Isidre Ferrer

Summary

Publications

  1. ncbi request reprint Phenotypic patterns of desminopathy associated with three novel mutations in the desmin gene
    Montse Olive
    Institut de Neuropatologia, IDIBELL Hospital de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain
    Neuromuscul Disord 17:443-50. 2007
  2. doi request reprint Cognitive impairment of vascular origin: neuropathology of cognitive impairment of vascular origin
    Isidre Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, 08907 Hospitalet de Llobregat, Spain
    J Neurol Sci 299:139-49. 2010
  3. doi request reprint Neuronal hemoglobin is reduced in Alzheimer's disease, argyrophilic grain disease, Parkinson's disease, and dementia with Lewy bodies
    Isidro Ferrer
    Institut Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain Instituto Carlos III, Madrid, Spain
    J Alzheimers Dis 23:537-50. 2011
  4. pmc Neuropathology and neurochemistry of nonmotor symptoms in Parkinson's disease
    Isidro Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, carrer Feixa Llarga sn, CIBERNED, 08907 Hospitalet de Llobregat, Spain
    Parkinsons Dis 2011:708404. 2011
  5. pmc Coexistence of protease sensitive and resistant prion protein in 129VV homozygous sporadic Creutzfeldt-Jakob disease: a case report
    Ana B Rodríguez-Martínez
    Department of Animal Health, NEIKER Tecnalia, Berreaga 1, Derio, Bizkaia, 48160, Spain
    J Med Case Rep 6:348. 2012
  6. pmc A highly expressed miR-101 isomiR is a functional silencing small RNA
    Franc Llorens
    Molecular and Cellular Neurobiotechnology Group, Institut de Bioenginyeria de Catalunya, Parc Cientific de Barcelona, Barcelona, Spain
    BMC Genomics 14:104. 2013
  7. ncbi request reprint Triheptanoin supplementation to ketogenic diet curbs cognitive impairment in APP/PS1 mice used as a model of familial Alzheimer's disease
    Ester Aso
    Institut de Neuropatologia, Servei d Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, L Hospitalet de Llobregat, Spain
    Curr Alzheimer Res 10:290-7. 2013
  8. ncbi request reprint Defining Alzheimer as a common age-related neurodegenerative process not inevitably leading to dementia
    Isidro Ferrer
    Institute of Neuropathology, University Hospital Bellvitge, University of Barcelona, IDIBELL, CIBERNED, Spain
    Prog Neurobiol 97:38-51. 2012
  9. ncbi request reprint PP2A and Alzheimer disease
    L Torrent
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Spain
    Curr Alzheimer Res 9:248-56. 2012
  10. pmc A novel form of human disease with a protease-sensitive prion protein and heterozygosity methionine/valine at codon 129: Case report
    Ana B Rodríguez-Martínez
    Department of Animal Health, NEIKER Tecnalia, Berreaga 1, 48160 Derio, Bizkaia, Spain
    BMC Neurol 10:99. 2010

Collaborators

Detail Information

Publications79

  1. ncbi request reprint Phenotypic patterns of desminopathy associated with three novel mutations in the desmin gene
    Montse Olive
    Institut de Neuropatologia, IDIBELL Hospital de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain
    Neuromuscul Disord 17:443-50. 2007
    ....
  2. doi request reprint Cognitive impairment of vascular origin: neuropathology of cognitive impairment of vascular origin
    Isidre Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, 08907 Hospitalet de Llobregat, Spain
    J Neurol Sci 299:139-49. 2010
    ....
  3. doi request reprint Neuronal hemoglobin is reduced in Alzheimer's disease, argyrophilic grain disease, Parkinson's disease, and dementia with Lewy bodies
    Isidro Ferrer
    Institut Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain Instituto Carlos III, Madrid, Spain
    J Alzheimers Dis 23:537-50. 2011
    ....
  4. pmc Neuropathology and neurochemistry of nonmotor symptoms in Parkinson's disease
    Isidro Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, carrer Feixa Llarga sn, CIBERNED, 08907 Hospitalet de Llobregat, Spain
    Parkinsons Dis 2011:708404. 2011
    ..These alterations appear at early stages of the disease and may precede by years the appearance of cell loss and cortical atrophy...
  5. pmc Coexistence of protease sensitive and resistant prion protein in 129VV homozygous sporadic Creutzfeldt-Jakob disease: a case report
    Ana B Rodríguez-Martínez
    Department of Animal Health, NEIKER Tecnalia, Berreaga 1, Derio, Bizkaia, 48160, Spain
    J Med Case Rep 6:348. 2012
    ..abstract:..
