Gene delivery of SOCS3 protects mice from lethal endotoxic shockMin Fang
Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Cell Mol Immunol 2:373-7. 2005
..These findings suggest that gene delivery of SOCS3 mediated by liposome is a promising approach for endotoxic septic shock treatment...
- A limited course of soluble CD83 delays acute cellular rejection of MHC-mismatched mouse skin allografts
Jun Fa Xu
Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Transpl Int 20:266-76. 2007
..Our results suggest that CD83-Ig could be useful for the treatment of allograft rejection in combination with other therapeutic strategies...
Gene delivery of indoleamine 2,3-dioxygenase prolongs cardiac allograft survival by shaping the types of T-cell responsesGuang Yu
Department of Immunology, Laboratory of Transplantation, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
J Gene Med 10:754-61. 2008
..We investigated the hypothesis that overexpression of indoleamine 2,3-dioxygenase (IDO) by a cardiac allograft may result in a survival advantage of the allograft by creating a tolerogenic microenvironment...
- Indoleamine 2,3-dioxygenase and regulatory dendritic cells contribute to the allograft protection induced by infusion of donor-specific splenic stromal cells
Li Liu
Laboratory of Transplantation, Department of Immunology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
Cell Mol Immunol 8:31-40. 2011
..Our data suggest that donor-derived SSCs could be used as a therapeutic target to promote transplantation tolerance...
- High-mobility group box 1 exacerbates concanavalin A-induced hepatic injury in mice
Quan Gong
Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People s Republic of China
J Mol Med (Berl) 88:1289-98. 2010
..These finding thus suggest a pivotal factor of HMGB1 in Con A-induced hepatitis. Blockage of extracellular HMGB1 may represent a novel therapeutic strategy to prevent hepatic injury in T cell-mediated hepatitis...
- High-mobility group box 1 promotes early acute allograft rejection by enhancing IL-6-dependent Th17 alloreactive response
Lihua Duan
Laboratory of Transplantation, Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Lab Invest 91:43-53. 2011
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Interleukin-33 ameliorates experimental colitis through promoting Th2/Foxp3⁺ regulatory T-cell responses in miceLihua Duan
Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Mol Med 18:753-61. 2012
..Thus, IL-33 is a promising candidate for the development of new treatments for CD...
- Steady state dendritic cells with forced IDO expression induce skin allograft tolerance by upregulation of regulatory T cells
Guang Yu
Laboratory of Transplantation, Department of Immunology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
Transpl Immunol 18:208-19. 2008
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- Adoptive transfer of FTY720-treated immature BMDCs significantly prolonged cardiac allograft survival
Yang Heng
Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Transpl Int 23:1259-70. 2010
..These results suggest that infusion of FTY720-DCs before cardiac transplantation could significantly prolong functional graft survival by acting as a balancer of alloimmune response...
- Programmed death-1 signaling is essential for the skin allograft protection by alternatively activated dendritic cell infusion in mice
Hong Dai
Department of Immunology, Laboratory of Transplantation, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
Transplantation 88:864-73. 2009
..Alternatively activated dendritic cell (aaDC) can prolong allograft survival in the mouse model. However, the molecular mechanism(s) by which these DCs function to regulate alloreactive T-cell responses remains to be clearly defined...
- B7-H4 transfection prolongs beta-cell graft survival
Chun Lei Yuan
Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Transpl Immunol 21:143-9. 2009
..More importantly, the survival time for recipients transplanted with B7-H4-NIT cells was significantly longer than that with EGFP-NIT cells. These results indicate that B7-H4 transfection prolongs beta-cell graft survival...
- Granzyme B is recovered by natural killer cells via clathrin-dependent endocytosis
Pan Li
Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
Cell Mol Life Sci 67:3197-208. 2010
..The NK cell recovery of its released effector molecules, in turn, suggests that endocytosis may well play a key role in the post exocytosis regulation of immune cells...
- Soluble mouse B7-H3 down-regulates dendritic cell stimulatory capacity to allogenic T cell proliferation and production of IL-2 and IFN-gamma
Junfa Xu
Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
Cell Mol Immunol 3:235-40. 2006
..Further studies revealed that soluble mB7h3-hIg could also inhibit IL-2 and IFN-gamma production of allogenic T cells. These results suggested a great potential of soluble B7-H3 for treatment of graft rejection and autoimmume disease...
- [Clone and expression of murine BTLA extracellular domain gene and its effect on the expression of B7 on dendritic cells]
Jun Fa Xu
Department of Immunology, Tongji Medical College, Huazhong Universite of Science and Technology, Wuhan 430030, China
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 22:413-6. 2006
..4...
- Perforin is recaptured by natural killer cells following target cells stimulation for cytotoxicity
Lei Wang
Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Peoples Republic of China
Cell Biol Int 36:223-8. 2012
..The data suggest that the recovery of Pfn contributes to the cytotoxicity of NK cells. The assay of endocytosis of lytic molecule presents a particular focus for exploring the mechanism of abnormal cytotoxicity of NK cells...
- Gene silencing of NALP3 protects against liver ischemia-reperfusion injury in mice
Ping Zhu
Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Hum Gene Ther 22:853-64. 2011
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- Blockade of IL-33 ameliorates Con A-induced hepatic injury by reducing NKT cell activation and IFN-γ production in mice
Jie Chen
Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Rd 13, Wuhan 430030, China
J Mol Med (Berl) 90:1505-15. 2012
..Blockade of IL-33 may represent a novel therapeutic strategy through IL-33/ST2L signal to prevent immune-mediated liver injury...
