Min Fang

Summary

Publications

  1. ncbi request reprint Gene delivery of SOCS3 protects mice from lethal endotoxic shock
    Min Fang
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Cell Mol Immunol 2:373-7. 2005
  2. ncbi request reprint A limited course of soluble CD83 delays acute cellular rejection of MHC-mismatched mouse skin allografts
    Jun Fa Xu
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Transpl Int 20:266-76. 2007
  3. doi request reprint Gene delivery of indoleamine 2,3-dioxygenase prolongs cardiac allograft survival by shaping the types of T-cell responses
    Guang Yu
    Department of Immunology, Laboratory of Transplantation, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
    J Gene Med 10:754-61. 2008
  4. doi request reprint Indoleamine 2,3-dioxygenase and regulatory dendritic cells contribute to the allograft protection induced by infusion of donor-specific splenic stromal cells
    Li Liu
    Laboratory of Transplantation, Department of Immunology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
    Cell Mol Immunol 8:31-40. 2011
  5. doi request reprint Extracellular acidosis modulates the endocytosis and maturation of macrophages
    Xiaoling Kong
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
    Cell Immunol 281:44-50. 2013
  6. doi request reprint High-mobility group box 1 exacerbates concanavalin A-induced hepatic injury in mice
    Quan Gong
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People s Republic of China
    J Mol Med (Berl) 88:1289-98. 2010
  7. doi request reprint High-mobility group box 1 promotes early acute allograft rejection by enhancing IL-6-dependent Th17 alloreactive response
    Lihua Duan
    Laboratory of Transplantation, Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Lab Invest 91:43-53. 2011
  8. doi request reprint Blockade of IL-33 ameliorates Con A-induced hepatic injury by reducing NKT cell activation and IFN-γ production in mice
    Jie Chen
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Rd 13, Wuhan 430030, China
    J Mol Med (Berl) 90:1505-15. 2012
  9. pmc Interleukin-33 ameliorates experimental colitis through promoting Th2/Foxp3⁺ regulatory T-cell responses in mice
    Lihua Duan
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Mol Med 18:753-61. 2012
  10. doi request reprint Adoptive transfer of FTY720-treated immature BMDCs significantly prolonged cardiac allograft survival
    Yang Heng
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Transpl Int 23:1259-70. 2010

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Gene delivery of SOCS3 protects mice from lethal endotoxic shock
    Min Fang
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Cell Mol Immunol 2:373-7. 2005
    ..These findings suggest that gene delivery of SOCS3 mediated by liposome is a promising approach for endotoxic septic shock treatment...
  2. ncbi request reprint A limited course of soluble CD83 delays acute cellular rejection of MHC-mismatched mouse skin allografts
    Jun Fa Xu
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Transpl Int 20:266-76. 2007
    ..Our results suggest that CD83-Ig could be useful for the treatment of allograft rejection in combination with other therapeutic strategies...
  3. doi request reprint Gene delivery of indoleamine 2,3-dioxygenase prolongs cardiac allograft survival by shaping the types of T-cell responses
    Guang Yu
    Department of Immunology, Laboratory of Transplantation, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
    J Gene Med 10:754-61. 2008
    ..We investigated the hypothesis that overexpression of indoleamine 2,3-dioxygenase (IDO) by a cardiac allograft may result in a survival advantage of the allograft by creating a tolerogenic microenvironment...
  4. doi request reprint Indoleamine 2,3-dioxygenase and regulatory dendritic cells contribute to the allograft protection induced by infusion of donor-specific splenic stromal cells
    Li Liu
    Laboratory of Transplantation, Department of Immunology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
    Cell Mol Immunol 8:31-40. 2011
    ..Our data suggest that donor-derived SSCs could be used as a therapeutic target to promote transplantation tolerance...
  5. doi request reprint Extracellular acidosis modulates the endocytosis and maturation of macrophages
    Xiaoling Kong
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
    Cell Immunol 281:44-50. 2013
    ..Our findings provide new insight into the role of extracellular acidosis in the regulation of immune function and suggest ASICs as new targets for the modulation of immune response...
  6. doi request reprint High-mobility group box 1 exacerbates concanavalin A-induced hepatic injury in mice
    Quan Gong
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People s Republic of China
    J Mol Med (Berl) 88:1289-98. 2010
    ..These finding thus suggest a pivotal factor of HMGB1 in Con A-induced hepatitis. Blockage of extracellular HMGB1 may represent a novel therapeutic strategy to prevent hepatic injury in T cell-mediated hepatitis...
  7. doi request reprint High-mobility group box 1 promotes early acute allograft rejection by enhancing IL-6-dependent Th17 alloreactive response
    Lihua Duan
    Laboratory of Transplantation, Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Lab Invest 91:43-53. 2011
    ....
  8. doi request reprint Blockade of IL-33 ameliorates Con A-induced hepatic injury by reducing NKT cell activation and IFN-γ production in mice
    Jie Chen
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Rd 13, Wuhan 430030, China
    J Mol Med (Berl) 90:1505-15. 2012
    ..Blockade of IL-33 may represent a novel therapeutic strategy through IL-33/ST2L signal to prevent immune-mediated liver injury...