  6. pmc A highly expressed miR-101 isomiR is a functional silencing small RNA
    Franc Llorens
    Molecular and Cellular Neurobiotechnology Group, Institut de Bioenginyeria de Catalunya, Parc Cientific de Barcelona, Barcelona, Spain
    BMC Genomics 14:104. 2013
    ..Here we have characterized the expression and function of a highly abundant miR-101 5'-trimming variant (5'-isomiR-101)...
  7. ncbi request reprint Triheptanoin supplementation to ketogenic diet curbs cognitive impairment in APP/PS1 mice used as a model of familial Alzheimer's disease
    Ester Aso
    Institut de Neuropatologia, Servei d Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, L Hospitalet de Llobregat, Spain
    Curr Alzheimer Res 10:290-7. 2013
    ..Present findings support the concept that ketogenic diets supplemented with anaplerotic compounds can be considered potential therapeutic strategies at early stages of Alzheimer's disease...
  8. ncbi request reprint Defining Alzheimer as a common age-related neurodegenerative process not inevitably leading to dementia
    Isidro Ferrer
    Institute of Neuropathology, University Hospital Bellvitge, University of Barcelona, IDIBELL, CIBERNED, Spain
    Prog Neurobiol 97:38-51. 2012
    ..In this context, the first stages of Alzheimer should be considered as primary targets of therapeutic intervention in order to prevent progression to diseased states...
  9. ncbi request reprint PP2A and Alzheimer disease
    L Torrent
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Spain
    Curr Alzheimer Res 9:248-56. 2012
    ..In spite of these achievements further studies are needed to replicate the reported individual different alterations converging in PP2A in AD...
  10. pmc A novel form of human disease with a protease-sensitive prion protein and heterozygosity methionine/valine at codon 129: Case report
    Ana B Rodríguez-Martínez
    Department of Animal Health, NEIKER Tecnalia, Berreaga 1, 48160 Derio, Bizkaia, Spain
    BMC Neurol 10:99. 2010
    ..This disease shows a distinct clinical and neuropathological phenotype and it is associated to an abnormal prion protein more sensitive to protease digestion...
  11. doi request reprint General aspects and neuropathology of X-linked adrenoleukodystrophy
    Isidro Ferrer
    Institut Neuropatologia, Servei Anatomia Patològica, Institut d Investigació Biomèdica de Bellvitge IDIBELL Hospital Universitari de Bellvitge, Hospitalet de Llobregat, CIBERNED, Spain
    Brain Pathol 20:817-30. 2010
    ....
  12. doi request reprint Altered mitochondria, energy metabolism, voltage-dependent anion channel, and lipid rafts converge to exhaust neurons in Alzheimer's disease
    Isidre Ferrer
    Institut Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, CIBERNED, carrer Feixa Llarga s n, Hospitalet de Llobregat, Spain
    J Bioenerg Biomembr 41:425-31. 2009
    ..Cell exhaustion is suggested as being a determining element to interpret impaired neuron function, reduced molecular turnover, and enhanced cell death...
  13. doi request reprint Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: preclinical Parkinson disease
    Isidre Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, CIBERNED, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Spain
    J Neural Transm 118:821-39. 2011
    ....
  14. ncbi request reprint Molecular pathology of myofibrillar myopathies
    Isidre Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Spain
    Expert Rev Mol Med 10:e25. 2008
    ....
  15. ncbi request reprint Type-dependent oxidative damage in frontotemporal lobar degeneration: cortical astrocytes are targets of oxidative damage
    Anna Martinez
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Spain
    J Neuropathol Exp Neurol 67:1122-36. 2008
    ..Astrocytes are, therefore, crucial elements of oxidative stress responses in FTLD...
  16. pmc Oxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophy
    Jone López-Erauskin
    Neurometabolic Diseases Laboratory, Institute of Neuropathology, IDIBELL, 08908 L Hospitalet de Llobregat, Barcelona, Catalonia, Spain
    Brain 135:3584-98. 2012
    ..These findings provide mechanistic insight into the beneficial effects of antioxidants in neurodegenerative and non-neurodegenerative cyclophilin D-dependent disorders...
  17. doi request reprint DNA methylation and Yin Yang-1 repress adenosine A2A receptor levels in human brain
    Sandra P Buira
    Institut de Neuropatologia, Servei d Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, L Hospitalet de Llobregat, Spain
    J Neurochem 115:283-95. 2010
    ....
  18. ncbi request reprint TAR DNA-Binding protein 43 accumulation in protein aggregate myopathies
    Montse Olive
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Spain
    J Neuropathol Exp Neurol 68:262-73. 2009
    ....
