Paul W M Fedak

Summary

Publications

  1. doi request reprint Cell therapy limits myofibroblast differentiation and structural cardiac remodeling: basic fibroblast growth factor-mediated paracrine mechanism
    Paul W M Fedak
    Department of Cardiac Sciences, University of Calgary, Libin Cardiovascular Institute of Alberta, Alberta, Canada
    Circ Heart Fail 5:349-56. 2012
  2. doi request reprint Enhancing sternal closure using Kryptonite bone adhesive: technical report
    Paul W M Fedak
    Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    Surg Innov 18:NP8-11. 2011
  3. doi request reprint Adhesive-enhanced sternal closure to improve postoperative functional recovery: a pilot, randomized controlled trial
    Paul W M Fedak
    Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada
    Ann Thorac Surg 92:1444-50. 2011
  4. ncbi request reprint Paracrine effects of cell transplantation: modifying ventricular remodeling in the failing heart
    Paul W M Fedak
    Division of Cardiac Surgery, Department of Cardiac Sciences and Surgery, University of Calgary, Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada
    Semin Thorac Cardiovasc Surg 20:87-93. 2008
  5. ncbi request reprint Kryptonite bone cement prevents pathologic sternal displacement
    Paul W M Fedak
    Department of Cardiac Sciences, Division of Cardiac Surgery, Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada
    Ann Thorac Surg 90:979-85. 2010
  6. ncbi request reprint Combined endothelial and myocardial protection by endothelin antagonism enhances transplant allograft preservation
    Paul W M Fedak
    Toronto General Hospital, University Health Network, Division of Cardiac Surgery, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 129:407-15. 2005
  7. ncbi request reprint Rosiglitazone facilitates angiogenic progenitor cell differentiation toward endothelial lineage: a new paradigm in glitazone pleiotropy
    Chao Hung Wang
    Division of Cardiac Surgery, Toronto General Hospital, Toronto, Ontario, Canada
    Circulation 109:1392-400. 2004
  8. ncbi request reprint C-reactive protein upregulates complement-inhibitory factors in endothelial cells
    Shu Hong Li
    Division of Cardiac Surgery, Toronto General Hospital, Toronto, Ontario, Canada
    Circulation 109:833-6. 2004
  9. ncbi request reprint TIMP-3 deficiency leads to dilated cardiomyopathy
    Paul W M Fedak
    Division of Cardiac Surgery, University of Toronto, Toronto General Research Institute, Ontario, Canada
    Circulation 110:2401-9. 2004
  10. ncbi request reprint Cell transplantation preserves matrix homeostasis: a novel paracrine mechanism
    Paul W M Fedak
    Division of Cardiac Surgery, University of Toronto, Toronto General Research Institute, Toronto General Hospital, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 130:1430-9. 2005

Collaborators

Detail Information

Publications45

  1. doi request reprint Cell therapy limits myofibroblast differentiation and structural cardiac remodeling: basic fibroblast growth factor-mediated paracrine mechanism
    Paul W M Fedak
    Department of Cardiac Sciences, University of Calgary, Libin Cardiovascular Institute of Alberta, Alberta, Canada
    Circ Heart Fail 5:349-56. 2012
    ..Paracrine mechanisms have been proposed. The effect of cell therapy on post infarction cardiac fibroblast and extracellular matrix (ECM) regulation was examined...
  2. doi request reprint Enhancing sternal closure using Kryptonite bone adhesive: technical report
    Paul W M Fedak
    Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    Surg Innov 18:NP8-11. 2011
    ..The technique is simple, safe, and expedient...
  3. doi request reprint Adhesive-enhanced sternal closure to improve postoperative functional recovery: a pilot, randomized controlled trial
    Paul W M Fedak
    Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada
    Ann Thorac Surg 92:1444-50. 2011
    ..We report the results of a single-center, pilot, randomized clinical trial of the effects of adhesive-enhanced closure of the sternum on functional postoperative recovery...
