Peter Ferdinandy

Summary

Publications

  1. Sárközy M, Fekete V, Szucs G, Torok S, Szűcs C, Bárkányi J, et al. Anti-diabetic effect of a preparation of vitamins, minerals and trace elements in diabetic rats: a gender difference. BMC Endocr Disord. 2014;14:72 pubmed publisher
    ..Moreover, we have confirmed that females are less sensitive to STZ-induced diabetes and MVT preparation did not show protection against prediabetic state. This may suggest a gender difference in the pathogenesis of diabetes. ..
  2. Baranyai T, Nagy C, Koncsos G, Onódi Z, Károlyi Szabó M, Makkos A, et al. Acute hyperglycemia abolishes cardioprotection by remote ischemic perconditioning. Cardiovasc Diabetol. 2015;14:151 pubmed publisher
    ..The mechanism of this phenomenon may involve an acute hyperglycemia-induced increase in nitrative stress and activation of the mTOR pathway. ..
  3. Varga Z, Agg B, Ferdinandy P. miR-125b is a protectomiR: A rising star for acute cardioprotection. J Mol Cell Cardiol. 2017;: pubmed publisher
    ..Micro-RNAs are promising novel targets for cardioprotection as highlighted by recent seminal position papers and reviews (Hausenloy et al., 2017; Varga et al., 2015; Perrino et al., 2017 [1-3]). ..
  4. Koncsos G, Varga Z, Baranyai T, Ferdinandy P, Schulz R, Giricz Z, et al. Nagarse treatment of cardiac subsarcolemmal and interfibrillar mitochondria leads to artefacts in mitochondrial protein quantification. J Pharmacol Toxicol Methods. 2018;91:50-58 pubmed publisher
    ..Therefore, protease sensitivity should be considered when assessing distribution of mitochondrial proteins using nagarse-based isolation. ..
  5. Baranyai T, Giricz Z, Varga Z, Koncsos G, Lukovic D, Makkos A, et al. In vivo MRI and ex vivo histological assessment of the cardioprotection induced by ischemic preconditioning, postconditioning and remote conditioning in a closed-chest porcine model of reperfused acute myocardial infarction: importance of microvascul. J Transl Med. 2017;15:67 pubmed publisher
    ..We conclude that IPostC and RIC interventions may protect the coronary microvasculature even without reducing myocardial necrosis. ..
  6. Bencsik P, Kupai K, Giricz Z, Gorbe A, Pipis J, Murlasits Z, et al. Role of iNOS and peroxynitrite-matrix metalloproteinase-2 signaling in myocardial late preconditioning in rats. Am J Physiol Heart Circ Physiol. 2010;299:H512-8 pubmed publisher
    ..Furthermore, increased expression of iNOS may play a role in the development of late PC; however, increased iNOS activity does not lead to increased NO production in late PC. ..
  7. Ferdinandy P, Hausenloy D, Heusch G, Baxter G, Schulz R. Interaction of risk factors, comorbidities, and comedications with ischemia/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote conditioning. Pharmacol Rev. 2014;66:1142-74 pubmed publisher
    ..This will hopefully maximize the success rate of developing rational approaches to effective cardioprotective therapies for the majority of patients with multiple risk factors. ..
  8. Kiss K, Csonka C, Pálóczi J, Pipis J, Gorbe A, Kocsis G, et al. Novel, selective EPO receptor ligands lacking erythropoietic activity reduce infarct size in acute myocardial infarction in rats. Pharmacol Res. 2016;113:62-70 pubmed publisher
    ..Therefore, non-erythropoietic EPO receptor peptide ligands may be promising cardioprotective agents. ..
  9. Kemeny A, Csekő K, Szitter I, Varga Z, Bencsik P, Kiss K, et al. Integrative characterization of chronic cigarette smoke-induced cardiopulmonary comorbidities in a mouse model. Environ Pollut. 2017;229:746-759 pubmed publisher
    ....
  10. Pipicz M, Kocsis G, Sárváry Arantes L, Bencsik P, Varga Z, Ferdinandy P, et al. Low-Dose Endotoxin Induces Late Preconditioning, Increases Peroxynitrite Formation, and Activates STAT3 in the Rat Heart. Molecules. 2017;22: pubmed publisher
    ..We conclude that LPS pretreatment enhances cardiac peroxynitrite formation and activates STAT3 24 h later, which may contribute to LPS-induced late preconditioning. ..