- Acid-sensing ion channels contribute to the effect of acidosis on the function of dendritic cells
Jing Tong
Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
J Immunol 186:3686-92. 2011
..Moreover, the effect of acidosis on DCs can be abolished by the nonsteroidal anti-inflammatory drugs ibuprofen and diclofenac. These results suggest that ASICs are involved in the acidosis-mediated effect on DC function...
- CpG ODN pretreatment attenuates concanavalin A-induced hepatitis in mice
Hui Zhang
Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
Int Immunopharmacol 10:79-85. 2010
..These results suggest that CpG ODN pretreatment protects the mice from Con A-induced liver injury via inhibiting hepatocyte apoptosis, inflammation and activation of lymphocytes...
- Extracellular acidosis modulates the endocytosis and maturation of macrophages
Xiaoling Kong
Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, People s Republic of China
Cell Immunol 281:44-50. 2013
..Our findings provide new insight into the role of extracellular acidosis in the regulation of immune function and suggest ASICs as new targets for the modulation of immune response...
- Flt3L combined with rapamycin promotes cardiac allograft tolerance by inducing regulatory dendritic cells and allograft autophagy in mice
Ali Xiong
Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
PLoS ONE 7:e46230. 2012
..All together, these data suggest that Flt3L combined with low-dose of Rapa could be an effective therapeutic approach to induce tolerance in clinical setting of transplantation...
- Heme oxygenase-1 upregulation significantly inhibits TNF-alpha and Hmgb1 releasing and attenuates lipopolysaccharide-induced acute lung injury in mice
Quan Gong
Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
Int Immunopharmacol 8:792-8. 2008
..These findings demonstrate the significant protection of CoPPIX against LPS-induced ALI, and the effect mechanism of CoPPIX was associated with decreasing the expression of TNF-a and Hmgb1...
- CD2AP is indispensable to multistep cytotoxic process by NK cells
Yuting Ma
Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Mol Immunol 47:1074-82. 2010
..Thus, CD2AP, through facilitating conjugate formation and directed transport of lytic granules, plays an important role in NK cells killing...
- ARF triggers cell G1 arrest by a P53 independent ERK pathway
Hansong Du
Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
Mol Cell Biochem 357:415-22. 2011
..The results indicate that ERK1/2 and p21 were activated upon p14ARF induction. Totally, the functional roles of ERK and p21 for ARF in p53-independent tumor suppression were demonstrated...
- Gene therapy using adenoviral vector encoding 4-1BBIg gene significantly prolonged murine cardiac allograft survival
Bao-jun Huang
Laboratory of Transplantation, Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Transpl Immunol 16:88-94. 2006
..Therefore, Ad4-1BBIg may be useful for preventing allograft rejection...
- Infectious nickel tolerance: a reciprocal interplay of tolerogenic APCs and T suppressor cells that is driven by immunization
Karin Roelofs-Haarhuis
, Heinrich Heine University, , Germany
J Immunol 171:2863-72. 2003
..Under these conditions, APCs and T suppressor effector cells infectiously spread the tolerance to naive T cells and APCs, respectively...
- Characterization of an anti-human ovarian carcinomaxanti-human CD3 bispecific single-chain antibody with an albumin-original interlinker
Min Fang
Group 102, Institute of Genetics and Developmental Biology, Academia Sinica, Beijing 100101, China
Gynecol Oncol 92:135-46. 2004
..7 h. CONCLUSION: This scBsAb with easy production and reasonable blood retention time should be developed for potential use in human ovarian cancer...
- Intraperitoneal administration of pMP6/liposome complexes inhibits the growth of co-localized colon-26 adenocarcinoma cells by inducing a tumor-specific immune response
Sanda Sturlan
Department of General Surgery, University of Vienna Medical School, Vienna, Austria
Anticancer Res 23:4843-51. 2003
..Therefore these complexes may be considered promising agents in the immunological gene therapy of cancer...
- Bacterial expression and purification of biologically active human TFF3
Min Fang
Department of Biochemistry and Molecular Biology, National Laboratory of Protein Engineering, College of Life Science, Peking University, Beijing, PR China
Peptides 25:785-92. 2004
..Oral administration of recombinant hTFF3 has a dose dependent protective effect against ethanol-induced or pylorus ligation-induced gastric mucosa injury in rat, which indicates that our recombinant hTFF3 is biologically active...
- Immunization with a single extracellular enveloped virus protein produced in bacteria provides partial protection from a lethal orthopoxvirus infection in a natural host
Min Fang
Program of Viral Pathogenesis, Division of Basic Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
Virology 345:231-43. 2006
..coli protects susceptible mice from a lethal ectromelia virus infection. This is the first report that a subunit vaccine can provide protection to a lethal Orthopoxvirus infection in its natural host...
- Imagable 4T1 model for the study of late stage breast cancer
Kai Tao
Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
BMC Cancer 8:228. 2008
..New information regarding the involvement of innate and acquired immunity in metastasis and other characteristics of the model relevant to its use in the study of late stage breast cancer are reported...
- Stable nonviral genetic correction of inherited human skin disease
Susana Ortiz-Urda
VA Palo Alto Healthcare System and the Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA
Nat Med 8:1166-70. 2002
..These findings establish a practical approach to nonviral genetic correction of severe human genetic disorders requiring stable genomic integration of large DNA sequences...