  19. ncbi request reprint Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease
    Ester Angulo
    Department of Biochemistry and Molecular Biology, School of Chemistry, Universitat de Barcelona, 08028 Barcelona, Spain
    J Neurochem 91:547-57. 2004
    ..Thus, Kv3.4 likely represents a novel therapeutic target for the disease...
  20. doi request reprint Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington's disease
    Izaskun Villar-Menéndez
    Institute of Neuropathology, Bellvitge University Hospital ICS, Bellvitge Biomedical Research Institute IDIBELL, c Feixa Llarga s n, 08908, L Hospitalet de Llobregat, Spain
    Neuromolecular Med 15:295-309. 2013
    ..Therefore, an altered DNA methylation pattern in ADORA2A seems to play a role in the pathologically decreased A2AR expression levels found in HD...
  21. ncbi request reprint Dopamine induces autophagic cell death and alpha-synuclein increase in human neuroblastoma SH-SY5Y cells
    Cristina Gómez-Santos
    Unitat de Bioquimica, Departament de Ciències Fisiològiques II, Universitat de Barcelona, Barcelona, Spain
    J Neurosci Res 73:341-50. 2003
    ..The results show that nonapoptotic death pathways are triggered by dopamine, leading to autophagy. These findings should be taken into account in the search for strategies to protect dopaminergic neurons from degeneration...
  22. doi request reprint Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy
    Stephane Fourcade
    Centre de Genètica Mèdica i Molecular, Institut d Investigació Biomèdica de Bellvitge IDIBELL, Hospitalet de Llobregat, Barcelona, Spain
    Hum Mol Genet 17:1762-73. 2008
    ..These results pave the way for the identification of therapeutic targets that could reverse the deregulated response to oxidative stress in X-ALD...
  23. ncbi request reprint Oxidative stress regulates the ubiquitin-proteasome system and immunoproteasome functioning in a mouse model of X-adrenoleukodystrophy
    Nathalie Launay
    Neurometabolic Diseases Laboratory, Institute of Neuropathology, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain
    Brain 136:891-904. 2013
    ..Our findings support a key role of i-proteasomes in quality control in mitochondria during oxidative damage in X-linked adrenoleukodystrophy, and perhaps in other neurodegenerative conditions with similar pathogeneses...
  24. ncbi request reprint Active stress kinase p38 enhances and perpetuates abnormal tau phosphorylation and deposition in Pick's disease
    Berta Puig
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital de Bellvitge, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Acta Neuropathol 107:185-9. 2004
    ....
  25. ncbi request reprint Abnormal alpha-synuclein solubility, aggregation and nitration in the frontal cortex in Pick's disease
    Esther Dalfo
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Neurosci Lett 400:125-9. 2006
    ..These findings demonstrate abnormal and distinct alpha-synuclein solubility and aggregation, and alpha-synuclein nitration without formation of Lewy bodies in the frontal cortex in PiD...
  26. doi request reprint DNA methylation regulates adenosine A(2A) receptor cell surface expression levels
    Sandra P Buira
    Institut de Neuropatologia, Servei d Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, L Hospitalet de Llobregat, Spain
    J Neurochem 112:1273-85. 2010
    ..Therefore, these results show for the first time that DNA methylation plays a role in ADORA2A transcription and, subsequently, in constitutive A(2A)R cell surface levels...
  27. doi request reprint Modification of brain lipids but not phenotype in alpha-synucleinopathy transgenic mice by long-term dietary n-3 fatty acids
    Gerard Muntane
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Hospitalet de Llobregat, CIBERNED, Barcelona, Spain
    Neurochem Int 56:318-28. 2010
    ..The present results show that diets may modify brain lipid composition and susceptibility to oxidative damage that do not interfere with phenotype in models with a genetic susceptibility to develop alpha-synucleinopathy...
  28. pmc Target genes of neuron-restrictive silencer factor are abnormally up-regulated in human myotilinopathy
    Marta Barrachina
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, carrer Feixa Llarga sn, 08907 L Hospitalet de Llobregat, Spain
    Am J Pathol 171:1312-23. 2007
    ....
