Activities of ABT-773 against microaerophilic and fastidious organismsSydney M Finegold
Infectious Diseases Section, VA Greater Los Angeles Healthcare System, West Los Angeles Division, Los Angeles, CA 90073, USA
Antimicrob Agents Chemother 46:2716-9. 2002
..With ampicillin-sulbactam and levofloxacin, only 2 and 6% of these strains, respectively, were resistant at the breakpoint. With clindamycin, penicillin G, and metronidazole, 22, 26, and 58% of the strains, respectively, were resistant...
Fastidiosipila sanguinis gen. nov., sp. nov., a new Gram-positive, coccus-shaped organism from human bloodEnevold Falsen
Culture Collection, Department of Clinical Bacteriology, , Sweden
Int J Syst Evol Microbiol 55:853-8. 2005
..nov., as Fastidiosipila sanguinis sp. nov. The type strain of Fastidiosipila sanguinis is CCUG 47711(T) (=CIP 108292(T))...
- Clostridium tertium isolated from gas gangrene wound; misidentified as Lactobacillus spp initially due to aerotolerant feature
Shigeki Fujitani
Infectious Diseases Section, VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
Anaerobe 13:161-5. 2007
..Clinicians should be aware of the phenomenon of aerotolerance of some anaerobes and need to clarify the identification of organisms if the clinical picture does not fit the isolated organism...
Innate immune recognition of, and response to, Clostridium sordelliiM J Aldape
Veterans Affairs Medical Center, Infectious Diseases Section, Boise, ID 83702, USA
Anaerobe 16:125-30. 2010
..sordellii infection is not related to inadequate immune detection of the organism, but rather is attributable to a species-specific immune system dysfunction that remains to be elucidated...
- State of the art; microbiology in health and disease. Intestinal bacterial flora in autism
Sydney M Finegold
Veterans Administration Medical Center, Infectious Diseases Section 111F, Los Angeles, CA 90073, USA
Anaerobe 17:367-8. 2011
..Pyrosequencing studies document an abnormal gut microflora in regressive autism subjects as compared to controls. Finally, we present preliminary evidence suggesting that Desulfovibrio may play a key role in this disease...
- Gastrointestinal microflora studies in late-onset autism
Sydney M Finegold
Infectious Diseases Section, Veterans Affairs Medical Center, West Los Angeles, CA, USA
Clin Infect Dis 35:S6-S16. 2002
..These studies demonstrate significant alterations in the upper and lower intestinal flora of children with late-onset autism and may provide insights into the nature of this disorder...
- Bacteriologic findings associated with chronic bacterial maxillary sinusitis in adults
S M Finegold
Veterans Affairs Medical Center West Los Angeles, and University of California, Los Angeles, School of Medicine, CA 90073, USA
Clin Infect Dis 35:428-33. 2002
..A pathogenic role for Granulicatella species in cases of chronic sinusitis was documented for the first time...
- Desulfovibrio species are potentially important in regressive autism
Sydney M Finegold
Infectious Diseases Section 111 F, VA Medical Center West Los Angeles, Los Angeles, CA 90073, USA
Med Hypotheses 77:270-4. 2011
....
- Study of the in vitro activities of rifaximin and comparator agents against 536 anaerobic intestinal bacteria from the perspective of potential utility in pathology involving bowel flora
S M Finegold
Department of Medicine, Medical and Research Services, VA Greater Los Angeles Healthcare System, UCLA School of Medicine, Los Angeles, California 90073, USA
Antimicrob Agents Chemother 53:281-6. 2009
..25 microg/ml. Ninety percent of the strains tested were inhibited by 256 microg/ml of rifaximin or less, an activity equivalent to those of teicoplanin and vancomycin but less than those of nitazoxanide and ampicillin-sulbactam...
- Therapy and epidemiology of autism--clostridial spores as key elements
Sydney M Finegold
Infectious Diseases Section 111 F, VA Medical Center West Los Angeles, Los Angeles, CA 90073, United States
Med Hypotheses 70:508-11. 2008
..These latter two hypotheses have major implications with regard to the epidemiology of this important and distressing disease and would encourage research into methods to eliminate clostridial spores from the home and other environments...
- Clostridium clostridioforme: a mixture of three clinically important species
S M Finegold
Infectious Diseases Section 111 F, VA Medical Center West Los Angeles, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Eur J Clin Microbiol Infect Dis 24:319-24. 2005
..It is important for microbiology laboratories to distinguish between these species and for clinicians to be aware of the differences between them...
