Examining the comorbidity between attention deficit hyperactivity disorder and bipolar I disorder: a meta-analysis of family genetic studiesStephen V Faraone
Departments of Psychiatry and Neuroscience and Physiology, SUNY Upstate Medical University, NY, USA
Am J Psychiatry 169:1256-66. 2012
..Yet questions remain about the validity of diagnosing bipolar I disorder in ADHD youth. The authors aim to clarify these issues by reviewing family genetic studies of ADHD and bipolar I disorder...
- Growth dysregulation and ADHD: an epidemiologic study of children in France
Stephen V Faraone
Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA
J Atten Disord 16:572-8. 2012
..The objective of this study is to sample the general French population for ADHD and evaluate if ADHD is associated with dysregulated growth...
Discriminant and concurrent validity of a simplified DSM-based structured diagnostic instrument for the assessment of autism spectrum disorders in youth and young adultsGagan Joshi
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA, USA
BMC Psychiatry 11:204. 2011
..To evaluate the concurrent and discriminant validity of a brief DSM-based structured diagnostic interview for referred individuals with autism spectrum disorders (ASDs)...
- Understanding the effect size of lisdexamfetamine dimesylate for treating ADHD in children and adults
Stephen V Faraone
SUNY Upstate Medical University SVF, Syracuse, NY 13210, USA
J Atten Disord 16:128-37. 2012
..This work tested the hypothesis that the apparent increased efficacy was artifactual...
- The impact of study design and diagnostic approach in a large multi-centre ADHD study: Part 2: Dimensional measures of psychopathology and intelligence
Ueli C Muller
Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland
BMC Psychiatry 11:55. 2011
..In particular, to investigate the influence of age, gender, family status (proband vs. sibling), informant, and centres on sample homogeneity in psychopathological measures...
- The impact of study design and diagnostic approach in a large multi-centre ADHD study. Part 1: ADHD symptom patterns
Ueli C Muller
Department of Child and Adolescent Psychiatry, University of Zurich, Switzerland
BMC Psychiatry 11:54. 2011
..A particular focus was on the effects of the study design and the diagnostic procedure on the homogeneity of the sample in terms of symptom-based behavioural data, and potential consequences for further analyses based on these data...
- Advances in understanding and treating ADHD
Kevin M Antshel
State University of New York, Upstate Medical University, Department of Psychiatry and Behavioral Sciences, 750 East Adams Street, Syracuse, NY 13210, USA
BMC Med 9:72. 2011
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- A comparison of the efficacy of medications for adult attention-deficit/hyperactivity disorder using meta-analysis of effect sizes
Stephen V Faraone
Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
J Clin Psychiatry 71:754-63. 2010
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- Genome-wide linkage analysis of heroin dependence in Han Chinese: results from Wave Two of a multi-stage study
Stephen J Glatt
Department of Psychiatry and Behavioral Sciences, and Medical Genetics Research Center, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
Drug Alcohol Depend 98:30-4. 2008
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Is attention deficit hyperactivity disorder a valid diagnosis in the presence of high IQ? Results from the MGH Longitudinal Family Studies of ADHDKevin M Antshel
State University of New York Upstate Medical University, Department of Psychiatry and Behavioral Sciences, NY, USA
J Child Psychol Psychiatry 48:687-94. 2007
..The aim of this study was to assess the validity of diagnosing attention deficit/hyperactivity disorder (ADHD) in high IQ children and to further characterize the clinical features associated with their ADHD...
- Sex differences in the functional neuroanatomy of working memory in adults with ADHD
Eve M Valera
Department of Psychiatry, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
Am J Psychiatry 167:86-94. 2010
..The authors examined sex differences in the neural functioning of adults with ADHD during performance of a verbal working memory task...
- Association between the 5HT1B receptor gene (HTR1B) and the inattentive subtype of ADHD
Jordan W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biol Psychiatry 59:460-7. 2006
..Association with a single nucleotide polymorphism (SNP; G861C) has been observed, but more extensive linkage disequilibrium analyses have not been reported...
- Familial transmission of derived phenotypes for molecular genetic studies of substance use disorders
Stephen V Faraone
Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
Drug Alcohol Depend 92:100-7. 2008
..001; cognitive impairment: OR=1.33, p=0.04); in offspring, baseline psychopathology predicted SUD at follow-up assessments (OR=1.55, p=0.01). Results suggest that these candidate SUD phenotypes may be useful for genetic studies of SUD...
