Bruno F Fernandes

Summary

Publications

  1. ncbi request reprint Hypoxia-inducible factor-1α and its role in the proliferation of retinoblastoma cells
    Bruno F Fernandes
    Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, 3775 University St, Room 216, Montreal, QC, Canada, H3A 2B4
    Pathol Oncol Res 20:557-63. 2014
  2. ncbi request reprint Local chemotherapeutic agents for the treatment of ocular malignancies
    Bruno F Fernandes
    Department of Ophthalmology and Pathology, The McGill University Health Center, and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada Electronic address
    Surv Ophthalmol 59:97-114. 2014
  3. pmc Immunohistochemical expression of melan-A and tyrosinase in uveal melanoma
    Bruno F Fernandes
    Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C, Witelson Ocular Pathology Laboratory, Montreal, Canada
    J Carcinog 6:6. 2007
  4. doi request reprint Orbital leiomyoma: histopathologic and immunohistochemical findings of a rare tumor
    Bruno F Fernandes
    Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
    Ophthal Plast Reconstr Surg 25:59-61. 2009
  5. doi request reprint Anetodermic variant of a periorbital pilomatricoma
    Bruno F Fernandes
    Department of Ophthalmology and Pathology, Henry C Witelson Ocular Pathology Laboratory, McGill University Health Centre, Montreal, Quebec, Canada
    Ophthal Plast Reconstr Surg 24:419-21. 2008
  6. doi request reprint Histopathological study of 49 cases of keratoconus
    Bruno F Fernandes
    Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Quebec, Canada
    Pathology 40:623-6. 2008
  7. ncbi request reprint Amfenac increases the radiosensitivity of uveal melanoma cell lines
    B F Fernandes
    Department of Ophthalmology and Pathology, The McGill University Health Center, Montreal, Canada
    Eye (Lond) 22:701-6. 2008
  8. ncbi request reprint [Detection of circulating malignant cells in patients with uveal melanoma]
    Bruno F Fernandes
    Departamento de Oftalmologia e Patologia da McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
    Arq Bras Oftalmol 70:593-8. 2007
  9. doi request reprint Management of iris melanomas with 125Iodine plaque radiotherapy
    Bruno F Fernandes
    Department of Ocular Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Ophthalmol 149:70-6. 2010
  10. doi request reprint Imatinib mesylate alters the expression of genes related to disease progression in an animal model of uveal melanoma
    Bruno F Fernandes
    Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
    Anal Cell Pathol (Amst) 34:123-30. 2011

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Hypoxia-inducible factor-1α and its role in the proliferation of retinoblastoma cells
    Bruno F Fernandes
    Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, 3775 University St, Room 216, Montreal, QC, Canada, H3A 2B4
    Pathol Oncol Res 20:557-63. 2014
    ..Stabilization of HIF-1α in retinoblastoma cells using CoCl2 was unsuccessful. ..
  2. ncbi request reprint Local chemotherapeutic agents for the treatment of ocular malignancies
    Bruno F Fernandes
    Department of Ophthalmology and Pathology, The McGill University Health Center, and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada Electronic address
    Surv Ophthalmol 59:97-114. 2014
    ..Recent innovations in many areas of ocular oncology have introduced promising new therapies, but, for the most part, the optimal treatment of ocular malignancies remains elusive...
  3. pmc Immunohistochemical expression of melan-A and tyrosinase in uveal melanoma
    Bruno F Fernandes
    Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C, Witelson Ocular Pathology Laboratory, Montreal, Canada
    J Carcinog 6:6. 2007
    ..The aim of this study was to investigate the correlation between radiotherapy or clinicohistopathological parameters and the expression of melan-A and tyrosinase in uveal melanoma...
  4. doi request reprint Orbital leiomyoma: histopathologic and immunohistochemical findings of a rare tumor
    Bruno F Fernandes
    Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
    Ophthal Plast Reconstr Surg 25:59-61. 2009
    ..Attention to the cytologic features that exclude the malignant variant is of utmost relevance for proper diagnosis and patient counseling...
  5. doi request reprint Anetodermic variant of a periorbital pilomatricoma
    Bruno F Fernandes
    Department of Ophthalmology and Pathology, Henry C Witelson Ocular Pathology Laboratory, McGill University Health Centre, Montreal, Quebec, Canada
    Ophthal Plast Reconstr Surg 24:419-21. 2008
    ..Compression of vessels by the neoplastic process and peritumoral inflammatory infiltration are the proposed pathogenic mechanisms underlying the atypical findings...