- Cetobacterium somerae sp. nov. from human feces and emended description of the genus Cetobacterium
Sydney M Finegold
Research Service, VA Medical Center West Los Angeles, CA 90073, USA
Syst Appl Microbiol 26:177-81. 2003
..nov. The proposed type strain of Cetobacterium somerae is WAL 14325(T) (ATCC BAA-474(T) = CCUG 46254T)...
- In vitro activities of OPT-80 and comparator drugs against intestinal bacteria
Sydney M Finegold
Medical Service, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
Antimicrob Agents Chemother 48:4898-902. 2004
..Poor activity against anaerobic gram-negative rods may maintain colonization resistance...
- Porphyromonas uenonis sp. nov., a pathogen for humans distinct from P. asaccharolytica and P. endodontalis
Sydney M Finegold
Infectious Diseases Section, Veterans Affairs Medical Center West Los Angeles, Los Angeles, CA 90073, USA
J Clin Microbiol 42:5298-301. 2004
..asaccharolytica. We propose the name Porphyromonas uenonis for the novel species. We have recovered P. uenonis from four clinical infections in adults, all likely of intestinal origin, and from the feces of six children...
- Pyrosequencing study of fecal microflora of autistic and control children
Sydney M Finegold
Infectious Diseases Section 111 F and Research Service, VA Medical Center West Los Angeles, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
Anaerobe 16:444-53. 2010
..If the unique microbial flora is found to be a causative or consequent factor in this type of autism, it may have implications with regard to a specific diagnostic test, its epidemiology, and for treatment and prevention...
- In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates
Sydney M Finegold
Medical Service, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California, USA
Antimicrob Agents Chemother 53:3996-4001. 2009
..25 microg/ml). As expected, gram-negative isolates were not inhibited by telavancin...
- Multilaboratory comparison of anaerobe susceptibility results using 3 different agar media
D E Roe
Anaerobe Systems, Morgan Hill, CA, USA
Clin Infect Dis 35:S40-6. 2002
..1%. These data indicate that a change in the NCCLS reference medium for testing of anaerobic bacteria susceptibility to either BRU or WCB will not affect the MIC results for the antibiotics and organisms evaluated...
- Reclassification of Clostridium coccoides, Ruminococcus hansenii, Ruminococcus hydrogenotrophicus, Ruminococcus luti, Ruminococcus productus and Ruminococcus schinkii as Blautia coccoides gen. nov., comb. nov., Blautia hansenii comb. nov., Blautia hydroge
Chengxu Liu
Research Service, VA Medical Center West Los Angeles, CA, USA
Int J Syst Evol Microbiol 58:1896-902. 2008
..nov. One of the new isolates, the hitherto unknown coccus-shaped bacterial strain WAL 14507T (=ATCC BAA-1564T=DSM 19850T) is proposed as representing the type strain of a novel species, Blautia wexlerae sp. nov...
- Corynebacterium pyruviciproducens sp. nov., a pyruvic acid producer
Jia Tong
Department of Medicine, University of California, Los Angeles School of Medicine, Los Angeles, CA, USA
Int J Syst Evol Microbiol 60:1135-40. 2010
..We propose the name Corynebacterium pyruviciproducens sp. nov. for the novel species. The type strain is 06-1773O(T) (=WAL 19168(T) =CCUG 57046(T) =ATCC BAA-1742(T))...
- "Bacteroides nordii" sp. nov. and "Bacteroides salyersae" sp. nov. isolated from clinical specimens of human intestinal origin
Y L Song
Research Service, VA Medical Center West Los Angeles, UCLA School of Medicine, Los Angeles, CA, USA
J Clin Microbiol 42:5565-70. 2004
..4 mol% for Bacteroides nordii and 42.0 mol% for Bacteroides salyersae. The type strains of Bacteroides nordii and Bacteroides salyersae are WAL 11050 (ATCC BAA-998 or CCUG 48943) and WAL 10018 (ATCC BAA-997 or CCUG 48945), respectively...
- Murdochiella asaccharolytica gen. nov., sp. nov., a Gram-stain-positive, anaerobic coccus isolated from human wound specimens
Nurver Ulger-Toprak
Research Service, VA Medical Center West Los Angeles, Los Angeles, CA 90073, USA
Int J Syst Evol Microbiol 60:1013-6. 2010
..nov., sp. nov., are proposed. Strain WAL 1855C(T) (=ATCC BAA-1631(T) =CCUG 55976(T)) is the type strain of Murdochiella asaccharolytica...
