Dietary red palm oil supplementation reduces myocardial infarct size in an isolated perfused rat heart modelDirk J Bester
Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville, South Africa
Lipids Health Dis 9:64. 2010
..The effects of dietary RPO supplementation on matrix metalloproteinase-2 (MMP2) activation and PKB/Akt phosphorylation were also investigated...
- The effect of dietary red palm oil on the functional recovery of the ischaemic/reperfused isolated rat heart: the involvement of the PI3-kinase signaling pathway
Anna Mart Engelbrecht
Department of Physiological Sciences, University of Stellenbosch, South Africa
Lipids Health Dis 8:18. 2009
..9 +/- 3.4 pixels in RPO + Wm). We have also demonstrated that PI3-K inhibition induced PARP cleavage (marker of apoptosis) in the hearts during ischaemia/reperfusion injury and that RPO supplementation counteracted this effect...
Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioningPeter Ferdinandy
Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged, H 6720, Hungary
Pharmacol Rev 59:418-58. 2007
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- Peroxynitrite: just an oxidative/nitrosative stressor or a physiological regulator as well?
Peter Ferdinandy
Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Hungary
Br J Pharmacol 148:1-3. 2006
Role of iNOS and peroxynitrite-matrix metalloproteinase-2 signaling in myocardial late preconditioning in ratsPeter Bencsik
Cardiovascular Research Group, Dept of Biochemistry, Univ of Szeged, Dom ter 9, Szeged H 6720, Hungary
Am J Physiol Heart Circ Physiol 299:H512-8. 2010
..Furthermore, increased expression of iNOS may play a role in the development of late PC; however, increased iNOS activity does not lead to increased NO production in late PC...
- Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis
Zoltan Giricz
Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged H 6720, Hungary
Basic Res Cardiol 98:304-10. 2003
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- Hyperlipidemia induced by a cholesterol-rich diet leads to enhanced peroxynitrite formation in rat hearts
Annamaria Onody
Cardiovascular Research Group, Department of Biochemistry, Faculty of Medicine, University of Szeged, Dom ter 9, H 6720 Szeged, Hungary
Cardiovasc Res 58:663-70. 2003
..We investigated the influence of experimental hyperlipidemia on the formation of cardiac NO, superoxide, and peroxynitrite (ONOO(-)) in rat hearts...
- Hypercholesterolemia increases myocardial oxidative and nitrosative stress thereby leading to cardiac dysfunction in apoB-100 transgenic mice
Tamas Csont
Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Szeged, Hungary
Cardiovasc Res 76:100-9. 2007
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- Hyperlipidemia attenuates the infarct size-limiting effect of ischemic preconditioning: role of matrix metalloproteinase-2 inhibition
Zoltan Giricz
Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, H 6720 Szeged, Hungary
J Pharmacol Exp Ther 316:154-61. 2006
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- Expression of genes related to oxidative/nitrosative stress in mouse hearts: effect of preconditioning and cholesterol diet
Gabriella F Kocsis
Department of Biochemistry, University of Szeged, Szeged, Hungary
Med Sci Monit 16:BR32-9. 2010
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- Nitrate tolerance does not increase production of peroxynitrite in the heart
Tamas Csont
Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Szeged, H 6720, Hungary
Am J Physiol Heart Circ Physiol 283:H69-76. 2002
..This is the first demonstration that, although the systemic effects of nitroglycerin may be deleterious due to enhancement of extracardiac peroxynitrite formation, nitroglycerin does not result in oxidative damage in the heart...
- Cholesterol diet-induced hyperlipidemia impairs the cardioprotective effect of postconditioning: role of peroxynitrite
Krisztina Kupai
Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Hungary
Am J Physiol Heart Circ Physiol 297:H1729-35. 2009
..Furthermore, hyperlipidemia blocks the cardioprotective effect of postconditioning at least in part via deterioration of the postconditioning-induced early increase in peroxynitrite formation...
- Role of cGMP-PKG signaling in the protection of neonatal rat cardiac myocytes subjected to simulated ischemia/reoxygenation
Aniko Gorbe
Department of Biochemistry, University of Szeged, Hungary
Basic Res Cardiol 105:643-50. 2010
..This is the first demonstration that elevated cGMP produced either by the sGC activator SNAP or the pGC activator BNP exerts cytoprotective effects via a common downstream signaling pathway involving PKG activation...
- Gene and protein expression changes in response to normoxic perfusion in mouse hearts
Nóra Faragó
Laboratory of Functional Genomics, Biological Research Center, Hungarian Academy of Sciences, H 6726, Szeged, Hungary
J Pharmacol Toxicol Methods 57:145-54. 2008
..Therefore, here we investigated the time-dependent effect of normoxic, normothermic perfusion on global gene expression at mRNA and protein levels...
- Cholesterol diet leads to attenuation of ischemic preconditioning-induced cardiac protection: the role of connexin 43
Aniko Gorbe
Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Hungary
Am J Physiol Heart Circ Physiol 300:H1907-13. 2011
..In conclusion, loss of cardioprotection by IP in hyperlipidemia is associated with a redistribution of both sarcolemmal and mitochondrial Cx43...
