Anthony Feinstein

..However, it is unclear whether depression may cause or exacerbate cognitive problems as data remain equivocal. The current review attempts to clarify the relationship between these behavioral disorders...

..These positive findings are offset by data showing that depression in a neurological setting is often overlooked and under treated...

..The importance of future research addressing this imbalance is emphasized, for neuropsychiatric sequelae add significantly to the morbidity associated with MS...

..This article summarizes these mental state changes, their pathogenesis and treatment. Correct diagnosis and treatment can substantially improve the quality of life for MS patients...

..There is no evidence from the recent war in Iraq suggesting that embedded journalists are at increased risk for psychological problems...

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..Traumatic brain injury was not associated with higher rates of amnestic mild cognitive impairment or dementia, and APOE-epsilon4 was not associated with cognition...

..To determine which serotonergic system-related single nucleotide polymorphisms (SNPs) predicted variation in treatment response to citalopram in depression following a traumatic brain injury (TBI)...

..This study examines whether continuation therapy with citalopram can prevent a relapse following remission of major depression due to traumatic brain injury...

..The clinical significance of this may become more evident with time in this vulnerable population...

..To investigate the role of personality and anxiety to self-report measures of cognition in patients with multiple sclerosis (MS)...

..These results suggest that depression post-TBI may influence patient perception of postconcussion symptoms...

..The findings highlight the utility of the MSFC as a predictor of unemployment in MS. Furthermore, a strong association was found between unemployment and the personality construct "Agreeableness", and severity of depression...

..The purpose of this study was to examine the role of the serotonin transporter gene polymorphisms on the risk of major depression following traumatic brain injury (TBI)...

..Given that MS is associated with cognitive deterioration, the aim of this study was to determine the neuropsychological effects of cannabis use in this population...

..To assess the utility of the Mini-Mental Status Examination (MMSE) among the older TBI population...

..4%), compared to those without, were found to have significantly lower scores on measures of working memory, processing speed, verbal memory and executive function. Potential mechanisms and implications for treatment are discussed...

..913), but for generalized anxiety disorder only. The study confirms the usefulness of the HADS as a marker of major depression and generalized anxiety disorder, but not other anxiety disorders, in multiple sclerosis patients...

..The informant version of the scale has proven to be a useful screen for cognitive impairment in multiple sclerosis (MS)...

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..Good test-retest reliability for the c-SDMT was shown (ICC = 0.94). The results support the validity of this version of the c-SDMT as a sensitive measure of cognitive dysfunction in MS. The methodology is also fMRI compatible...

..Our hypothesis was that difficulty sustaining attention in patients with MS would paradoxically be associated with less inattentional blindness...

..The aim of this review is to summarize the current literature on the neuropsychiatry of multiple sclerosis (MS)...

..The lesion data support a widely-dispersed neural network involving frontal, parietal, and brainstem regions in the pathophysiology of PBA...

..The aim of this study was to assess the relative importance of diffusion tensor imaging (DTI) indices derived from normal appearing white matter (NAWM) and grey matter (NAGM) in determining cognitive dysfunction in MS patients...

..War journalists often confront situations of extreme danger in their work. Despite this, information on their psychological well-being is lacking...

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..In mild to moderate TBI, subjective cognitive deficits are linked in large measure to comorbid major depression. However, other mechanisms may also account for these deficits...

..RESULTS: Older patients (age 60-plus) had lower rates of major depression than younger patients. CONCLUSION: Older patients seem to be relatively resilient to major depression shortly after mild TBI...

..Total CHIPS score and total hyperintense lesion load were correlated (sigma = 0.82, P < .0001). CONCLUSION: CHIPS is helpful in clinically predicting cognitive impairment in MS...

..01). CONCLUSIONS: These findings suggest that routine treatment of all MTBI patients offers little benefit; rather, targeting individuals with preinjury psychiatric problems may prove a more rational and cost-effective approach...

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..CONCLUSIONS: Major depression is associated with poor outcome across multiple domains. This study highlights the need for the early diagnosis and prompt treatment of major depression following mild traumatic brain injury...

..Clues to problem drinking in MS patients are the presence of a positive family history of mental illness and prominent anxiety...

..Major depression is common following traumatic brain injury (TBI), yet no studies to date have explored its relationship to psychosocial outcome in older adults with TBI...

..A significant minority of patients with multiple sclerosis (MS) use cannabis, yet no study has examined the possible effects on mentation. Here, we report the emotional and cognitive correlates of street cannabis use in patients with MS...

..No study has yet combined neuropsychological inquiry, brain imaging, and genetic determination, an approach that has the potential to pull together various pieces of the puzzle...

..To examine neurologic and psychiatric correlates of suicidal intent in a community sample of 140 patients with MS...

..This study provides the first empirical data showing that a significant minority of contractors working in war zones are psychologically distressed and not receiving therapy...

..Thus, all health professionals involved in the care of multiple sclerosis patients should have a good working knowledge of the neurotherapeutics of multiple sclerosis-related behavioral disorders...

..1) To examine the variability in diagnosis of mild traumatic brain injury (mTBI) in primary care relative to that of an expert reviewer; and (2) to determine the incidence rate of mTBI in Ontario, Canada...

..This paper presents a descriptive study, undertaken in 1993, of a Psychiatric Intensive Care Unit (PICU) serving a deprived inner-city area, investigating the role of ethnicity as a risk factor for admission to the unit...

..Clinicians need to be alert to the presence of dizziness as an adverse prognostic indicator after mild to moderate TBI...

..We found that use of epigenomic microarray profiling in a relatively small number (15-25) of phenotypically discordant twin pairs has sufficient power to detect 1.2 fold epigenetic changes...

..The threefold decline in prevalence rates for major depression over the course of a year demonstrates a good response to anti-depressant medication and possible beneficial effects of interferon beta-1b on mood...

..Information regarding an individual's occupation is easily acquired and may serve as a useful proxy for cognitive reserve in clinical settings...

..Possible mechanisms that could account for this finding are discussed...

..Simultaneous quantification of atrophy and anatomically distinct hyperintensities is important for understanding cognitive impairments in dementia...

..These findings implicate selective alterations in primary sensorimotor cortex activity in conversion disorder, and may also reconcile the discordant results of previous studies...