  9. pmc Interleukin-33 ameliorates experimental colitis through promoting Th2/Foxp3⁺ regulatory T-cell responses in mice
    Lihua Duan
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Mol Med 18:753-61. 2012
    ..Thus, IL-33 is a promising candidate for the development of new treatments for CD...
  10. doi request reprint Adoptive transfer of FTY720-treated immature BMDCs significantly prolonged cardiac allograft survival
    Yang Heng
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Transpl Int 23:1259-70. 2010
    ..These results suggest that infusion of FTY720-DCs before cardiac transplantation could significantly prolong functional graft survival by acting as a balancer of alloimmune response...
  11. doi request reprint Programmed death-1 signaling is essential for the skin allograft protection by alternatively activated dendritic cell infusion in mice
    Hong Dai
    Department of Immunology, Laboratory of Transplantation, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
    Transplantation 88:864-73. 2009
    ..Alternatively activated dendritic cell (aaDC) can prolong allograft survival in the mouse model. However, the molecular mechanism(s) by which these DCs function to regulate alloreactive T-cell responses remains to be clearly defined...
  12. ncbi request reprint Steady state dendritic cells with forced IDO expression induce skin allograft tolerance by upregulation of regulatory T cells
    Guang Yu
    Laboratory of Transplantation, Department of Immunology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
    Transpl Immunol 18:208-19. 2008
    ....
  13. pmc Flt3L combined with rapamycin promotes cardiac allograft tolerance by inducing regulatory dendritic cells and allograft autophagy in mice
    Ali Xiong
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    PLoS ONE 7:e46230. 2012
    ..All together, these data suggest that Flt3L combined with low-dose of Rapa could be an effective therapeutic approach to induce tolerance in clinical setting of transplantation...
  14. doi request reprint Granzyme B is recovered by natural killer cells via clathrin-dependent endocytosis
    Pan Li
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
    Cell Mol Life Sci 67:3197-208. 2010
    ..The NK cell recovery of its released effector molecules, in turn, suggests that endocytosis may well play a key role in the post exocytosis regulation of immune cells...
  15. ncbi request reprint Soluble mouse B7-H3 down-regulates dendritic cell stimulatory capacity to allogenic T cell proliferation and production of IL-2 and IFN-gamma
    Junfa Xu
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    Cell Mol Immunol 3:235-40. 2006
    ..Further studies revealed that soluble mB7h3-hIg could also inhibit IL-2 and IFN-gamma production of allogenic T cells. These results suggested a great potential of soluble B7-H3 for treatment of graft rejection and autoimmume disease...
  16. doi request reprint B7-H4 transfection prolongs beta-cell graft survival
    Chun Lei Yuan
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Transpl Immunol 21:143-9. 2009
    ..More importantly, the survival time for recipients transplanted with B7-H4-NIT cells was significantly longer than that with EGFP-NIT cells. These results indicate that B7-H4 transfection prolongs beta-cell graft survival...
  17. ncbi request reprint [Clone and expression of murine BTLA extracellular domain gene and its effect on the expression of B7 on dendritic cells]
    Jun Fa Xu
    Department of Immunology, Tongji Medical College, Huazhong Universite of Science and Technology, Wuhan 430030, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 22:413-6. 2006
    ..4...
  18. doi request reprint Perforin is recaptured by natural killer cells following target cells stimulation for cytotoxicity
    Lei Wang
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Peoples Republic of China
    Cell Biol Int 36:223-8. 2012
    ..The data suggest that the recovery of Pfn contributes to the cytotoxicity of NK cells. The assay of endocytosis of lytic molecule presents a particular focus for exploring the mechanism of abnormal cytotoxicity of NK cells...
  19. doi request reprint Gene silencing of NALP3 protects against liver ischemia-reperfusion injury in mice
    Ping Zhu
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Hum Gene Ther 22:853-64. 2011
    ....
  20. doi request reprint Acid-sensing ion channels contribute to the effect of acidosis on the function of dendritic cells
    Jing Tong
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
    J Immunol 186:3686-92. 2011
    ..Moreover, the effect of acidosis on DCs can be abolished by the nonsteroidal anti-inflammatory drugs ibuprofen and diclofenac. These results suggest that ASICs are involved in the acidosis-mediated effect on DC function...
  21. doi request reprint CpG ODN pretreatment attenuates concanavalin A-induced hepatitis in mice
    Hui Zhang
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Int Immunopharmacol 10:79-85. 2010
    ..These results suggest that CpG ODN pretreatment protects the mice from Con A-induced liver injury via inhibiting hepatocyte apoptosis, inflammation and activation of lymphocytes...
  22. doi request reprint Heme oxygenase-1 upregulation significantly inhibits TNF-alpha and Hmgb1 releasing and attenuates lipopolysaccharide-induced acute lung injury in mice
    Quan Gong
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
    Int Immunopharmacol 8:792-8. 2008
    ..These findings demonstrate the significant protection of CoPPIX against LPS-induced ALI, and the effect mechanism of CoPPIX was associated with decreasing the expression of TNF-a and Hmgb1...
