J M Fernandez-Real

Summary

Publications

  1. ncbi request reprint Effects of iron overload on chronic metabolic diseases
    Jose Manuel Fernandez-Real
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, Hospital de Girona Doctor Josep Trueta, Girona, Spain CIBER Fisiopatología de la Obesidad y Nutrición, Girona, Spain Electronic address
    Lancet Diabetes Endocrinol 2:513-26. 2014
  2. pmc The MRC1/CD68 ratio is positively associated with adipose tissue lipogenesis and with muscle mitochondrial gene expression in humans
    José María Moreno-Navarrete
    Service of Diabetes, Endocrinology and Nutrition, Institut d Investigacio Biomedica de Girona IdIBGi, CIBEROBN CB06 03 010 and Instituto de Salud Carlos III ISCIII, Girona, Spain
    PLoS ONE 8:e70810. 2013
  3. pmc Common genetic variants of surfactant protein-D (SP-D) are associated with type 2 diabetes
    Neus Pueyo
    Service of Diabetes, Endocrinology and Nutrition UDEN, Institut d Investigacio Biomedica de Girona IdIBGi, CIBER de la Fisiopatología de la Obesidad y la Nutrición CIBERobn, CB06 03 0010 and Instituto de Salud Carlos III ISCIII, Girona, Spain
    PLoS ONE 8:e60468. 2013
  4. ncbi request reprint Profiling of circulating microRNAs reveals common microRNAs linked to type 2 diabetes that change with insulin sensitization
    Francisco J Ortega
    Corresponding author Jose Manuel Fernandez Real
    Diabetes Care 37:1375-83. 2014
  5. doi request reprint Insulin resistance modulates iron-related proteins in adipose tissue
    José María Moreno-Navarrete
    Corresponding author Jose Manuel Fernandez Real
    Diabetes Care 37:1092-100. 2014
  6. ncbi request reprint Human omental and subcutaneous adipose tissue exhibit specific lipidomic signatures
    Mariona Jove
    1Section of Diabetes, Endocrinology and Nutrition, Hospital of Girona Dr Josep Trueta, Carretera de França s n, 17007, Girona, Spain
    FASEB J 28:1071-81. 2014
  7. doi request reprint Changes in circulating microRNAs are associated with childhood obesity
    Anna Prats-Puig
    MD, PhD, Section of Diabetes, Endocrinology, and Nutrition Hospital Dr Josep Trueta of Girona, Carretera de França s n, 17007 Girona, Spain
    J Clin Endocrinol Metab 98:E1655-60. 2013
  8. pmc Iron and obesity status-associated insulin resistance influence circulating fibroblast-growth factor-23 concentrations
    Jose Manuel Fernandez-Real
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, CIBERobn Fisiopatología de la Obesidad y Nutrición CB06 03 010, Girona, Spain
    PLoS ONE 8:e58961. 2013
  9. doi request reprint Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance
    José María Moreno-Navarrete
    Department of Diabetes, Endocrinology, and Nutrition, Hospital of Girona Dr Josep Trueta, Girona, Spain
    J Clin Endocrinol Metab 98:E769-78. 2013
  10. pmc A Mediterranean diet enriched with olive oil is associated with higher serum total osteocalcin levels in elderly men at high cardiovascular risk
    Jose Manuel Fernandez-Real
    Diabetes, Endocrinology, and Nutrition Unit, Hospital Dr Josep Trueta, Carretera de França s n, 17007 Girona, Spain
    J Clin Endocrinol Metab 97:3792-8. 2012

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Effects of iron overload on chronic metabolic diseases
    Jose Manuel Fernandez-Real
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, Hospital de Girona Doctor Josep Trueta, Girona, Spain CIBER Fisiopatología de la Obesidad y Nutrición, Girona, Spain Electronic address
    Lancet Diabetes Endocrinol 2:513-26. 2014
    ..Regular assessment of iron balance should be recommended for patients with chronic metabolic diseases, and further research is needed to produce guidelines for the identification of patients who would benefit from iron depletion. ..
