P A Ferchmin

Summary

Publications

  1. pmc 4R-cembranoid protects against diisopropylfluorophosphate-mediated neurodegeneration
    P A Ferchmin
    Department of Biochemistry, Universidad Central del Caribe School of Medicine, Bayamon, PR 00960, USA Electronic address
    Neurotoxicology 44:80-90. 2014
  2. pmc Kinin-B2 receptor mediated neuroprotection after NMDA excitotoxicity is reversed in the presence of kinin-B1 receptor agonists
    Antonio H Martins
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 7:e30755. 2012
  3. pmc γ-Aminobutyric acid type A receptor inhibition triggers a nicotinic neuroprotective mechanism
    P A Ferchmin
    School of Medicine, Universidad Central del Caribe, Bayamon, Puerto Rico
    J Neurosci Res 91:416-25. 2013
  4. ncbi request reprint Tobacco cembranoids protect the function of acute hippocampal slices against NMDA by a mechanism mediated by alpha4beta2 nicotinic receptors
    P A Ferchmin
    Center for Molecular and Behavioral Neuroscience, Universidad Central del Caribe, Bayamon, Puerto Rico
    J Neurosci Res 82:631-41. 2005
  5. pmc A cembranoid protects acute hippocampal slices against paraoxon neurotoxicity
    Vesna A Eterovic
    Department of Biochemistry, Universidad Central del Caribe, Bayamon, PR 00960 6032
    Toxicol In Vitro 25:1468-74. 2011
  6. pmc Kinin-B2 receptor exerted neuroprotection after diisopropylfluorophosphate-induced neuronal damage
    W Torres-Rivera
    Department of Biochemistry, Universidad Central del Caribe, Bayamon, PR 00956, USA
    Neuroscience 247:273-9. 2013
  7. ncbi request reprint Spermine is neuroprotective against anoxia and N-methyl-D-aspartate in hippocampal slices
    P A Ferchmin
    Center for Molecular and Behavioral Neuroscience, Department of Biochemistry, Universidad Central del Caribe School of Medicine, Bayamon, USA
    Brain Res 859:273-9. 2000
  8. pmc Actions of octocoral and tobacco cembranoids on nicotinic receptors
    P A Ferchmin
    Department of Biochemistry, Universidad Central del Caribe, Bayamon, PR, USA
    Toxicon 54:1174-82. 2009
  9. ncbi request reprint Tobacco cembranoids block behavioral sensitization to nicotine and inhibit neuronal acetylcholine receptor function
    P A Ferchmin
    Center for Molecular and Behavioral Neuroscience, Universidad Central del Caribe, Bayamon, 00960 6032, Puerto Rico
    J Neurosci Res 64:18-25. 2001
  10. doi request reprint Neuroprotective activity of (1S,2E,4R,6R,-7E,11E)-2,7,11-cembratriene-4,6-diol (4R) in vitro and in vivo in rodent models of brain ischemia
    A H Martins
    Department of Biochemistry, Universidad Central del Caribe, Ave Laurel 100, Santa Juanita, Bayamon, PR 00956, USA
    Neuroscience 291:250-9. 2015

Collaborators

  • Henning Ulrich
  • Z Xu
  • A D Rodriguez
  • ONE R PAGAN
  • Vesna A Eterovic
  • A H Martins
  • Antonio H Martins
  • Wanda Velez-Carrasco
  • V A Eterovic
  • W Torres-Rivera
  • Marimée Carrasco
  • Dinely Perez
  • B D Ford
  • Anna Furimsky
  • C Mu
  • J Hao
  • Kathleen O'Loughlin
  • K El Sayed
  • P Alvarez
  • J Hu
  • Carol E Green
  • Paul Catz
  • M Carrasco
  • M O Platt
  • K Y Park
  • D Perez
  • Janaina M Alves
  • Wilmarie Torres-Rivera
  • Brenda L Cuadrado