  4. ncbi request reprint Paracrine effects of cell transplantation: modifying ventricular remodeling in the failing heart
    Paul W M Fedak
    Division of Cardiac Surgery, Department of Cardiac Sciences and Surgery, University of Calgary, Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada
    Semin Thorac Cardiovasc Surg 20:87-93. 2008
    ....
  5. ncbi request reprint Kryptonite bone cement prevents pathologic sternal displacement
    Paul W M Fedak
    Department of Cardiac Sciences, Division of Cardiac Surgery, Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada
    Ann Thorac Surg 90:979-85. 2010
    ..This translational research report provides proof-of-concept (part A) and first-in-man clinical data (part B) with use of a triglyceride-based porous adhesive to rapidly enhance the stability of conventional sternal closure...
  6. ncbi request reprint Combined endothelial and myocardial protection by endothelin antagonism enhances transplant allograft preservation
    Paul W M Fedak
    Toronto General Hospital, University Health Network, Division of Cardiac Surgery, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 129:407-15. 2005
    ..We hypothesized that endothelin antagonism during cardiac allograft storage would limit early endothelial dysfunction and improve myocardial performance after transplantation...
  7. ncbi request reprint Rosiglitazone facilitates angiogenic progenitor cell differentiation toward endothelial lineage: a new paradigm in glitazone pleiotropy
    Chao Hung Wang
    Division of Cardiac Surgery, Toronto General Hospital, Toronto, Ontario, Canada
    Circulation 109:1392-400. 2004
    ..It is unknown whether PPAR-gamma agonists favorably modulate bone marrow (BM)-derived angiogenic progenitor cells (APCs) to promote endothelial lineage differentiation and early reendothelialization after vascular intervention...
  8. ncbi request reprint C-reactive protein upregulates complement-inhibitory factors in endothelial cells
    Shu Hong Li
    Division of Cardiac Surgery, Toronto General Hospital, Toronto, Ontario, Canada
    Circulation 109:833-6. 2004
    ....
  9. ncbi request reprint TIMP-3 deficiency leads to dilated cardiomyopathy
    Paul W M Fedak
    Division of Cardiac Surgery, University of Toronto, Toronto General Research Institute, Ontario, Canada
    Circulation 110:2401-9. 2004
    ....
  10. ncbi request reprint Cell transplantation preserves matrix homeostasis: a novel paracrine mechanism
    Paul W M Fedak
    Division of Cardiac Surgery, University of Toronto, Toronto General Research Institute, Toronto General Hospital, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 130:1430-9. 2005
    ....
  11. ncbi request reprint Epicardial infarct repair with basic fibroblast growth factor-enhanced CorMatrix-ECM biomaterial attenuates postischemic cardiac remodeling
    Holly E M Mewhort
    Campbell Cardiovascular Translational Research Program, Division of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    J Thorac Cardiovasc Surg 147:1650-9. 2014
    ..Basic fibroblast growth factor is a potent inhibitor of fibrosis. We propose a novel surgical procedure leveraging a commercially available ECM biomaterial for the treatment of ischemic heart failure...
  12. ncbi request reprint Restoration and regeneration of failing myocardium with cell transplantation and tissue engineering
    Paul W M Fedak
    Division of Cardiac Surgery, Toronto General Hospital, Toronto, Ontario M5G 2C4, Canada
    Semin Thorac Cardiovasc Surg 15:277-86. 2003
    ....
  13. ncbi request reprint C-reactive protein activates the nuclear factor-kappaB signal transduction pathway in saphenous vein endothelial cells: implications for atherosclerosis and restenosis
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 126:1886-91. 2003
    ..This study examines the direct effects of C-reactive protein on nuclear factor-kappaB activation and related mechanisms in saphenous vein endothelial cells...