- Lovastatin interferes with the infarct size-limiting effect of ischemic preconditioning and postconditioning in rat hearts
Gabriella F Kocsis
Cardiovascular Research Group and PharmaHungary Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged, Hungary
Am J Physiol Heart Circ Physiol 294:H2406-9. 2008
..We conclude that, although lovastatin may lead to cardioprotection, it interferes with the mechanisms of cardiac adaptation to ischemic stress...
- Cholesterol diet-induced hyperlipidemia influences gene expression pattern of rat hearts: a DNA microarray study
Laszlo G Puskas
Laboratory of Functional Genomics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary
FEBS Lett 562:99-104. 2004
..Although some of these genes have been suspected to be related to cardiovascular diseases, none of the genes has been previously shown to be involved in the mechanism of the cardiac effect of hyperlipidemia...
- Measurement of myocardial infarct size in preclinical studies
Csaba Csonka
Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Szeged, Hungary
J Pharmacol Toxicol Methods 61:163-70. 2010
..This paper highlights recent advances of the different techniques to measure infarct size...
- Dietary red palm oil supplementation decreases infarct size in cholesterol fed rats
Gergo Szucs
Cardiovascular Research Group, University of Szeged, Szeged, Hungary
Lipids Health Dis 10:103. 2011
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- Capillary injury in the ischemic brain of hyperlipidemic, apolipoprotein B-100 transgenic mice
Zoltan Sule
Department of Anatomy, Faculty of Medicine, University of Szeged, Kossuth Lajos sgt 40, H 6724 Szeged, Hungary
Life Sci 84:935-9. 2009
..Our aim was to investigate whether the expression of human apoB-100 in transgenic mice and/or a high-cholesterol diet cause cerebral microvascular lesions, and whether these conditions augment ischemia-related capillary damage...
- Effect of classic preconditioning on the gene expression pattern of rat hearts: a DNA microarray study
Annamaria Onody
Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, H 6720 Szeged, Hungary
FEBS Lett 536:35-40. 2003
..None of these genes has previously been shown to be involved in the mechanism of preconditioning...
- Capsaicin-sensitive sensory neurons regulate myocardial nitric oxide and cGMP signaling
Tamas Csont
Cardiovascular Research Group, Department of Biochemistry, Faculty of Medicine, University of Szeged, Dom ter 9, Szeged H 6720, Hungary
Eur J Pharmacol 476:107-13. 2003
..Vagal sensory nerves may be involved in the regulation of basal myocardial cGMP but not basal NO level. Consequently, basal NO content in the heart is regulated primarily by spinal afferent nerves...
- Biglycan protects cardiomyocytes against hypoxia/reoxygenation injury: role of nitric oxide
Tamas Csont
Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Szeged, Hungary
J Mol Cell Cardiol 48:649-52. 2010
..This is the first demonstration that biglycan leads to cytoprotection against hypoxia/reoxygenation injury, and that this phenomenon is partially mediated by an NO-dependent mechanism...
- Preconditioning protects the heart in a prolonged uremic condition
Gabriella F Kocsis
Cardiovascular Research Group, Department of Biochemistry, Faculty of Medicine, University of Szeged, Szeged, Hungary
Am J Physiol Heart Circ Physiol 303:H1229-36. 2012
..We conclude that although prolonged experimental uremia leads to severe metabolic changes and the development of a mild myocardial dysfunction, the cardioprotective effect of ischemic preconditioning is still preserved...
- Cardioprotective effects of glyceryl trinitrate: beyond vascular nitrate tolerance
Tamas Csont
Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, H 6720 Szeged, Hungary
Pharmacol Ther 105:57-68. 2005
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- Myocardial ischaemia/reperfusion injury and preconditioning: effects of hypercholesterolaemia/hyperlipidaemia
Peter Ferdinandy
Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged, H 6720 Hungary
Br J Pharmacol 138:283-5. 2003
- Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia-reperfusion injury and preconditioning
Peter Ferdinandy
Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged, H 6720 Hungary
Br J Pharmacol 138:532-43. 2003
..Here we review the roles of NO, O(2)(-)*, and ONOO(-) in both ischaemia-reperfusion injury and preconditioning...
- Selective sensory denervation by capsaicin aggravates adriamycin-induced cardiomyopathy in rats
Marta Katona
Department of Pediatrics, University of Szeged, Koranyi fasor 14 15, 6725 Szeged, Hungary
Naunyn Schmiedebergs Arch Pharmacol 370:436-43. 2004
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- Hyperlipidemia induced by high cholesterol diet inhibits heat shock response in rat hearts
Tamas Csont
Cardiovascular Research Group, University of Szeged, Szeged, Hungary
Biochem Biophys Res Commun 290:1535-8. 2002
..This is the first demonstration that hyperlipidemia inhibits cardiac heat shock response. We further conclude that basal HSP70 expression might be downregulated at a posttranscriptional level in hyperlipidemia...
- Human apoB overexpression and a high-cholesterol diet differently modify the brain APP metabolism in the transgenic mouse model of atherosclerosis
Annamária Bjelik
Alzheimer s Research Centre, Department of Psychiatry, Albert Szent Györgyi Center for Medical and Pharmaceutical Sciences, University of Szeged, 6 Semmelweis u, Szeged H 6725, Hungary
Neurochem Int 49:393-400. 2006
..Our data indicate that the two atherogenic factors, the HC diet and the overexpression of the human apoB-100 gene by the liver, could exert different effects on the processing and expression of APP in the mice brain...