  2. pmc The MRC1/CD68 ratio is positively associated with adipose tissue lipogenesis and with muscle mitochondrial gene expression in humans
    José María Moreno-Navarrete
    Service of Diabetes, Endocrinology and Nutrition, Institut d Investigacio Biomedica de Girona IdIBGi, CIBEROBN CB06 03 010 and Instituto de Salud Carlos III ISCIII, Girona, Spain
    PLoS ONE 8:e70810. 2013
    ..The effects of surgery-induced weight loss were also longitudinally evaluated (n = 6)...
  3. pmc Common genetic variants of surfactant protein-D (SP-D) are associated with type 2 diabetes
    Neus Pueyo
    Service of Diabetes, Endocrinology and Nutrition UDEN, Institut d Investigacio Biomedica de Girona IdIBGi, CIBER de la Fisiopatología de la Obesidad y la Nutrición CIBERobn, CB06 03 0010 and Instituto de Salud Carlos III ISCIII, Girona, Spain
    PLoS ONE 8:e60468. 2013
    ..We aimed to study the association of single nucleotide polymorphisms (SNPs) affecting SP-D with insulin resistance and type 2 diabetes (T2D)...
  4. ncbi request reprint Profiling of circulating microRNAs reveals common microRNAs linked to type 2 diabetes that change with insulin sensitization
    Francisco J Ortega
    Corresponding author Jose Manuel Fernandez Real
    Diabetes Care 37:1375-83. 2014
    ..This study sought to identify the profile of circulating microRNAs (miRNAs) in type 2 diabetes (T2D) and its response to changes in insulin sensitivity...
  5. doi request reprint Insulin resistance modulates iron-related proteins in adipose tissue
    José María Moreno-Navarrete
    Corresponding author Jose Manuel Fernandez Real
    Diabetes Care 37:1092-100. 2014
    ..CONCLUSIONS These results suggest that iron overload impacts on AT in association with insulin resistance. ..
  6. ncbi request reprint Human omental and subcutaneous adipose tissue exhibit specific lipidomic signatures
    Mariona Jove
    1Section of Diabetes, Endocrinology and Nutrition, Hospital of Girona Dr Josep Trueta, Carretera de França s n, 17007, Girona, Spain
    FASEB J 28:1071-81. 2014
    ..In summary, in obesity, adipose tissue exhibits a location-specific differential lipid profile that may contribute to explaining part of its distinct pathogenic role...
  7. doi request reprint Changes in circulating microRNAs are associated with childhood obesity
    Anna Prats-Puig
    MD, PhD, Section of Diabetes, Endocrinology, and Nutrition Hospital Dr Josep Trueta of Girona, Carretera de França s n, 17007 Girona, Spain
    J Clin Endocrinol Metab 98:E1655-60. 2013
    ..Circulating microRNAs (miRNAs) are valuable biomarkers of metabolic diseases and potential therapeutic targets in this field...
  8. pmc Iron and obesity status-associated insulin resistance influence circulating fibroblast-growth factor-23 concentrations
    Jose Manuel Fernandez-Real
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, CIBERobn Fisiopatología de la Obesidad y Nutrición CB06 03 010, Girona, Spain
    PLoS ONE 8:e58961. 2013
    ..In summary, the associations of circulating FGF-23 concentration with parameters of glucose metabolism, bone density and atherosclerosis are dependent on iron and obesity status-associated insulin resistance...
  9. doi request reprint Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance
    José María Moreno-Navarrete
    Department of Diabetes, Endocrinology, and Nutrition, Hospital of Girona Dr Josep Trueta, Girona, Spain
    J Clin Endocrinol Metab 98:E769-78. 2013
    ..Recently irisin (encoded by Fndc5 gene) has been reported to stimulate browning and uncoupling protein 1 expression in sc adipose tissue of mice...
  10. pmc A Mediterranean diet enriched with olive oil is associated with higher serum total osteocalcin levels in elderly men at high cardiovascular risk
    Jose Manuel Fernandez-Real
    Diabetes, Endocrinology, and Nutrition Unit, Hospital Dr Josep Trueta, Carretera de França s n, 17007 Girona, Spain
    J Clin Endocrinol Metab 97:3792-8. 2012
    ..The intake of olive oil has been related to the prevention of osteoporosis in experimental and in in vitro models. Very few prospective studies have evaluated the effects of olive oil intake on circulating osteocalcin (OC) in humans...