  14. ncbi request reprint Transplantation of cryopreserved muscle cells in dilated cardiomyopathy: effects on left ventricular geometry and function
    Nobuhisa Ohno
    Division of Cardiac Surgery, Department of Surgery, Toronto General Hospital, University of Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 126:1537-48. 2003
    ..However, the effects of cryopreservation on peripheral muscle cells harvested from a cardiomyopathic recipient and their subsequent ability to restore cardiac structure and function after transplantation are unknown...
  15. ncbi request reprint Altered expression of disintegrin metalloproteinases and their inhibitor in human dilated cardiomyopathy
    Paul W M Fedak
    General Research Institute, Division of Cardiac Surgery, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada
    Circulation 113:238-45. 2006
    ..We compared expression of ADAMs, their endogenous inhibitor tissue inhibitor of metalloproteinases (TIMP)-3, and integrins in human heart tissue with varied patterns of structural remodeling...
  16. ncbi request reprint C-reactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle
    Chao Hung Wang
    Division of Cardiac Surgery, University of Toronto, Toronto, Ontario, Canada
    Circulation 107:1783-90. 2003
    ..Lastly, the effects of CRP (and losartan) on neointimal formation were examined in vivo in a rat carotid angioplasty model...
  17. ncbi request reprint Cell transplantation preserves cardiac function after infarction by infarct stabilization: augmentation by stem cell factor
    Shafie Fazel
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 130:1310. 2005
    ....
  18. ncbi request reprint Off-pump coronary artery bypass surgery: fundamentals for the clinical cardiologist
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, Toronto, Ontario, Canada
    Circulation 109:1206-11. 2004
  19. ncbi request reprint Novel cardioprotective effects of pravastatin in human ventricular cardiomyocytes subjected to hypoxia and reoxygenation: beneficial effects of statins independent of endothelial cells
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Ontario, Canada
    J Surg Res 119:66-71. 2004
    ..Statin therapy may restore ischemic hearts to full functional integrity during cardioplegic arrest through a direct effect on cardiomyocyte survival...
  20. ncbi request reprint Glitazones and heart failure: critical appraisal for the clinician
    Chao Hung Wang
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada
    Circulation 107:1350-4. 2003
  21. ncbi request reprint Caveolin: a key target for modulating nitric oxide availability in health and disease
    Bikramjit Dhillon
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Toronto, ON, Canada
    Mol Cell Biochem 247:101-9. 2003
    ..Recognizing the potential of this specialized domain may provide the fundamental knowledge to target the endothelium in disease...
  22. doi request reprint Evolving concepts and technologies in mitral valve repair
    Paul W M Fedak
    Libin Cardiovascular Institute of Alberta, Division of Cardiac Surgery, Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada
    Circulation 117:963-74. 2008
  23. ncbi request reprint Cell transplantation in non-ischemic dilated cardiomyopathy. A novel biological approach for ventricular restoration
    Nobuhisa Ohno
    Toronto General Hospital, Division of Cardiac Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Jpn J Thorac Cardiovasc Surg 50:457-60. 2002
    ..Thus novel management strategies for improved treatment of DCM are awaited...
  24. ncbi request reprint Bicuspid aortic valve disease: recent insights in pathophysiology and treatment
    Paul W M Fedak
    University of Toronto, Division of Cardiac Surgery, Toronto General Hospital, 14EN 200 Elizabeth Street, Toronto, Ontario, M5C 2G4, Canada
    Expert Rev Cardiovasc Ther 3:295-308. 2005
    ..Novel molecular mechanisms underlying the valve and vascular pathologies, as well as new surgical therapies for these patients have been proposed in the past 10 years...
  25. pmc Bicuspid aortic cusp fusion morphology alters aortic three-dimensional outflow patterns, wall shear stress, and expression of aortopathy
    Riti Mahadevia
    Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL R M, A J B, SS, P E, J Collins, J Carr, M M Division of Cardiology, Northwestern University, Chicago, IL P K Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Canada P W M F Division of Cardiothoracic Surgery, Northwestern University, Chicago, IL P W M F, S C M, P M and Department Biomedical Engineering, McCormick School of Engineering, Northwestern University, Chicago, IL M M
    Circulation 129:673-82. 2014
    ....