  29. doi request reprint Glial and neuronal tau pathology in tauopathies: characterization of disease-specific phenotypes and tau pathology progression
    Isidre Ferrer
    From the Institut de Neuropatologia IF, IL G, MC, LA, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, CIBERNED Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas Neurometabolic Disease Lab ED, IDIBELL Hospital Universitari de Bellvitge, Hospitalet de Llobregat, CIBERER Centro de Investigación Biomédica en Red de Enfermedades Raras Unitat de Biologia BT E, Serveis Cientifics I Tecnics, Universitat de Barcelona, Hospitalet de Llobregat, Spain Sao Paulo Brain Bank, Brazil RD and Institute of Neurology, Medical University of Vienna, Austria GG K
    J Neuropathol Exp Neurol 73:81-97. 2014
    ..These observations indicate that tau pathology in glial cells largely parallels, but is not identical to, that in neurons in many tauopathies. ..
  30. ncbi request reprint Risk of transmission of systemic transthyretin amyloidosis after domino liver transplantation
    Laura Llado
    Departments of Surgery, Liver Transplant Unit, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain
    Liver Transpl 16:1386-92. 2010
    ..Sural nerve biopsy with EMG and clinical correlation is mandatory for confirming the disease. Indeed, other causes of neuropathy should be excluded. Liver Transpl 16:1386-1392, 2010. © 2010 AASLD...
  31. ncbi request reprint Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid
    Carme Pelegri
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
    Int J Dev Neurosci 26:665-71. 2008
    ..These results indicate that cell cycle re-entry is activated in Huntington's disease and may contribute to the neurodegenerative process...
  32. doi request reprint Activation of ataxia telangiectasia muted under experimental models and human Parkinson's disease
    Antoni Camins
    Institut de Biomedicina, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona, Spain
    Cell Mol Life Sci 67:3865-82. 2010
    ..Therefore, this study demonstrates a new link between DNA damage by MPP(+) and cell-cycle re-entry through retinoblastoma protein phosphorylation...
  33. doi request reprint Involvement of the cerebral cortex in Parkinson disease linked with G2019S LRRK2 mutation without cognitive impairment
    Anna Gomez
    Institut de Neuropatologia, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Spain
    Acta Neuropathol 120:155-67. 2010
    ..These findings show that the cerebral cortex in familial PD linked with G2019S LRRK2 is affected in a similar way than that seen in sporadic PD without cognitive impairment...
  34. ncbi request reprint Oxidative stress in desminopathies and myotilinopathies: a link between oxidative damage and abnormal protein aggregation
    Anna Janué
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge CIBERNED, Hospitalet de Llobregat, Barcelona, Spain
    Brain Pathol 17:377-88. 2007
    ..As oxidized proteins are vulnerable to misfolding and are resistant to degradation by the UPS, the present observations support a link between oxidative stress, protein aggregation and abnormal protein deposition in MFMs...
  35. ncbi request reprint Increased striatal adenosine A2A receptor levels is an early event in Parkinson's disease-related pathology and it is potentially regulated by miR-34b
    Izaskun Villar-Menéndez
    Institute of Neuropathology, Bellvitge University Hospital ICS, Bellvitge Biomedical Research Institute IDIBELL, L Hospitalet de Llobregat, Spain
    Neurobiol Dis 69:206-14. 2014
    ....
  36. doi request reprint PrP(C) regulates epidermal growth factor receptor function and cell shape dynamics in Neuro2a cells
    Franc Llorens
    Molecular and Cellular Neurobiotechnology Group, Institute for Bioengineering of Catalonia IBEC, Barcelona Science Park, Barcelona, Spain Department of Cell Biology, University of Barcelona UB, Barcelona, Spain Center for Networker Biomedical Research in Neurodegenerative Diseases CIBERNED, Barcelona, Spain Institute of Neuropathology, Bellvitge Biomedical Research Institute, Hospitalet de Llobregat, Spain
    J Neurochem 127:124-38. 2013
    ..We also describe how PrP(C) over-expression modulates filopodia formation by Rho GTPase regulation mainly in an AKT-Cdc42-N-WASP-dependent pathway...
  37. ncbi request reprint Dystrophic neurites of senile plaques in Alzheimer's disease are deficient in cytochrome c oxidase
    Esther Pérez-Gracia
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Facultat de Medicina, Universitat de Barcelona, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, CIBERNED, Spain
    Acta Neuropathol 116:261-8. 2008
    ..These findings support a local link between amyloid deposition, abnormal mitochondria and impaired respiratory chain function (resulting from decrease of COX expression) in dystrophic neurites of senile plaques in AD...
  38. ncbi request reprint Characterization of thorn-shaped astrocytes in white matter of temporal lobe in Alzheimer's disease brains
    Irene López-González
    CIBERNED Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Institut de Neuropatologia, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Spain
    Brain Pathol 23:144-53. 2013
    ..These observations support the concept that tau lesions in neurons differ from those seen in TsA in AD...