  11. doi request reprint Innate immunity, insulin resistance and type 2 diabetes
    J M Fernandez-Real
    University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Diabetologia 55:273-8. 2012
    ....
  12. doi request reprint Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance
    J M Moreno-Navarrete
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona IdIBGi and University Hospital Dr Josep Trueta, CIBER Fisiopatología de la Obesidad y Nutrición CB06 03 010, Girona, Catalonia, Spain
    Int J Obes (Lond) 34:240-9. 2010
    ....
  13. ncbi request reprint Plasma levels of the soluble fraction of tumor necrosis factor receptor 2 and insulin resistance
    J M Fernandez-Real
    Department of Endocrinology, University Hospital of Girona Dr Josep Trueta, Spain
    Diabetes 47:1757-62. 1998
    ..These findings support TNF-alpha as a system regulating insulin action in human obesity...
  14. ncbi request reprint Polymorphism of the tumor necrosis factor-alpha receptor 2 gene is associated with obesity, leptin levels, and insulin resistance in young subjects and diet-treated type 2 diabetic patients
    J M Fernandez-Real
    Diabetes Unit, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Barcelona, Spain
    Diabetes Care 23:831-7. 2000
    ..The purpose of this study was to evaluate a polymorphism in the 3' untranslated region of the TNFR2 gene on chromosome 1 in relation to BMI, leptin levels, and insulin resistance...
  15. ncbi request reprint Tumor necrosis factor system activity is associated with insulin resistance and dyslipidemia in myotonic dystrophy
    J M Fernandez-Real
    Unitat de Diabetes, Endocrinologia, i Nutrició, University Hospital of Girona Dr Josep Trueta, Spain
    Diabetes 48:1108-12. 1999
    ..Whether TNF action is implicated in the pathogenesis of MyD or is a simple marker of disease activity awaits further studies...
  16. ncbi request reprint Interleukin-6 gene polymorphism and insulin sensitivity
    J M Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Spain
    Diabetes 49:517-20. 2000
    ..6+/-2.9 vs. 37.6+/-4.6 mg/l, P = 0.03). In summary, a polymorphism of the IL-6 gene influences the relationship among insulin sensitivity, postload glucose levels, and peripheral white blood cell count...
  17. ncbi request reprint Body mass index has a greater impact on pregnancy outcomes than gestational hyperglycaemia
    W Ricart
    Unit of Diabetes, Endocrinology and Nutrition, University Hospital Doctor Josep Trueta, Avgda de França s n, 17007, Girona, Spain
    Diabetologia 48:1736-42. 2005
    ..We evaluated diabetes-related pregnancy outcomes in a cohort of Spanish women in relation to their glucose tolerance status, prepregnancy BMI and other predictive variables...
  18. ncbi request reprint The fat-free mass compartment influences serum leptin in men
    J M Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Girona, Hormonal Laboratory, University Hospital Clinic, Barcelona, Spain
    Eur J Endocrinol 142:25-9. 2000
    ..As this latter tissue is the main target for insulin-estimulated glucose disposal, we hypothesized that the muscular and fat-free mass (FFM) compartments might influence serum leptin levels in humans through increased insulin resistance...
  19. doi request reprint Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance
    J M Moreno-Navarrete
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigacio Biomedica de Girona IdIBGi, CIBEROBN CB06 03 010 and Instituto de Salud Carlos III ISCIII, Girona, Spain
    Int J Obes (Lond) 36:1442-9. 2012
    ....
  20. ncbi request reprint Circulating IL-18 concentration is associated with insulin sensitivity and glucose tolerance through increased fat-free mass
    M Bosch
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona, Dr Josep Trueta, Girona, Spain
    Diabetologia 48:1841-3. 2005
    ..IL-18 has recently been described as one of the factors which, in addition to insulin resistance, may also contribute to atherosclerosis. However, the source of IL-18 is not well characterised...
