Peter Ferdinandy

Summary

Publications

  1. pmc Dietary red palm oil supplementation reduces myocardial infarct size in an isolated perfused rat heart model
    Dirk J Bester
    Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville, South Africa
    Lipids Health Dis 9:64. 2010
  2. pmc The effect of dietary red palm oil on the functional recovery of the ischaemic/reperfused isolated rat heart: the involvement of the PI3-kinase signaling pathway
    Anna Mart Engelbrecht
    Department of Physiological Sciences, University of Stellenbosch, South Africa
    Lipids Health Dis 8:18. 2009
  3. ncbi request reprint Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning
    Peter Ferdinandy
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged, H 6720, Hungary
    Pharmacol Rev 59:418-58. 2007
  4. doi request reprint Role of iNOS and peroxynitrite-matrix metalloproteinase-2 signaling in myocardial late preconditioning in rats
    Peter Bencsik
    Cardiovascular Research Group, Dept of Biochemistry, Univ of Szeged, Dom ter 9, Szeged H 6720, Hungary
    Am J Physiol Heart Circ Physiol 299:H512-8. 2010
  5. pmc Peroxynitrite: just an oxidative/nitrosative stressor or a physiological regulator as well?
    Peter Ferdinandy
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Hungary
    Br J Pharmacol 148:1-3. 2006
  6. ncbi request reprint Hypercholesterolemia increases myocardial oxidative and nitrosative stress thereby leading to cardiac dysfunction in apoB-100 transgenic mice
    Tamas Csont
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Szeged, Hungary
    Cardiovasc Res 76:100-9. 2007
  7. ncbi request reprint Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis
    Zoltan Giricz
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged H 6720, Hungary
    Basic Res Cardiol 98:304-10. 2003
  8. ncbi request reprint Expression of genes related to oxidative/nitrosative stress in mouse hearts: effect of preconditioning and cholesterol diet
    Gabriella F Kocsis
    Department of Biochemistry, University of Szeged, Szeged, Hungary
    Med Sci Monit 16:BR32-9. 2010
  9. ncbi request reprint Hyperlipidemia induced by a cholesterol-rich diet leads to enhanced peroxynitrite formation in rat hearts
    Annamaria Onody
    Cardiovascular Research Group, Department of Biochemistry, Faculty of Medicine, University of Szeged, Dom ter 9, H 6720 Szeged, Hungary
    Cardiovasc Res 58:663-70. 2003
  10. ncbi request reprint Hyperlipidemia attenuates the infarct size-limiting effect of ischemic preconditioning: role of matrix metalloproteinase-2 inhibition
    Zoltan Giricz
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, H 6720 Szeged, Hungary
    J Pharmacol Exp Ther 316:154-61. 2006