Detail Information

Publications12

  1. pmc 4R-cembranoid protects against diisopropylfluorophosphate-mediated neurodegeneration
    P A Ferchmin
    Department of Biochemistry, Universidad Central del Caribe School of Medicine, Bayamon, PR 00960, USA Electronic address
    Neurotoxicology 44:80-90. 2014
    ....
  2. pmc Kinin-B2 receptor mediated neuroprotection after NMDA excitotoxicity is reversed in the presence of kinin-B1 receptor agonists
    Antonio H Martins
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 7:e30755. 2012
    ....
  3. pmc γ-Aminobutyric acid type A receptor inhibition triggers a nicotinic neuroprotective mechanism
    P A Ferchmin
    School of Medicine, Universidad Central del Caribe, Bayamon, Puerto Rico
    J Neurosci Res 91:416-25. 2013
    ..These results shed light on how α7 nAChR inhibition can be neuroprotective through a mechanism mediated by activation of α4β2 nAChRs...
  4. ncbi request reprint Tobacco cembranoids protect the function of acute hippocampal slices against NMDA by a mechanism mediated by alpha4beta2 nicotinic receptors
    P A Ferchmin
    Center for Molecular and Behavioral Neuroscience, Universidad Central del Caribe, Bayamon, Puerto Rico
    J Neurosci Res 82:631-41. 2005
    ..In conclusion, these findings demonstrate that there are two different nicotinic neuroprotective mechanisms mediated by alpha4beta2...
  5. pmc A cembranoid protects acute hippocampal slices against paraoxon neurotoxicity
    Vesna A Eterovic
    Department of Biochemistry, Universidad Central del Caribe, Bayamon, PR 00960 6032
    Toxicol In Vitro 25:1468-74. 2011
    ..In conclusion, 4R is a promising neuroprotective compound against OP neurotoxins...
  6. pmc Kinin-B2 receptor exerted neuroprotection after diisopropylfluorophosphate-induced neuronal damage
    W Torres-Rivera
    Department of Biochemistry, Universidad Central del Caribe, Bayamon, PR 00956, USA
    Neuroscience 247:273-9. 2013
    ..These findings again confirm the neuroprotective feature of bradykinin, which is, diminished by its endogenous metabolites, stimulating the B1BKR, providing a novel understanding of the physiological roles of these receptors. ..
  7. ncbi request reprint Spermine is neuroprotective against anoxia and N-methyl-D-aspartate in hippocampal slices
    P A Ferchmin
    Center for Molecular and Behavioral Neuroscience, Department of Biochemistry, Universidad Central del Caribe School of Medicine, Bayamon, USA
    Brain Res 859:273-9. 2000
    ..In addition, several noxious stimuli trigger the release of intracellular spermine and could raise local levels of spermine. Therefore, it is possible that spermine has a neuroprotective role in vivo...
  8. pmc Actions of octocoral and tobacco cembranoids on nicotinic receptors
    P A Ferchmin
    Department of Biochemistry, Universidad Central del Caribe, Bayamon, PR, USA
    Toxicon 54:1174-82. 2009
    ..In addition, cembranoids are known to act as anti-tumor compounds. In conclusion, cembranoids provide a promising source of lead drugs for many clinical areas, including neuroprotection, smoking-cessation, and anti-cancer therapies...
  9. ncbi request reprint Tobacco cembranoids block behavioral sensitization to nicotine and inhibit neuronal acetylcholine receptor function
    P A Ferchmin
    Center for Molecular and Behavioral Neuroscience, Universidad Central del Caribe, Bayamon, 00960 6032, Puerto Rico
    J Neurosci Res 64:18-25. 2001
    ..IC(50) values were in the submicromolar to low-micromolar range, with 4R displaying an order of magnitude higher potency than its diastereoisomer, 4S...
  10. doi request reprint Neuroprotective activity of (1S,2E,4R,6R,-7E,11E)-2,7,11-cembratriene-4,6-diol (4R) in vitro and in vivo in rodent models of brain ischemia
    A H Martins
    Department of Biochemistry, Universidad Central del Caribe, Ave Laurel 100, Santa Juanita, Bayamon, PR 00956, USA
    Neuroscience 291:250-9. 2015
    ..Inhibition of ICAM-1 expression and restoration of Akt phosphorylation are the possible mechanisms involved in cellular protection by 4R. ..
  11. doi request reprint Pharmacokinetics and Metabolism of 4R-Cembranoid
    Wanda Velez-Carrasco
    Department of Biochemistry, Universidad Central del Caribe, Bayamon, Puerto Rico, United States of America
    PLoS ONE 10:e0121540. 2015
    ..4, reached 10 min after dose, whereas in the i.m. and s.c. groups was 2.49 and 2.48, respectively, at 90 min after dose. Our data show that 4R crosses the BBB and concentrates in the brain where it exerts its neuroprotective effect. ..
  12. ncbi request reprint Nicotinic receptors differentially regulate N-methyl-D-aspartate damage in acute hippocampal slices
    P A Ferchmin
    Department of Biochemistry, Universidad Central del Caribe, P O Box 60 327, Bayamon, Puerto Rico 00960 6032
    J Pharmacol Exp Ther 305:1071-8. 2003
    ....