Zhong Ze Fang
Li S, Cao Y, Sun X, Yang K, Liang Y, Gao S, et al
. Hydroxy metabolites of polychlorinated biphenyls (OH-PCBs) exhibit inhibitory effects on UDP-glucuronosyltransferases (UGTs). Chemosphere. 2018;212:513-522 pubmed publisher
..In conclusion, these data will be helpful for understanding the toxicity mechanisms of PCBs from a view of metabolic interference. ..
Li J, Huo X, Cao Y, Li S, Du Z, Shao P, et al
. Bile acid metabolites in early pregnancy and risk of gestational diabetes in Chinese women: A nested case-control study. EBioMedicine. 2018;: pubmed publisher
..28?nmol/mL in early pregnancy were independently associated with increased risk of GDM in Chinese pregnant women. Talent Recruitment Scheme grant of Tianjin Medical University and National Key Research and Development Program, etc. ..
Yang K, Fu Z, Cao Y, Li S, Du Z, Sun X, et al
. New insights for risks of chlorophenols (CPs) exposure: Inhibition of UDP-glucuronosyltransferases (UGTs). Chemosphere. 2018;206:9-16 pubmed publisher
..18??M, 0.01??M and 5.37??M for the inhibition of PCP towards UGT1A6, UGT1A9 and UGT2B7. All these information will be beneficial for elucidating the risk of CPs exposure from a new perspective. ..
Liu X, Cao Y, Ran R, Dong P, Gonzalez F, Wu X, et al
. New insights into the risk of phthalates: Inhibition of UDP-glucuronosyltransferases. Chemosphere. 2016;144:1966-72 pubmed publisher
..089 µM. Taken together, this study reveales the potential for adverse effects of phthalates DNOP and DPhP as a result of UGT inhibition. ..
Liu X, Chen D, Wu X, Zhao Z, Fu Z, Huang C, et al
. The Inhibition of UDP-Glucuronosyltransferase (UGT) Isoforms by Praeruptorin A and B. Phytother Res. 2016;30:1872-1878 pubmed publisher
..Therefore, closely monitoring the interaction between PA and drugs mainly undergoing UGT1A6 or UGT2B7-catalyzed metabolism is very necessary. Copyright © 2016 John Wiley & Sons, Ltd. ..
Du Z, Cao Y, Li S, Hu C, Fu Z, Huang C, et al
. Inhibition of UDP-glucuronosyltransferases (UGTs) by phthalate monoesters. Chemosphere. 2018;197:7-13 pubmed publisher
..All these information will be beneficial for understanding the adverse effects of PAEs. ..
Ran R, Zhang C, Li R, Chen B, Zhang W, Zhao Z, et al
. Evaluation and Comparison of the Inhibition Effect of Astragaloside IV and Aglycone Cycloastragenol on Various UDP-Glucuronosyltransferase (UGT) Isoforms. Molecules. 2016;21: pubmed
..034 ?M and 20.98 ?M, respectively. ..
Sun D, Zhang C, Ran R, Cao Y, Du Z, Fu Z, et al
. In Vitro Comparative Study of the Inhibitory Effects of Mangiferin and Its Aglycone Norathyriol towards UDP-Glucuronosyl Transferase (UGT) Isoforms. Molecules. 2017;22: pubmed publisher
..6, 2.0 and 2.8 μM, respectively. ..
Cao Y, Du Z, Zhu Z, Sun H, Fu Z, Yang K, et al
. Inhibitory effects of fifteen phthalate esters in human cDNA-expressed UDP-glucuronosyltransferase supersomes. Chemosphere. 2017;185:983-990 pubmed publisher
..In conclusion, exposure to PAEs might influence the metabolic elimination of endogenous compounds and xenobiotics through inhibiting UGTs. ..