Regioselective synthesis and antitumor screening of some novel N-phenylpyrazole derivativesAhmad M Farag
Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
Bioorg Med Chem 16:881-9. 2008
..The preliminary screening for the antitumor activity of all newly synthesized compounds was carried out against Ehrlich Ascites Carcinoma tumor cells...
Synthesis of new N-phenylpyrazole derivatives with potent antimicrobial activityAhmad M Farag
Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
Bioorg Med Chem 16:4569-78. 2008
..From structure-activity relationship (SAR) point of view, the attachment of bromoacetyl moiety to pyrazole ring can be considered as a breakthrough in developing a new therapeutic antifungal agent related to phenylpyrazole system...
- Synthesis and structure-activity relationship studies of pyrazole-based heterocycles as antitumor agents
Ahmad M Farag
Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt
Arch Pharm (Weinheim) 343:384-96. 2010
..The oral LD(50) values revealed that most of the tested compounds are relatively nontoxic...
- Design, synthesis and structure-activity relationship study of novel pyrazole-based heterocycles as potential antitumor agents
Ahmad M Farag
Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
Eur J Med Chem 45:5887-98. 2010
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- Recent advances in the therapeutic applications of pyrazolines
Mohamed R Shaaban
Cairo University, Faculty of Science, Department of Chemistry, Giza 12613, Egypt
Expert Opin Ther Pat 22:253-91. 2012
..Many new pyrazoline derivatives have been synthesized and patented, but there are still new aspects to explore and work on...
- Synthesis of new 3-pyridinecarboxylates of potential vasodilation properties
Adel S Girgis
Pesticide Chemistry Department, National Research Centre, El Behoos Street, Dokki, 12622 Cairo, Egypt
Eur J Med Chem 43:1818-27. 2008
..Compounds 5b, 5c, 6b and 8g reveal remarkable vasodilation potency (IC50, concentrations necessary for 50% reduction of maximal norepinephrine hydrochloride induced contracture) 0.175, 0.146, 0.229 and 0.233 mM, respectively...
- Synthesis and analgesic/anti-inflammatory evaluation of fused heterocyclic ring systems incorporating phenylsulfonyl moiety
Mohamed R Shaaban
Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
Bioorg Med Chem 16:6344-52. 2008
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