Jessica M Rosenholm

Summary

Affiliation: Abo Akademi University
Country: Finland

Publications

  1. doi Functionalization of graphene oxide nanostructures improves photoluminescence and facilitates their use as optical probes in preclinical imaging
    Neeraj Prabhakar
    Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Abo Akademi University, 20520 Turku, Finland
    Nanoscale 7:10410-20. 2015
  2. doi Mesoporous silica nanoparticles with redox-responsive surface linkers for charge-reversible loading and release of short oligonucleotides
    Jixi Zhang
    Centre for Functional Materials, Laboratory for Physical Chemistry, Department of Natural Sciences, Abo Akademi University, Porthansgatan 3 5, Turku 20500, Finland
    Dalton Trans 43:4115-26. 2014
  3. pmc Shape engineering vs organic modification of inorganic nanoparticles as a tool for enhancing cellular internalization
    Didem Sen Karaman
    Centre for Functional Materials, Laboratory of Physical Chemistry, Department of Natural Sciences, Abo Akademi University, Porthansgatan 3 5, Turku, FI 20500, Finland
    Nanoscale Res Lett 7:358. 2012
  4. doi Core-shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery II: application
    Neeraj Prabhakar
    Centre for Functional Materials, Laboratory for Physical Chemistry, Department of Natural Sciences, Abo Akademi University, 20500 Turku, Finland
    Nanoscale 5:3713-22. 2013
  5. doi Nanoparticles in targeted cancer therapy: mesoporous silica nanoparticles entering preclinical development stage
    Jessica M Rosenholm
    Center for Functional Materials, Laboratory for Physical Chemistry, Department of Natural Sciences, Abo Akademi University, Porthansgatan 3 5, FI 20500, Turku, Finland
    Nanomedicine (Lond) 7:111-20. 2012
  6. pmc Mesoporous silica nanoparticles as drug delivery systems for targeted inhibition of Notch signaling in cancer
    Veronika Mamaeva
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
    Mol Ther 19:1538-46. 2011
  7. doi Targeting of porous hybrid silica nanoparticles to cancer cells
    Jessica M Rosenholm
    Center for Functional Materials, Department of Physical Chemistry, Abo Akademi University, Porthansgatan 3 5, FI 2500 Turku, Finland
    ACS Nano 3:197-206. 2009
  8. doi Towards multifunctional, targeted drug delivery systems using mesoporous silica nanoparticles--opportunities & challenges
    Jessica M Rosenholm
    Department of Physical Chemistry, Abo Akademi University, Center for Functional Materials, Porthansgatan 3 5, FI 20500 Turku, Finland
    Nanoscale 2:1870-83. 2010
  9. doi Cancer-cell-specific induction of apoptosis using mesoporous silica nanoparticles as drug-delivery vectors
    Jessica M Rosenholm
    Center for Functional Materials, Department of Physical Chemistry, Abo Akademi University, Porthansgatan 3 5, 2500 Turku, Finland
    Small 6:1234-41. 2010
  10. ncbi Multifunctional mesoporous silica nanoparticles for combined therapeutic, diagnostic and targeted action in cancer treatment
    Jessica M Rosenholm
    Center for Functional Materials, Department of Physical Chemistry, Abo Akademi University, Porthansgatan 3 5, FI 20500, Turku, Finland
    Curr Drug Targets 12:1166-86. 2011

Collaborators

  • Tuomas Näreoja
  • Igor I Vlasov
  • Michael Schäferling
  • Patrik Eklund
  • Jukka Westermarck
  • Jixi Zhang
  • Didem Sen Karaman
  • Neeraj Prabhakar
  • John E Eriksson
  • Rajendran Senthilkumar
  • Veronika Mamaeva
  • Cecilia Sahlgren
  • Erik Niemelä
  • Riikka Arppe
  • Eva von Haartman
  • Pekka E Hänninen
  • Tatiana A Dolenko
  • Diti Desai
  • Magnus Odén
  • Sami Koho
  • Alain Duchanoy
  • Diana M Toivola
  • Emma M Björk
  • Sergey A Burikov
  • Olga A Shenderova
  • Yves Nkizinkiko
  • Takahiro Deguchi
  • Preethy Paul
  • Sami Nylund
  • Tina Gulin-Sarfraz
  • Gun Hedström
  • Tero Soukka
  • Leena Mattsson
  • Hua Jiang
  • Satoru Hosomi
  • Victor G Ralchenko
  • Denis I Vlasov
  • Natalie Råtts
  • Emma M Johansson
  • Lotta Bergman
  • Sebastian Landor
  • Laurel Tabe Bate-Eya
  • Mika Linden
  • Lina E Fortelius
  • Emilia Peuhu