  21. ncbi request reprint Plasma levels of the soluble fraction of tumor necrosis factor receptors 1 and 2 are independent determinants of plasma cholesterol and LDL-cholesterol concentrations in healthy subjects
    J M Fernandez-Real
    Unitat d Endocrinologia, Diabetes i Nutrició, University Hospital of Girona Dr Josep Trueta, Spain
    Atherosclerosis 146:321-7. 1999
    ..0084 and 0.0005) were significantly associated with LDL-cholesterol, contributing to 39 and 32% of its variance. In summary, plasma levels of sTNFR1 and sTNFR2 circulate in proportion to total and LDL-cholesterol in healthy subjects...
  22. doi request reprint Thyroid hormone responsive Spot 14 increases during differentiation of human adipocytes and its expression is down-regulated in obese subjects
    F J Ortega
    Service of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, CIBEROBN CB06 03 0010 and Instituto de Salud Carlos III, Girona, Spain
    Int J Obes (Lond) 34:487-99. 2010
    ..Very limited information is available regarding the function of human thyroid hormone responsive Spot 14 (human S14, hS14) in adipogenesis and human adiposity...
  23. ncbi request reprint Plasma total and glycosylated corticosteroid-binding globulin levels are associated with insulin secretion
    J M Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Spain
    J Clin Endocrinol Metab 84:3192-6. 1999
    ..As high plasma CBG levels have been associated with increased incidence of type 2 diabetes, this important issue merits further investigations...
  24. ncbi request reprint Smoking, fat mass and activation of the tumor necrosis factor-alpha pathway
    J M Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Int J Obes Relat Metab Disord 27:1552-6. 2003
    ..As smoking significantly increases cytokine production, we aimed to study how smoking influences the relationship between fat mass and soluble tumor necrosis factor-alpha (TNF-alpha) receptors 1 and 2 (sTNFR1 and sTNFR2)...
  25. ncbi request reprint Interleukin-6 gene polymorphism and lipid abnormalities in healthy subjects
    J M Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Spain
    J Clin Endocrinol Metab 85:1334-9. 2000
    ..Whether this polymorphism contributes to lipid alterations associated with other metabolic disorders awaits additional studies...
  26. ncbi request reprint Potential impact of American Diabetes Association (2000) criteria for diagnosis of gestational diabetes mellitus in Spain
    W Ricart
    Unit of Diabetes, Endocrinology and Nutrition, Hospital Universitari de Girona Doctor Josep Trueta, Avgda de França s n, 17007, Girona, Spain
    Diabetologia 48:1135-41. 2005
    ..This study was carried out to determine the impact of American Diabetes Association (ADA) 2000 criteria for the diagnosis of gestational diabetes mellitus (GDM) in the Spanish population...
  27. doi request reprint Decreased serum creatinine concentration is associated with short telomeres of adipose tissue cells
    J M Fernandez-Real
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, CIBERobn Fisiopatología de la Obesidad y Nutrición CB06 03 010, Girona, Spain
    Obesity (Silver Spring) 19:1511-4. 2011
    ..In conclusion, the association of serum creatinine with a marker of cellular senescence suggests an underlying mechanism influencing both decreased serum creatinine and increased risk of type 2 diabetes...
  28. ncbi request reprint Thyroid hormone receptor alpha gene variants increase the risk of developing obesity and show gene-diet interactions
    J M Fernandez-Real
    1 Department of Diabetes, Endocrinology and Nutrition Institut d Investigació Biomédica de Girona, Girona, Spain 2 CIBER Fisiopatologia de la Obesidad y la Nutrición, CIBEROBN CB06 03, Instituto de Salud Carlos III, Girona, Spain
    Int J Obes (Lond) 37:1499-505. 2013
    ..THRA gene sequencing of an obese woman (index case) who presented as empirical thyroid hormone receptor-α (THRA) resistance, disclosed a polymorphism (rs12939700) in a critical region involved in TRα alternative processing...
  29. ncbi request reprint Liver, but not adipose tissue PEDF gene expression is associated with insulin resistance
    J M Moreno-Navarrete
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, and CIBER Fisiopatologia Obesidad y Nutricion CB06 03 010, Instituto de Salud Carlos III, Girona, Spain
    Int J Obes (Lond) 37:1230-7. 2013
    ..We aimed to investigate liver and adipose tissue PEDF gene expression in association with obesity and insulin resistance...
