Prognostic significance and clinical relevance of Sprouty 2 protein expression in human hepatocellular carcinomaKang Song
Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Hepatobiliary Pancreat Dis Int 11:177-84. 2012
..However, the prognostic value of Spry2 in cancer patients remains unknown. This study is aimed to investigate the clinical relevance and prognostic significance of Spry2 expression in patients with hepatocellular carcinoma (HCC)...
- Complete resection of the caudate lobe of the liver with tumor: technique and experience
J Fan
Liver Cancer Institute, Zhongshan Hospital, Shanghai Medical University, 136 Yi Xue Yuan Road, Shanghai, 200032 P R China
Hepatogastroenterology 48:808-11. 2001
..To study the technique and curative effects of complete resection of the caudate lobe of the liver with tumors...
Liver transplantation outcomes in 1,078 hepatocellular carcinoma patients: a multi-center experience in Shanghai, ChinaJia Fan
Liver Cancer Institute, Shanghai Medical School, Zhong Shan Hospital, Fudan University, 200032 Shanghai, People s Republic of China
J Cancer Res Clin Oncol 135:1403-12. 2009
..To evaluate current selection criteria for patients undergoing liver transplantation (LT) in response to hepatocellular carcinoma (HCC), and to analyze the prognostic factors for successful transplantation...
- Efficacy of different treatment strategies for hepatocellular carcinoma with portal vein tumor thrombosis
Jia Fan
Liver Cancer Institute, Zhongshan Hospital, Fudan University, 136 Yixueyuan Road, Shanghai 200032, China
World J Gastroenterol 11:1215-9. 2005
..To evaluate the efficacy of different treatment strategies for hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) and investigate factors influencing prognosis...
- Hepatocellular carcinoma associated with tumor thrombosis in the portal vein: the effects of different treatments
Jia Fan
Liver Cancer Institute, Zhongshan Hospital, Fudan University Shanghai Medical School, 136 Yi Xue Yuan Road, Shanghai 200032, China
Hepatobiliary Pancreat Dis Int 2:513-9. 2003
..To compare the effects of different treatments for hepatocellular carcinoma (HCC) with tumor thrombosis in the portal vein (TTPV) and evaluate the factors influencing the prognosis...
- Plasma microRNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma
Jian Zhou
Liver Cancer Institute, Zhongshan Hospital, Fudan University, People s Republic of China
J Clin Oncol 29:4781-8. 2011
..We aimed to identify plasma microRNAs for diagnosing hepatitis B virus (HBV) -related HCC...
Profiling of the tetraspanin CD151 web and conspiracy of CD151/integrin β1 complex in the progression of hepatocellular carcinomaRanjan Prasad Devbhandari
Liver Cancer Institute, Shanghai Medical School, Fudan University, Zhongshan Hospital, Shanghai, People s Republic of China
PLoS ONE 6:e24901. 2011
..Together, our data show that CD151 acts as an important player in the progression of HCC in an integrin β1-dependent manner...
- [Up-regulation of thymidine phosphorylase and anti-angiogenesis by interferon alpha in human hepatocellular carcinoma cell line and xenograft]
Yong-sheng Xiao
Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai 200032, China
Zhonghua Yi Xue Za Zhi 85:3205-9. 2005
..kg(-1).d(-1) IFN-alpha group was 68%, significantly higher than that of the untreated group (P < 0.05). CONCLUSION: IFN-alpha of certain doses up-regulate the TP expression, and inhibit the angiogenesis induced by TP as well...
- Effect of rapamycin alone and in combination with sorafenib in an orthotopic model of human hepatocellular carcinoma
Zheng Wang
Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, PR China
Clin Cancer Res 14:5124-30. 2008
..This study was to investigate the effect of rapamycin, alone and in combination with sorafenib, on HCC in vivo...
- Metadherin promotes hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition
Kai Zhu
Liver Cancer Institute, Zhong Shan Hospital, Fudan University, Shanghai, China
Clin Cancer Res 17:7294-302. 2011
..To investigate the expression of metadherin (MTDH) for its prognostic value in hepatocellular carcinoma (HCC) and its role in promoting HCC metastasis...
