Jing-Yuan Fang

Summary

Publications

  1. ncbi request reprint Effects of histone acetylation and DNA methylation on p21( WAF1) regulation
    Jing Yuan Fang
    Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai Second Medical School, Shanghai 200001, China
    World J Gastroenterol 8:400-5. 2002
  2. pmc MiR-29a inhibits cell proliferation and induces cell cycle arrest through the downregulation of p42.3 in human gastric cancer
    Yun Cui
    Division of Gastroenterology and Hepatology, Shanghai Jiao Tong University School of Medicine Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai, China
    PLoS ONE 6:e25872. 2011
  3. doi request reprint Folic acid prevents the initial occurrence of sporadic colorectal adenoma in Chinese older than 50 years of age: a randomized clinical trial
    Qin Yan Gao
    Division of Gastroenterology and Hepatology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Cancer Prev Res (Phila) 6:744-52. 2013
  4. ncbi request reprint Chronic atrophic gastritis is a progressive disease: analysis of medical reports from Shanghai (1985-2009)
    Eugene Yuo Hao Chooi
    Division of Gastroenterology and Hepatology, Shanghai Jiao Tong University School of Medicine, Renji Hospital, Shanghai 200001, China
    Singapore Med J 53:318-24. 2012
  5. pmc Methodological reporting of randomized controlled trials in major hepato-gastroenterology journals in 2008 and 1998: a comparative study
    Ji Lin Wang
    Department of Gastroenterology, Shanghai Jiao Tong University School of Medicine Ren Ji Hospital, Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai, 200001, China
    BMC Med Res Methodol 11:110. 2011
  6. pmc Folate and fiber in the prevention of colorectal cancer: Between shadows and the light
    Wan Du
    Shanghai Institute of Digestive Disease, Shanghai Jiaotong University School of Medicine Renji Hospital, 145 Shandong Middle Road, Shanghai 200001, China
    World J Gastroenterol 16:921-6. 2010
  7. ncbi request reprint Regulation of hMSH2 and hMLH1 expression in the human colon cancer cell line SW1116 by DNA methyltransferase 1
    Jing Yuan Fang
    Shanghai Second Medical University Renji Hospital, Shanghai Institute of Digestive Disease, 145 Shandong Zhong Road, Shanghai 200001, China
    Cancer Lett 233:124-30. 2006
  8. ncbi request reprint Histone deacetylase inhibitors, anticancerous mechanism and therapy for gastrointestinal cancers
    Jing Yuan Fang
    Shanghai Second Medical University Renji Hospital, Shanghai Institute of Digestive Disease, China
    J Gastroenterol Hepatol 20:988-94. 2005
  9. ncbi request reprint Expression of Dnmt1, demethylase, MeCP2 and methylation of tumor-related genes in human gastric cancer
    Jing Yuan Fang
    Shanghai Institute of Digestive Disease, Shanghai Second Medical University Renji Hospital, Shanghai 200001, China
    World J Gastroenterol 10:3394-8. 2004
  10. ncbi request reprint Epigenetic modification regulates both expression of tumor-associated genes and cell cycle progressing in human colon cancer cell lines: Colo-320 and SW1116
    Jing Yuan Fang
    Shanghai Institute of Digestive Disease, Renji Hospital Shanghai Second Medical University, Shanghai 200001, China
    Cell Res 14:217-26. 2004

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Effects of histone acetylation and DNA methylation on p21( WAF1) regulation
    Jing Yuan Fang
    Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai Second Medical School, Shanghai 200001, China
    World J Gastroenterol 8:400-5. 2002
    ..Here, we review the influence of histone acetylation and DNA methylation on p21(WAF1) transcription, and affection of pathways or factors associated such as p 53, E2A, Sp1 as well as several histone deacetylation inhibitors...
  2. pmc MiR-29a inhibits cell proliferation and induces cell cycle arrest through the downregulation of p42.3 in human gastric cancer
    Yun Cui
    Division of Gastroenterology and Hepatology, Shanghai Jiao Tong University School of Medicine Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai, China
    PLoS ONE 6:e25872. 2011
    ..3 was downregulated. Taken together, we have elucidated previously unrecognized roles of miR-29a and indicated that miR-29a may function, at least partially, by targeting the p42.3 gene in human GC...
  3. doi request reprint Folic acid prevents the initial occurrence of sporadic colorectal adenoma in Chinese older than 50 years of age: a randomized clinical trial
    Qin Yan Gao
    Division of Gastroenterology and Hepatology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Cancer Prev Res (Phila) 6:744-52. 2013
    ..Those with low plasma folate should be encouraged to take adequate supplements; plasma folate should be elevated to an effective therapeutic level, which may reduce the incidence of CRA...
