Calluna vulgaris extract modulates NF-κB/ERK signaling pathway and matrix metalloproteinase expression in SKH-1 hairless mice skin exposed to ultraviolet B irradiationG A Filip
Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
J Physiol Pharmacol 63:423-32. 2012
..0001) and decreased TIMP-1 level (p<0.001). These results demonstrated the dual behavior of Cv extract in skin protection against single versus multiple doses of UVB irradiation...
The effects of grape seeds polyphenols on SKH-1 mice skin irradiated with multiple doses of UV-BAdriana Filip
Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, 1 3 Clinicilor str, 400012 Cluj Napoca, Romania
J Photochem Photobiol B 105:133-42. 2011
..Our results suggest that BM extract might be a potential chemo-preventive candidate in reducing the oxidative stress and apoptosis induced by multiple doses of UV-B in skin...
- Chemopreventive effects of Calluna vulgaris and Vitis vinifera extracts on UVB-induced skin damage in SKH-1 hairless mice
A Filip
Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
J Physiol Pharmacol 62:385-92. 2011
..0001). Our results suggest that BM extracts might be a potential candidate in preventing the damages induced by UV in skin...
- Photoprotective effects of two natural products on ultraviolet B-induced oxidative stress and apoptosis in SKH-1 mouse skin
Adriana Filip
Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
J Med Food 14:761-6. 2011
..These results suggest that C. vulgaris and BM extracts might be chemopreventive candidates for reducing UV-induced risk for skin cancer...
- Possible in vivo mechanisms involved in photodynamic therapy using tetrapyrrolic macrocycles
A G Filip
Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
Braz J Med Biol Res 44:53-61. 2011
..These results suggest that PDT activates the innate immune system and that the effects of PDT with TMPP and ZnTMPP are mediated by reactive oxygen species, which induce cell membrane damage and apoptosis...
- Photodynamic therapy--indications and limits in malignant tumors treatment
Adriana Gabriela Filip
Physiology Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
Rom J Intern Med 46:285-93. 2008
..Despite the promising results from earlier clinical trials of PDT considerable additional work is needed to bring this new modality of treatment into modern clinical practice...
- Photochemoprevention of cutaneous neoplasia through natural products
A Filip
Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy Cluj Napoca 400023, Romania
Exp Oncol 31:9-15. 2009
..We also discuss the current state of knowledge on their photosuppression mechanism in humans as well as in animal models, and efficiency in cancer prevention...
- Effects of PDT with 5-aminolevulinic acid and chitosan on Walker carcinosarcoma
A Filip
Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
Exp Oncol 30:212-9. 2008
..Porphyrins and new chitosan hydrogels based composites with porphyrins are used as active cytotoxic antitumor agents in photodynamic therapy (PDT)...
- Studies on antioxidant effects of the red grapes seed extract from Vitis vinifera, Burgund Mare, Recaş in pregnant rats
Adriana Muresan
Iuliu Hatieganu, University of Medicine and Pharmacy, Cluj Napoca, Romania, Cluj Napoca, Romania
Acta Physiol Hung 97:240-6. 2010
..In conclusion, in the chosen dose, the red grapes seed extract enhanced the plasma antioxidant capacity and did not influence the nitric oxide levels in pregnant rats...
- The dynamics of reactive oxygen species in photodynamic therapy with tetra sulfophenyl-porphyrin
Simona Clichici
Physiology Department, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
Acta Physiol Hung 97:41-51. 2010
..The MMP-2 activity increases exponentially in the 24 hours-14 days post PDT interval. PDT with TSPP offers, in vivo , consistent results regarding ROS generation, MMP2 activation and cytotoxic capacity...
- Iodide excess exerts oxidative stress in some target tissues of the thyroid hormones
A E Joanta
Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, Str Emil Isac nr 13, 400023 Cluj Napoca, Romania
Acta Physiol Hung 93:347-59. 2006
..Selenium supplementation had opposite effects. Present data allow us to conclude that the alterations due to iodide excess in thyroid gland, hepatic tissue and in blood are mediated through oxidative stress...
- Photodynamic therapy in melanoma--an update
I Baldea
Department of Physiology, University of Medicine and Pharmacy, Cluj Napoca, Romania
J Physiol Pharmacol 63:109-18. 2012
..Combination of PDT with immune stimulation therapies might increase the efficiency in destroying the initial tumor as well as micro metastases and decrease the melanoma relapses...