- In vitro activity of levofloxacin against a selected group of anaerobic bacteria isolated from skin and soft tissue infections
H M Wexler
Veterans Administration Medical Center, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90024, USA
Antimicrob Agents Chemother 42:984-6. 1998
..The geometric mean MIC of levofloxacin was lower than those of ofloxacin and ciprofloxacin for every group except Veillonella...
- "Bacteroides goldsteinii sp. nov." isolated from clinical specimens of human intestinal origin
Yuli Song
Resaerch Service, VA Medical Center West Lost Angeles, CA 90073, USA
J Clin Microbiol 43:4522-7. 2005
..nov," is proposed. The G+C content of the DNA is 43 mol% for Bacteroides. The type strain of "B. goldsteinii" is WAL 12034(T) (= CCUG 48944(T) = ATCC BAA-1180(T))...
- Gemella asaccharolytica sp. nov., isolated from human clinical specimens
Nurver Ulger-Toprak
Research Service, VA Medical Center West Los Angeles, CA, USA
Int J Syst Evol Microbiol 60:1023-6. 2010
..nov. The type strain is WAL 1945J(T) (=ATCC BAA-1630(T) =CCUG 57045(T))...
- Evaluation of genotypic and phenotypic methods for differentiation of the members of the Anginosus group streptococci
P H Summanen
Research Service, Veterans Affair Medical Center West Los Angeles, Los Angeles, CA, USA
Eur J Clin Microbiol Infect Dis 28:1123-8. 2009
..S. intermedius can be readily differentiated from the other two species by phenotypic tests; however, 16S rRNA gene or tuf gene sequencing may be needed for separating some strains of S. constellatus from S. anginosus...
- In vitro activity of telithromycin (HMR 3647) against 502 strains of anaerobic bacteria
H M Wexler
Research Services, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
J Antimicrob Chemother 47:467-9. 2001
..Telithromycin inhibited 100% of Clostridium perfringens, 46-56% of Clostridium difficile and Clostridium ramosum and approximately 90% of non-spore-forming Gram-positive bacilli...
- Peptoniphilus gorbachii sp. nov., Peptoniphilus olsenii sp. nov., and Anaerococcus murdochii sp. nov. isolated from clinical specimens of human origin
Yuli Song
Research Service, VAMedical Center, West Los Angeles, CA 90073, USA
J Clin Microbiol 45:1746-52. 2007
..nov., and Anaerococcus murdochii sp. nov. are WAL 10418(T) (= CCUG 53341(T) = ATCC BAA-1383(T)), WAL 12922(T) (= CCUG 53342(T) = ATCC BAA-1384(T)), and WAL 17230(T) (= CCUG 53340(T) = ATCC BAA-1385(T)), respectively...
- In vitro activities of MK-826 (L-749,345) against 363 strains of anaerobic bacteria
H M Wexler
Research Services, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Antimicrob Agents Chemother 44:2222-4. 2000
..At least 98% of the strains were susceptible to the carbapenems. All strains of Clostridium perfringens, Fusobacterium nucleatum, Peptostreptococcus, and Sutterella wadsworthensis were susceptible to all agents tested...
- Ampicillin/sulbactam and cefoxitin in the treatment of cutaneous and other soft-tissue abscesses in patients with or without histories of injection drug abuse
D A Talan
Department of Medicine, Division of Emergency Medicine and Infectious Diseases, Olive View University of California Los Angeles Medical Center, Sylmar, CA 91342, USA
Clin Infect Dis 31:464-71. 2000
..9%. The 2 drugs were well tolerated. Ampicillin/sulbactam and cefoxitin were equally effective for the empirical treatment of cutaneous or other soft-tissue infections in injection drug abusers and patients who did not inject drugs...
- In vitro activity of cefotetan compared with that of other antimicrobial agents against anaerobic bacteria
H M Wexler
Research Service, Veterans Administration Wadsworth Medical Center, Los Angeles, California
Antimicrob Agents Chemother 32:601-4. 1988
..Cefotetan and metronidazole were the most active agents against Clostridium difficile. Percent susceptible values for all strains were 72, 79, 44, 82, 93, and 98%, respectively...
- 16S ribosomal DNA sequence-based analysis of clinically significant gram-positive anaerobic cocci
Yuli Song
Research Service Clinical Microbiology Laboratory, VA Medical Center West Los Angeles, California 90073, USA
J Clin Microbiol 41:1363-9. 2003
..This finding is in contrast to the phenotypic identification results, by which only 56% of isolates were correctly identified to species level...