  4. ncbi request reprint Chronic atrophic gastritis is a progressive disease: analysis of medical reports from Shanghai (1985-2009)
    Eugene Yuo Hao Chooi
    Division of Gastroenterology and Hepatology, Shanghai Jiao Tong University School of Medicine, Renji Hospital, Shanghai 200001, China
    Singapore Med J 53:318-24. 2012
    ..We aimed to examine the turnover of chronic atrophic gastritis (CAG) pathologically and endoscopically and explore its potential causes...
  5. pmc Methodological reporting of randomized controlled trials in major hepato-gastroenterology journals in 2008 and 1998: a comparative study
    Ji Lin Wang
    Department of Gastroenterology, Shanghai Jiao Tong University School of Medicine Ren Ji Hospital, Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai, 200001, China
    BMC Med Res Methodol 11:110. 2011
    ....
  6. pmc Folate and fiber in the prevention of colorectal cancer: Between shadows and the light
    Wan Du
    Shanghai Institute of Digestive Disease, Shanghai Jiaotong University School of Medicine Renji Hospital, 145 Shandong Middle Road, Shanghai 200001, China
    World J Gastroenterol 16:921-6. 2010
    ..Therefore, more evidence from clinical studies is needed regarding the mechanisms that underlie the actions of bioactive food components in minimizing the risk of CRC...
  7. ncbi request reprint Regulation of hMSH2 and hMLH1 expression in the human colon cancer cell line SW1116 by DNA methyltransferase 1
    Jing Yuan Fang
    Shanghai Second Medical University Renji Hospital, Shanghai Institute of Digestive Disease, 145 Shandong Zhong Road, Shanghai 200001, China
    Cancer Lett 233:124-30. 2006
    ..Furthermore, antisense DNMT1 expression induced promoter demethylation and up-regulated transcription of hMSH2 (P<0.05) and hMLH1 (P=0.064) in SW1116 cells...
  8. ncbi request reprint Histone deacetylase inhibitors, anticancerous mechanism and therapy for gastrointestinal cancers
    Jing Yuan Fang
    Shanghai Second Medical University Renji Hospital, Shanghai Institute of Digestive Disease, China
    J Gastroenterol Hepatol 20:988-94. 2005
    ..In recent years, many studies have shown that specific HDAC inhibitors are helpful for gastrointestinal cancer therapy...
  9. ncbi request reprint Expression of Dnmt1, demethylase, MeCP2 and methylation of tumor-related genes in human gastric cancer
    Jing Yuan Fang
    Shanghai Institute of Digestive Disease, Shanghai Second Medical University Renji Hospital, Shanghai 200001, China
    World J Gastroenterol 10:3394-8. 2004
    ..To explore the effect of DNA methyltransferase, demethylase and methyl-CpG binding protein MeCP2 on the expressions and methylation of hMSH2 and proto-oncogene in human gastric cancer...
  10. ncbi request reprint Epigenetic modification regulates both expression of tumor-associated genes and cell cycle progressing in human colon cancer cell lines: Colo-320 and SW1116
    Jing Yuan Fang
    Shanghai Institute of Digestive Disease, Renji Hospital Shanghai Second Medical University, Shanghai 200001, China
    Cell Res 14:217-26. 2004
    ..In conclusion, regulation by epigenetic modification of the transcription of tumor-associated genes and the cell cycle progression in both human colon cancer cell lines Colo-320 and SW1116 is gene-specific...
  11. ncbi request reprint The MAPK signalling pathways and colorectal cancer
    Jing Yuan Fang
    Shanghai Second Medical University Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai 200001, China
    Lancet Oncol 6:322-7. 2005
    ..Future challenges for the assessment of these targeted agents in the clinic are also presented...
  12. ncbi request reprint 5-Aza-2'-deoxycitydine induces demethylation and up-regulates transcription of p16INK4A gene in human gastric cancer cell lines
    Jing Yuan Fang
    Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai 200001, China
    Chin Med J (Engl) 117:99-103. 2004
    ..To investigate the effects of DNA methylation on the expression of tumor-associated genes and the cell cycle in human gastric cancer cells...
  13. ncbi request reprint Effects of DNA methylation on expression of tumor suppressor genes and proto-oncogene in human colon cancer cell lines
    Jing Yuan Fang
    Shanghai Institute of Digestive Diseases, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China
    World J Gastroenterol 9:1976-80. 2003
    ..To investigate the effects of DNA methylation on the expression of tumor suppressor genes and proto-oncogene in human colon cancer cell lines...