- Capn4 overexpression underlies tumor invasion and metastasis after liver transplantation for hepatocellular carcinoma
Dou sheng Bai
Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, PR China
Hepatology 49:460-70. 2009
..Conclusion: Our study revealed that Capn4 overexpression underlies invasion and metastasis after LT for HCC and might be a candidate biomarker for future diagnosis and a target for therapy...
- [Time dependency of factors influencing survival of hepatocellular carcinoma patients with portal vein tumor thrombosis after surgery]
Jian Zhou
Liver Cancer Institute, Zhongshan Hospital, Fudam University, Shanghai 200032, China
Zhonghua Yi Xue Za Zhi 86:3005-8. 2006
..To investigate the surgical outcome of the hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT) after surgery and the time-dependency of the factors influencing survival...
- [Inhibition of growth and metastasis of hepatocellular carcinoma by rapamycin: experiment with mice]
Zheng Wang
Liver Cancer Institute, Fudan University, Shanghai 200032, China
Zhonghua Yi Xue Za Zhi 86:1666-70. 2006
..046). CONCLUSION: RPM significantly inhibits the growth and metastasis of HCC. RPM-based immunosuppressive regimen may be of value in HCC patients receiving liver transplantation...
- CD151 modulates expression of matrix metalloproteinase 9 and promotes neoangiogenesis and progression of hepatocellular carcinoma
Guo Ming Shi
Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Shanghai, People s Republic of China
Hepatology 52:183-96. 2010
..CD151-dependent neoangiogenesis appeared to promote the progression of HCC, and this suggests that CD151 may be useful as a high-priority therapeutic target for antiangiogenesis in HCC...
- Downstaging followed by resection plays a role in improving prognosis of unresectable hepatocellular carcinoma
Zhao You Tang
Liver Cancer Institute of Fudan University, 136 Yi Xue Yuan Road, Zhongshan Hospital, Shanghai 200032, China
Hepatobiliary Pancreat Dis Int 3:495-8. 2004
..This study was designed to assess the role of downstaging followed by resection (downstaging-resection) in the improvement of prognosis of unresectable HCC...
- Oxaliplatin induces apoptosis in hepatocellular carcinoma cells and inhibits tumor growth
Zheng Wang
Fudan University, Liver Cancer Institute and Zhongshan Hospital, 136 Yi Xue Yuan Road, 200032 Shanghai, PR China
Expert Opin Investig Drugs 18:1595-604. 2009
..To date, no detailed data are available about the effects of oxaliplatin on hepatocellular carcinoma (HCC) cells. Herein, the anti-proliferation effects of oxaliplatin on HCCLM3 and Hep3B cells in vitro and in vivo are studied...
- High expression levels of putative hepatic stem/progenitor cell biomarkers related to tumour angiogenesis and poor prognosis of hepatocellular carcinoma
Xin Rong Yang
Liver Cancer Institute, Zhong Shan Hospital and Shanghai Medical School, Fudan University, 136 Yi Xue Yuan Road, Shanghai, PR China
Gut 59:953-62. 2010
..To investigate the prognostic values of putative hepatic stem/progenitor cell (HSC/HPC) biomarkers in patients with hepatocellular carcinoma (HCC)...
- The antiangiogenic effects of tyroservatide on animal models of hepatocellular carcinoma
Ning Zhang
Liver Cancer Institute of Fudan University, 200032 Shanghai, People s Republic of China
J Cancer Res Clin Oncol 135:1447-53. 2009
..The chemical structure of YSV is l-tyrosine-l-serine-l-valine, molecular structure is C(17)H(25)N(3)O(6), and molecular weight is 367.40 Da) on human hepatocarcinoma SMMC-7721 transplanted tumors in nude mice...
- Consideration of the role of radiotherapy for unresectable intrahepatic cholangiocarcinoma: a retrospective analysis of 75 patients
Zhao Chong Zeng
Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China
Cancer J 12:113-22. 2006
..We undertook this study to determine if radiotherapy is appropriate for patients with unresectable or lymph node metastatic intrahepatic cholangiocarcinoma...