- Evaluation of 16S rRNA sequencing and reevaluation of a short biochemical scheme for identification of clinically significant Bacteroides species
Yuli Song
Research Service, VA Medical Center West Los Angeles, 11301 Wilshire Blvd, Room E3 237, Bldg 304, Los Angeles, CA 90073, USA
J Clin Microbiol 43:1531-7. 2005
....
- Characterization of Slackia exigua isolated from human wound infections, including abscesses of intestinal origin
Keun Sung Kim
Department of Medicine, University of California at Los Angeles School of Medicine, Los Angeles, California, USA
J Clin Microbiol 48:1070-5. 2010
..exigua species can be isolated from extraoral infections as well as from oral infections. The profiles of susceptibility to selected antimicrobials of this species were also investigated for the first time...
- Phenotypic and molecular characterization of Solobacterium moorei isolates from patients with wound infection
Guili Zheng
Research Service, VA Medical Center, West Los Angeles, California 90073, USA
J Clin Microbiol 48:873-6. 2010
....
- In vitro activities of DX-619 and four comparator agents against 376 anaerobic bacterial isolates
D Molitoris
Medical Service, Greater Los Angeles VAMC, 11301 Wilshire Blvd, Bldg. 304, Rm. E3-237, Los Angeles, CA 90073, USA
Antimicrob Agents Chemother 50:1887-9. 2006
..Overall, 90% of the strains were susceptible to DX-619 at < or =1 microg/ml. It was more active than the other four compounds tested except for meropenem, which showed virtually identical overall activity...
- Current susceptibility patterns of anaerobic bacteria
H M Wexler
Research Services Veterans Administration Medical Center, West Los Angeles, California 90073, USA
Yonsei Med J 39:495-501. 1998
..As a general guide, antibiograms from the last several years of susceptibility testing at the Wadsworth Anaerobe Laboratory are reported...
- Short-term benefit from oral vancomycin treatment of regressive-onset autism
R H Sandler
Section of Pediatric Gastroenterology and Nutrition, Rush Children s Hospital, Rush Medical College, Chicago, IL 60612, USA
J Child Neurol 15:429-35. 2000
....
- Porphyromonas bennonis sp. nov., isolated from human clinical specimens
Paula H Summanen
Research Service, Anaerobe Laboratory, Building 304, Room E3 237, Veterans Affairs VA West Los Angeles Healthcare Center, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Int J Syst Evol Microbiol 59:1727-32. 2009
..nov., with WAL 1926C(T) (=ATCC BAA-1629(T) =CCUG 55979(T)) as the type strain...
- Alistipes onderdonkii sp. nov. and Alistipes shahii sp. nov., of human origin
Yuli Song
Research Service, VA Medical Center West Los Angeles, Building 304, Room E3 227, 11301 Wilshire Boulevard, CA 90073, USA
Int J Syst Evol Microbiol 56:1985-90. 2006
..are proposed. The type strains of A. onderdonkii and A. shahii are WAL 8169(T) (=CCUG 48946(T)=ATCC BAA-1178(T)) and WAL 8301(T) (=CCUG 48947(T)=ATCC BAA-1179(T)), respectively; their DNA G+C contents are 58 and 56 mol%, respectively...
- In vitro activities of faropenem against 579 strains of anaerobic bacteria
Hannah M Wexler
Department of Medicine, Immunology and Molecular Genetics, University of California Los Angeles School of Medicine, Los Angeles, California 90024, USA
Antimicrob Agents Chemother 46:3669-75. 2002
..wadsworthensis (18% resistant); 63% of gram-positive non-spore-forming rods were resistant. Some degree of clindamycin resistance was seen in most of the groups tested...
- Clostridium bolteae sp. nov., isolated from human sources
Yuli Song
Research Service, VA Medical Center West Los Angeles 90073, USA
Syst Appl Microbiol 26:84-9. 2003
..nov. The type strain of Clostridium bolteae is WAL 16351T (= ATCC(T) = BAA-613T, CCUG(T) = 46953T)...
- Porphyromonas somerae sp. nov., a pathogen isolated from humans and distinct from porphyromonas levii
Paula H Summanen
Research Service, Veterans Affair Medical Center West Los Angeles, CA 90073, USA
J Clin Microbiol 43:4455-9. 2005
..levii-like organisms. P. somerae was predominantly isolated from patients with chronic skin and soft tissue or bone infections, especially in the lower extremities...