  26. doi request reprint Knowledge, attitudes, and practice patterns in surgical management of bicuspid aortopathy: a survey of 100 cardiac surgeons
    Subodh Verma
    Division of Cardiac Surgery, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 146:1033-1040.e4. 2013
    ..We hypothesized that surgeons' knowledge of and attitudes toward bicuspid aortic valve aortopathy influence their surgical approaches...
  27. doi request reprint Canadian cardiac surgeons' perspectives on biomedical innovation
    Gretchen Snyman
    Master of Biomedical Technology Program, Faculty of Graduate Studies, University of Calgary, Calgary, Alberta, Canada
    Can J Cardiol 28:607-10. 2012
    ..The perspectives of cardiac surgeons provide an intriguing portal into the challenges and opportunities for healthcare innovation in Canada...
  28. ncbi request reprint Mechanical stretch regimen enhances the formation of bioengineered autologous cardiac muscle grafts
    Payam Akhyari
    Toronto General Research Institute, Toronto General Hospital, Division of Cardiac Surgery, University of Toronto, Toronto, Ontario, Canada
    Circulation 106:I137-42. 2002
    ..We hypothesized that a mechanical stretch regimen applied to human heart cells that were seeded on a three-dimensional gelatin scaffold (Gelfoam) would improve tissue formation and enhance graft strength...
  29. ncbi request reprint Novel cardioprotective effects of tetrahydrobiopterin after anoxia and reoxygenation: Identifying cellular targets for pharmacologic manipulation
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 123:1074-83. 2002
    ..Measures of endothelial function, oxidant production, cell survival, and cardiac function were used to assess outcome...
  30. ncbi request reprint A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada
    Circulation 106:913-9. 2002
    ....
  31. ncbi request reprint Endothelial progenitor cells: new hope for a broken heart
    Paul E Szmitko
    Division of Cardiac Surgery, Toronto General Hospital, 14EN 215, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    Circulation 107:3093-100. 2003
  32. ncbi request reprint Cardiac remodeling and failure: from molecules to man (Part III)
    Paul W M Fedak
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Toronto, ON, Canada M5G 2C4
    Cardiovasc Pathol 14:109-19. 2005
    ..The following review outlines recent advances in medical and surgical approaches to control the remodeling process that underlies the progression of heart failure...
  33. ncbi request reprint L-arginine protects human heart cells from low-volume anoxia and reoxygenation
    Noritsugu Shiono
    Division of Cardiac Surgery, University of Toronto, Toronto, Ontario, M5G 2C4 Canada
    Am J Physiol Heart Circ Physiol 282:H805-15. 2002
    ..In addition, L-arginine cardioprotection was achieved by the activation of guanylate cyclase, leading to increased cGMP levels in human heart cells. This action involves a glibenclamide-sensitive, NO-cGMP-dependent pathway...
  34. ncbi request reprint Matrix remodeling in experimental and human heart failure: a possible regulatory role for TIMP-3
    Paul W M Fedak
    Division of Cardiac Surgery, Toronto General Research Institute, University of Toronto, Toronto General Hospital, Ontario, Canada M5B 1W8
    Am J Physiol Heart Circ Physiol 284:H626-34. 2003
    ..TIMP-3 may contribute to the regulation of myocardial remodeling and its reduction may promote a transition from compensated to end-stage congestive heart failure...
  35. ncbi request reprint Cardiac remodeling and failure From molecules to man (Part II)
    Paul W M Fedak
    Division of Cardiac Surgery, University of Toronto, Toronto General Hospital, 14EN 215, 200 Elizabeth Street, Toronto ON, Canada M5G 2C4
    Cardiovasc Pathol 14:49-60. 2005
    ....