- Cognitive and psychiatric predictors to psychosis in velocardiofacial syndrome: a 3-year follow-up study
Kevin M Antshel
Department of Psychiatry and Behavioral Sciences, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
J Am Acad Child Adolesc Psychiatry 49:333-44. 2010
..To predict prodromal psychosis in adolescents with velocardiofacial syndrome (VCFS)...
- Comparing ADHD in velocardiofacial syndrome to idiopathic ADHD: a preliminary study
Kevin M Antshel
SUNY Upstate Medical University, NY, USA
J Atten Disord 11:64-73. 2007
..Children with velocardiofacial syndrome (VCFS), a contiguous deletion syndrome, have an increased prevalence of attention deficit/hyperactivity disorder (ADHD)...
- Evidence for genetic association of RORB with bipolar disorder
Casey L McGrath
Department of Psychiatry, Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, IN, USA
BMC Psychiatry 9:70. 2009
..Here we report association studies between bipolar disorder and single-nucleotide polymorphisms (SNPs) in RORA and RORB...
- A functional MRI study of working memory in adolescents and young adults at genetic risk for bipolar disorder: preliminary findings
Heidi W Thermenos
Division of Public Psychiatry, Department of Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston, USA
Bipolar Disord 13:272-86. 2011
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- Diagnosing adult attention deficit hyperactivity disorder: are late onset and subthreshold diagnoses valid?
Stephen V Faraone
Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
Am J Psychiatry 163:1720-9; quiz 1859. 2006
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- Atomoxetine and adult attention-deficit/hyperactivity disorder: the effects of comorbidity
Thomas J Spencer
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, USA
J Clin Psychiatry 67:415-20. 2006
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- Psychopathology in adolescent offspring of parents with panic disorder, major depression, or both: a 10-year follow-up
Dina R Hirshfeld-Becker
Department of Psychiatry, Massachusetts General Hospital, USA
Am J Psychiatry 169:1175-84. 2012
..The authors examined the specificity and course of psychiatric disorders from early childhood through adolescence in offspring of parents with confirmed panic disorder and major depressive disorder...
- A controlled longitudinal 5-year follow-up study of children at high and low risk for panic disorder and major depression
Joseph Biederman
Pediatric Psychopharmacology Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
Psychol Med 36:1141-52. 2006
..To evaluate the longitudinal course of psychiatric disorders in children of parents with panic disorder (PD) and major depression (MD) as they transition through the period of risk from childhood into adolescence...
- Effect of dopamine transporter gene (SLC6A3) variation on dorsal anterior cingulate function in attention-deficit/hyperactivity disorder
Ariel B Brown
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Am J Med Genet B Neuropsychiatr Genet 153:365-75. 2010
..Alterations in activation of attention and EF networks found previously to be involved in ADHD are likely influenced by SLC6A3 genotype. This genotype may contribute to heterogeneity of brain alterations found within ADHD samples...
- Elaborative verbal encoding and altered anterior parahippocampal activation in adolescents and young adults at genetic risk for schizophrenia using FMRI
Heidi W Thermenos
Harvard Medical School, Massachusetts Mental Health Center in the Division of Public Psychiatry, Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, USA
Biol Psychiatry 61:564-74. 2007
..We used functional magnetic resonance imaging (fMRI) to assess brain activity in the MTL during novel and repeated word-pair encoding...
- Hypothalamic abnormalities in schizophrenia: sex effects and genetic vulnerability
Jill M Goldstein
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 61:935-45. 2007
..We tested the hypothesis that normal hypothalamic sexual dimorphism is disrupted in schizophrenia...
- Adult psychiatric outcomes of girls with attention deficit hyperactivity disorder: 11-year follow-up in a longitudinal case-control study
Joseph Biederman
Clinical and Research Programs in Pediatric Psychopharmacology, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 167:409-17. 2010
..Few follow-up studies have been conducted of girls with ADHD, and none have followed girls into adulthood. The authors sought to estimate the prevalence of psychopathology in girls with and without ADHD followed into young adulthood...
