Fernando Costa Ferreira



  1. Soares M, Ribeiro R, Carvalho S, Peleteiro M, Correia J, Ferreira F. Ki-67 as a Prognostic Factor in Feline Mammary Carcinoma: What Is the Optimal Cutoff Value?. Vet Pathol. 2016;53:37-43 pubmed publisher
    ..0001; r = 0.75). On the basis of the above results, the authors propose the adoption of the 14% value as the optimal cutoff for Ki-67 to identify tumors with high risk of disease progression. ..
  2. Coelho J, Martins C, Ferreira F, Leitão A. African swine fever virus ORF P1192R codes for a functional type II DNA topoisomerase. Virology. 2015;474:82-93 pubmed publisher
    ..Overall, this work strengthens the idea that P1192R constitutes a target for studying, and possibly controlling, ASFV transcription and replication. ..
  3. Simões M, Martins C, Ferreira F. Early intranuclear replication of African swine fever virus genome modifies the landscape of the host cell nucleus. Virus Res. 2015;210:1-7 pubmed publisher
    ..Altogether, our results contribute for a better understanding of ASFV replication strategies, starting with an essential intranuclear DNA replication phase which induces host nucleus changes towards a successful viral infection. ..
  4. Ferreira F, Soares M, Carvalho S, Borralho L, Vicente G, Branco S, et al. Four cases of cell cannibalism in highly malignant feline and canine tumors. Diagn Pathol. 2015;10:199 pubmed publisher
    ..Such event could be regarded as an important hallmark of very high malignancy. ..
  5. Freitas F, Frouco G, Martins C, Ferreira F. African swine fever virus encodes for an E2-ubiquitin conjugating enzyme that is mono- and di-ubiquitinated and required for viral replication cycle. Sci Rep. 2018;8:3471 pubmed publisher
    ..Altogether, our results emphasize the potential use of this enzyme as target for drug and vaccine development against ASF. ..
  6. Simões M, Rino J, Pinheiro I, Martins C, Ferreira F. Alterations of Nuclear Architecture and Epigenetic Signatures during African Swine Fever Virus Infection. Viruses. 2015;7:4978-96 pubmed publisher
  7. Soares M, Correia J, Peleteiro M, Ferreira F. St Gallen molecular subtypes in feline mammary carcinoma and paired metastases-disease progression and clinical implications from a 3-year follow-up study. Tumour Biol. 2016;37:4053-64 pubmed publisher
    ..Altogether, the results obtained also demonstrate that FMC can be used as a model to study human breast cancer. ..
  8. Soares M, Madeira S, Correia J, Peleteiro M, Cardoso F, Ferreira F. Molecular based subtyping of feline mammary carcinomas and clinicopathological characterization. Breast. 2016;27:44-51 pubmed publisher
    ..Finally, the similarities between the subtypes of feline mammary tumors and human breast cancer, reveal that feline can be a valuable model for comparative studies. ..
  9. Freitas F, Frouco G, Martins C, Leitão A, Ferreira F. In vitro inhibition of African swine fever virus-topoisomerase II disrupts viral replication. Antiviral Res. 2016;134:34-41 pubmed publisher

More Information


  1. Frouco G, Freitas F, Coelho J, Leitão A, Martins C, Ferreira F. DNA-Binding Properties of African Swine Fever Virus pA104R, a Histone-Like Protein Involved in Viral Replication and Transcription. J Virol. 2017;91: pubmed publisher
    ..These results suggest that pA104R participates in the modulation of viral DNA topology and genome packaging, indicating that A104R deletion mutants may be a good strategy for vaccine development against ASFV. ..
  2. Frouco G, Freitas F, Martins C, Ferreira F. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14. Virus Res. 2017;242:24-29 pubmed publisher
    ..Altogether, our results strongly suggest that cellular HDACs are involved in the establishment of ASFV infection and emphasize that further in vivo studies are needed to better understand the antiviral activity of HDAC inhibitors. ..