- Sirolimus inhibits the growth and metastatic progression of hepatocellular carcinoma
Zheng Wang
Liver Cancer Institute, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai, People s Republic of China
J Cancer Res Clin Oncol 135:715-22. 2009
..Sirolimus, a potent immunosuppressant, has been reported to be an effective inhibitor in a variety of tumors. The present study is designed to explore whether sirolimus could block the growth and metastatic progression of HCC...
- Impact factors for microinvasion in intrahepatic cholangiocarcinoma: a possible system for defining clinical target volume
Ai Hong Bi
Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China
Int J Radiat Oncol Biol Phys 78:1427-36. 2010
..To quantify microscopic invasion of intrahepatic cholangiocarcinoma (IHC) into nontumor tissue and define the gross tumor volume (GTV)-to-clinical target volume (CTV) expansion necessary for radiotherapy...
- Liver-intestine cadherin predicts microvascular invasion and poor prognosis of hepatitis B virus-positive hepatocellular carcinoma
Zhen Bin Ding
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China
Cancer 115:4753-65. 2009
..The study was designed to investigate the role of LI-cadherin in tumor invasion and prognosis of human hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC)...
- Peritumoral activated hepatic stellate cells predict poor clinical outcome in hepatocellular carcinoma after curative resection
Min Jie Ju
Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School of Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Shanghai, Peoples Republic of China
Am J Clin Pathol 131:498-510. 2009
..It is important to note that the density of peritumoral activated HSCs, in combination with seprase and osteonectin mRNA or density of Tregs and MPhi, might predict prognoses more effectively...
- The role of polymeric immunoglobulin receptor in inflammation-induced tumor metastasis of human hepatocellular carcinoma
Jing Ai
Division of Anti tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Rd, Shanghai, People s Republic of China
J Natl Cancer Inst 103:1696-712. 2011
..Abnormal expression of pIgR in cancer was also observed, but its clinical relevance remains uncertain...
- Aryl hydrocarbon receptor nuclear translocator is associated with tumor growth and progression of hepatocellular carcinoma
Ying Liang
Liver Cancer Institute and Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People s Republic of China
Int J Cancer 130:1745-54. 2012
..In summary, ARNT is an important regulator of HCC growth and metastasis and could be a promising prognostic candidate in HCC patients...
- Identification of side population cells in human hepatocellular carcinoma cell lines with stepwise metastatic potentials
Guo Ming Shi
Key Laboratory for Carcinogenesis and Cancer Invasion, Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, the Chinese Ministry of Education, 136 Yi Xue Yuan Road, Shanghai, 200032, People s Republic of China
J Cancer Res Clin Oncol 134:1155-63. 2008
..To identify the side population (SP) cells from four hepatocellular carcinoma (HCC) cell lines with stepwise metastatic potentials...
- [Analysis of the risk factors influencing the prognosis of orthotopic liver transplantation for hepatocellular carcinoma and summary of relevant clinical experience]
Yi-feng He
Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Zhonghua Yi Xue Za Zhi 86:1232-5. 2006
..It is important to discover the micro-metastasis and explore more effective approaches to prevent recurrence after transplantation...
- [Interferon alpha enhances the sensitivity of SMMC-7721 hepatocellular carcinoma cells to 5'-deoxy-5-fluorouridine related to up-regulation of thymidine phosphorylase]
Yong Sheng Xiao
Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai 200032, China
Zhonghua Yi Xue Za Zhi 87:2098-100. 2007
....
- Tumor-infiltrating macrophages can predict favorable prognosis in hepatocellular carcinoma after resection
Yi Wei Li
Liver Cancer Institute, Zhong Shan Hospital and Institutes of Biomedical Sciences, Shanghai Medical School, Fudan University, 136 Yi Xue Yuan Road, 200032, Shanghai, People s Republic of China
J Cancer Res Clin Oncol 135:439-49. 2009
..To evaluate the prognostic value of tumor-associated macrophages (TAM), individually or synergistically with CD45RO + memory T cells (T(M)), in hepatocellular carcinoma (HCC) patients following resection...
