P A Ferchmin

Summary

Publications

  1. doi request reprint γ-Aminobutyric acid type a receptor inhibition triggers a nicotinic neuroprotective mechanism
    P A Ferchmin
    School of Medicine, Universidad Central del Caribe, Bayamon, Puerto Rico
    J Neurosci Res 91:416-25. 2013
  2. ncbi request reprint Tobacco cembranoids protect the function of acute hippocampal slices against NMDA by a mechanism mediated by alpha4beta2 nicotinic receptors
    P A Ferchmin
    Center for Molecular and Behavioral Neuroscience, Universidad Central del Caribe, Bayamon, Puerto Rico
    J Neurosci Res 82:631-41. 2005
  3. ncbi request reprint Tobacco cembranoids block behavioral sensitization to nicotine and inhibit neuronal acetylcholine receptor function
    P A Ferchmin
    Center for Molecular and Behavioral Neuroscience, Universidad Central del Caribe, Bayamon, 00960 6032, Puerto Rico
    J Neurosci Res 64:18-25. 2001
  4. pmc Actions of octocoral and tobacco cembranoids on nicotinic receptors
    P A Ferchmin
    Department of Biochemistry, Universidad Central del Caribe, Bayamon, PR, USA
    Toxicon 54:1174-82. 2009
  5. pmc A cembranoid protects acute hippocampal slices against paraoxon neurotoxicity
    Vesna A Eterovic
    Department of Biochemistry, Universidad Central del Caribe, Bayamon, PR 00960 6032
    Toxicol In Vitro 25:1468-74. 2011
  6. ncbi request reprint Nicotinic receptors differentially regulate N-methyl-D-aspartate damage in acute hippocampal slices
    P A Ferchmin
    Department of Biochemistry, Universidad Central del Caribe, P O Box 60 327, Bayamon, Puerto Rico 00960 6032
    J Pharmacol Exp Ther 305:1071-8. 2003

Collaborators

Detail Information

Publications6

  1. doi request reprint γ-Aminobutyric acid type a receptor inhibition triggers a nicotinic neuroprotective mechanism
    P A Ferchmin
    School of Medicine, Universidad Central del Caribe, Bayamon, Puerto Rico
    J Neurosci Res 91:416-25. 2013
    ..These results shed light on how α7 nAChR inhibition can be neuroprotective through a mechanism mediated by activation of α4β2 nAChRs...
  2. ncbi request reprint Tobacco cembranoids protect the function of acute hippocampal slices against NMDA by a mechanism mediated by alpha4beta2 nicotinic receptors
    P A Ferchmin
    Center for Molecular and Behavioral Neuroscience, Universidad Central del Caribe, Bayamon, Puerto Rico
    J Neurosci Res 82:631-41. 2005
    ..In conclusion, these findings demonstrate that there are two different nicotinic neuroprotective mechanisms mediated by alpha4beta2...
  3. ncbi request reprint Tobacco cembranoids block behavioral sensitization to nicotine and inhibit neuronal acetylcholine receptor function
    P A Ferchmin
    Center for Molecular and Behavioral Neuroscience, Universidad Central del Caribe, Bayamon, 00960 6032, Puerto Rico
    J Neurosci Res 64:18-25. 2001
    ..IC(50) values were in the submicromolar to low-micromolar range, with 4R displaying an order of magnitude higher potency than its diastereoisomer, 4S...
  4. pmc Actions of octocoral and tobacco cembranoids on nicotinic receptors
    P A Ferchmin
    Department of Biochemistry, Universidad Central del Caribe, Bayamon, PR, USA
    Toxicon 54:1174-82. 2009
    ..In addition, cembranoids are known to act as anti-tumor compounds. In conclusion, cembranoids provide a promising source of lead drugs for many clinical areas, including neuroprotection, smoking-cessation, and anti-cancer therapies...
  5. pmc A cembranoid protects acute hippocampal slices against paraoxon neurotoxicity
    Vesna A Eterovic
    Department of Biochemistry, Universidad Central del Caribe, Bayamon, PR 00960 6032
    Toxicol In Vitro 25:1468-74. 2011
    ..In conclusion, 4R is a promising neuroprotective compound against OP neurotoxins...
  6. ncbi request reprint Nicotinic receptors differentially regulate N-methyl-D-aspartate damage in acute hippocampal slices
    P A Ferchmin
    Department of Biochemistry, Universidad Central del Caribe, P O Box 60 327, Bayamon, Puerto Rico 00960 6032
    J Pharmacol Exp Ther 305:1071-8. 2003
    ....