Fabian V Filipp

Summary

Publications

  1. pmc Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells
    Fabian V Filipp
    Sanford Burnham Medical Research Institute, Cancer Research Center, La Jolla, CA, USA
    Pigment Cell Melanoma Res 25:375-83. 2012
  2. pmc Glutamine-fueled mitochondrial metabolism is decoupled from glycolysis in melanoma
    Fabian V Filipp
    Cancer Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    Pigment Cell Melanoma Res 25:732-9. 2012
  3. pmc Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect
    David A Scott
    Cancer Research Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Biol Chem 286:42626-34. 2011
  4. pmc Unusual binding of ursodeoxycholic acid to ileal bile acid binding protein: role in activation of FXRα
    Changming Fang
    Cancer Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    J Lipid Res 53:664-73. 2012

Collaborators

  • Jeffrey W Smith
  • Changming Fang
  • David A Scott
  • Ze ev A Ronai
  • Adam D Richardson
  • Andrei L Osterman
  • Gary G Chiang
  • Christine A Knutzen

Detail Information

Publications4

  1. pmc Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells
    Fabian V Filipp
    Sanford Burnham Medical Research Institute, Cancer Research Center, La Jolla, CA, USA
    Pigment Cell Melanoma Res 25:375-83. 2012
    ..This reductive carboxylation is catalyzed by two isocitrate dehydrogenases, IDH1 and IDH2. Their combined action is necessary and sufficient to effect the reverse TCA flux and maintain cellular viability...
  2. pmc Glutamine-fueled mitochondrial metabolism is decoupled from glycolysis in melanoma
    Fabian V Filipp
    Cancer Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    Pigment Cell Melanoma Res 25:732-9. 2012
    ..Biosynthetic networks linked with non-essential amino acids alanine, serine, arginine, and proline are also significantly impacted by the use of glutamine as an alternate carbon source...
  3. pmc Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect
    David A Scott
    Cancer Research Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Biol Chem 286:42626-34. 2011
    ..Altogether, this study, which is the first comprehensive comparative analysis of metabolism in melanoma cells, provides a foundation for targeting metabolism for therapeutic benefit in melanoma...
  4. pmc Unusual binding of ursodeoxycholic acid to ileal bile acid binding protein: role in activation of FXRα
    Changming Fang
    Cancer Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    J Lipid Res 53:664-73. 2012
    ..Furthermore, IBABP is necessary for the full activation of farnesoid X receptor α (FXRα) by bile acids, including UDCA. These observations suggest that IBABP may have a role in mediating some of the intestinal effects of UDCA...