P A Ferchmin

Summary

Publications

  1. pmc Kinin-B2 receptor mediated neuroprotection after NMDA excitotoxicity is reversed in the presence of kinin-B1 receptor agonists
    Antonio H Martins
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 7:e30755. 2012
  2. doi request reprint γ-Aminobutyric acid type A receptor inhibition triggers a nicotinic neuroprotective mechanism
    P A Ferchmin
    School of Medicine, Universidad Central del Caribe, Bayamon, Puerto Rico
    J Neurosci Res 91:416-25. 2013
  3. ncbi request reprint Tobacco cembranoids protect the function of acute hippocampal slices against NMDA by a mechanism mediated by alpha4beta2 nicotinic receptors
    P A Ferchmin
    Center for Molecular and Behavioral Neuroscience, Universidad Central del Caribe, Bayamon, Puerto Rico
    J Neurosci Res 82:631-41. 2005
  4. pmc A cembranoid protects acute hippocampal slices against paraoxon neurotoxicity
    Vesna A Eterovic
    Department of Biochemistry, Universidad Central del Caribe, Bayamon, PR 00960 6032
    Toxicol In Vitro 25:1468-74. 2011
  5. pmc Actions of octocoral and tobacco cembranoids on nicotinic receptors
    P A Ferchmin
    Department of Biochemistry, Universidad Central del Caribe, Bayamon, PR, USA
    Toxicon 54:1174-82. 2009
  6. pmc Kinin-B2 receptor exerted neuroprotection after diisopropylfluorophosphate-induced neuronal damage
    W Torres-Rivera
    Department of Biochemistry, Universidad Central del Caribe, Bayamon, PR 00956, USA
    Neuroscience 247:273-9. 2013
  7. ncbi request reprint Tobacco cembranoids block behavioral sensitization to nicotine and inhibit neuronal acetylcholine receptor function
    P A Ferchmin
    Center for Molecular and Behavioral Neuroscience, Universidad Central del Caribe, Bayamon, 00960 6032, Puerto Rico
    J Neurosci Res 64:18-25. 2001
  8. ncbi request reprint Nicotinic receptors differentially regulate N-methyl-D-aspartate damage in acute hippocampal slices
    P A Ferchmin
    Department of Biochemistry, Universidad Central del Caribe, P O Box 60 327, Bayamon, Puerto Rico 00960 6032
    J Pharmacol Exp Ther 305:1071-8. 2003

Collaborators

  • Henning Ulrich
  • A D Rodriguez
  • ONE R PAGAN
  • Antonio H Martins
  • Vesna A Eterovic
  • W Torres-Rivera
  • Dinely Perez
  • Marimée Carrasco
  • K Y Park
  • V A Eterovic
  • M Carrasco
  • A H Martins
  • D Perez
  • M O Platt
  • Wilmarie Torres-Rivera
  • Janaina M Alves
  • Brenda L Cuadrado

Detail Information

Publications8

  1. pmc Kinin-B2 receptor mediated neuroprotection after NMDA excitotoxicity is reversed in the presence of kinin-B1 receptor agonists
    Antonio H Martins
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 7:e30755. 2012
    ....
  2. doi request reprint γ-Aminobutyric acid type A receptor inhibition triggers a nicotinic neuroprotective mechanism
    P A Ferchmin
    School of Medicine, Universidad Central del Caribe, Bayamon, Puerto Rico
    J Neurosci Res 91:416-25. 2013
    ..These results shed light on how α7 nAChR inhibition can be neuroprotective through a mechanism mediated by activation of α4β2 nAChRs...
  3. ncbi request reprint Tobacco cembranoids protect the function of acute hippocampal slices against NMDA by a mechanism mediated by alpha4beta2 nicotinic receptors
    P A Ferchmin
    Center for Molecular and Behavioral Neuroscience, Universidad Central del Caribe, Bayamon, Puerto Rico
    J Neurosci Res 82:631-41. 2005
    ..In conclusion, these findings demonstrate that there are two different nicotinic neuroprotective mechanisms mediated by alpha4beta2...
  4. pmc A cembranoid protects acute hippocampal slices against paraoxon neurotoxicity
    Vesna A Eterovic
    Department of Biochemistry, Universidad Central del Caribe, Bayamon, PR 00960 6032
    Toxicol In Vitro 25:1468-74. 2011
    ..In conclusion, 4R is a promising neuroprotective compound against OP neurotoxins...
  5. pmc Actions of octocoral and tobacco cembranoids on nicotinic receptors
    P A Ferchmin
    Department of Biochemistry, Universidad Central del Caribe, Bayamon, PR, USA
    Toxicon 54:1174-82. 2009
    ..In addition, cembranoids are known to act as anti-tumor compounds. In conclusion, cembranoids provide a promising source of lead drugs for many clinical areas, including neuroprotection, smoking-cessation, and anti-cancer therapies...
  6. pmc Kinin-B2 receptor exerted neuroprotection after diisopropylfluorophosphate-induced neuronal damage
    W Torres-Rivera
    Department of Biochemistry, Universidad Central del Caribe, Bayamon, PR 00956, USA
    Neuroscience 247:273-9. 2013
    ..These findings again confirm the neuroprotective feature of bradykinin, which is, diminished by its endogenous metabolites, stimulating the B1BKR, providing a novel understanding of the physiological roles of these receptors. ..
  7. ncbi request reprint Tobacco cembranoids block behavioral sensitization to nicotine and inhibit neuronal acetylcholine receptor function
    P A Ferchmin
    Center for Molecular and Behavioral Neuroscience, Universidad Central del Caribe, Bayamon, 00960 6032, Puerto Rico
    J Neurosci Res 64:18-25. 2001
    ..IC(50) values were in the submicromolar to low-micromolar range, with 4R displaying an order of magnitude higher potency than its diastereoisomer, 4S...
  8. ncbi request reprint Nicotinic receptors differentially regulate N-methyl-D-aspartate damage in acute hippocampal slices
    P A Ferchmin
    Department of Biochemistry, Universidad Central del Caribe, P O Box 60 327, Bayamon, Puerto Rico 00960 6032
    J Pharmacol Exp Ther 305:1071-8. 2003
    ....