- Transfection of thymidine phosphorylase cDNA to human hepatocellular carcinoma cells enhances sensitivity to fluoropyrimidine but augments endothelial cell migration
Jian Zhou
Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China
J Cancer Res Clin Oncol 131:547-51. 2005
..However, EC migration was also promoted at the same time. Therefore, transfection with TP alone might have no potential to enhance anti-tumoral effects of fluoropyrimidine in HCC...
- Intrahepatic cholangiocarcinoma: report of 272 patients compared with 5,829 patients with hepatocellular carcinoma
Xin Da Zhou
Liver Cancer Institute, Zhong Shan Hospital, Fudan University, 136 Yi Xue Yuan Rd, Shanghai, China
J Cancer Res Clin Oncol 135:1073-80. 2009
..To clarify clinicopathologic differences between patients with intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC), and identify potential factors influencing survival after hepatectomy for ICC...
- Overexpression of galectin-1 is associated with poor prognosis in human hepatocellular carcinoma following resection
Han Wu
Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China
J Gastroenterol Hepatol 27:1312-9. 2012
..The high expression of the galectin-1 predicts poor patient outcome in several tumors. The aim of this study was to investigate its prognostic value in patients with hepatocellular carcinoma (HCC) after resection...
- Low level of low-density lipoprotein receptor-related protein 1 predicts an unfavorable prognosis of hepatocellular carcinoma after curative resection
Xiao Yong Huang
Liver Cancer Institute, Fudan University, Zhongshan Hospital, Shanghai, People s Republic of China
PLoS ONE 7:e32775. 2012
..The aim of this study was to elucidate the expression and mechanism of LRP1 in hepatocellular carcinoma (HCC)...
- Gene expression profiling of fixed tissues identified hypoxia-inducible factor-1α, VEGF, and matrix metalloproteinase-2 as biomarkers of lymph node metastasis in hepatocellular carcinoma
Zuo Lin Xiang
Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China
Clin Cancer Res 17:5463-72. 2011
..Differential gene expression profiling is useful for investigating genes associated with lymph node metastasis (LNM). We screened genes to identify potential biomarkers for LNM in HCC...
- Clinical features and prognostic factors in patients with bone metastases from hepatocellular carcinoma after liver transplantation
Jian He
Department of Radiation Oncology, Fudan University, Shanghai, China
BMC Cancer 11:492. 2011
..Little is known about the clinical features and prognostic factors of bone metastases of hepatocellular carcinoma (HCC) following liver transplantation (LT)...
- Genetic variations in plasma circulating DNA of HBV-related hepatocellular carcinoma patients predict recurrence after liver transplantation
Jie Hu
Liver Cancer Institute, Zhong Shan Hospital, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, the Chinese Ministry of Education, Shanghai Key Laboratory for Organ Transplantation, Shanghai, People s Republic of China
PLoS ONE 6:e26003. 2011
..Genetic variations play an important role in tumor development and metastasis...
- Hypoxia-inducible factor-1 alpha, in association with inflammation, angiogenesis and MYC, is a critical prognostic factor in patients with HCC after surgery
Chen Xin Dai
Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Shanghai, PR China
BMC Cancer 9:418. 2009
..We investigated the prognostic value of hypoxia-inducible factor-1 alpha (HIF-1alpha) in hepatocellular carcinoma (HCC), and its correlations with inflammation, angiogenesis and MYC oncogene...
- High expressions of vascular endothelial growth factor and platelet-derived endothelial cell growth factor predict poor prognosis in alpha-fetoprotein-negative hepatocellular carcinoma patients after curative resection
Jie Hu
Key Laboratory for Carcinogenesis and Cancer Invasion, the Chinese Ministry of Education, Liver Cancer Institute, Zhong Shan Hospital and Shanghai Medical School, Fudan University, 200032 Shanghai, People s Republic of China
J Cancer Res Clin Oncol 135:1359-67. 2009
..To evaluate the prognosis value of vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) in alpha-fetoprotein (AFP)-negative hepatocellular carcinoma (HCC) patients after curative resection...
