Peter Findeisen

Summary

Publications

  1. pmc Transmigration of polymorphnuclear neutrophils and monocytes through the human blood-cerebrospinal fluid barrier after bacterial infection in vitro
    Ulrike Steinmann
    Department of Pediatrics, Pediatric Infectious Diseases, Medical Faculty Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, Mannheim 68167, Germany
    J Neuroinflammation 10:31. 2013
  2. doi request reprint MS-based monitoring of proteolytic decay of synthetic reporter peptides for quality control of plasma and serum specimens
    Peter Findeisen
    Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, Theodor Kutzer Ufer 1, 68167 Mannheim, Germany
    Am J Clin Pathol 140:314-23. 2013
  3. pmc Functional protease profiling with reporter peptides in serum specimens of colorectal cancer patients: demonstration of its routine diagnostic applicability
    Peter Findeisen
    Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, Mannheim, Germany
    J Exp Clin Cancer Res 31:56. 2012
  4. doi request reprint Characterization and identification of proteases secreted by Aspergillus fumigatus using free flow electrophoresis and MS
    Madlen Neustadt
    Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, University Hospital Mannheim, Mannheim, Germany
    Electrophoresis 30:2142-50. 2009
  5. doi request reprint Substrate optimization and clinical validation of reporter peptides for MS-based protease profiling in serum specimens: a new approach for diagnosis of malignant disease
    Diego Yepes
    Institute for Clinical Chemistry, Medical Faculty Mannheim of University of Heidelberg, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Int J Oncol 39:145-54. 2011
  6. doi request reprint Endoprotease profiling with double-tagged peptide substrates: a new diagnostic approach in oncology
    Teresa Peccerella
    Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, University Hospital Mannheim, Mannheim, Germany
    Clin Chem 56:272-80. 2010
  7. doi request reprint Functional protease profiling for diagnosis of malignant disease
    Peter Findeisen
    Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, Heidelberg, Germany
    Proteomics Clin Appl 6:60-78. 2012
  8. doi request reprint Spiking of serum specimens with exogenous reporter peptides for mass spectrometry based protease profiling as diagnostic tool
    Peter Findeisen
    Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, Germany
    Rapid Commun Mass Spectrom 22:1223-9. 2008
  9. ncbi request reprint Multiplex profiling of tumor-associated proteolytic activity in serum of colorectal cancer patients
    Diego Yepes
    Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, University Hospital Mannheim, Mannheim, Germany
    Proteomics Clin Appl 8:308-16. 2014
  10. doi request reprint Serum amyloid A as a prognostic marker in melanoma identified by proteomic profiling
    Peter Findeisen
    Institute for Clinical Chemistry, Medical Faculty Mannheim of University of Heidelberg, Heidelberg, Germany
    J Clin Oncol 27:2199-208. 2009

Collaborators

  • Claudio Kupfahl
  • Dirk Schadendorf
  • Holger Kalthoff
  • Ulrich Bocker
  • Selma Ugurel
  • Peter Kienle
  • Michael Neumaier
  • Diego Yepes
  • Victor Costina
  • Ralf Hofheinz
  • Wilhelm Schneiderhan
  • Ulrike Steinmann
  • Julia Weh
  • René Hummerich
  • Tobias B Schuster
  • Teresa Peccerella
  • Madlen Neustadt
  • Dieter Buchheidt
  • René Schaal
  • Lothar R Pilz
  • Horst Schroten
  • Birgit Schröppel
  • Matthias Ebert
  • Julia Borkowski
  • Tobias Tenenbaum
  • Christel Weiss
  • Christoph Antoni
  • Christel Weiß
  • Alexander Grundt
  • Christian Schwerk
  • Stefan Wörner
  • Hartwig Wolburg
  • Hiroshi Ishikawa
  • Patrick Schloss
  • Dusan Bartsch
  • Jörg Oliver Thumfart
  • Anette Jacob
  • Parviz Ahmad-Nejad
  • Marc Dauber
  • Nadine Lukan
  • Markus Kostrezewa
  • Christoph Eckerskorn