- Neuropsychological functioning in adolescents and young adults at genetic risk for schizophrenia and affective psychoses: results from the Harvard and Hillside Adolescent High Risk Studies
Larry J Seidman
Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, Division of Public Psychiatry, Beth Israel Deaconess Medical Center, Boston, USA
Schizophr Bull 32:507-24. 2006
..Ascertainment criteria for controls may markedly influence results and interpretation of group differences...
- Latent class analysis shows strong heritability of the child behavior checklist-juvenile bipolar phenotype
Robert R Althoff
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 60:903-11. 2006
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- The CBCL predicts DSM bipolar disorder in children: a receiver operating characteristic curve analysis
Stephen V Faraone
Medical Genetics Research Program and Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Bipolar Disord 7:518-24. 2005
..The CBCL-PBD profile on the Child Behavior Checklist (CBCL) has been consistently reported showing deviant findings on the Attention Problems, Aggressive Behavior, and Anxious-Depressed subscales...
- Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children
Eric Mick
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
BMC Psychiatry 9:2. 2009
..In this report we test for association with genes coding brain-derived neurotrophic factor (BDNF), the serotonin transporter (SLC6A4), and catechol-O-methyltransferase (COMT)...
- Severity of the aggression/anxiety-depression/attention child behavior checklist profile discriminates between different levels of deficits in emotional regulation in youth with attention-deficit hyperactivity disorder
Joseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Yawkey Center for Outpatient Care, Boston, MA, USA
J Dev Behav Pediatr 33:236-43. 2012
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- Meta-analysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders
Jessica A Lasky-Su
Department of Psychiatry, Harvard Medical School at the Massachusetts Mental Health Center, Boston, Massachusetts, USA
Am J Med Genet B Neuropsychiatr Genet 133:110-5. 2005
..The small but significant effects of the 44-bp insertion/deletion polymorphism for BP is consistent with being one of many genes that contributes to the multi-factorial nature of these psychiatric disorders...
- Regional prefrontal cortex gray matter volumes in youth at familial risk for schizophrenia from the Harvard Adolescent High Risk Study
Isabelle M Rosso
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Schizophr Res 123:15-21. 2010
..We conducted a region-of-interest morphometric study of prefrontal subregions in adolescent and young adult relatives of schizophrenia patients...
- How persistent is ADHD? A controlled 10-year follow-up study of boys with ADHD
Joseph Biederman
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, USA
Psychiatry Res 177:299-304. 2010
..Persistence of ADHD is associated with greater psychiatric comorbidity, familiality and functional impairments...
- Predictors of persistent ADHD: an 11-year follow-up study
Joseph Biederman
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, YAW 6A 6900, Boston, MA 02114, USA
J Psychiatr Res 45:150-5. 2011
..The main aim of this study was to evaluate predictors of persistence of ADHD in a large sample of boys with and without ADHD followed prospectively for 11 years into young adulthood...
- Neuroanatomic predictors to prodromal psychosis in velocardiofacial syndrome (22q11.2 deletion syndrome): a longitudinal study
Wendy R Kates
Department of Psychiatry and Behavioral Sciences, State University of New York at Upstate Medical University, Syracuse, New York 13210, USA
Biol Psychiatry 69:945-52. 2011
..2 deletion syndrome) develop schizophrenia or psychosis. Identifying the neuroanatomic trajectories that increase risk for psychosis in youth with this genetic disorder is of great interest...
- Is cigarette smoking a gateway to alcohol and illicit drug use disorders? A study of youths with and without attention deficit hyperactivity disorder
Joseph Biederman
Department of Psychiatry, Harvard Medical School, USA
Biol Psychiatry 59:258-64. 2006
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- Attention-deficit/hyperactivity disorder endophenotypes
Alysa E Doyle
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 57:1324-35. 2005
..We conclude that these endophenotypes will not be a quick fix for the field but offer potential if careful consideration is given to issues of heterogeneity, measurement and statistical power...
- Neuropsychological functioning in youth with bipolar disorder
Alysa E Doyle
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 58:540-8. 2005
..We compared neuropsychological and academic functioning of youth with and without DSM-IV BPD, controlling for effects of comorbid ADHD...
- Gender effects on attention-deficit/hyperactivity disorder in adults, revisited
Joseph Biederman
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 55:692-700. 2004
..These results bear striking similarities to findings reported in pediatric samples, supporting the validity of ADHD and stressing the importance of identifying and treating the disorder in adulthood...