  30. ncbi request reprint Decreased circulating lactoferrin in insulin resistance and altered glucose tolerance as a possible marker of neutrophil dysfunction in type 2 diabetes
    J M Moreno-Navarrete
    Section of Diabetes, Endocrinology, and Nutrition, Institut d Investigació Biomédica de Girona, 17007 Girona, Spain
    J Clin Endocrinol Metab 94:4036-44. 2009
    ..Lactoferrin is an innate immune system protein with multiple beneficial health activities...
  31. doi request reprint Type I iodothyronine 5'-deiodinase mRNA and activity is increased in adipose tissue of obese subjects
    F J Ortega
    Service of Diabetes, Endocrinology and Nutrition UDEN, Institut d Investigació Biomédica de Girona, CIBER de Fisiopatología de Obesidad y Nutrición CIBERobn, CB06 03 0010, and Instituto de Salud Carlos III, Girona, Spain
    Int J Obes (Lond) 36:320-4. 2012
    ..Our results document increased D1 gene expression and activity in adipose tissue of obese humans and suggest a role of 3,5,3'-triiodo-L-thyronine formed by D1 in response to leptin in the modulation of adipose tissue metabolism...
  32. ncbi request reprint The insulin resistance syndrome and the binding capacity of cortisol binding globulin (CBG) in men and women
    J M Fernandez-Real
    Unitat d Endocrinologia, Diabetes i Nutrició, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Clin Endocrinol (Oxf) 52:93-9. 2000
    ..Both insulin resistance and cortisol binding globulin (CBG) capacity have been found to correlate with plasma free fatty acid (FFA) concentration...
  33. doi request reprint Circulating osteocalcin concentrations are associated with parameters of liver fat infiltration and increase in parallel to decreased liver enzymes after weight loss
    J M Fernandez-Real
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona IdIBGi CIBEROBN Fisiopatología de la Obesidad y Nutrición CB06 03 010, Girona, Catalonia, Spain
    Osteoporos Int 21:2101-7. 2010
    ..The expression of liver genes was associated with insulin action in osteocalcin knockout mice. Our findings suggest that osteocalcin may play a role in the development of insulin resistance-associated fatty liver disease...
  34. ncbi request reprint Inflammation and insulin resistance exert dual effects on adipose tissue tumor protein 53 expression
    F J Ortega
    1 CIBER de la Fisiopatología de la Obesidad y Nutrición CIBERobn, CB06 03 0010, and Instituto de Salud Carlos III ISCIII, Santiago de Compostela, Spain 2 Service of Diabetes, Endocrinology and Nutrition UDEN, Institut d Investigacio Biomedica de Girona IdIBGi, Hospital Dr Josep Trueta of Girona, Girona, Spain
    Int J Obes (Lond) 38:737-45. 2014
    ..We also analyzed different in vivo and in vitro models to try to comprehend the associations found in humans...
  35. ncbi request reprint No decrease in free IGF-I with increasing insulin in obesity-related insulin resistance
    W Ricart
    Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona, Spain
    Obes Res 9:631-6. 2001
    ..This study was undertaken to evaluate the effects of acute changes in plasma glucose and insulin levels on free IGF-I and IGFBP-1 in obese and non-obese subjects...
  36. ncbi request reprint Plasma soluble tumor necrosis factor-alpha receptors circulate in proportion to leptin levels during the menstrual cycle in lean but not in obese women
    J M Fernandez-Real
    Unitat de Diabetes, Endocrinologia i Nutricio, Hospital Universitario de Girona Dr Josep Trueta, Girona, Spain
    Eur J Endocrinol 143:235-41. 2000
    ..As TNF-alpha appears to regulate leptin secretion, we speculated that TNF-alpha might be involved in leptin variations during the menstrual cycle...
