Geoffrey J Faulkner
Nguyen T, Carreira P, Sánchez Luque F, Schauer S, Fagg A, Richardson S, et al
. L1 Retrotransposon Heterogeneity in Ovarian Tumor Cell Evolution. Cell Rep. 2018;23:3730-3740 pubmed publisher
..These congruent in vitro and in vivo results highlight L1 insertional mutagenesis as a common component of ovarian tumorigenesis and cancer genome heterogeneity. ..
Bodea G, McKelvey E, Faulkner G. Retrotransposon-induced mosaicism in the neural genome. Open Biol. 2018;8: pubmed publisher
Sánchez Luque F, Richardson S, Faulkner G. Retrotransposon Capture Sequencing (RC-Seq): A Targeted, High-Throughput Approach to Resolve Somatic L1 Retrotransposition in Humans. Methods Mol Biol. 2016;1400:47-77 pubmed publisher
..Furthermore, RC-seq can be used to detect and characterize somatic insertions, providing a valuable tool to elucidate the extent and characteristics of MGE activity in healthy tissues and in various disease states. ..
Gerdes P, Richardson S, Mager D, Faulkner G. Transposable elements in the mammalian embryo: pioneers surviving through stealth and service. Genome Biol. 2016;17:100 pubmed publisher
..Here, we discuss recent evidence suggesting that TEs may contribute regulatory innovation to mammalian embryonic and pluripotent states as a means to ward off complete repression by their host genome. ..
Richardson S, Morell S, Faulkner G. L1 retrotransposons and somatic mosaicism in the brain. Annu Rev Genet. 2014;48:1-27 pubmed publisher
..Finally, we discuss the unresolved impact of L1-mediated somatic mosaicism upon normal neurobiology, as well as its potential to drive neurological disease. ..
Upton K, Gerhardt D, Jesuadian J, Richardson S, SÃ¡nchez Luque F, Bodea G, et al
. Ubiquitous L1 mosaicism in hippocampal neurons. Cell. 2015;161:228-39 pubmed publisher
..These experiments demonstrate pervasive L1 mosaicism at genomic loci expressed in hippocampal neurons. ..
Gerdes P, Richardson S, Faulkner G. TET enzymes: double agents in the transposable element-host genome conflict. Genome Biol. 2016;17:259 pubmed
..Please see related Research article: http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1096-8. ..
Faulkner G, Garcia Perez J. L1 Mosaicism in Mammals: Extent, Effects, and Evolution. Trends Genet. 2017;33:802-816 pubmed publisher