J N Feder

Summary

Publications

  1. pmc The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding
    J N Feder
    Progenitor, Inc formerly Mercator Genetics, Inc, 4040 Campbell Avenue, Menlo Park, CA 94025, USA
    Proc Natl Acad Sci U S A 95:1472-7. 1998
  2. ncbi Transferrin receptor mutation analysis in hereditary hemochromatosis patients
    Z Tsuchihashi
    Progenitor, Inc, Menlo Park, CA 94025, USA
    Blood Cells Mol Dis 24:317-21. 1998
  3. ncbi A 1.1-Mb transcript map of the hereditary hemochromatosis locus
    D A Ruddy
    Mercator Genetics, Menlo Park, California 94025, USA
    Genome Res 7:441-56. 1997
  4. ncbi The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression
    J N Feder
    Mercator Genetics, Inc, Menlo Park, California 94025, USA
    J Biol Chem 272:14025-8. 1997
  5. ncbi A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
    J N Feder
    Mercator Genetics, Inc, Menlo Park, California 94025, USA
    Nat Genet 13:399-408. 1996
  6. ncbi The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells
    C N Roy
    Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, Oregon 97201 3098, USA
    J Biol Chem 274:9022-8. 1999
  7. ncbi Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor
    J A Lebron
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Cell 93:111-23. 1998
  8. pmc Hereditary hemochromatosis: effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells
    A Waheed
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 94:12384-9. 1997
  9. pmc Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract
    S Parkkila
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, MO 63104, USA
    Proc Natl Acad Sci U S A 94:2534-9. 1997
  10. ncbi The discovery of the new haemochromatosis gene. 1996
    J N Feder
    J Hepatol 38:704-9. 2003

Collaborators

  • J A Lebron
  • S Parkkila
  • W S Sly
  • Z Tsuchihashi
  • C N Roy
  • R K Wolff
  • G S Kronmal
  • L Quintana
  • F A Mapa
  • A Waheed
  • D A Ruddy
  • R C Schatzman
  • W Zhong
  • C A Enns
  • D M Penny
  • S L Hansen
  • S Tomatsu
  • E E McClelland
  • B R Bacon
  • A Irrinki
  • G A Mintier
  • N C Meyer
  • C Harmon
  • A Fullan
  • V K Lee
  • D B Loeb
  • X Y Zhou
  • W Thomas
  • R Domingo
  • R S Britton
  • T Moore
  • L Y Jan
  • M M Jiang
  • Y N Jan

Detail Information

Publications11

  1. pmc The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding
    J N Feder
    Progenitor, Inc formerly Mercator Genetics, Inc, 4040 Campbell Avenue, Menlo Park, CA 94025, USA
    Proc Natl Acad Sci U S A 95:1472-7. 1998
    ....
  2. ncbi Transferrin receptor mutation analysis in hereditary hemochromatosis patients
    Z Tsuchihashi
    Progenitor, Inc, Menlo Park, CA 94025, USA
    Blood Cells Mol Dis 24:317-21. 1998
    ..Thus, amino acid changes in the TFR gene do not appear to play a role in HH even when the patients do not have a HFE mutation. However, this study does not rule out the possibility of the involvement of mutations in non-coding regions...
  3. ncbi A 1.1-Mb transcript map of the hereditary hemochromatosis locus
    D A Ruddy
    Mercator Genetics, Menlo Park, California 94025, USA
    Genome Res 7:441-56. 1997
    ..1-Mb region may be derived from noncoding genomic DNA...
  4. ncbi The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression
    J N Feder
    Mercator Genetics, Inc, Menlo Park, California 94025, USA
    J Biol Chem 272:14025-8. 1997
    ..This report describes the first functional significance of the C282Y mutation by suggesting that an abnormality in protein trafficking and/or cell-surface expression of HLA-H leads to HH disease...
  5. ncbi A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
    J N Feder
    Mercator Genetics, Inc, Menlo Park, California 94025, USA
    Nat Genet 13:399-408. 1996
    ..A role of this gene in haemochromatosis is supported by the frequency and nature of the major mutation and prior studies implicating MHC class I-like proteins in iron metabolism...
  6. ncbi The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells
    C N Roy
    Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, Oregon 97201 3098, USA
    J Biol Chem 274:9022-8. 1999
    ..These results also have implications for the understanding of cellular iron homeostasis in organs such as the liver, pancreas, heart, and spleen that are iron loaded in hereditary hemochromatotic individuals lacking functional HFE...
  7. ncbi Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor
    J A Lebron
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Cell 93:111-23. 1998
    ..TfR:HFE stoichiometry (2:1) differs from TfR:transferrin stoichiometry (2:2), implying a different mode of binding for HFE and transferrin to TfR, consistent with our demonstration that HFE, transferrin, and TfR form a ternary complex...
  8. pmc Hereditary hemochromatosis: effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells
    A Waheed
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 94:12384-9. 1997
    ..The block in intracellular transport, accelerated turnover, and failure of the C282Y protein to be presented normally on the cell surface provide a possible basis for impaired function of this mutant protein in HH...
  9. pmc Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract
    S Parkkila
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, MO 63104, USA
    Proc Natl Acad Sci U S A 94:2534-9. 1997
    ....
  10. ncbi The discovery of the new haemochromatosis gene. 1996
    J N Feder
    J Hepatol 38:704-9. 2003
  11. ncbi Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis
    W Zhong
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724, USA
    Neuron 17:43-53. 1996
    ..We propose that some shared molecular mechanisms, both cell-intrinsic and cell-extrinsic, generate asymmetric cell divisions during neurogenesis of vertebrates and invertebrates...