- Clinical correlates of bipolar disorder in a large, referred sample of children and adolescents
Joseph Biederman
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
J Psychiatr Res 39:611-22. 2005
..To compare the prevalence, clinical correlates, and comorbidity among children and adolescents with bipolar disorder (BPD) assessed in the early 1990s (first cohort) with those evaluated over the last 7 years (second cohort)...
- Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report
Hamid Mostafavi Abdolmaleky
Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, Boston, Massachusetts, USA
Am J Med Genet B Neuropsychiatr Genet 134:60-6. 2005
..Further studies with a larger sample set would be required to validate these preliminary observations...
- The corticotropin-releasing hormone gene and behavioral inhibition in children at risk for panic disorder
Jordan W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
Biol Psychiatry 57:1485-92. 2005
..To evaluate this further, we genotyped additional families for this marker and a panel of markers encompassing the CRH locus...
- Substance use among ADHD adults: implications of late onset and subthreshold diagnoses
Stephen V Faraone
Department of Psychiatry, SUNY Upstate Medical University, Syracuse, New York 13210, USA
Am J Addict 16:24-32; quiz 33-4. 2007
..In contrast, subthreshold ADHD seems to be a milder form of the disorder, or perhaps a heterogeneous group of true ADHD cases and false positives...
- Evaluation of OPRM1 variants in heroin dependence by family-based association testing and meta-analysis
Stephen J Glatt
Department of Psychiatry and Behavioral Sciences, Medical Genetics Research Center, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
Drug Alcohol Depend 90:159-65. 2007
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- A discordant twin study of premorbid cognitive ability in schizophrenia
William S Kremen
Institute of Behavioral Genomics, Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093 0603, USA
J Clin Exp Neuropsychol 28:208-24. 2006
..Educational advancement may be slightly slowed by this familial vulnerability, but results were equivocal with regard to attenuation of one's ultimate educational attainment...
- Preliminary examination of the reliability and concurrent validity of the attention-deficit/hyperactivity disorder self-report scale v1.1 symptom checklist to rate symptoms of attention-deficit/hyperactivity disorder in adolescents
Lenard A Adler
Department of Psychiatry, NYU School of Medicine, New York, NY 10016, USA
J Child Adolesc Psychopharmacol 22:238-44. 2012
..To validate the attention-deficit/hyperactivity disorder (ADHD) Self-Report Scale (ASRS) v1.1 Symptom Checklist versus the clinician-administered ADHD Rating Scale (ADHD-RS) in adolescents with ADHD...
- Copy number variants for schizophrenia and related psychotic disorders in Oceanic Palau: risk and transmission in extended pedigrees
Nadine Melhem
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 70:1115-21. 2011
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- Reliability and validity of the Time-Sensitive ADHD Symptom Scale in adults
Lenard A Adler
Department of Psychiatry, NYU School of Medicine, New York, NY 10010, USA
Compr Psychiatry 52:769-73. 2011
..The objective of this study was to examine the psychometric properties of the Time-Sensitive ADHD Symptom Scale (TASS) to evaluate change of attention-deficit/hyperactivity disorder (ADHD) symptoms over the course of a day in adults...
- Effects of lisdexamfetamine dimesylate treatment for ADHD on growth
Stephen V Faraone
State University of New York Upstate Medical University, Syracuse, NY 13210, USA
J Am Acad Child Adolesc Psychiatry 49:24-32. 2010
..To complete an exploratory uncontrolled study of the effects of lisdexamfetamine dimesylate (LDX) on growth of children treated for attention-deficit/hyperactivity disorder (ADHD)...
- Altered brain activation in dorsolateral prefrontal cortex in adolescents and young adults at genetic risk for schizophrenia: an fMRI study of working memory
Larry J Seidman
Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center Public Psychiatry Division, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
Schizophr Res 85:58-72. 2006
..Because substantially less is known about these phenotypes in adolescent subjects we sought to demonstrate that young relatives of persons with schizophrenia manifest impaired WM and altered prefrontal activation...
- Parsing the associations between prenatal exposure to nicotine and offspring psychopathology in a nonreferred sample
Joseph Biederman
Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Adolesc Health 45:142-8. 2009
..The main aim of this study was to disentangle the association between maternal smoking during pregnancy with psychopathological outcomes, adjusting for possible confounders...