- Human leukocyte antigen-G protein expression is an unfavorable prognostic predictor of hepatocellular carcinoma following curative resection
Ming Yan Cai
Liver Cancer Institute, Zhong Shan Hospital, Fudan University, Shanghai 200032, People s Republic of China
Clin Cancer Res 15:4686-93. 2009
..Human leukocyte antigen-G (HLA-G) is a tumor-associated immunosuppressive molecule involved in tumor escape mechanisms. The aim of this study is to elucidate its prognostic significance in hepatocellular carcinoma (HCC)...
- Positive serum hepatitis B e antigen is associated with higher risk of early recurrence and poorer survival in patients after curative resection of hepatitis B-related hepatocellular carcinoma
Hui Chuan Sun
Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai 200032, China
J Hepatol 47:684-90. 2007
..To study the impact of hepatitis B e antigen on tumor recurrence and patients' survival after curative resection of hepatocellular carcinoma...
- Factors influencing survival in hepatocellular carcinoma patients with macroscopic portal vein tumor thrombosis after surgery, with special reference to time dependency: a single-center experience of 381 cases
Jian Zhou
Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, P. R. China
Hepatogastroenterology 53:275-80. 2006
..Evaluation of time-dependency of risk factors may have important clinical implication in determining the therapeutic strategy...
- An investigation of the effect of sorafenib on tumour growth and recurrence after liver cancer resection in nude mice independent of phosphorylated extracellular signal-regulated kinase levels
Zheng Wang
Fudan University, Liver Cancer Institute and Zhongshan Hospital, Shanghai, P R China
Expert Opin Investig Drugs 20:1039-45. 2011
..Conclusions: Sorafenib inhibits tumor growth and prevents metastatic recurrence after resection of hepatocellular carcinoma in nude mice. The effect of sorafenib does not exclusively depend on high levels of pERK in tumors...
- Consideration of role of radiotherapy for lymph node metastases in patients with HCC: retrospective analysis for prognostic factors from 125 patients
Zhao Chong Zeng
Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China
Int J Radiat Oncol Biol Phys 63:1067-76. 2005
..To evaluate the role of radiotherapy (RT) for hepatocellular carcinoma (HCC) patients with abdominal lymph node (LN) metastasis at our institution in the past 7 years...
- A comparison of chemoembolization combination with and without radiotherapy for unresectable hepatocellular carcinoma
Zhao Chong Zeng
Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China
Cancer J 10:307-16. 2004
..Historically, radiotherapy for hepatocellular carcinoma has yielded poor long-term survival. Multimodality therapy has been initiated in an effort to improve survival statistics...
- Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection
Qiang Gao
Liver Cancer Institute, Zhong Shan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, the Chinese Ministry of Education, Shanghai, People s Republic of China
J Clin Oncol 25:2586-93. 2007
..To investigate the prognostic value of tumor-infiltrating lymphocytes (TILs), especially regulatory T cells (Tregs), in hepatocellular carcinoma (HCC) patients after resection...
- A decade's studies on metastasis of hepatocellular carcinoma
Zhao You Tang
Liver Cancer Institute, Zhongshan Hospital, 136 Yi Xue Yuan Road, 200032, Shanghai, PR China
J Cancer Res Clin Oncol 130:187-96. 2004
..The further elucidation of the mechanism underlying HCC metastasis will provide a more solid basis for the prediction and prevention of the metastatic recurrence of HCC...
- Postoperative interferon alpha treatment postponed recurrence and improved overall survival in patients after curative resection of HBV-related hepatocellular carcinoma: a randomized clinical trial
Hui-Chuan Sun
Liver Cancer Institute and Zhong Shan Hospital, Fudan University, 136 Yi Xue Yuan Road, 200032, Shanghai, People's Republic of China
J Cancer Res Clin Oncol 132:458-65. 2006
..CONCLUSIONS: IFN alpha treatment improved the overall survival of patients with HBV-related HCC after curative resection, probably by postponing recurrence...
- Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis
Ying Hong Shi
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China
Autophagy 7:1159-72. 2011
..The combination of autophagy modulation and molecular targeted therapy is a promising therapeutic strategy in treatment of HCC...
