Immunohistochemical expression of melan-A and tyrosinase in uveal melanomaBruno F Fernandes
Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C, Witelson Ocular Pathology Laboratory, Montreal, Canada
J Carcinog 6:6. 2007
..The aim of this study was to investigate the correlation between radiotherapy or clinicohistopathological parameters and the expression of melan-A and tyrosinase in uveal melanoma...
Anetodermic variant of a periorbital pilomatricomaBruno F Fernandes
Department of Ophthalmology and Pathology, Henry C Witelson Ocular Pathology Laboratory, McGill University Health Centre, Montreal, Quebec, Canada
Ophthal Plast Reconstr Surg 24:419-21. 2008
..Compression of vessels by the neoplastic process and peritumoral inflammatory infiltration are the proposed pathogenic mechanisms underlying the atypical findings...
- Orbital leiomyoma: histopathologic and immunohistochemical findings of a rare tumor
Bruno F Fernandes
Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
Ophthal Plast Reconstr Surg 25:59-61. 2009
..Attention to the cytologic features that exclude the malignant variant is of utmost relevance for proper diagnosis and patient counseling...
- Histopathological study of 49 cases of keratoconus
Bruno F Fernandes
Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Quebec, Canada
Pathology 40:623-6. 2008
..The pathophysiology of this disorder has yet to be fully elucidated. The purpose of our study was to document the prevalence of the most common morphological features of keratoconic corneas...
- Management of iris melanomas with 125Iodine plaque radiotherapy
Bruno F Fernandes
Department of Ocular Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
Am J Ophthalmol 149:70-6. 2010
..To report the experience of the Princess Margaret Hospital/University Health Network with the treatment of iris melanoma (IM) with (125)Iodine plaque brachytherapy...
Amfenac increases the radiosensitivity of uveal melanoma cell linesB F Fernandes
Department of Ophthalmology and Pathology, The McGill University Health Center, Montreal, Canada
Eye (Lond) 22:701-6. 2008
..To evaluate the proliferation rates of five human uveal melanoma (UM) cell lines after treatment with amfenac, a cyclooxygenase (COX)-2 inhibitor, and subsequent radiation exposure...
- [Detection of circulating malignant cells in patients with uveal melanoma]
Bruno F Fernandes
Departamento de Oftalmologia e Patologia da McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
Arq Bras Oftalmol 70:593-8. 2007
..The expression of beta-actin and GAPDH were used to assess the quality of the material...
- Imatinib mesylate alters the expression of genes related to disease progression in an animal model of uveal melanoma
Bruno F Fernandes
Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
Anal Cell Pathol (Amst) 34:123-30. 2011
..Proangiogenic genes such as VEGFA, PDGFA and PDGFB were downregulated in the treated group. To the best of our knowledge, this is the first report detailing the altered expression of specific genes in UM cells after treatment with IM...
- Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia) of the orbit: a case report
Bruno F Fernandes
Department of Ophthalmology and Pathology, Henry C, Witelson Ocular Pathology Laboratory and Mcgill University Health Centre, Montreal, QC, Canada
J Med Case Reports 1:30. 2007
..Recently, ALHE is being called epithelioid hemangioma (EH), a term that better describes the possible neoplastic nature of the entity...
- SPARC is expressed in human uveal melanoma and its abrogation reduces tumor cell proliferation
Shawn C Maloney
The Henry C Witelson Ocular Pathology Laboratory, McGill University, Montreal, QC, H3A 2B4, Canada
Anticancer Res 29:3059-64. 2009
..Secreted protein acidic and rich in cysteine (SPARC) has been shown to play an integral role in the progression of numerous malignancies. The aim of this study was to investigate the expression of SPARC in uveal melanoma (UM)...
- The effect of blue light exposure in an ocular melanoma animal model
Sebastian Di Cesare
The Henry C Witelson Ophthalmic Pathology Laboratory and Registry, McGill University Health Center, Montreal, PQ, Canada
J Exp Clin Cancer Res 28:48. 2009
..In order to determine if similar effects could be seen in vivo, we investigated the effect of blue light exposure in a xenograft animal model of UM...
- Molecular pathways mediating liver metastasis in patients with uveal melanoma
Silvin Bakalian
Henry C Witelson Ocular Pathology Laboratory, McGill University, Montreal, Quebec, Canada
Clin Cancer Res 14:951-6. 2008
..The aim of this review is to describe new insights into the genetic and molecular pathways that may play a role in the development of liver metastases in uveal melanoma patients...