Collaborators

Detail Information

Publications38

  1. pmc Dietary red palm oil supplementation reduces myocardial infarct size in an isolated perfused rat heart model
    Dirk J Bester
    Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville, South Africa
    Lipids Health Dis 9:64. 2010
    ..The effects of dietary RPO supplementation on matrix metalloproteinase-2 (MMP2) activation and PKB/Akt phosphorylation were also investigated...
  2. pmc The effect of dietary red palm oil on the functional recovery of the ischaemic/reperfused isolated rat heart: the involvement of the PI3-kinase signaling pathway
    Anna Mart Engelbrecht
    Department of Physiological Sciences, University of Stellenbosch, South Africa
    Lipids Health Dis 8:18. 2009
    ..9 +/- 3.4 pixels in RPO + Wm). We have also demonstrated that PI3-K inhibition induced PARP cleavage (marker of apoptosis) in the hearts during ischaemia/reperfusion injury and that RPO supplementation counteracted this effect...
  3. ncbi request reprint Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning
    Peter Ferdinandy
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged, H 6720, Hungary
    Pharmacol Rev 59:418-58. 2007
    ....
  4. doi request reprint Role of iNOS and peroxynitrite-matrix metalloproteinase-2 signaling in myocardial late preconditioning in rats
    Peter Bencsik
    Cardiovascular Research Group, Dept of Biochemistry, Univ of Szeged, Dom ter 9, Szeged H 6720, Hungary
    Am J Physiol Heart Circ Physiol 299:H512-8. 2010
    ..Furthermore, increased expression of iNOS may play a role in the development of late PC; however, increased iNOS activity does not lead to increased NO production in late PC...
  5. pmc Peroxynitrite: just an oxidative/nitrosative stressor or a physiological regulator as well?
    Peter Ferdinandy
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Hungary
    Br J Pharmacol 148:1-3. 2006
  6. ncbi request reprint Hypercholesterolemia increases myocardial oxidative and nitrosative stress thereby leading to cardiac dysfunction in apoB-100 transgenic mice
    Tamas Csont
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Szeged, Hungary
    Cardiovasc Res 76:100-9. 2007
    ....
  7. ncbi request reprint Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis
    Zoltan Giricz
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged H 6720, Hungary
    Basic Res Cardiol 98:304-10. 2003
    ....
  8. ncbi request reprint Expression of genes related to oxidative/nitrosative stress in mouse hearts: effect of preconditioning and cholesterol diet
    Gabriella F Kocsis
    Department of Biochemistry, University of Szeged, Szeged, Hungary
    Med Sci Monit 16:BR32-9. 2010
    ....
  9. ncbi request reprint Hyperlipidemia induced by a cholesterol-rich diet leads to enhanced peroxynitrite formation in rat hearts
    Annamaria Onody
    Cardiovascular Research Group, Department of Biochemistry, Faculty of Medicine, University of Szeged, Dom ter 9, H 6720 Szeged, Hungary
    Cardiovasc Res 58:663-70. 2003
    ..We investigated the influence of experimental hyperlipidemia on the formation of cardiac NO, superoxide, and peroxynitrite (ONOO(-)) in rat hearts...
  10. ncbi request reprint Hyperlipidemia attenuates the infarct size-limiting effect of ischemic preconditioning: role of matrix metalloproteinase-2 inhibition
    Zoltan Giricz
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, H 6720 Szeged, Hungary
    J Pharmacol Exp Ther 316:154-61. 2006
    ....
  11. ncbi request reprint Capsaicin-sensitive sensory neurons regulate myocardial function and gene expression pattern of rat hearts: a DNA microarray study
    Agnes Zvara
    Laboratory of Functional Genomics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary
    FASEB J 20:160-2. 2006
    ..We conclude that capsaicin-sensitive sensory nerves play a significant role in the regulation of a variety of neuronal and non-neuronal genes in the heart and possibly in other tissues as well...
  12. ncbi request reprint Nitrate tolerance does not increase production of peroxynitrite in the heart
    Tamas Csont
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Szeged, H 6720, Hungary
    Am J Physiol Heart Circ Physiol 283:H69-76. 2002
    ..This is the first demonstration that, although the systemic effects of nitroglycerin may be deleterious due to enhancement of extracardiac peroxynitrite formation, nitroglycerin does not result in oxidative damage in the heart...
  13. doi request reprint Cholesterol diet-induced hyperlipidemia impairs the cardioprotective effect of postconditioning: role of peroxynitrite
    Krisztina Kupai
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Hungary
    Am J Physiol Heart Circ Physiol 297:H1729-35. 2009
    ..Furthermore, hyperlipidemia blocks the cardioprotective effect of postconditioning at least in part via deterioration of the postconditioning-induced early increase in peroxynitrite formation...
  14. doi request reprint Role of cGMP-PKG signaling in the protection of neonatal rat cardiac myocytes subjected to simulated ischemia/reoxygenation
    Aniko Gorbe
    Department of Biochemistry, University of Szeged, Hungary
    Basic Res Cardiol 105:643-50. 2010