Detail Information

Publications19

  1. pmc Transmigration of polymorphnuclear neutrophils and monocytes through the human blood-cerebrospinal fluid barrier after bacterial infection in vitro
    Ulrike Steinmann
    Department of Pediatrics, Pediatric Infectious Diseases, Medical Faculty Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, Mannheim 68167, Germany
    J Neuroinflammation 10:31. 2013
    ..In this study, we analyzed the cellular and molecular mechanisms of polymorphonuclear neutrophil (PMN) and monocyte transepithelial transmigration (TM) across the BCSFB after bacterial infection...
  2. doi request reprint MS-based monitoring of proteolytic decay of synthetic reporter peptides for quality control of plasma and serum specimens
    Peter Findeisen
    Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, Theodor Kutzer Ufer 1, 68167 Mannheim, Germany
    Am J Clin Pathol 140:314-23. 2013
    ..To determine the preanalytical quality of serum and plasma by monitoring the time-dependent ex vivo decay of a synthetic reporter peptide (RP) with liquid chromatography/mass spectrometry (LC/MS)...
  3. pmc Functional protease profiling with reporter peptides in serum specimens of colorectal cancer patients: demonstration of its routine diagnostic applicability
    Peter Findeisen
    Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, Mannheim, Germany
    J Exp Clin Cancer Res 31:56. 2012
    ..Here we describe a mass spectrometry-based functional proteomic profiling approach that tracks the ex-vivo degradation of a synthetic endoprotease substrate in serum specimens of colorectal tumor patients...
  4. doi request reprint Characterization and identification of proteases secreted by Aspergillus fumigatus using free flow electrophoresis and MS
    Madlen Neustadt
    Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, University Hospital Mannheim, Mannheim, Germany
    Electrophoresis 30:2142-50. 2009
    ..Furthermore, several proteases were identified that facilitate the optimization of reporter peptides for functional protease profiling as a diagnostic tool for invasive aspergillosis...
  5. doi request reprint Substrate optimization and clinical validation of reporter peptides for MS-based protease profiling in serum specimens: a new approach for diagnosis of malignant disease
    Diego Yepes
    Institute for Clinical Chemistry, Medical Faculty Mannheim of University of Heidelberg, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Int J Oncol 39:145-54. 2011
    ..Furthermore, the combination of different RPs can additionally increase the classification accuracy of functional protease profiling, and this in turn could lead to improved diagnosis, monitoring and prognosis of malignant disease...
  6. doi request reprint Endoprotease profiling with double-tagged peptide substrates: a new diagnostic approach in oncology
    Teresa Peccerella
    Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, University Hospital Mannheim, Mannheim, Germany
    Clin Chem 56:272-80. 2010
    ..We developed a mass spectrometry (MS)-based functional proteomic profiling approach that tracks degradation of artificial endoprotease substrates in serum specimens...
  7. doi request reprint Functional protease profiling for diagnosis of malignant disease
    Peter Findeisen
    Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, Heidelberg, Germany
    Proteomics Clin Appl 6:60-78. 2012
    ..Thereby, we focus on the potential diagnostic use of the respective approaches...
  8. doi request reprint Spiking of serum specimens with exogenous reporter peptides for mass spectrometry based protease profiling as diagnostic tool
    Peter Findeisen
    Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, Germany
    Rapid Commun Mass Spectrom 22:1223-9. 2008
    ..RPS circumvents preanalytical variabilities and improves classification accuracies. Our approach will be helpful to introduce MS-based proteomic profiling into routine laboratory testing...
  9. ncbi request reprint Multiplex profiling of tumor-associated proteolytic activity in serum of colorectal cancer patients
    Diego Yepes
    Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, University Hospital Mannheim, Mannheim, Germany
    Proteomics Clin Appl 8:308-16. 2014
    ..In this paper, we describe the screening of a peptide library for identification of reporter peptides (RPs) that are selectively cleaved in serum specimens from colorectal cancer patients and investigate the benefits of RP multiplexing...