Detail Information

Publications15

  1. doi Functionalization of graphene oxide nanostructures improves photoluminescence and facilitates their use as optical probes in preclinical imaging
    Neeraj Prabhakar
    Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Abo Akademi University, 20520 Turku, Finland
    Nanoscale 7:10410-20. 2015
    ..The good biocompatibility and easy detection of the functionalized nGOs suggest that they could address the limitations faced with quantum dots and organic fluorophores in long-term in vivo biomedical imaging. ..
  2. doi Mesoporous silica nanoparticles with redox-responsive surface linkers for charge-reversible loading and release of short oligonucleotides
    Jixi Zhang
    Centre for Functional Materials, Laboratory for Physical Chemistry, Department of Natural Sciences, Abo Akademi University, Porthansgatan 3 5, Turku 20500, Finland
    Dalton Trans 43:4115-26. 2014
    ..Thus, it is expected to lay the possibility for the development of innovative and strategic approaches for advancing related gene delivery technology. ..
  3. pmc Shape engineering vs organic modification of inorganic nanoparticles as a tool for enhancing cellular internalization
    Didem Sen Karaman
    Centre for Functional Materials, Laboratory of Physical Chemistry, Department of Natural Sciences, Abo Akademi University, Porthansgatan 3 5, Turku, FI 20500, Finland
    Nanoscale Res Lett 7:358. 2012
    ....
  4. doi Core-shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery II: application
    Neeraj Prabhakar
    Centre for Functional Materials, Laboratory for Physical Chemistry, Department of Natural Sciences, Abo Akademi University, 20500 Turku, Finland
    Nanoscale 5:3713-22. 2013
    ..This study serves as a demonstration how this novel nanomaterial can be exploited for both bioimaging and drug delivery for future theranostic applications...
  5. doi Nanoparticles in targeted cancer therapy: mesoporous silica nanoparticles entering preclinical development stage
    Jessica M Rosenholm
    Center for Functional Materials, Laboratory for Physical Chemistry, Department of Natural Sciences, Abo Akademi University, Porthansgatan 3 5, FI 20500, Turku, Finland
    Nanomedicine (Lond) 7:111-20. 2012
    ..Here, we report on these recent advances regarding therapeutic efficacy, targeting and safety issues related to the application of mesoporous silica nanoparticles in cancer therapy...
  6. pmc Mesoporous silica nanoparticles as drug delivery systems for targeted inhibition of Notch signaling in cancer
    Veronika Mamaeva
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
    Mol Ther 19:1538-46. 2011
    ..The data highlights MSNPs as an attractive platform for targeted drug delivery of anticancer drugs with otherwise restricted clinical application, and as interesting constituents in the quest for more refined Notch therapies...
  7. doi Targeting of porous hybrid silica nanoparticles to cancer cells
    Jessica M Rosenholm
    Center for Functional Materials, Department of Physical Chemistry, Abo Akademi University, Porthansgatan 3 5, FI 2500 Turku, Finland
    ACS Nano 3:197-206. 2009
    ..In addition, the biospecifically tagged hybrid PEI-silica particles were shown to be noncytotoxic and able to specifically target folate receptor-expressing cancer cells also under coculture conditions...
  8. doi Towards multifunctional, targeted drug delivery systems using mesoporous silica nanoparticles--opportunities & challenges
    Jessica M Rosenholm
    Department of Physical Chemistry, Abo Akademi University, Center for Functional Materials, Porthansgatan 3 5, FI 20500 Turku, Finland
    Nanoscale 2:1870-83. 2010
    ..Addressing these burning questions will facilitate the application of MSNs in nanomedicine...
  9. doi Cancer-cell-specific induction of apoptosis using mesoporous silica nanoparticles as drug-delivery vectors
    Jessica M Rosenholm
    Center for Functional Materials, Department of Physical Chemistry, Abo Akademi University, Porthansgatan 3 5, 2500 Turku, Finland
    Small 6:1234-41. 2010
    ..As MTX is mainly attached to the particle surface, an additional advantage is that the presented carrier design allows for adsorption (loading) of additional drugs into the pore network for therapies based on a combination of drugs...
  10. ncbi Multifunctional mesoporous silica nanoparticles for combined therapeutic, diagnostic and targeted action in cancer treatment
    Jessica M Rosenholm
    Center for Functional Materials, Department of Physical Chemistry, Abo Akademi University, Porthansgatan 3 5, FI 20500, Turku, Finland
    Curr Drug Targets 12:1166-86. 2011
    ..This review covers the latest developments related to the use of mesoporous silica nanoparticles (MSNs) as nanocarriers in biomedical applications, with special focus on cancer therapy and diagnostics...
  11. doi Rational evaluation of the utilization of PEG-PEI copolymers for the facilitation of silica nanoparticulate systems in biomedical applications
    Didem Sen Karaman
    Centre for Functional Materials, Laboratory of Physical Chemistry, Åbo Akademi University, Porthansgatan 3 5, FI 20500 Turku, Finland
    J Colloid Interface Sci 418:300-10. 2014
    ..Here, we attempt to provide a solid rationale to utilize PEG-PEI copolymers as surface modifiers and stabilizers/dispersion agents in solid colloidal systems with focus on biomedical applicability...
  12. doi Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect
    Rajendran Senthilkumar
    Department of Biosciences, Cell Biology, Abo Akademi University, Tykistökatu 6B, FI 20520 Turku, Finland
    Biomater Sci 3:103-11. 2015
    ....
  13. doi Photon upconversion sensitized nanoprobes for sensing and imaging of pH
    Riikka Arppe
    Department of Biochemistry Biotechnology, University of Turku, Tykistokatu 6A, 20520 Turku, Finland
    Nanoscale 6:6837-43. 2014
    ....
  14. doi Sugar-decorated mesoporous silica nanoparticles as delivery vehicles for the poorly soluble drug celastrol enables targeted induction of apoptosis in cancer cells
    Erik Niemelä
    Cell Biology, Faculty of Science and Engineering, Abo Akademi University, Turku, Finland
    Eur J Pharm Biopharm 96:11-21. 2015
    ..In summary, we show that glucose-functionalized MSNs can be used as efficient carriers for targeted celastrol delivery to achieve specific induction of apoptosis in cancer cells. ..
  15. doi Targeted intracellular delivery of hydrophobic agents using mesoporous hybrid silica nanoparticles as carrier systems
    Jessica M Rosenholm
    Department of Physical Chemistry, Abo Akademi University, Center for Functional Materials, Porthansgatan 3 5, FI 20500 Turku, Finland
    Nano Lett 9:3308-11. 2009
    ..Furthermore, the incorporated agent is shown to be able to escape from the endosomes into the cytoplasm, making the particles promising candidates as carriers for targeted drug delivery for cancer treatment...