  37. ncbi request reprint Maternal soluble tumour necrosis factor receptor type 2 (sTNFR2) and adiponectin are both related to blood pressure during gestation and infant's birthweight
    A Lopez-Bermejo
    Diabetes, Endocrinology and Nutrition Unit, Hospital of Girona, Girona, Spain
    Clin Endocrinol (Oxf) 61:544-52. 2004
    ..We aimed to study the contributions of maternal serum concentrations of soluble TNF-alpha receptors (sTNFR1 and sTNFR2) and adiponectin to infant's birthweight...
  38. ncbi request reprint Protection from inflammatory disease in insulin resistance: the role of mannan-binding lectin
    J M Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Carretera de França s n, 17007, Girona, Spain
    Diabetologia 49:2402-11. 2006
    ..Decreased sensing of the innate immune system may lead to chronic activation of the inflammatory cascade. We hypothesised that mannan-binding lectin (MBL) deficiency may confer risk of obesity and insulin resistance...
  39. doi request reprint LIGHT is associated with hypertriglyceridemia in obese subjects and increased cytokine secretion from cultured human adipocytes
    J Bassols
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigacio Biomedica de Girona IdIBGi, Girona, Catalonia, Spain
    Int J Obes (Lond) 34:146-56. 2010
    ..We aimed to analyze whether LIGHT has a role in the human obesity-associated inflammatory status...
  40. doi request reprint The lung innate immune gene surfactant protein-D is expressed in adipose tissue and linked to obesity status
    F J Ortega
    1 CIBER de la Fisiopatología de la Obesidad y la Nutrición CIBERobn, CB06 03 0010 and Instituto de Salud Carlos III ISCIII, Santiago de Compostela, Spain 2 Service of Diabetes, Endocrinology and Nutrition UDEN, Institut d Investigacio Biomedica de Girona IdIBGi, Girona, Spine
    Int J Obes (Lond) 37:1532-8. 2013
    ..An inverse association of putative, lung-derived circulating SFTPD with obesity has been reported but no information is available concerning possible SFTPD gene expression in human adipose tissue...
  41. doi request reprint Circulating soluble transferrin receptor concentration decreases after exercise-induced improvement of insulin sensitivity in obese individuals
    J M Fernandez-Real
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona IdIBGi CIBER Fisiopatología de la Obesidad y Nutrición CB06 03 010, Girona, Catalonia, Spain
    Int J Obes (Lond) 33:768-74. 2009
    ..Circulating soluble transferrin receptor (sTfR) has been recently found to be associated negatively with insulin sensitivity...
  42. ncbi request reprint CIDEC/FSP27 and PLIN1 gene expression run in parallel to mitochondrial genes in human adipose tissue, both increasing after weight loss
    J M Moreno-Navarrete
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigacio Biomedica de Girona IdIBGi, CIBEROBN CB06 03 010 and Instituto de Salud Carlos III ISCIII, Girona, Spain
    Int J Obes (Lond) 38:865-72. 2014
    ..Here, we aimed to investigate lipid droplet protein (CIDEC/FSP27 and perilipinA (PLIN1)) gene expression in human adipose tissue in association with obesity, insulin resistance and mitochondrial gene expression...
  43. ncbi request reprint Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women
    J M Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr. Josep Trueta, 17007 Girona, Spain
    J Clin Endocrinol Metab 86:1154-9. 2001
    ..In summary, circulating IL-6 levels, by inducing either hypertension in women or insulin resistance in men, constitute a significant proatherogenic cytokine. The mechanisms of these associations should be further investigated...
  44. doi request reprint [Insulin resistance as a mechanism of adaptation during human evolution]
    W Ricart
    Servicio de Diabetis, Endocrinologia i Nutricio, Hospital Universitari de Girona Dr Josep Trueta, Institut d Investigació Biomédica de Girona, Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y Nutrición, Girona, Espana
    Endocrinol Nutr 57:381-90. 2010
    ..The relationship with some components of the diet and, particularly, with the symbiotic intestinal microflora points to new paradigms in understanding the pathophysiology of obesity, metabolic syndrome and type 2 diabetes mellitus...
  45. doi request reprint Telomere length of subcutaneous adipose tissue cells is shorter in obese and formerly obese subjects
    J M Moreno-Navarrete
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, CIBER Fisiopatología de la Obesidad y Nutrición CB06 03 010, Girona, Spain
    Int J Obes (Lond) 34:1345-8. 2010
    ..The shorter telomere length of formerly obese subjects suggests that this is an established, irreversible feature of obesity that could contribute to its comorbidities...