    ..This is the first demonstration that elevated cGMP produced either by the sGC activator SNAP or the pGC activator BNP exerts cytoprotective effects via a common downstream signaling pathway involving PKG activation...
  15. doi request reprint Gene and protein expression changes in response to normoxic perfusion in mouse hearts
    Nóra Faragó
    Laboratory of Functional Genomics, Biological Research Center, Hungarian Academy of Sciences, H 6726, Szeged, Hungary
    J Pharmacol Toxicol Methods 57:145-54. 2008
    ..Therefore, here we investigated the time-dependent effect of normoxic, normothermic perfusion on global gene expression at mRNA and protein levels...
  16. doi request reprint Lovastatin interferes with the infarct size-limiting effect of ischemic preconditioning and postconditioning in rat hearts
    Gabriella F Kocsis
    Cardiovascular Research Group and PharmaHungary Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged, Hungary
    Am J Physiol Heart Circ Physiol 294:H2406-9. 2008
    ..We conclude that, although lovastatin may lead to cardioprotection, it interferes with the mechanisms of cardiac adaptation to ischemic stress...
  17. doi request reprint Cholesterol diet leads to attenuation of ischemic preconditioning-induced cardiac protection: the role of connexin 43
    Aniko Gorbe
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Hungary
    Am J Physiol Heart Circ Physiol 300:H1907-13. 2011
    ..In conclusion, loss of cardioprotection by IP in hyperlipidemia is associated with a redistribution of both sarcolemmal and mitochondrial Cx43...
  18. doi request reprint Preconditioning protects the heart in a prolonged uremic condition
    Gabriella F Kocsis
    Cardiovascular Research Group, Department of Biochemistry, Faculty of Medicine, University of Szeged, Szeged, Hungary
    Am J Physiol Heart Circ Physiol 303:H1229-36. 2012
    ..We conclude that although prolonged experimental uremia leads to severe metabolic changes and the development of a mild myocardial dysfunction, the cardioprotective effect of ischemic preconditioning is still preserved...
  19. doi request reprint Measurement of myocardial infarct size in preclinical studies
    Csaba Csonka
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Szeged, Hungary
    J Pharmacol Toxicol Methods 61:163-70. 2010
    ..This paper highlights recent advances of the different techniques to measure infarct size...
  20. ncbi request reprint Cholesterol diet-induced hyperlipidemia influences gene expression pattern of rat hearts: a DNA microarray study
    Laszlo G Puskas
    Laboratory of Functional Genomics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary
    FEBS Lett 562:99-104. 2004
    ..Although some of these genes have been suspected to be related to cardiovascular diseases, none of the genes has been previously shown to be involved in the mechanism of the cardiac effect of hyperlipidemia...
  21. pmc Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats
    Márta Sárközy
    Cardiovascular Research Group, Department of Biochemistry, Faculty of Medicine, University of Szeged, Szeged, Hungary
    Cardiovasc Diabetol 12:16. 2013
    ..Therefore, we examined the possible alterations in cardiac gene expression pattern in male Zucker Diabetic Fatty (ZDF) rats, a model of metabolic syndrome...
  22. pmc Dietary red palm oil supplementation decreases infarct size in cholesterol fed rats
    Gergo Szucs
    Cardiovascular Research Group, University of Szeged, Szeged, Hungary
    Lipids Health Dis 10:103. 2011
    ....
  23. ncbi request reprint Defibrillatory action of glibenclamide is independent from ATP-sensitive K+ channels and free radicals
    Csaba Csonka
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Szeged, Hungary
    J Cardiovasc Pharmacol 41:916-22. 2003
    ..The conclusion is that glibenclamide exerts a defibrillatory action and improves post-VF cardiac function in rat hearts and these effects are independent from K(ATP) and free radicals...
  24. doi request reprint Cardioprotection by farnesol: role of the mevalonate pathway
    Gergo Szucs
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, 6720, 9 Dóm tér, Szeged, Hungary
    Cardiovasc Drugs Ther 27:269-77. 2013
    ..Farnesol is a key metabolite of the mevalonate pathway and known as an antioxidant. We examined whether farnesol treatment protects the ischemic heart...
  25. doi request reprint Myocardial postconditioning is lost in vascular nitrate tolerance
    Veronika Fekete
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Hungary and Pharmahungary Group, Szeged, Hungary and Departments of Pathophysiology and Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
    J Cardiovasc Pharmacol 62:298-303. 2013
    ..Vascular nitrate tolerance interferes with the infarct size limiting effect of IPost. Activation of survival kinases is not crucial in the molecular mechanism of postconditioning, which remains unaffected in nitrate tolerance. ..
  26. doi request reprint MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative/nitrative stress and subsequent dysfunction in the heart
    Zoltán V Varga
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Szeged, Hungary Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
    J Mol Cell Cardiol 62:111-21. 2013