- Immune expression and inhibition of heat shock protein 90 in uveal melanoma
Dana Faingold
Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Quebec, Canada
Clin Cancer Res 14:847-55. 2008
..To examine the immunohistochemical profile of heat shock protein 90 (Hsp90) in uveal melanoma and the cytotoxicity of an Hsp90 inhibitor, 17-allylamino-17-demethoxygeldanamycin (17-AAG), in uveal melanoma cell lines...
- Expression profiling of formalin-fixed paraffin embedded primary human uveal melanomas using DASL matrices
Sebastian Di Cesare
The Henry C Witelson Ophthalmic Pathology Laboratory and Registry, McGill University Health Center, 3775 University St, Lyman Duff Building, Room 216, Montreal, QC, H3A 2B4, Canada
J Cancer Res Clin Oncol 136:577-86. 2010
..We aimed to correlate gene transcript differences between two uveal melanoma (UM) clinical-histopathological parameters (metastasis, cell type)...
- Expression of cyclooxygenase-2 in choroidal neovascular membranes from age-related macular degeneration patients
Shawn C Maloney
The Henry C Witelson Ocular Pathology Laboratory and Registry, McGill University, Montreal, Quebec, Canada
Retina 29:176-80. 2009
..The objective of this study was to investigate the expression of cyclooxygenase (COX)-2 in human choroidal neovascular membranes...
- Single-cell tumor dormancy model of uveal melanoma
Patrick T Logan
The Henry C Witelson Ophthalmic Pathology Laboratory and Registry, McGill University Health Center, Montreal, QC, Canada
Clin Exp Metastasis 25:509-16. 2008
..It has been reported that difficulties in imaging single cells and the propensity for tumor cells to replicate rapidly in animal models account for the deficit of single-cell tumor dormancy models...
- The use of a cyclooxygenase-2 inhibitor (Nepafenac) in an ocular and metastatic animal model of uveal melanoma
Jean Claude A Marshall
The Henry C Witelson Ophthalmic Pathology Laboratory and Registry, McGill University Health Center, 3775 University Street, Lyman Duff Building, Room 216, Montreal, Quebec H3A 2B4, Canada
Carcinogenesis 28:2053-8. 2007
..These results indicate that the topical administration of a COX-2 inhibitor delayed the progression of this malignancy in our animal model. A clinical trail using an anti-COX-2 inhibitor for patients with UM should be considered...
- Choroidal neovascular membranes express toll-like receptor 3
Shawn C Maloney
Henry C Witelson Ocular Pathology Laboratory, McGill University, Montreal, Que, Canada
Ophthalmic Res 44:237-41. 2010
..To date, however, few data exist about TLR3 in human AMD. The purpose of this study was to investigate the expression of TLR3 in human choroidal neovascular (CNV) membranes...
- Immunohistochemical panel of undifferentiated orbital metastatic carcinomas
Katyanne D Godeiro
Department of Ophthalmology, Henry C Witelson Ocular Pathology Laboratory, McGill University, Montreal, Canada
Orbit 26:101-6. 2007
..To examine the applicability of an immunohistochemical panel of seven monoclonal antibodies to identify the primary site of poorly differentiated orbital metastatic carcinomas...
- Histopathological study of delayed regraft after corneal graft failure
Leonardo N Santos
Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
Cornea 30:167-70. 2011
..To evaluate the histopathological features of corneal graft failures over time...
- Incidence of melanocytic lesions of the conjunctiva in a review of 10 675 ophthalmic specimens
Gustavo A Novais
Department of Ophthalmology, The McGill University Health Center, Montreal, Quebec, Canada
Int J Surg Pathol 18:60-3. 2010
..5%). Primary acquired melanoses was the predisposing lesion in 75% of the cases of melanoma. In our sample, referral bias could alter the distribution of conjunctival pigmented lesions, with a shift toward the malignant end...
- Expression of C-kit in retinoblastoma: a potential therapeutic target
Robert J Barry
Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
Br J Ophthalmol 91:1532-6. 2007
..This study aims to determine the immunoexpression of C-kit in retinoblastoma and correlate this expression with histopathological prognostic features...