  46. doi request reprint Maternal glucose tolerance status influences the risk of macrosomia in male but not in female fetuses
    W Ricart
    Hospital Universitari de Girona Doctor Josep Trueta, Girona, IdlBGi, CIBER Fisiopatologia de la Obesidad y Nutrició, Spain
    J Epidemiol Community Health 63:64-8. 2009
    ..To elucidate whether the risk of macrosomia, large for gestational age (LGA) and small for gestational age (SGA) is influenced by maternal body mass index and glucose tolerance differently in male and female fetuses...
  47. pmc Short-term mortality of myocardial infarction patients with diabetes or hyperglycaemia during admission
    J Sala
    Servei de Cardiologia i Unitat Coronaria, Hospital de Girona Josep Trueta, Girona, Spain
    J Epidemiol Community Health 56:707-12. 2002
    ..The objective was to assess the role of hyperglycaemia on short-term mortality after myocardial infarction (MI)...
  48. ncbi request reprint Lowering of blood pressure leads to decreased circulating interleukin-6 in hypertensive subjects
    G Vázquez-Oliva
    Cardiology Unit, Hospital de Blanes, Corporació de Salut del Maresme i La Selva, Girona, Spain
    J Hum Hypertens 19:457-62. 2005
    ..33+/-0.3 pg/ml) after treatment with irbesartan. No significant changes were observed in any other of the tested parameters. In conclusion, the treatment of high blood pressure lowers circulating IL-6 in young hypertensive patients...
  49. doi request reprint Lactoferrin increases (172Thr)AMPK phosphorylation and insulin-induced (p473Ser)AKT while impairing adipocyte differentiation
    J M Moreno-Navarrete
    Unit of Diabetes, Endocrinology and Nutrition Unit, Biomedical Research Institute of Girona, Hospital de Girona Dr Josep Trueta, and CIBER Fisiopatologia Obesidad y Nutricion CB06 03 010 Instituto de Salud Carlos III, Girona, Spain
    Int J Obes (Lond) 33:991-1000. 2009
    ..To gain an insight into the interaction among obesity, inflammation and insulin action, we aimed to examine the effects of lactoferrin on adipogenesis and the response to insulin in human hepatocarcinoma (HepG2) and 3T3-L1 cell lines...
  50. ncbi request reprint [Ponderal evolution in the Girona population, 1989-1999]
    J M Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, Hospital Universitari de Girona, Dr Josep Trueta, Girona, Spain
    Rev Clin Esp 203:57-63. 2003
    ..The objective of the present paper was to determine the modifications in the different degrees of body adiposity in a population in Catalunya...
  51. doi request reprint Inflammation in adipose tissue and fatty acid anabolism: when enough is enough!
    F J Ortega
    Department of Diabetes, Endocrinology and Nutrition UDEN, Institut d Investigacio Biomedica de Girona IdIBGi, Girona, Spain
    Horm Metab Res 45:1009-19. 2013
    ..This response may be induced by an important inflammatory component that promotes angiogenesis and insulin resistance, but also by leptin and the increase of T3 in hyperplastic AT. ..
  52. ncbi request reprint Study of the effect of changing glucose, insulin, and insulin-like growth factor-I levels on serum corticosteroid binding globulin in lean, obese, and obese subjects with glucose intolerance
    J M Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona, Dr Josep Trueta, Girona, Spain
    Metabolism 50:1248-52. 2001
    ..The mechanisms of this CBG inhibitory effect exerted by insulin and its implication on cortisol homeostasis and fat distribution in humans await further investigations...
  53. ncbi request reprint Asymptomatic bilateral adrenal pheochromocytoma in a patient with a germline V804M mutation in the RET proto-oncogene
    M Recasens
    Endocrinology, Hospital de Girona Dr Josep Trueta, Girona, Spain
    Clin Endocrinol (Oxf) 67:29-33. 2007
    ..A diagnosis of bilateral pheochromocytoma warrants exclusion of hereditary pheochromocytoma...