- The importance of black-pigmented gram-negative anaerobes in human infections
S M Finegold
Research Service, VA Medical Center, Los Angeles, California
FEMS Immunol Med Microbiol 6:77-82. 1993
..Much remains to be done to determine the relative importance of the various taxa of black-pigmented Gram-negative anaerobes and of the different virulence factors produced by them...
- In vitro activity of cefoxitin and parenterally administered cephalosporins against anaerobic bacteria
V L Sutter
Research Service, Wadsworth Veterans Administration Hospital Center, Los Angeles, California 90073
Rev Infect Dis 1:218-23. 1979
..fragilis group and is least active against Clostridium species other than C. perfringens...
- Real-time PCR quantitation of clostridia in feces of autistic children
Yuli Song
Research Service, VA Medical Center West Los Angeles, Los Angeles, California 90073, USA
Appl Environ Microbiol 70:6459-65. 2004
..8 x 10(8) CFU/g in controls; respectively). More subjects need to be studied. The assay is a rapid and reliable method, and it should have great potential for quantitation of other bacteria in the intestinal tract...
- Use of 16S-23S rRNA spacer-region (SR)-PCR for identification of intestinal clostridia
Yuli Song
Research Service, VA Medical Center West Los Angeles, CA 90073, USA
Syst Appl Microbiol 25:528-35. 2002
..These results indicate that SR-PCR provides an accurate and rapid molecular method for the identification of human intestinal Clostridium species...
- Multilaboratory comparison of growth characteristics for anaerobes, using 5 different agar media
D E Roe
Anaerobe Systems, San Jose, CA, USA
Clin Infect Dis 35:S36-9. 2002
..Brucella agar supplemented with whole or laked blood supports the growth of fastidious anaerobic species better than the WC agars do...
- Media- and method-dependent variation in MIC values of ceftizoxime for clinical isolates of the Bacteroides fragilis group
H M Wexler
Research Service, VA Wadsworth Medical Center, Los Angeles, California
J Chemother 3:12-9. 1991
..The results of the broth disk elution procedure were difficult to read and often did not agree with other values...
- Development of a flow chart for identification of gram-positive anaerobic cocci in the clinical laboratory
Yuli Song
Research Service, Veterans Administration Medical Center West Los Angeles, Los Angeles, CA 90073, USA
J Clin Microbiol 45:512-6. 2007
..Based on the results, a short biochemical scheme that involves the minimum essential biochemical tests for accurate identification of clinically important GPAC was developed...
- Mobilization and prevalence of a Fusobacterial plasmid
Brianna M Claypool
Sections of Periodontics, UCLA School of Dentistry, Los Angeles, CA 90095 1668, USA
Plasmid 63:11-9. 2010
..Plasmid or plasmid-related sequences were identified in 11.5% of the strains examined. These findings demonstrate mobilization properties of a fusobacterial plasmid that may be important in horizontal gene transfer...
- Rapid identification of Gram-positive anaerobic coccal species originally classified in the genus Peptostreptococcus by multiplex PCR assays using genus- and species-specific primers
Yuli Song
Research Service, VA Medical Center West Los Angeles, LA, USA yulis
Microbiology 149:1719-27. 2003
..It will permit a more accurate assessment of the role of various GPAC species in infection and of the degree of antimicrobial resistance in each of the group members...
- Isolation of a strictly anaerobic strain of Staphylococcus epidermidis
Marie Claire Rowlinson
Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, California 90095, USA
J Clin Microbiol 44:857-60. 2006
..This paper presents the first documented isolation of a strictly anaerobic Staphylococcus epidermidis strain, confirmed by rpoB gene sequencing...
- Rapid identification of the species of the Bacteroides fragilis group by multiplex PCR assays using group- and species-specific primers
Chengxu Liu
Research Service, VA Medical Center West Los Angeles, Room E3 237, Bldg 304, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
FEMS Microbiol Lett 222:9-16. 2003
..fragilis group species. This will permit more accurate assessment of the role of various B. fragilis group members in infections and of the degree of antimicrobial resistance in each of the group members...
- Anaerotruncus colihominis gen. nov., sp. nov., from human faeces
Paul A Lawson
School of Biosciences, University of Reading, UK
Int J Syst Evol Microbiol 54:413-7. 2004
..nov., sp. nov. The type strain of Anaerotruncus colihominis is WAL 14565(T)=CCUG 45055(T)=CIP 107754(T)...