- Psychopathology, personality traits and social development of young first-degree relatives of patients with schizophrenia
Stephen J Glatt
Center for Behavioral Genomics, Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 920923, USA
Br J Psychiatry 189:337-45. 2006
..Evaluation of individuals at high genetic risk of schizophrenia is a powerful method for identifying precursors of the illness...
- Is there heterogeneity among syndromes of substance use disorder for illicit drugs?
Cheryl Beseler
Center for Behavioral Genomics, Department of Psychiatry, University of California, 9500 Gilman Drive, Mail Code 0603, La Jolla, San Diego, CA 92093, and Veterans Medical Research Foundation, La Jolla 92161, USA
Addict Behav 31:929-47. 2006
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- The Palau Early Psychosis Study: distribution of cases by level of genetic risk
Marina Myles-Worsley
Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA
Am J Med Genet B Neuropsychiatr Genet 144:5-9. 2007
..These young subjects can contribute valuable information about the familial transmission of schizophrenia, the developmental course of the illness, and rates of transition to frank psychosis...
- IQ decline in cross-sectional studies of schizophrenia: methodology and interpretation
William S Kremen
Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego School of Medicine, 9500 Gilman Drive MC 0738, La Jolla, CA 92093 0738, USA
Psychiatry Res 158:181-94. 2008
..Overall, these results strongly suggest that differences in current neuropsychological function in schizophrenia are attributable primarily to current IQ instead of to IQ trajectory over time...
- Family based association study of pediatric bipolar disorder and the dopamine transporter gene (SLC6A3)
Eric Mick
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Med Genet B Neuropsychiatr Genet 147:1182-5. 2008
..These data provide suggestive evidence supporting a role for SLC6A3 in the etiology of pediatric bipolar disorder...
- Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder
Eric Mick
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Am J Med Genet B Neuropsychiatr Genet 147:1412-8. 2008
..These results should be considered preliminary until replicated in larger adequately powered, controlled samples but do suggest that noradrenergic and possibly glutaminergic genes may be involved with response to methylphenidate...
- The Palau Early Psychosis Study: neurocognitive functioning in high-risk adolescents
Marina Myles-Worsley
Department of Psychiatry, SUNY Upstate Medical University, Syracuse NY 13210, USA
Schizophr Res 89:299-307. 2007
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- Differential expression of SLC9A9 and interacting molecules in the hippocampus of rat models for attention deficit/hyperactivity disorder
Yanli Zhang-James
Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Dev Neurosci 34:218-27. 2012
..Our results suggest that abnormalities in SLC9A9-mediated signaling pathways could contribute to the ADHD phenotype of two rat models (WKY/NCrl and SHR/NCrl), and that the perturbation of the SLC9A9 network is age-dependent...
- Forecasting three-month outcomes in a laboratory school comparison of mixed amphetamine salts extended release (Adderall XR) and atomoxetine (Strattera) in school-aged children With ADHD
Stephen V Faraone
State University of New York Upstate Medical University, NY, USA
J Atten Disord 11:74-82. 2007
..Compare observed and forecasted efficacy of mixed amphetamine salts extended release (MAS-XR; Adderall) with atomoxetine (Strattera) in ADHD children...
- Can a subtype of conduct disorder linked to bipolar disorder be identified? Integration of findings from the Massachusetts General Hospital Pediatric Psychopharmacology Research Program
Joseph Biederman
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA
Biol Psychiatry 53:952-60. 2003
..Our data suggest that when BPD and CD co-occur in children, both are correctly diagnosed. In these comorbid cases, CD symptoms should not be viewed as secondary to BPD, and manic symptoms should not be viewed as secondary to CD...
- Molecular genetics of attention-deficit/hyperactivity disorder
Stephen V Faraone
Medical Genetics Research Center and Department of Psychiatry, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
Biol Psychiatry 57:1313-23. 2005
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- Three potential susceptibility loci shown by a genome-wide scan for regions influencing the age at onset of mania
Stephen V Faraone
Department of Psychiatry, Harvard Medical School, Boston, USA
Am J Psychiatry 161:625-30. 2004
..Because age at onset may have utility in resolving the complexity and heterogeneity of the disorder, the authors sought to identify chromosomal loci that harbor the genes influencing this trait...
- Absence of association with DAT1 polymorphism and response to methylphenidate in a sample of adults with ADHD
Eric Mick
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Am J Med Genet B Neuropsychiatr Genet 141:890-4. 2006
..We failed to identify an association with DAT1 and the response or tolerability of methylphenidate in adults with ADHD...
