cell Res 314:1753-64. 2008..Manipulation of autophagy may offer a strategy to address the importance of inclusion formation and its significance in inclusion-associated diseases...
- Protein phosphatases maintain the organization and structural interactions of hepatic keratin intermediate filamentsD M Toivola
Department of Biology, Abo Akademi University, Turku, Finland
J Cell Sci 110:23-33. 1997....
- Keratin 8 overexpression promotes mouse Mallory body formationIkuo Nakamichi
Department of Medicine, Stanford University, and Veterans Affairs Palo Alto Health Care System, CA 94305, USA
J Cell Biol 171:931-7. 2005..K8 overexpression is sufficient to form pre-MB and primes animals to accumulate MBs upon DDC challenge, which may help explain MB formation in human liver diseases...
- Keratin-8 null mice have different gallbladder and liver susceptibility to lithogenic diet-induced injuryGuo Zhong Tao
Palo Alto VA Medical Center, Palo Alto, Mail code 154J, 3801 Miranda Avenue, Palo Alto, CA 94304 and Stanford University School of Medicine Digestive Disease Center, Stanford, CA 94305, USA
J Cell Sci 116:4629-38. 2003..Differences between K8-null mouse gallbladder and hepatocyte susceptibility to injury may be related to their minimal versus absent keratin expression, respectively...
- Keratins modulate the shape and function of hepatocyte mitochondria: a mechanism for protection from apoptosisGuo Zhong Tao
Department of Surgery, Stanford University, Palo Alto, CA 94305, USA
J Cell Sci 122:3851-5. 2009..The effects of keratin mutation on mitochondria are likely to contribute to hepatocyte predisposition to apoptosis and oxidative injury, and to play a pathogenic role in keratin-mutation-related human liver disease...
- Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide modelsPavel Strnad
Department of Medicine, Palo Alto VA Medical Center, Palo Alto, California, USA
Gastroenterology 134:1169-79. 2008..We sought direct evidence for a keratin mutation-related predisposition to liver fibrosis using transgenic mouse models because the relationship between keratin mutations and cirrhosis is based primarily on human association studies...
- Keratin 20 helps maintain intermediate filament organization in intestinal epitheliaQin Zhou
Department of Medicine, VA Palo Alto Health Care System, Palo Alto, California 94304, USA
Mol Biol Cell 14:2959-71. 2003..Our data suggest the presence of unique regulatory domains for pancreatic and gastric K20 expression and support a significant role for K20 in maintaining keratin filaments in intestinal epithelia...
- "Heads and tails" of intermediate filament phosphorylation: multiple sites and functional insightsM Bishr Omary
Department of Medicine, Palo Alto VA Medical Center and Stanford University School of Medicine, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
Trends Biochem Sci 31:383-94. 2006....
- Adrenoceptor activity of muscarinic toxins identified from mamba venomsK Näreoja
Department of Biosciences, Biochemistry, Abo Akademi University, Turku, Finland
Br J Pharmacol 164:538-50. 2011..Recent data infer that these toxins may have other G-protein-coupled receptor targets than the mAChRs. The purpose of this study was to systematically investigate the interactions of MTs with the adrenoceptor family members...
- Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver diseaseDiana M Toivola
Department of Medicine, Palo Alto VA Medical Center, Stanford University School of Medicine Digestive Disease Center, Palo Alto, CA 94304, USA
Hepatology 40:459-66. 2004..In conclusion, site-specific keratin phosphorylation in liver disease is a progression marker when increased and a likely regression marker when decreased...
- Reg-II is an exocrine pancreas injury-response product that is up-regulated by keratin absence or mutationBihui Zhong
Department of Medicine, Palo Alto Veterans Affairs Medical Center, Palo Alto, CA 94304, USA
Mol Biol Cell 18:4969-78. 2007..Thus, Reg-II is a likely mouse exocrine pancreas cytoprotective candidate protein whose expression is regulated by keratin filament organization and phosphorylation...
- Organ-specific stress induces mouse pancreatic keratin overexpression in association with NF-kappaB activationBihui Zhong
VA Palo Alto Health Care System, Department of Medicine, 3801 Miranda Avenue, 154J, Palo Alto, CA 94304, USA
J Cell Sci 117:1709-19. 2004..Pancreatic keratin overexpression is associated with NF-kappaB activation and may serve unique functions in acinar or ductal cell response to injury...
- Studying simple epithelial keratins in cells and tissuesNam On Ku
Department of Medicine, Palo Alto VA Medical Center and Stanford University, Palo Alto, California 94304, USA
Methods Cell Biol 78:489-517. 2004
- Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatmentAida Habtezion
Department of Medicine, Palo Alto VA Medical Center, 3801 Miranda Avenue, 154J, Palo Alto, CA 94304, USA
J Cell Sci 118:1971-80. 2005..These mice provide a model to investigate epithelial-leukocyte and epithelial-microbial cross-talk...
- Keratins modulate colonocyte electrolyte transport via protein mistargetingDiana M Toivola
Palo Alto VA Medical Center, 3801 Miranda Ave, Mail code 154J, Palo Alto, CA 94304, USA
J Cell Biol 164:911-21. 2004..Therefore, colonic keratins have a novel function in regulating electrolyte transport, likely by targeting ion transporters to their cellular compartments...
- Keratins: guardians of the liverM Bishr Omary
Department of Medicine, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
Hepatology 35:251-7. 2002
- Type II keratins are phosphorylated on a unique motif during stress and mitosis in tissues and cultured cellsDiana M Toivola
Department of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
Mol Biol Cell 13:1857-70. 2002..In conclusion, type II keratins of proliferating epithelia undergo phosphorylation at a unique and conserved motif as part of physiological mitotic and stress-related signals...
- Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formationMasaru Harada
Department of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
Hepatology 47:2026-35. 2008..Rap also led to resorption of spontaneously formed MDBs in aging K8-overexpressing mice. Immune EM demonstrated K8-positive and ubiquitin-positive structures in autophagic vacuoles in the mouse liver...
- Cellular integrity plus: organelle-related and protein-targeting functions of intermediate filamentsDiana M Toivola
Palo Alto VA Medical Center, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
Trends Cell Biol 15:608-17. 2005..The IF-related organelle-specific and protein-targeting roles, which are likely interrelated, provide functions beyond cell scaffolding and integrity and contribute to the cytoprotective and tissue-specific functions of IF proteins...
- From Mallory to Mallory-Denk bodies: what, how and why?Kurt Zatloukal
Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
Exp Cell Res 313:2033-49. 2007..Although it remains unclear whether MDBs serve a bystander, protective or injury promoting function, they do serve an important role as histological and potential progression markers in several liver diseases...
- Absence of keratin 19 in mice causes skeletal myopathy with mitochondrial and sarcolemmal reorganizationMichele R Stone
Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Cell Sci 120:3999-4008. 2007..This is the first demonstration of a mammalian phenotype associated with a genetic perturbation of keratin 19...