  14. doi request reprint Knock-down of methylenetetrahydrofolate reductase reduces gastric cancer cell survival: an in vitro study
    Dan Feng Sun
    Shanghai Jiao Tong University School of Medicine Renji Hospital, Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China
    Cell Biol Int 32:879-87. 2008
    ..Inhibiting MTHFR with either antisense or siRNA decreases the viability of methionine-dependent transformed gastric cancer cells and suggests that MTHFR inhibition may be a novel anticancer approach...
  15. ncbi request reprint Histone acetylation regulates p21WAF1 expression in human colon cancer cell lines
    Ying Xuan Chen
    Renji Hospital, Shanghai Second Medical University, Shanghai Institute of Digestive Disease, Shanghai 200001, China
    World J Gastroenterol 10:2643-6. 2004
    ..To investigate the effect of histone acetylation on regulation of p21WAF1 gene expression in human colon cancer cell lines...
  16. ncbi request reprint [Regulation of histone acetylation on the expression of cell cycle-associated genes in human colon cancer cell lines]
    Ying Xuan Chen
    Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai 200001, China
    Zhonghua Yi Xue Za Zhi 84:312-7. 2004
    ..To investigate the effects of histone acetylation on the expression of p21(WAF1) and p16(INK4A) genes in two human colon cancer cell lines...
  17. ncbi request reprint Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells
    Rong Lu
    Shanghai Jiaotong University School of Medicine, Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai 200001, China
    J Biol Chem 282:12249-59. 2007
    ..05). Thus, the ERK-MAPK inhibitor treatment or siRNA-mediated knockdown of ERK-MAPK decreases DNA methylation via down-regulating DNMT1 expression and other unknown mediator(s) in SW1116 colon cancer cells...
  18. ncbi request reprint [Effect of eukaryotic expression plasmid DNA methyltransferase gene on methylation status and transcription level of DNA mismatch repair genes in human colon cancer cell line]
    Rong Lu
    Shanghai Institute of Digestive Diseases, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China
    Zhonghua Yi Xue Za Zhi 84:1014-7. 2004
    ....
  19. ncbi request reprint Expression of p21(WAF1) is related to acetylation of histone H3 in total chromatin in human colorectal cancer
    Ying Xuan Chen
    Shanghai Jiaotong University School of Medicine Renji Hospital, Shanghai Institute of Digestive Disease, 145 Shandong Zhong Lu, Shanghai 200001, China
    World J Gastroenterol 13:2209-13. 2007
    ..To explore the relationship between acetylation of histone in total chromatin and p21(WAF1) expression regulation in human colorectal carcinoma...
  20. ncbi request reprint [Effects of extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway activation on proliferation and cell cycle associated genes in human colon cancer cells]
    Xia Wang
    Renji Hospital, Medical College of Shanghai Jiaotong University, Shanghai Institute of Digestive Disease, Shanghai 200001, China
    Zhonghua Yi Xue Za Zhi 87:982-6. 2007
    ..To investigate the effects of extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling pathway activation on the proliferation and cell cycle associated genes in human colon cancer cells...
  21. ncbi request reprint [The effect of PKC-delta inhibitor Rottlerin on human colon cancer cell line SW1116 and its mechanism]
    Zhao Fei Chen
    Institute of Digestive Diseases, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China
    Zhonghua Zhong Liu Za Zhi 28:564-7. 2006
    ..To evaluate the effect of PKC-delta inhibitor Rottlerin on human colon cancer cells and its mechanism...
  22. ncbi request reprint [The relationship of mTOR signaling pathway and histone acetylation in human gastric cancer cell lines]
    Dan Feng Sun
    Renji Hospital, Shanghai Institute of Digestive Disease, School of Medicine, Shanghai Jiaotong University, Shanghai, 200001 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 24:387-91. 2007
    ..To evaluate the relationship between mammalian target of rapamycin (mTOR) signaling pathway and histone acetylation in cell survival, cell cycle, gene expression and protein level on human gastric cancer cells...
  23. ncbi request reprint Folic acid and sodium butyrate prevent tumorigenesis in a mouse model of colorectal cancer
    Rong Lu
    Shanghai Jiaotong University School of Medicine Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai, China
    Epigenetics 3:330-5. 2008
    ....
  24. pmc Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells
    Hua Xiong
    Department of Gastroenterology, Shanghai Jiao Tong University School of Medicine, Ren Ji Hospital, Shanghai Institute of Digestive Disease, Shanghai, 200001, China
    Neoplasia 10:287-97. 2008
    ..Therefore, our findings illustrate the biologic significance of JAK1, 2/STAT3 signaling in CRC progression and provide novel evidence that the JAK/STAT3 pathway may be a new potential target for therapy of CRC...