  39. doi request reprint Functional genomics reveals dysregulation of cortical olfactory receptors in Parkinson disease: novel putative chemoreceptors in the human brain
    Paula Garcia-Esparcia
    Institut de Neuropatologia, IDIBELL Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain
    J Neuropathol Exp Neurol 72:524-39. 2013
    ..Together, these findings support the concept that ORs and TASRs in the cerebral cortex may have novel physiologic functions that are affected in PD patients...
  40. pmc Oxidative damage compromises energy metabolism in the axonal degeneration mouse model of X-adrenoleukodystrophy
    Jorge Galino
    Neurometabolic Diseases Laboratory, Institut d Investigacio Biomedica de Bellvitge, Hospitalet de Llobregat, Gran Via 199, Barcelona, Spain
    Antioxid Redox Signal 15:2095-107. 2011
    ..Oxidative stress due to VLCFA excess appears early in the neurodegenerative cascade...
  41. doi request reprint Delineation of early changes in cases with progressive supranuclear palsy-like pathology. Astrocytes in striatum are primary targets of tau phosphorylation and GFAP oxidation
    Gabriel Santpere
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, carrer Feixa Llarga s n, Hospitalet de Llobregat, Spain
    Brain Pathol 19:177-87. 2009
    ....
  42. doi request reprint Clinical and myopathological evaluation of early- and late-onset subtypes of myofibrillar myopathy
    Montse Olive
    Institute of Neuropathology, Department of Pathology, IDIBELL Hospital de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain
    Neuromuscul Disord 21:533-42. 2011
    ....
  43. ncbi request reprint Effects of formalin fixation, paraffin embedding, and time of storage on DNA preservation in brain tissue: a BrainNet Europe study
    Isidre Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, 08907 Hospitalet de Llobregat, Spain
    Brain Pathol 17:297-303. 2007
    ..Genomiphi and TaKaRa Ex Taq methods were also assayed in paraffin blocks and in formalin-fixed samples with limited success...
  44. ncbi request reprint Expression of transcription factors c-Fos, c-Jun, CREB-1 and ATF-2, and caspase-3 in relation with abnormal tau deposits in Pick's disease
    María Nieto-Bodelón
    Unitat de Neuropatologia Experimental, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain
    Acta Neuropathol 111:341-50. 2006
    ..The present findings are in line with the previous studies showing tau products cleaved by caspase-3, as recognized by specific tau-cleaved antibodies, in Alzheimer's disease and other tauopathies...
  45. doi request reprint Increased oxidation of certain glycolysis and energy metabolism enzymes in the frontal cortex in Lewy body diseases
    Anna Gomez
    Institut Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain
    J Neurosci Res 87:1002-13. 2009
    ..Modifications of these enzymes may result in decreased activity and may partly account for impaired metabolism and function of the frontal lobe in PD...
  46. doi request reprint Reduced striatal adenosine A2A receptor levels define a molecular subgroup in schizophrenia
    Izaskun Villar-Menéndez
    Institute of Neuropathology, Bellvitge University Hospital ICS, Bellvitge Biomedical Research Institute IDIBELL, L Hospitalet de Llobregat, Spain
    J Psychiatr Res 51:49-59. 2014
    ..Therefore, there may be a subgroup of SZ patients with reduced striatal A2AR levels accompanied by an altered motor phenotype. ..
  47. ncbi request reprint TGF-beta1 increases tyrosine hydroxylase expression by a mechanism blocked by BMP-2 in human neuroblastoma SH-SY5Y cells
    Cristina Gómez-Santos
    Unitat de Bioquimica, Departament de Ciències Fisiològiques II, Campus de Bellvitge, Universitat de Barcelona, c Feixa Llarga s n, E 08907 Hospitalet del Llobregat, Barcelona, Spain
    Brain Res 958:152-60. 2002
    ..In conclusion, our results suggest that TGF-beta1 and BMP-2 may contribute, in opposite ways, to regulation of the neuronal catecholaminergic phenotype...
  48. doi request reprint Brain banks: benefits, limitations and cautions concerning the use of post-mortem brain tissue for molecular studies
    Isidre Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Spain
    Cell Tissue Bank 9:181-94. 2008
    ..Most brains are appropriate for morphological approaches but not all brains are useful for certain biochemical and molecular studies...
  49. ncbi request reprint Evidence of oxidative stress in the neocortex in incidental Lewy body disease
    Esther Dalfo
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Spain
    J Neuropathol Exp Neurol 64:816-30. 2005
    ..These findings further support antioxidant therapy in the treatment of PD to reduce cortical damage associated with oxidative stress...