- Histopathologic study of corneal stromal dystrophies: a 10-year experience
Leonardo N Santos
Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
Cornea 26:1027-31. 2007
..To determine the frequency and describe the histopathologic features of stromal corneal dystrophies over a 10-year period...
- Neovascular glaucoma after stereotactic radiotherapy for juxtapapillary choroidal melanoma: histopathologic and dosimetric findings
Bruno F Fernandes
Department of Ocular Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
Int J Radiat Oncol Biol Phys 80:377-84. 2011
..We compare pathologic changes and dosimetric findings in those eyes enucleated secondary to NVG as opposed to TP to better understand potential mechanisms...
- p16ink4a expression in benign and malignant melanocytic conjunctival lesions
Pablo Zoroquiain
The Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
Int J Surg Pathol 20:240-5. 2012
..However, additional studies of larger series and follow-up are needed to confirm these findings...
- Expression of SIRT1 and DBC1 in Developing and Adult Retinas
Shawn C Maloney
Henry C Witelson Ocular Pathology Laboratory, McGill University, Montreal, QC, Canada H3A 2B4
Stem Cells Int 2012:908183. 2012
..Collectively, the data presented in this study provide support for SIRT1 and DBC1 as regulators of retinal development and normal retinal physiology...
- Expression of SIRT1 in ocular surface squamous neoplasia
Luiz Filipe de A Alves
Department of Ophthalmology, Brazilian Air Force Central Hospital Rio de Janeiro, Rio de Janeiro, Brazil
Cornea 31:817-9. 2012
..In the current study, we examined the expression of SIRT1 in normal epithelium (NE) compared with ocular surface squamous neoplasia (OSSN) to elucidate a possible role for SIRT1 in the development or progression of this malignancy...
- Localized retinal ischemia as an ocular manifestation of primary antiphospholipid syndrome
Moyses E Zajdenweber
Department of Ophthalmology and Pathology, McGill University Hospital Centre, Montreal, Quebec, Canada
Can J Ophthalmol 42:479-80. 2007
..COMMENTS: The ocular manifestation led to the diagnosis and successful treatment of the systemic disease...
- A histopathologic review of undiagnosed neoplasms in 205 evisceration specimens
Eduardo A Novais
Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
Ophthal Plast Reconstr Surg 28:331-4. 2012
..Given the lack of such studies in the literature, our aim was to review a large sample of eviscerated specimens to document the prevalence of unexpected neoplasms...
- Extranodal Rosai-Dorfman Disease presenting as an epibulbar tumor
Bruno F Fernandes
Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
Cornea 27:378-81. 2008
..To describe a case of an epibulbar tumor as a manifestation of Rosai-Dorfman Disease (RDD) and review the pertinent literature...
- Histopathological diagnosis of corneal button specimens: an epidemiological study
Katyanne D Godeiro
Department of Ophthalmology and Pathology, Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
Ophthalmic Epidemiol 14:70-5. 2007
..To determine the most common histopathological diagnosis of corneal specimens from penetrating keratoplasty (PKP)...
- Clinical and histopathological features of orbital granular cell tumor: case report
Bruno F Fernandes
Department of Ophthalmology and Pathology, Henry C Witelson Ocular Pathology Laboratory and McGill University Health Centre, Montreal, QC, Canada
Arq Bras Oftalmol 75:137-9. 2012
..Granular cell tumors are uncommon benign soft tissue neoplasms that have a predilection for the head and neck region. Awareness of the typical histopathological features is crucial for the correct diagnosis...
- Bilateral macular hemorrhage as a complication of drug-induced anemia: a case report
Rubens N Belfort
Henry C Witelson Ocular Pathology Laboratory, Ophthalmology Department, McGill University, Montreal, QC, Canada
J Med Case Reports 3:16. 2009
..Bilateral macular hemorrhage is a rare ocular finding and to the best of our knowledge, this is the first report of such hemorrhages as a presentation of drug-induced anemia...
- Choroidal mass as the presenting sign of small cell lung carcinoma
Bruno F Fernandes
Department of Ophthalmology, Henry C Witelson Ophthalmic Pathology Laboratory, McGill University Health Centre, Montreal, Quebec, Canada, and Department of Ophthalmology, Hospital dos Servidores do Estado, Rio de Janeiro, Brazil
Can J Ophthalmol 41:605-8. 2006
..The possibility of ocular metastases in patients with choroidal masses should always be considered whether or not there is a diagnosis of cancer elsewhere...