  25. ncbi request reprint Folate levels in mucosal tissue but not methylenetetrahydrofolate reductase polymorphisms are associated with gastric carcinogenesis
    Yu Rong Weng
    Shanghai Institute of Digestive Disease, Shanghai Jiao Tong University School of Medicine, Renji Hospital, Shanghai 200001, China
    World J Gastroenterol 12:7591-7. 2006
    ..To evaluate whether folate levels in mucosal tissue and some common methylenetetrahydrofolate reductase (MTHFR) variants are associated with the risk of gastric cancer through DNA methylation...
  26. doi request reprint RAF may induce cell proliferation through hypermethylation of tumor suppressor gene promoter in gastric epithelial cells
    Xia Wang
    Shanghai Jiao Tong University School of Medicine Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai, China
    Cancer Sci 100:117-25. 2009
    ..These data suggest that RAF may induce cell proliferation through hypermethylation of tumor suppressor gene p16INK4A, while the epigenetic inactivation of p21WAF1 and p27KIP1 may be not a key factor in RAF-transformed cells...
  27. doi request reprint Inhibition of STAT5 induces G1 cell cycle arrest and reduces tumor cell invasion in human colorectal cancer cells
    Hua Xiong
    Department of Gastroenterology, Shanghai Jiao Tong University School of Medicine Ren Ji Hospital, Shanghai Institute of Digestive Disease, Shanghai, China
    Lab Invest 89:717-25. 2009
    ..Our findings illustrate the biological significance of STAT5 signaling in CRC progression, and provide novel evidence that intervention in STAT5 signaling may have potential therapeutic value in the prevention of human colorectal cancer...
  28. doi request reprint The expression and clinical significance of DNA methyltransferase proteins in human gastric cancer
    Wen Jin Ding
    Shanghai Jiao Tong University School of Medicine Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai, China
    Dig Dis Sci 53:2083-9. 2008
    ..The DNMT3 family was not associated with these factors. Therefore, DNMT overexpression is involved in gastric tumorigenesis, but there is no correlation between the DNMTs and the biological behaviors of tissues...
  29. ncbi request reprint [Effect of magnesium isoglycyrrhizinate on the proliferation and oxidative stress of rat hepatic stellate cells in vitro]
    Wei Hua Chen
    Department of Gastroenterology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China
    Zhonghua Gan Zang Bing Za Zhi 14:426-30. 2006
    ..To investigate the effect of magnesium isoglycyrrhizinate on the proliferation and oxidative stress of rat hepatic stellate cells (HSCs)...
  30. doi request reprint mTOR signaling pathway is a target for the treatment of colorectal cancer
    Yan Jie Zhang
    Shanghai Institute of Digestive Disease, Shanghai Jiaotong University School of Medicine Renji Hospital, Shanghai, China
    Ann Surg Oncol 16:2617-28. 2009
    ..Herein, the purpose of this study was to analyze the distribution pattern of mTOR signaling components in CRC and adenoma and to determine whether targeted inhibition of mTOR could be a potential therapeutic strategy for CRC...
  31. doi request reprint Combined inhibition of Dnmt and mTOR signaling inhibits formation and growth of colorectal cancer
    Yan Jie Zhang
    Shanghai Institute of Digestive Disease, Shanghai Jiaotong University School of Medicine Renji Hospital, 145 Shandong Road Middle, Shanghai, 200001, China
    Int J Colorectal Dis 24:629-39. 2009
    ..This study addresses the effect of AZA and RPM combination therapy on CRC and its influence on the mammalian target of rapamycin (mTOR) and its signal transduction pathway...
  32. ncbi request reprint Molecular staging of gastric cancer
    Yan Jie Zhang
    Shanghai Institute of Digestive Disease, Shanghai Jiaotong University School of Medicine Renji Hospital, Shanghai, China
    J Gastroenterol Hepatol 23:856-60. 2008
    ..Technologies used in molecular staging as well as future directions for the optimization of molecular staging of gastric cancer are also discussed...
  33. ncbi request reprint [Synergistic effect of rapamycin (RPM) and PD98059 on cell cycle and mTOR signal transduction in human colorectal cancer cells]
    Yan Jie Zhang
    Shanghai Institute of Digestive Diseases, Shanghai Jiaotong University, School of Medicine, Renji Hospital, Shanghai 200001, China
    Zhonghua Zhong Liu Za Zhi 29:889-93. 2007
    ..To investigate the synergistic effect of rapamycin (RPM) and PD98059 on human colorectal cancer cells and its potential mechanisms...