  50. pmc A myriad of miRNA variants in control and Huntington's disease brain regions detected by massively parallel sequencing
    Eulalia Marti
    Genetic Causes of Disease Group, Genes and Disease Program, Centre for Genomic Regulation CRG, Catalonia, Spain
    Nucleic Acids Res 38:7219-35. 2010
    ..Our results show that miRNA variability is a ubiquitous phenomenon in the adult human brain, which may influence gene expression in physiological and pathological conditions...
  51. doi request reprint Early involvement of the cerebral cortex in Parkinson's disease: convergence of multiple metabolic defects
    Isidre Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, carrer Feixa Llarga sn, Hospitalet de Llobregat, CIBERNED, Spain
    Prog Neurobiol 88:89-103. 2009
    ..Lewy pathology is a relative late event, geared to isolate unremoved damaged protein, with little significance on cortical neurological deficits...
  52. doi request reprint Protein targets of oxidative damage in human neurodegenerative diseases with abnormal protein aggregates
    Anna Martinez
    Institut de Neuropatologia, Institut d Investigacio de Bellvitge Hospital Universitari de Bellvitge, Universitat de Barcelona, Centro de Inbvestigación Biomédica en Red de Enfermedades Neurodegenerativas, Spain
    Brain Pathol 20:281-97. 2010
    ..A better understanding of proteins susceptible to oxidation and nitration may serve to define damaged metabolic networks at early stages of disease and to advance therapeutic interventions to attenuate disease progression...
  53. ncbi request reprint Low molecular weight species of tau in Alzheimer's disease are dependent on tau phosphorylation sites but not on delayed post-mortem delay in tissue processing
    Gabriel Santpere
    Institut Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, 08907 Hospitalet de Llobregat, Spain
    Neurosci Lett 399:106-10. 2006
    ..On the contrary, tau degradation, manifested as a reduction in the number and intensity of the bands, may occur between 8 and 26 h post-mortem and is universal in samples with post-mortem delays of 50h...
  54. doi request reprint Gene expression profile in JNK3 null mice: a novel specific activation of the PI3K/AKT pathway
    Felix Junyent
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Barcelona, Spain
    J Neurochem 117:244-52. 2011
    ..Therefore, our results indicate that the activation of PI3K/AKT pathway in hippocampus because of the increase in pik3cb transcription and that this mechanism is specifically related to the lack of Jnk3...
  55. ncbi request reprint Brain protein preservation largely depends on the postmortem storage temperature: implications for study of proteins in human neurologic diseases and management of brain banks: a BrainNet Europe Study
    Isidre Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona IF, 08907 Hospitalet de Llobregat, Barcelona, Spain
    J Neuropathol Exp Neurol 66:35-46. 2007
    ..These results emphasize the necessity of reducing the body temperature after death to minimize protein degradation...
  56. ncbi request reprint Aquaporin expression in the cerebral cortex is increased at early stages of Alzheimer disease
    Esther Perez
    Institut de Neuropatologia, Servei Anatomia Patològica, Hospital Universitari de Bellvitge, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Brain Res 1128:164-74. 2007
    ..These results indicate abnormal expression of AQP1 in astrocytes in AD, and they add support to the idea that abnormal regulation of mechanisms involved in the control of water fluxes occurs at early stages in AD...
  57. ncbi request reprint Individual and regional variations of phospho-tau species in progressive supranuclear palsy
    Berta Puig
    Institut de Neuropatologia, Servei Anatomia Patològica, Hospital Universitari de Bellvitge, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Acta Neuropathol 110:261-8. 2005
    ....
  58. ncbi request reprint α-Synuclein accumulates in huntingtin inclusions but forms independent filaments and its deficiency attenuates early phenotype in a mouse model of Huntington's disease
    Cristina Tomás-Zapico
    Center for Molecular Biology Severo Ochoa, CSIC UAM, Madrid, Spain
    Hum Mol Genet 21:495-510. 2012
    ..This study therefore demonstrates that α-syn is a modifier of polyQ toxicity in vivo and raises the possibility that potential PD-related therapies aimed to counteract α-syn toxicity might help to slow HD...
  59. ncbi request reprint A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation
    Ester Angulo
    Departament de Bioquimica i Biologia Molecular, University of Barcelona, Spain
    Brain Pathol 13:440-51. 2003
    ..Furthermore, activation of A1R led to and ERK-dependent increase of tau phosphorylation and translocation towards the cytoskeleton. These results indicate that adenosine receptors are potential targets for AD...