  6. doi request reprint Histopathological study of 49 cases of keratoconus
    Bruno F Fernandes
    Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Quebec, Canada
    Pathology 40:623-6. 2008
    ..The pathophysiology of this disorder has yet to be fully elucidated. The purpose of our study was to document the prevalence of the most common morphological features of keratoconic corneas...
  7. ncbi request reprint Amfenac increases the radiosensitivity of uveal melanoma cell lines
    B F Fernandes
    Department of Ophthalmology and Pathology, The McGill University Health Center, Montreal, Canada
    Eye (Lond) 22:701-6. 2008
    ..To evaluate the proliferation rates of five human uveal melanoma (UM) cell lines after treatment with amfenac, a cyclooxygenase (COX)-2 inhibitor, and subsequent radiation exposure...
  8. ncbi request reprint [Detection of circulating malignant cells in patients with uveal melanoma]
    Bruno F Fernandes
    Departamento de Oftalmologia e Patologia da McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
    Arq Bras Oftalmol 70:593-8. 2007
    ..The expression of beta-actin and GAPDH were used to assess the quality of the material...
  9. doi request reprint Management of iris melanomas with 125Iodine plaque radiotherapy
    Bruno F Fernandes
    Department of Ocular Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Ophthalmol 149:70-6. 2010
    ..To report the experience of the Princess Margaret Hospital/University Health Network with the treatment of iris melanoma (IM) with (125)Iodine plaque brachytherapy...
  10. doi request reprint Imatinib mesylate alters the expression of genes related to disease progression in an animal model of uveal melanoma
    Bruno F Fernandes
    Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
    Anal Cell Pathol (Amst) 34:123-30. 2011
    ..Proangiogenic genes such as VEGFA, PDGFA and PDGFB were downregulated in the treated group. To the best of our knowledge, this is the first report detailing the altered expression of specific genes in UM cells after treatment with IM...
  11. pmc Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia) of the orbit: a case report
    Bruno F Fernandes
    Department of Ophthalmology and Pathology, Henry C, Witelson Ocular Pathology Laboratory and Mcgill University Health Centre, Montreal, QC, Canada
    J Med Case Reports 1:30. 2007
    ..Recently, ALHE is being called epithelioid hemangioma (EH), a term that better describes the possible neoplastic nature of the entity...
  12. ncbi request reprint SPARC is expressed in human uveal melanoma and its abrogation reduces tumor cell proliferation
    Shawn C Maloney
    The Henry C Witelson Ocular Pathology Laboratory, McGill University, Montreal, QC, H3A 2B4, Canada
    Anticancer Res 29:3059-64. 2009
    ..Secreted protein acidic and rich in cysteine (SPARC) has been shown to play an integral role in the progression of numerous malignancies. The aim of this study was to investigate the expression of SPARC in uveal melanoma (UM)...
  13. pmc The effect of blue light exposure in an ocular melanoma animal model
    Sebastian Di Cesare
    The Henry C Witelson Ophthalmic Pathology Laboratory and Registry, McGill University Health Center, Montreal, PQ, Canada
    J Exp Clin Cancer Res 28:48. 2009
    ..In order to determine if similar effects could be seen in vivo, we investigated the effect of blue light exposure in a xenograft animal model of UM...
  14. doi request reprint Molecular pathways mediating liver metastasis in patients with uveal melanoma
    Silvin Bakalian
    Henry C Witelson Ocular Pathology Laboratory, McGill University, Montreal, Quebec, Canada
    Clin Cancer Res 14:951-6. 2008
    ..The aim of this review is to describe new insights into the genetic and molecular pathways that may play a role in the development of liver metastases in uveal melanoma patients...
  15. doi request reprint Expression of cyclooxygenase-2 in choroidal neovascular membranes from age-related macular degeneration patients
    Shawn C Maloney
    The Henry C Witelson Ocular Pathology Laboratory and Registry, McGill University, Montreal, Quebec, Canada
    Retina 29:176-80. 2009
    ..The objective of this study was to investigate the expression of cyclooxygenase (COX)-2 in human choroidal neovascular membranes...
  16. doi request reprint Expression profiling of formalin-fixed paraffin embedded primary human uveal melanomas using DASL matrices
    Sebastian Di Cesare
    The Henry C Witelson Ophthalmic Pathology Laboratory and Registry, McGill University Health Center, 3775 University St, Lyman Duff Building, Room 216, Montreal, QC, H3A 2B4, Canada
    J Cancer Res Clin Oncol 136:577-86. 2010
    ..We aimed to correlate gene transcript differences between two uveal melanoma (UM) clinical-histopathological parameters (metastasis, cell type)...