  23. doi request reprint CD2AP is indispensable to multistep cytotoxic process by NK cells
    Yuting Ma
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Mol Immunol 47:1074-82. 2010
    ..Thus, CD2AP, through facilitating conjugate formation and directed transport of lytic granules, plays an important role in NK cells killing...
  24. doi request reprint ARF triggers cell G1 arrest by a P53 independent ERK pathway
    Hansong Du
    Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Mol Cell Biochem 357:415-22. 2011
    ..The results indicate that ERK1/2 and p21 were activated upon p14ARF induction. Totally, the functional roles of ERK and p21 for ARF in p53-independent tumor suppression were demonstrated...
  25. ncbi request reprint Gene therapy using adenoviral vector encoding 4-1BBIg gene significantly prolonged murine cardiac allograft survival
    Bao Jun Huang
    Laboratory of Transplantation, Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Transpl Immunol 16:88-94. 2006
    ..Therefore, Ad4-1BBIg may be useful for preventing allograft rejection...
  26. ncbi request reprint Hemochromatosis gene (HFE) polymorphisms and risk of type 2 diabetes mellitus: a meta-analysis
    Ying Rong
    Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Am J Epidemiol 176:461-72. 2012
    ..12, 95% CI: 1.00, 1.25; P = 0.04). The C282Y variant was not significantly associated with diabetes risk. In summary, persons with a D allele may have a moderately increased risk of type 2 diabetes mellitus...
  27. pmc The Association between the Pro12Ala Variant in the PPARγ2 Gene and Type 2 Diabetes Mellitus and Obesity in a Chinese Population
    Xia Wang
    Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan, China Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    PLoS ONE 8:e71985. 2013
    ..Conflicting results have been reported on the association of the Pro12Ala polymorphism of the PPARγ2 gene with the risk of type 2 diabetes or obesity...
  28. pmc Imagable 4T1 model for the study of late stage breast cancer
    Kai Tao
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    BMC Cancer 8:228. 2008
    ..New information regarding the involvement of innate and acquired immunity in metastasis and other characteristics of the model relevant to its use in the study of late stage breast cancer are reported...
  29. ncbi request reprint Immunization with a single extracellular enveloped virus protein produced in bacteria provides partial protection from a lethal orthopoxvirus infection in a natural host
    Min Fang
    Program of Viral Pathogenesis, Division of Basic Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Virology 345:231-43. 2006
    ..coli protects susceptible mice from a lethal ectromelia virus infection. This is the first report that a subunit vaccine can provide protection to a lethal Orthopoxvirus infection in its natural host...
  30. ncbi request reprint Bacterial expression and purification of biologically active human TFF3
    Min Fang
    Department of Biochemistry and Molecular Biology, National Laboratory of Protein Engineering, College of Life Science, Peking University, Beijing, PR China
    Peptides 25:785-92. 2004
    ..Oral administration of recombinant hTFF3 has a dose dependent protective effect against ethanol-induced or pylorus ligation-induced gastric mucosa injury in rat, which indicates that our recombinant hTFF3 is biologically active...
  31. ncbi request reprint Intraperitoneal administration of pMP6/liposome complexes inhibits the growth of co-localized colon-26 adenocarcinoma cells by inducing a tumor-specific immune response
    Sanda Sturlan
    Department of General Surgery, University of Vienna Medical School, Vienna, Austria
    Anticancer Res 23:4843-51. 2003
    ..In our previous study, we found complexes of the non-coding pMP6 plasmid and cationic liposomes which exerted antitumor activity in the C26 model. We now sought to unravel the underlying protective effector mechanism(s)...
  32. ncbi request reprint Characterization of an anti-human ovarian carcinomaxanti-human CD3 bispecific single-chain antibody with an albumin-original interlinker
    Min Fang
    Group 102, Institute of Genetics and Developmental Biology, Academia Sinica, Beijing 100101, China
    Gynecol Oncol 92:135-46. 2004
    ..The objective of this study was to determine the properties of a single-chain bispecific antibody (scBsAb) against human ovarian carcinoma and to develop this agent for potential use in human ovarian cancer...
  33. ncbi request reprint Infectious nickel tolerance: a reciprocal interplay of tolerogenic APCs and T suppressor cells that is driven by immunization
    Karin Roelofs-Haarhuis
    Institut für umweltmedizinische Forschung and Dermatology Clinic, Heinrich Heine University, Dusseldorf, Germany
    J Immunol 171:2863-72. 2003
    ..Under these conditions, APCs and T suppressor effector cells infectiously spread the tolerance to naive T cells and APCs, respectively...
  34. ncbi request reprint Stable nonviral genetic correction of inherited human skin disease
    Susana Ortiz-Urda
    VA Palo Alto Healthcare System and the Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA
    Nat Med 8:1166-70. 2002
    ..These findings establish a practical approach to nonviral genetic correction of severe human genetic disorders requiring stable genomic integration of large DNA sequences...