  60. doi request reprint Molecular mechanisms of MLC1 and GLIALCAM mutations in megalencephalic leukoencephalopathy with subcortical cysts
    Tania López-Hernández
    Seccion de Fisiologia, IDIBELL Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Universitat de Barcelona, Barcelona, Spain
    Hum Mol Genet 20:3266-77. 2011
    ..GLIALCAM mutations also affect the trafficking of its associated molecule MLC1, explaining why GLIALCAM and MLC1 mutations lead to the same disease: MLC...
  61. ncbi request reprint DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain
    Marta Barrachina
    Institut de Neuropatologia, Servei d Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Spain
    J Neuropathol Exp Neurol 68:880-91. 2009
    ....
  62. doi request reprint Mitochondrial dysfunction and oxidative damage cooperatively fuel axonal degeneration in X-linked adrenoleukodystrophy
    Stephane Fourcade
    Neurometabolic Diseases Laboratory, Institut d Investigació Biomèdica de Bellvitge IDIBELL, Hospitalet de Llobregat, 08908 Barcelona, Catalonia, Spain Institute of Neuropathology, Pathologic Anatomy Service, Bellvitge Biomedical Research Institute, IDIBELL Hospital Universitari de Bellvitge, L Hospitalet de Llobregat, 08908 Barcelona, Spain Center for Biomedical Research on Rare Diseases CIBERER, U759, ISCIII, Spain
    Biochimie 98:143-9. 2014
    ..Drugs targeting the redox imbalance/mitochondria dysfunction interplay have shown efficacy at halting axonal degeneration and associated disability in the mouse, and thus offer therapeutic hope. ..
  63. ncbi request reprint Metabolomics of human brain aging and age-related neurodegenerative diseases
    Mariona Jove
    From the Department of Experimental Medicine, University of Lleida Biomedical Research Institute of Lleida, Lleida MJ, MP O, AN, RP Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, Biomedical Research Institute of Bellvitge, L Hospitalet de Llobregat, Barcelona IF and Center for Biomedical Research on Neurodegenerative Diseases, Spanish Institute for Health Carlos III, Madrid IF, Spain
    J Neuropathol Exp Neurol 73:640-57. 2014
    ..Neurometabolomics will increase knowledge of the physiologic and pathologic functions of neural cells and will place the concept of selective neuronal vulnerability in a metabolic context. ..
  64. doi request reprint LRRK2 and neurodegeneration
    Gabriel Santpere
    Institut de Neuropatologia, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, CIBERNED, Barcelona, Spain
    Acta Neuropathol 117:227-46. 2009
    ..Truncated forms of Lrrk2 and additional transcripts related with LRRK2, in the absence of spliced forms of Lrrk2 may account for Lrrk2 immunoreactivity in distinct intraneuronal inclusions...
  65. ncbi request reprint Early alpha-synuclein lipoxidation in neocortex in Lewy body diseases
    Esther Dalfo
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Spain
    Neurobiol Aging 29:408-17. 2008
    ..Moreover, it demonstrates that alpha-synuclein lipoxidation is an early event in LBDs which precedes alpha-synuclein solubility modification and aggregation, and formation of Lewy bodies and neurites...
  66. ncbi request reprint Group I mGluR signaling in BSE-infected bovine-PrP transgenic mice
    Agustin Rodriguez
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Spain
    Neurosci Lett 410:115-20. 2006
    ..The present results show, for the first time impairment of the mGluR1/PLCbeta1/PKCdelta pathway signaling with disease-progression in a murine model of BSE...
  67. doi request reprint Analysis of Sp transcription factors in the postmortem brain of chronic schizophrenia: a pilot study of relationship to negative symptoms
    Raquel Pinacho
    Unitat de Recerca, Parc Sanitari Sant Joan de Deu, Fundació Sant Joan de Déu, Universitat de Barcelona, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Dr Antoni Pujadas, 42, 08830 Sant Boi de Llobregat, Barcelona, Spain
    J Psychiatr Res 47:926-34. 2013
    ....
  68. doi request reprint Histone tail acetylation in brain occurs in an unpredictable fashion after death
    Marta Barrachina
    Institute of Neuropathology, Bellvitge Biomedical Research Institute IDIBELL, Bellvitge University Hospital ICS, c Feixa Llarga s n, 08908 L Hospitalet de Llobregat, Spain
    Cell Tissue Bank 13:597-606. 2012
    ..Therefore, the present observations show that human post-mortem brain is probably not suitable for comparative studies of histone acetylation...
  69. ncbi request reprint Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease
    Daniel Alvira
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
    Parkinsonism Relat Disord 14:309-13. 2008
    ..Our results implicate the cdk5/p25 pathway and re-entry into the cell cycle in the process of neuronal loss in patients with PD...