  17. pmc Expression of C-kit in retinoblastoma: a potential therapeutic target
    Robert J Barry
    Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
    Br J Ophthalmol 91:1532-6. 2007
    ..This study aims to determine the immunoexpression of C-kit in retinoblastoma and correlate this expression with histopathological prognostic features...
  18. doi request reprint Immune expression and inhibition of heat shock protein 90 in uveal melanoma
    Dana Faingold
    Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Quebec, Canada
    Clin Cancer Res 14:847-55. 2008
    ..To examine the immunohistochemical profile of heat shock protein 90 (Hsp90) in uveal melanoma and the cytotoxicity of an Hsp90 inhibitor, 17-allylamino-17-demethoxygeldanamycin (17-AAG), in uveal melanoma cell lines...
  19. doi request reprint Choroidal neovascular membranes express toll-like receptor 3
    Shawn C Maloney
    Henry C Witelson Ocular Pathology Laboratory, McGill University, Montreal, Que, Canada
    Ophthalmic Res 44:237-41. 2010
    ..To date, however, few data exist about TLR3 in human AMD. The purpose of this study was to investigate the expression of TLR3 in human choroidal neovascular (CNV) membranes...
  20. ncbi request reprint The use of a cyclooxygenase-2 inhibitor (Nepafenac) in an ocular and metastatic animal model of uveal melanoma
    Jean Claude A Marshall
    The Henry C Witelson Ophthalmic Pathology Laboratory and Registry, McGill University Health Center, 3775 University Street, Lyman Duff Building, Room 216, Montreal, Quebec H3A 2B4, Canada
    Carcinogenesis 28:2053-8. 2007
    ..These results indicate that the topical administration of a COX-2 inhibitor delayed the progression of this malignancy in our animal model. A clinical trail using an anti-COX-2 inhibitor for patients with UM should be considered...
  21. doi request reprint Incidence of melanocytic lesions of the conjunctiva in a review of 10 675 ophthalmic specimens
    Gustavo A Novais
    Department of Ophthalmology, The McGill University Health Center, Montreal, Quebec, Canada
    Int J Surg Pathol 18:60-3. 2010
    ..5%). Primary acquired melanoses was the predisposing lesion in 75% of the cases of melanoma. In our sample, referral bias could alter the distribution of conjunctival pigmented lesions, with a shift toward the malignant end...
  22. doi request reprint Single-cell tumor dormancy model of uveal melanoma
    Patrick T Logan
    The Henry C Witelson Ophthalmic Pathology Laboratory and Registry, McGill University Health Center, Montreal, QC, Canada
    Clin Exp Metastasis 25:509-16. 2008
    ..It has been reported that difficulties in imaging single cells and the propensity for tumor cells to replicate rapidly in animal models account for the deficit of single-cell tumor dormancy models...
  23. ncbi request reprint Immunohistochemical panel of undifferentiated orbital metastatic carcinomas
    Katyanne D Godeiro
    Department of Ophthalmology, Henry C Witelson Ocular Pathology Laboratory, McGill University, Montreal, Canada
    Orbit 26:101-6. 2007
    ..To examine the applicability of an immunohistochemical panel of seven monoclonal antibodies to identify the primary site of poorly differentiated orbital metastatic carcinomas...
  24. ncbi request reprint Histopathologic study of corneal stromal dystrophies: a 10-year experience
    Leonardo N Santos
    Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
    Cornea 26:1027-31. 2007
    ..To determine the frequency and describe the histopathologic features of stromal corneal dystrophies over a 10-year period...
  25. doi request reprint Histopathological study of delayed regraft after corneal graft failure
    Leonardo N Santos
    Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
    Cornea 30:167-70. 2011
    ..To evaluate the histopathological features of corneal graft failures over time...
  26. doi request reprint Neovascular glaucoma after stereotactic radiotherapy for juxtapapillary choroidal melanoma: histopathologic and dosimetric findings
    Bruno F Fernandes
    Department of Ocular Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 80:377-84. 2011
    ..We compare pathologic changes and dosimetric findings in those eyes enucleated secondary to NVG as opposed to TP to better understand potential mechanisms...
  27. pmc Expression of SIRT1 and DBC1 in Developing and Adult Retinas
    Shawn C Maloney
    Henry C Witelson Ocular Pathology Laboratory, McGill University, Montreal, QC, Canada H3A 2B4
    Stem Cells Int 2012:908183. 2012
    ..Collectively, the data presented in this study provide support for SIRT1 and DBC1 as regulators of retinal development and normal retinal physiology...