- Selection of reference genes for real-time PCR in human hepatocellular carcinoma tissues
Qiang Gao
Key Laboratory for Carcinogenesis and Cancer Invasion, the Chinese Ministry of Education, Liver Cancer Institute, Zhong Shan Hospital and Shanghai Medical School, Fudan University, Shanghai, People s Republic of China
J Cancer Res Clin Oncol 134:979-86. 2008
..To investigate the most suitable housekeeping genes for quantifying a change in mRNA expression levels due to hepatitis virus B related hepatocellular carcinoma (HCC)...
- Interferon-alpha 2a up-regulated thymidine phosphorylase and enhanced antitumor effect of capecitabine on hepatocellular carcinoma in nude mice
Yong-sheng Xiao
Liver Cancer Institute and Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, 200032 Shanghai, P.R. China
J Cancer Res Clin Oncol 130:546-50. 2004
..CONCLUSION: IFN-alpha2a enhanced the antitumor effect of capecitabine on HCC in nude mice, which might be ascribed to the up-regulation of TP expression in liver cancer tissues by IFN-alpha2a...
- [Influence of tumor characteristics on the outcome of liver transplantation among patients with hepatocellular carcinoma]
Yang Xu
Department of Hepato Surgery, Zhongshan Hospital, Liver Cancer Institute, Fudan University, Shanghai 200032, China
Zhonghua Yi Xue Za Zhi 87:2101-4. 2007
..To identify the influence of tumor characteristics on the outcome of liver transplantation (LT) among patients with hepatocellular carcinoma (HCC)...
- Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma
Zhen Bin Ding
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Shanghai 200032, China
Cancer Res 68:9167-75. 2008
..The autophagy defects synergized with altered apoptotic activity might facilitate tumor malignant differentiation, which results in a more aggressive cancer cell phenotype and poor prognosis of HCC...
- Role of overexpression of CD151 and/or c-Met in predicting prognosis of hepatocellular carcinoma
Ai Wu Ke
Experimental Research Center of Zhongshan Hospital, Fudan University, Shanghai, PR China
Hepatology 49:491-503. 2009
..Conclusion: CD151 is positively associated with invasiveness of HCC, and CD151 or combination of CD151/c-Met is a novel marker in predicting the prognosis of HCC and a potential therapeutic target...
- [Effect of postoperative adjuvant transarterial chemoembolization on late recurrence of hepatocellular carcinoma after radical resection]
Xiao hong Chen
Liver Cancer Institute and Zhongshan Hospital of Fudan University, Shanghai 200032, China
Zhonghua Gan Zang Bing Za Zhi 18:599-603. 2010
..To identify the effect of postoperative adjuvant transarterial chemoembolization (TACE) on late recurrence of hepatocellular carcinoma (HCC) patients after radical resection...
- [Indication of liver transplantation for hepatocellular carcinoma: Shanghai Fudan Criteria]
Jia Fan
Department of Liver Surgery and Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China
Zhonghua Yi Xue Za Zhi 86:1227-31. 2006
..CONCLUSION: Shanghai Fudan Criteria, which expanded the tumor size limits, does not adversely impact survival of HCC patients after LT...
- [Nuclear accumulation of CXCR4 and overexpressions of VEGF-C and CK19 are associated with a higher risk of lymph node metastasis in hepatocellular carcinoma]
Zuo Lin Xiang
Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Zhonghua Zhong Liu Za Zhi 32:344-9. 2010
....
- Conversion to sirolimus immunosuppression in liver transplantation recipients with hepatocellular carcinoma: Report of an initial experience
Jian Zhou
Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai 200032, China
World J Gastroenterol 12:3114-8. 2006
..To report a retrospective analysis of preliminary results of 36 patients who received sirolimus (SRL, Rapamune, rapamycin) in a consecutive cohort of 248 liver allograft recipients...
- [Effects of ARNT2 gene on invasion and migration of human hepatocellular carcinoma HCCLM6 cell line]
Wei Wei Li
Liver Cancer Institute and Zhongshan Hospital, Fudan Unviersity, Shanghai 200032, China
Zhonghua Gan Zang Bing Za Zhi 18:27-31. 2010
..To investigate the effects of ARNT2 on invasion and migration of HCCLM6 cells...