  70. ncbi request reprint Inactivation of the peroxisomal ABCD2 transporter in the mouse leads to late-onset ataxia involving mitochondria, Golgi and endoplasmic reticulum damage
    Isidre Ferrer
    Institut de Neuropatologia, Hospital Universitari de Bellvitge, Department de Biologia Cel lular i Anatomia Patologica, Facultat de Medicina, Universitat de Barcelona, Spain
    Hum Mol Genet 14:3565-77. 2005
    ..We have identified mitochondrial, Golgi and endoplasmic reticulum damage as the underlying pathological mechanism, thus providing evidence of a disturbed organelle cross-talk, which may be at the origin of the pathological cascade...
  71. ncbi request reprint MPP+ increases alpha-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells
    Cristina Gómez-Santos
    Unitat de Bioquimica, Departament Ciències Fisiològiques II, Campus Bellvitge, Universitat de Barcelona, c Feixa Llarga s n, L Hospitalet del Llobregat, E 08907 Barcelona, Spain
    Brain Res 935:32-9. 2002
    ..Inhibition of ERK/MAPK reduced the damage caused by MPP+. We suggest that alpha-synuclein increase and ERK/MAPK activation have a prominent role in the cell mechanisms of rescue and damage, respectively, after MPP+ -treatment...
  72. doi request reprint The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo
    Sonia Mazzitelli
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 31:16969-76. 2011
    ..Therefore, inhibition of increased JNK activity associated with aging or with a pathological condition constitutes a potential strategy for the treatment of AD...
  73. doi request reprint It may be possible to delay the onset of neurodegenerative diseases with an immunosuppressive drug (rapamycin)
    Ester Aso
    Institut de Neuropatologia, Servei d Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, c Feixa Llarga s n, 08907 L Hospitalet de Llobregat, Spain
    Expert Opin Biol Ther 13:1215-9. 2013
    ..Studies are needed to uncover more specific inhibitors of particular mTOR signaling pathways, and to establish realistic guidelines for treatment at early stages of neurodegenerative processes. ..
  74. doi request reprint Atypical neuropathological sCJD-MM phenotype with abundant white matter Kuru-type plaques sparing the cerebellar cortex
    Ellen Gelpi
    Neurological Tissue Bank of the Biobank Hospital Clinic IDIBAPS, Facultat de Medicina, Spain
    Neuropathology 33:204-8. 2013
    ..This case further highlights the complexity of the correlations between histopathological phenotype and PrP(res) isotype in prion diseases...
  75. doi request reprint Risk of transmission of systemic transthyretin amyloidosis after domino liver transplantation
    Laura Llado
    Departments of Surgery, Liver Transplant Unit, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain
    Liver Transpl 16:1386-92. 2010
    ..Sural nerve biopsy with EMG and clinical correlation is mandatory for confirming the disease. Indeed, other causes of neuropathy should be excluded...
  76. ncbi request reprint Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease
    Isidre Ferrer
    Servei Anatomia Patològica, Institut de Neuropatologia, Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain
    Brain Pathol 14:11-20. 2004
    ..Release of antigenic peptides derived from beta-amyloid processing may enhance T-cell inflammatory responses accounting for the meningoencephalitis following amyloid-beta peptide immunization...
  77. ncbi request reprint Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis
    Ekaterina V Ilieva
    Fisiopatologia Metabòlica, IRBLLEIDA, Departament de Medicina Experimental, Facultat de Medicina, Universitat de Lleida, Lleida, Spain
    Brain 130:3111-23. 2007
    ....
  78. ncbi request reprint Proteomic and oxidative stress analysis in human brain samples of Huntington disease
    Ma Alba Sorolla
    Departament de Ciencies Mediques Basiques, IRBLLEIDA, Universitat de Lleida, 25008 Lleida, Spain
    Free Radic Biol Med 45:667-78. 2008
    ..Also, these data support the rationale for therapeutic strategies that either potentiate antioxidant defenses or avoid oxidative stress generation to delay disease progression...
  79. ncbi request reprint Stress response in the central nervous system of a transgenic mouse model of bovine spongiform encephalopathy
    Raul Tortosa
    Animal Medicine and Surgery Department, Veterinary Faculty, Autonomous University of Barcelona, 08193 Bellaterra Cerdanyola del Valles, Barcelona, Spain
    Vet J 178:126-9. 2008
    ..These proteins are associated with oxidative stress and heavy metal metabolism, which may have a role in the pathogenesis of BSE...