Detail Information

Publications10

  1. Sárközy M, Fekete V, Szucs G, Torok S, Szűcs C, Bárkányi J, et al. Anti-diabetic effect of a preparation of vitamins, minerals and trace elements in diabetic rats: a gender difference. BMC Endocr Disord. 2014;14:72 pubmed publisher
    ..Moreover, we have confirmed that females are less sensitive to STZ-induced diabetes and MVT preparation did not show protection against prediabetic state. This may suggest a gender difference in the pathogenesis of diabetes. ..
  2. Baranyai T, Nagy C, Koncsos G, Onódi Z, Károlyi Szabó M, Makkos A, et al. Acute hyperglycemia abolishes cardioprotection by remote ischemic perconditioning. Cardiovasc Diabetol. 2015;14:151 pubmed publisher
    ..The mechanism of this phenomenon may involve an acute hyperglycemia-induced increase in nitrative stress and activation of the mTOR pathway. ..
  3. Varga Z, Agg B, Ferdinandy P. miR-125b is a protectomiR: A rising star for acute cardioprotection. J Mol Cell Cardiol. 2017;: pubmed publisher
    ..Micro-RNAs are promising novel targets for cardioprotection as highlighted by recent seminal position papers and reviews (Hausenloy et al., 2017; Varga et al., 2015; Perrino et al., 2017 [1-3]). ..
  4. Koncsos G, Varga Z, Baranyai T, Ferdinandy P, Schulz R, Giricz Z, et al. Nagarse treatment of cardiac subsarcolemmal and interfibrillar mitochondria leads to artefacts in mitochondrial protein quantification. J Pharmacol Toxicol Methods. 2018;91:50-58 pubmed publisher
    ..Therefore, protease sensitivity should be considered when assessing distribution of mitochondrial proteins using nagarse-based isolation. ..
  5. Baranyai T, Giricz Z, Varga Z, Koncsos G, Lukovic D, Makkos A, et al. In vivo MRI and ex vivo histological assessment of the cardioprotection induced by ischemic preconditioning, postconditioning and remote conditioning in a closed-chest porcine model of reperfused acute myocardial infarction: importance of microvascul. J Transl Med. 2017;15:67 pubmed publisher
    ..We conclude that IPostC and RIC interventions may protect the coronary microvasculature even without reducing myocardial necrosis. ..
  6. Bencsik P, Kupai K, Giricz Z, Gorbe A, Pipis J, Murlasits Z, et al. Role of iNOS and peroxynitrite-matrix metalloproteinase-2 signaling in myocardial late preconditioning in rats. Am J Physiol Heart Circ Physiol. 2010;299:H512-8 pubmed publisher
    ..Furthermore, increased expression of iNOS may play a role in the development of late PC; however, increased iNOS activity does not lead to increased NO production in late PC. ..
  7. Ferdinandy P, Hausenloy D, Heusch G, Baxter G, Schulz R. Interaction of risk factors, comorbidities, and comedications with ischemia/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote conditioning. Pharmacol Rev. 2014;66:1142-74 pubmed publisher
    ..This will hopefully maximize the success rate of developing rational approaches to effective cardioprotective therapies for the majority of patients with multiple risk factors. ..
  8. Kiss K, Csonka C, Pálóczi J, Pipis J, Gorbe A, Kocsis G, et al. Novel, selective EPO receptor ligands lacking erythropoietic activity reduce infarct size in acute myocardial infarction in rats. Pharmacol Res. 2016;113:62-70 pubmed publisher
    ..Therefore, non-erythropoietic EPO receptor peptide ligands may be promising cardioprotective agents. ..
  9. Kemeny A, Csekő K, Szitter I, Varga Z, Bencsik P, Kiss K, et al. Integrative characterization of chronic cigarette smoke-induced cardiopulmonary comorbidities in a mouse model. Environ Pollut. 2017;229:746-759 pubmed publisher
    ....
  10. Pipicz M, Kocsis G, Sárváry Arantes L, Bencsik P, Varga Z, Ferdinandy P, et al. Low-Dose Endotoxin Induces Late Preconditioning, Increases Peroxynitrite Formation, and Activates STAT3 in the Rat Heart. Molecules. 2017;22: pubmed publisher
    ..We conclude that LPS pretreatment enhances cardiac peroxynitrite formation and activates STAT3 24 h later, which may contribute to LPS-induced late preconditioning. ..