  10. doi request reprint Serum amyloid A as a prognostic marker in melanoma identified by proteomic profiling
    Peter Findeisen
    Institute for Clinical Chemistry, Medical Faculty Mannheim of University of Heidelberg, Heidelberg, Germany
    J Clin Oncol 27:2199-208. 2009
    ..This study was aimed to identify new prognostic biomarkers of melanoma by serum mass spectrometry (MS) proteomic profiling, and to validate candidates compared with established markers...
  11. ncbi request reprint Systematic identification and validation of candidate genes for detection of circulating tumor cells in peripheral blood specimens of colorectal cancer patients
    Peter Findeisen
    Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, 68167 Mannheim, Germany
    Int J Oncol 33:1001-10. 2008
    ..In conclusion SERPINB5 seems to be a promising marker for detection of circulating tumor cells in peripheral blood of colorectal cancer patients...
  12. ncbi request reprint Systematic identification of substrates for profiling of secreted proteases from Aspergillus species
    René Schaal
    Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    J Microbiol Methods 71:93-100. 2007
    ..These reporter peptides might be feasible for future protease profiling of serum specimens to improve diagnosis and monitoring of invasive aspergillosis...
  13. doi request reprint Mass spectrometry based proteomics profiling as diagnostic tool in oncology: current status and future perspective
    Peter Findeisen
    Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, Heidelberg, Germany
    Clin Chem Lab Med 47:666-84. 2009
    ..The promises and challenges of this new technology are discussed with particular emphasis on diagnostic perspectives of mass-spectrometry based proteomics profiling for malignant diseases...
  14. ncbi request reprint The future of targeted peptidomics
    Peter Findeisen
    Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany
    Proteomics Clin Appl 7:721-2. 2013
    ..We anticipate that validation of new biomarkers will speed up with this technology and the palette of laboratory-based diagnostic tools will hopefully be augmented significantly in the near future. ..
  15. ncbi request reprint Preanalytical impact of sample handling on proteome profiling experiments with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    Peter Findeisen
    Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, Germany
    Clin Chem 51:2409-11. 2005
  16. doi request reprint Transglutaminase-mediated transamidation of serotonin, dopamine and noradrenaline to fibronectin: evidence for a general mechanism of monoaminylation
    René Hummerich
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    FEBS Lett 586:3421-8. 2012
    ..All three biogenic monoamines also block TGase-mediated transamidation of another monoamine, monodansylacadaverine, into fibronectin, suggesting a general mechanism of TGase-mediated "monoaminylation"...
  17. doi request reprint Identification and functional characterization of 14-3-3 in TLR2 signaling
    Tobias B Schuster
    Institute for Clinical Chemistry, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    J Proteome Res 10:4661-70. 2011
    ..Our results identify 14-3-3 theta as a new and important regulatory protein in the TLR signaling suppressing the MyD88-dependent pathway...
  18. doi request reprint Discriminatory potential of C-reactive protein, cytokines, and fecal markers in infectious gastroenteritis in adults
    Julia Weh
    Department of Medicine II, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Diagn Microbiol Infect Dis 77:79-84. 2013
    ..To differentiate between bacterial and viral gastroenteritis, CRP, serum IFNγ, and the fecal proteins lactoferrin and calprotectin may be useful. A corresponding algorithm should be evaluated prospectively. ..
  19. doi request reprint Work flow analysis of around-the-clock processing of blood culture samples and integrated MALDI-TOF mass spectrometry analysis for the diagnosis of bloodstream infections
    Wilhelm Schneiderhan
    Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany
    Clin Chem 59:1649-56. 2013
    ..The effectiveness of MALDI-TOF mass spectrometry (MALDI-TOF MS) analysis in reducing turnaround times (TATs) for blood culture (BC) pathogen identification when available in a 24-h hospital setting has not been determined...