  36. ncbi request reprint Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, 14EN 215, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    Circulation 108:736-40. 2003
    ..Adipocyte-derived hormones may represent a mechanism linking insulin resistance to cardiovascular disease. In the present study, we evaluated the direct effects of resistin, a novel adipocyte-derived hormone, on endothelial activation...
  37. ncbi request reprint Improved left ventricular aneurysm repair with bioengineered vascular smooth muscle grafts
    Keiji Matsubayashi
    Department of Surgery, Division of Cardiovascular Surgery, Shiga University of Medical Science, Shiga, Japan
    Circulation 108:II219-25. 2003
    ..Use of an autologous bioengineered muscle graft to replace resected scar tissue may prevent recurrent dilatation and improve cardiac function...
  38. ncbi request reprint Use of diffusion tensor imaging to predict myocardial viability after warm global ischemia: possible avenue for use of non-beating donor hearts
    Michael J Collins
    Division of Cardiac Surgery, Department of Surgery, University of Maryland Medical System, Baltimore, Maryland 21201, USA
    J Heart Lung Transplant 26:376-83. 2007
    ....
  39. ncbi request reprint Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice
    Huanzhang Lu
    Cancer Research Program, Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Circulation 114:2271-9. 2006
    ..Integrin-linked kinase (ILK) is a multifunctional protein kinase that physically links beta-integrins with the actin cytoskeleton, suggesting a potential mechanoreceptor role...
  40. ncbi request reprint Stem cell factor deficiency is vasculoprotective: unraveling a new therapeutic potential of imatinib mesylate
    Chao Hung Wang
    Cardiology and Internal Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan
    Circ Res 99:617-25. 2006
    ..These data indicate that SCF/c-Kit signaling plays a pivotal role in the development of neointima by BM-derived PCs and that the inhibition of this pathway may serve as a novel therapeutic target to limit aberrant vascular remodeling...
  41. ncbi request reprint C-reactive protein alters antioxidant defenses and promotes apoptosis in endothelial progenitor cells
    Hiroko Fujii
    Toronto General Research Institute, St Michael s Hospital, University of Toronto, Canada
    Arterioscler Thromb Vasc Biol 26:2476-82. 2006
    ..In the present study, we evaluated the effects of CRP on antioxidative enzymes, reactive oxygen species production, telomerase activity, and apoptosis in human circulating EPCs...
  42. ncbi request reprint C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: further evidence of a mechanistic link between C-reactive protein and cardiovascular disease
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, 14EN 215, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    Circulation 109:2058-67. 2004
    ..An elevated level of C-reactive protein (CRP) has emerged as one of the most powerful predictors of cardiovascular disease. However, the impact of CRP on EPC biology is unknown...
  43. ncbi request reprint Enhanced IGF-1 expression improves smooth muscle cell engraftment after cell transplantation
    Tian Biao Liu
    Toronto General Hospital, NU 1 115A, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    Am J Physiol Heart Circ Physiol 287:H2840-9. 2004
    ..Gene enhancement with IGF-1 improved donor cell proliferation, survival, and engraftment after cell transplantation, perhaps mediated by enhanced angiogenesis and reduced apoptosis...
  44. ncbi request reprint Cardiac remodeling and failure: from molecules to man (Part I)
    Paul W M Fedak
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, 14EN 215, 200 Elizabeth Street, Toronto, ON, Canada M5G 2C4
    Cardiovasc Pathol 14:1-11. 2005
    ..To define new therapeutic targets and to control the process of remodeling, novel biomolecules and mechanisms for the coordinated control of CR must be further defined...
  45. ncbi request reprint TIMP-3 deficiency accelerates cardiac remodeling after myocardial infarction
    Hai Tian
    Division of Cardiovascular Surgery, Toronto General Research Institute, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    J Mol Cell Cardiol 43:733-43. 2007
    ..This study supports further investigations to determine whether such remodeling could be reduced by augmenting TIMP-3 expression in the infarcted myocardium...