  28. doi request reprint p16ink4a expression in benign and malignant melanocytic conjunctival lesions
    Pablo Zoroquiain
    The Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
    Int J Surg Pathol 20:240-5. 2012
    ..However, additional studies of larger series and follow-up are needed to confirm these findings...
  29. doi request reprint Expression of SIRT1 in ocular surface squamous neoplasia
    Luiz Filipe de A Alves
    Department of Ophthalmology, Brazilian Air Force Central Hospital Rio de Janeiro, Rio de Janeiro, Brazil
    Cornea 31:817-9. 2012
    ..In the current study, we examined the expression of SIRT1 in normal epithelium (NE) compared with ocular surface squamous neoplasia (OSSN) to elucidate a possible role for SIRT1 in the development or progression of this malignancy...
  30. ncbi request reprint Localized retinal ischemia as an ocular manifestation of primary antiphospholipid syndrome
    Moyses E Zajdenweber
    Department of Ophthalmology and Pathology, McGill University Hospital Centre, Montreal, Quebec, Canada
    Can J Ophthalmol 42:479-80. 2007
    ..Herein, a case of an unusual ocular presentation of primary antiphospholipid syndrome. The patient disclosed localized retinal ischemia due to branch retinal artery occlusion, confirmed by fluorescein angiography and manual perimetry...
  31. ncbi request reprint Histopathological diagnosis of corneal button specimens: an epidemiological study
    Katyanne D Godeiro
    Department of Ophthalmology and Pathology, Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
    Ophthalmic Epidemiol 14:70-5. 2007
    ..To determine the most common histopathological diagnosis of corneal specimens from penetrating keratoplasty (PKP)...
  32. pmc Expression of the Metastasis Suppressor KAI1 in Uveal Melanoma
    Shawn C Maloney
    The Henry C Witelson Ocular Pathology Laboratory, McGill University, 3775 University Street, Room 216, Montreal, QC, Canada H3A 2B4
    J Ophthalmol 2013:683963. 2013
    ..14 months (median: 44 months) for patients with metastasis. Conclusions. KAI1 is a promising candidate marker that may offer prognostic value in UM; it may also represent a therapeutic target in metastatic disease...
  33. doi request reprint A histopathologic review of undiagnosed neoplasms in 205 evisceration specimens
    Eduardo A Novais
    Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
    Ophthal Plast Reconstr Surg 28:331-4. 2012
    ..Given the lack of such studies in the literature, our aim was to review a large sample of eviscerated specimens to document the prevalence of unexpected neoplasms...
  34. doi request reprint Extranodal Rosai-Dorfman Disease presenting as an epibulbar tumor
    Bruno F Fernandes
    Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
    Cornea 27:378-81. 2008
    ..To describe a case of an epibulbar tumor as a manifestation of Rosai-Dorfman Disease (RDD) and review the pertinent literature...
  35. ncbi request reprint Clinical and histopathological features of orbital granular cell tumor: case report
    Bruno F Fernandes
    Department of Ophthalmology and Pathology, Henry C Witelson Ocular Pathology Laboratory and McGill University Health Centre, Montreal, QC, Canada
    Arq Bras Oftalmol 75:137-9. 2012
    ..Granular cell tumors are uncommon benign soft tissue neoplasms that have a predilection for the head and neck region. Awareness of the typical histopathological features is crucial for the correct diagnosis...
  36. ncbi request reprint Choroidal mass as the presenting sign of small cell lung carcinoma
    Bruno F Fernandes
    Department of Ophthalmology, Henry C Witelson Ophthalmic Pathology Laboratory, McGill University Health Centre, Montreal, Quebec, Canada, and Department of Ophthalmology, Hospital dos Servidores do Estado, Rio de Janeiro, Brazil
    Can J Ophthalmol 41:605-8. 2006
    ..Discovery of the primary site was made 10 months after the ocular diagnosis, and the patient was then treated with systemic chemotherapy and local radiation therapy...
  37. pmc Bilateral macular hemorrhage as a complication of drug-induced anemia: a case report
    Rubens N Belfort
    Henry C Witelson Ocular Pathology Laboratory, Ophthalmology Department, McGill University, Montreal, QC, Canada
    J Med Case Reports 3:16. 2009
    ..Bilateral macular hemorrhage is a rare ocular finding and to the best of our knowledge, this is the first report of such hemorrhages as a presentation of drug-induced anemia...