  34. doi request reprint Combined inhibition of MEK and mTOR signaling inhibits initiation and progression of colorectal cancer
    Yan Jie Zhang
    Shanghai Institute of Digestive Disease, Shanghai Jiaotong University School of Medicine Renji Hospital, Shanghai, China
    Cancer Invest 27:273-85. 2009
    ..These findings indicate that PD98059 combined with rapamycin appears to be a promising strategy for inhibiting the initiation, and progression of CRC, which may provide a novel strategy for CRC prevention...
  35. doi request reprint The role of postoperative adjuvant chemotherapy following curative resection for gastric cancer: a meta-analysis
    Shu Liang Zhao
    Shanghai Jiao Tong University School of Medicine Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai, China
    Cancer Invest 26:317-25. 2008
    ..Postoperative adjuvant chemotherapy for gastric cancer confers slightly significant benefits compared to the surgery only group. The prognoses after surgery may differ among various population groups or because of different regimens...
  36. ncbi request reprint Inhibitory effect of oxymatrine on serum hepatitis B virus DNA in HBV transgenic mice
    Lun Gen Lu
    Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China
    World J Gastroenterol 10:1176-9. 2004
    ..To study the inhibitory effect of oxymatrine on serum hepatitis B virus (HBV) DNA in HBV transgenic mice...
  37. ncbi request reprint Two common reasons of malabsorption syndromes: celiac disease and Whipple's disease
    Dan Feng Sun
    Shanghai Jiao Tong University School of Medicine, Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai, PR China
    Digestion 74:174-83. 2006
    ..Since most diagnostic tests have a limited availability, it will also provide a diagnostic algorithm of malabsorption syndromes...
  38. ncbi request reprint T cell immune response is correlated with fibrosis and inflammatory activity in hepatitis B cirrhotics
    Jie Ting Tang
    Department of Gastroenterology, Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai Jiaotong University, Shanghai 200001, China
    World J Gastroenterol 12:3015-9. 2006
    ..To explore the relationship among interferon-gamma (IFN-gamma) activity, fibrogenesis, T cell immune responses and hepatic inflammatory activity...
  39. ncbi request reprint Folic acid, polymorphism of methyl-group metabolism genes, and DNA methylation in relation to GI carcinogenesis
    Jing Yuan Fang
    Shanghai Institute of Digestive Disease, Shanghai Second Medical University Renji Hospital, 145 Shandong Zhong Road, Shanghai 200001, PR China
    J Gastroenterol 38:821-9. 2003
    ..During human GI carcinogenesis, MTHFR is highly polymorphic, and the variant genotypes result in decreased MTHFR enzyme activity and lower plasma folate level, as well as aberrant methylation...
  40. ncbi request reprint Natural antisense transcripts regulate gene expression in an epigenetic manner
    Wen Yu Su
    Department of Gastroenterology, Shanghai Jiao Tong University School of Medicine Renji Hospital, Shanghai Institution of Digestive Disease, Shanghai 200001, China
    Biochem Biophys Res Commun 396:177-81. 2010
    ..As one of the important components in epigenetics, NATs could be a potentially rich source for scientists to exploit in the therapy of cancers and other diseases...
  41. ncbi request reprint MicroRNA regulatory network in human colorectal cancer
    Jie Ting Tang
    Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai 200001, China
    Mini Rev Med Chem 9:921-6. 2009
    ..We, thus, hope to open up new avenues for anticancer therapy based on the epigenetic regulation of miRNA...
  42. ncbi request reprint Meta-analysis: perioperative regional liver chemotherapy for improving survival and preventing liver metastases in patients with colorectal carcinoma
    Jie Ting Tang
    Department of Gastroenterology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai, China
    J Dig Dis 11:208-14. 2010
    ..To evaluate the effect of prophylactic regional liver chemotherapy during the perioperative period on improving survival and preventing liver metastases in patients with colorectal cancer (CRC)...
  43. ncbi request reprint [Microarray-based methods to identify DNA methylation in cancer]
    Xiao Qing Tian
    Shanghai Jiaotong University School of Medicine, Renji Hospital, Shanghai Institute of Digestive Diseases, Shanghai 200001, China
    Yi Chuan 30:295-303. 2008
    ..Together they provide many choices to the study of genome-wide DNA methylation profile in cancer...
  44. ncbi request reprint Impaired T cell protein kinase C delta activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupus
    Gabriela Gorelik
    Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 179:5553-63. 2007
    ..These results suggest that defective T cell PKCdelta activation may contribute to the development of idiopathic and hydralazine-induced lupus through effects on T cell DNA methylation...