    ..We conclude that hypercholesterolemia-induced microRNA alterations play an important role in the regulation of oxidative/nitrative stress and in consequent myocardial dysfunction. ..
  27. doi request reprint Biglycan protects cardiomyocytes against hypoxia/reoxygenation injury: role of nitric oxide
    Tamas Csont
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Szeged, Hungary
    J Mol Cell Cardiol 48:649-52. 2010
    ..This is the first demonstration that biglycan leads to cytoprotection against hypoxia/reoxygenation injury, and that this phenomenon is partially mediated by an NO-dependent mechanism...
  28. doi request reprint Capillary injury in the ischemic brain of hyperlipidemic, apolipoprotein B-100 transgenic mice
    Zoltan Sule
    Department of Anatomy, Faculty of Medicine, University of Szeged, Kossuth Lajos sgt 40, H 6724 Szeged, Hungary
    Life Sci 84:935-9. 2009
    ..Our aim was to investigate whether the expression of human apoB-100 in transgenic mice and/or a high-cholesterol diet cause cerebral microvascular lesions, and whether these conditions augment ischemia-related capillary damage...
  29. ncbi request reprint Effect of classic preconditioning on the gene expression pattern of rat hearts: a DNA microarray study
    Annamaria Onody
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, H 6720 Szeged, Hungary
    FEBS Lett 536:35-40. 2003
    ..None of these genes has previously been shown to be involved in the mechanism of preconditioning...
  30. ncbi request reprint Capsaicin-sensitive sensory neurons regulate myocardial nitric oxide and cGMP signaling
    Tamas Csont
    Cardiovascular Research Group, Department of Biochemistry, Faculty of Medicine, University of Szeged, Dom ter 9, Szeged H 6720, Hungary
    Eur J Pharmacol 476:107-13. 2003
    ..Vagal sensory nerves may be involved in the regulation of basal myocardial cGMP but not basal NO level. Consequently, basal NO content in the heart is regulated primarily by spinal afferent nerves...
  31. ncbi request reprint Hypercholesterolemia attenuates the anti-ischemic effect of preconditioning during coronary angioplasty
    Imre Ungi
    Second Department of Internal Medicine and Cardiology Center, University of Szeged, Hungary
    Chest 128:1623-8. 2005
    ..We studied ischemic preconditioning induced by coronary angioplasty in hypercholesterolemic and normocholesterolemic patients by means of a beat-to-beat analysis of ST segments...
  32. pmc Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia-reperfusion injury and preconditioning
    Peter Ferdinandy
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged, H 6720 Hungary
    Br J Pharmacol 138:532-43. 2003
    ..Here we review the roles of NO, O(2)(-)*, and ONOO(-) in both ischaemia-reperfusion injury and preconditioning...
  33. pmc Myocardial ischaemia/reperfusion injury and preconditioning: effects of hypercholesterolaemia/hyperlipidaemia
    Peter Ferdinandy
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged, H 6720 Hungary
    Br J Pharmacol 138:283-5. 2003
  34. ncbi request reprint Cardioprotective effects of glyceryl trinitrate: beyond vascular nitrate tolerance
    Tamas Csont
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, H 6720 Szeged, Hungary
    Pharmacol Ther 105:57-68. 2005
    ....
  35. ncbi request reprint Selective sensory denervation by capsaicin aggravates adriamycin-induced cardiomyopathy in rats
    Marta Katona
    Department of Pediatrics, University of Szeged, Koranyi fasor 14 15, 6725 Szeged, Hungary
    Naunyn Schmiedebergs Arch Pharmacol 370:436-43. 2004
    ....
  36. ncbi request reprint Hyperlipidemia induced by high cholesterol diet inhibits heat shock response in rat hearts
    Tamas Csont
    Cardiovascular Research Group, University of Szeged, Szeged, Hungary
    Biochem Biophys Res Commun 290:1535-8. 2002
    ..This is the first demonstration that hyperlipidemia inhibits cardiac heat shock response. We further conclude that basal HSP70 expression might be downregulated at a posttranscriptional level in hyperlipidemia...
  37. doi request reprint Different administration schedules of darbepoetin alfa affect oxidized and reduced glutathione levels to a similar extent in 5/6 nephrectomized rats
    Péter Monostori
    Department of Pediatrics, Albert Szent Gyorgyi Clinical Center, University of Szeged, Koranyi fasor 14 15, Szeged, 6720, Hungary
    Clin Exp Nephrol 17:569-74. 2013
    ..The level of oxidative stress is increased in chronic kidney disease, and is reportedly decreased after long-term ESA treatment. However, the effect of different dosing regimens of ESAs on oxidative stress has not been elucidated...
  38. ncbi request reprint Human apoB overexpression and a high-cholesterol diet differently modify the brain APP metabolism in the transgenic mouse model of atherosclerosis
    Annamária Bjelik
    Alzheimer s Research Centre, Department of Psychiatry, Albert Szent Györgyi Center for Medical and Pharmaceutical Sciences, University of Szeged, 6 Semmelweis u, Szeged H 6725, Hungary
    Neurochem Int 49:393-400. 2006
    ..Our data indicate that the two atherogenic factors, the HC diet and the overexpression of the human apoB-100 gene by the liver, could exert different effects on the processing and expression of APP in the mice brain...