- An fMRI study of working memory in persons with bipolar disorder or at genetic risk for bipolar disorder
Heidi W Thermenos
Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center Division of Public Psychiatry, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Am J Med Genet B Neuropsychiatr Genet 153:120-31. 2010
..Persons with BD and RELs exhibit altered activity in the frontopolar cortex and insula, which may represent biomarkers of genetic risk for BD...
- Family-based association study of the NOTCH4 gene in schizophrenia using Japanese and Chinese samples
Sakae Takahashi
Department of Psychiatry, Massachusetts Mental Health Center, Harvard Medical School, Boston, Massachusetts 02115, USA
Biol Psychiatry 54:129-35. 2003
..A family based association study in a British sample found the NOTCH4 gene to be associated with schizophrenia; however, all six replication studies failed to confirm the finding...
- Gray matter alterations in adults with attention-deficit/hyperactivity disorder identified by voxel based morphometry
Larry J Seidman
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biol Psychiatry 69:857-66. 2011
..This study used voxel based morphometry and applied an a priori region of interest approach based on our previous work, as well as from well-developed neuroanatomical theories of ADHD...
- Neurocognition in first-episode schizophrenia: a meta-analytic review
Raquelle I Mesholam-Gately
Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Department of Psychiatry, Harvard Medical School, MA, USA
Neuropsychology 23:315-36. 2009
..Considerable heterogeneity of effect sizes across studies, however, underscores variability in manifestations of the illness and a need for improved reporting of sample characteristics to support moderator variable analyses...
- Treating common psychiatric disorders associated with attention-deficit/hyperactivity disorder
Arun Kunwar
Department of Psychiatry, State University of New York Upstate Medical University, Syracuse, NY 13210 USA
Expert Opin Pharmacother 8:555-62. 2007
..This paper also discusses knowledge gaps in the understanding of treatment of comorbid disorders associated with ADHD, and directions for future research...
- Familial risk analysis of the association between attention-deficit/hyperactivity disorder and psychoactive substance use disorder in female adolescents: a controlled study
Joseph Biederman
Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
J Child Psychol Psychiatry 50:352-8. 2009
..However, this literature has been based almost exclusively on male only samples and, therefore, the findings may not generalize to females...
- Effect of stimulants on height and weight: a review of the literature
Stephen V Faraone
Departments of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA
J Am Acad Child Adolesc Psychiatry 47:994-1009. 2008
..Stimulant medications are effective treatments for attention-deficit/hyperactivity disorder, but concerns remain about their effects on growth...
- Prevalence and genetic architecture of Child Behavior Checklist-juvenile bipolar disorder
James J Hudziak
Department of Psychiatry, University of Vermont, Burlington 05405, USA
Biol Psychiatry 58:562-8. 2005
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- Family, twin, adoption, and molecular genetic studies of juvenile bipolar disorder
Robert R Althoff
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
Bipolar Disord 7:598-609. 2005
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- Early onset bipolar disorder: possible linkage to chromosome 9q34
Stephen V Faraone
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
Bipolar Disord 8:144-51. 2006
..We hypothesized that using age at onset to look at subsets of BD families in a genetic linkage analysis would prove useful in separating etiologically homogeneous BD sub-groups and subsequently identifying genetic susceptibility regions...
- Partial replication of a DRD4 association in ADHD individuals using a statistically derived quantitative trait for ADHD in a family-based association test
Jessica Lasky-Su
Department of Psychiatry, SUNY Upstate Medical University, Syracuse, New York 13210, USA
Biol Psychiatry 62:985-90. 2007
..We sought to replicate this finding by using the same methodology in an independent sample of ADHD individuals...
- Dorsolateral prefrontal and anterior cingulate cortex volumetric abnormalities in adults with attention-deficit/hyperactivity disorder identified by magnetic resonance imaging
Larry J Seidman
Harvard Medical School, Department of Psychiatry, Center for Morphometric Analysis, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA
Biol Psychiatry 60:1071-80. 2006
..This structural MRI study used an a priori region of interest approach...
- A naturalistic study of the effects of pharmacotherapy on substance use disorders among ADHD adults
Stephen V Faraone
Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Psychol Med 37:1743-52. 2007
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