- Proteasome inhibitor interacts synergistically with autophagy inhibitor to suppress proliferation and induce apoptosis in hepatocellular carcinoma
Bo Hui
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China Key Laboratory of Carcinogenesis and Cancer Invasion Fudan University, Ministry of Education, China Department of Surgery, The Second Affiliated Hospital, School of Medicine, Xi an Jiaotong University, Xi an, China
Cancer 118:5560-71. 2012
..Proteasome inhibitors have been approved in clinical use against hematologic malignancies, but their application in solid tumors is uncertain. Moreover, the role of autophagy after proteasome inhibition is controversial...
- IL-17 induces AKT-dependent IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma
Fang Ming Gu
Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, P R China
Mol Cancer 10:150. 2011
..However, their relevance in cancer biology remains controversial. This study aimed to clarify the biological action of IL-17 on hepatocellular carcinoma (HCC)...
- Polymeric nanoparticle-encapsulated hedgehog pathway inhibitor HPI-1 (NanoHHI) inhibits systemic metastases in an orthotopic model of human hepatocellular carcinoma
Yang Xu
Liver Cancer Institute, Zhong Shan Hospital and Shanghai Medical School, Key Laboratory for Carcinogenesis and Cancer Invasion, Shanghai, PR China
Clin Cancer Res 18:1291-302. 2012
....
- Infiltrating memory/senescent T cell ratio predicts extrahepatic metastasis of hepatocellular carcinoma
Qiang Gao
Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Shanghai, People s Republic of China
Ann Surg Oncol 19:455-66. 2012
..However, the relative roles of TIC density in predicting tumor extrahepatic metastasis remain to be elucidated...
- Screening and detection of portal vein tumor thrombi-associated serum low molecular weight protein biomarkers in human hepatocellular carcinoma
Ji Gang Qiu
Liver Cancer Institute and Department of Liver Surgery, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan, Shanghai 200032, China
J Cancer Res Clin Oncol 134:299-305. 2008
..Serum low molecular weight protein biomarkers might be important in relation to portal vein tumor thrombi (PVTT) in hepatocellular carcinoma (HCC). This study aimed to screen and to detect these biomarkers...
- CD24 is a novel predictor for poor prognosis of hepatocellular carcinoma after surgery
Xin Rong Yang
Liver Cancer Institute, Zhong Shan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Shanghai, People s Republic of China
Clin Cancer Res 15:5518-27. 2009
..To investigate the role of CD24 in tumor invasion and prognostic significance in hepatocellular carcinoma (HCC)...
- Prognostic factors for patients with hepatocellular carcinoma with macroscopic portal vein or inferior vena cava tumor thrombi receiving external-beam radiation therapy
Zhao Chong Zeng
Department of Radiation Oncology, Zhongshan Hospital, Fudan University, 136 Yi Xue Road, Shanghai 200032, China
Cancer Sci 99:2510-7. 2008
....
- [Effect of postoperative adjuvant transarterial chemoembolization upon early recurrence after radical resection of hepatocellular carcinoma]
Xiao hong Chen
Department of Liver Medical Oncology, Liver Cancer Institute, Zhongshan Hospital of Fudan University, Shanghai 200032, China
Zhonghua Yi Xue Za Zhi 90:826-9. 2010
..To explore the effect of postoperative adjuvant transarterial chemoembolization (TACE) upon early recurrence of hepatocellular carcinoma (HCC) patients after radical resection...
- Preoperative serum gamma-glutamyl transferase to alanine aminotransferase ratio is a convenient prognostic marker for Child-Pugh A hepatocellular carcinoma after operation
Min Jie Ju
Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School of Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Shanghai, People s Republic of China
J Gastroenterol 44:635-42. 2009
..The relationship between the prognosis of hepatitis B-associated hepatocellular carcinoma (HCC) and preoperative GGT/ALT is studied in hepatectomized Child-Pugh A patients...
- Isomalto oligosaccharide sulfate inhibits tumor growth and metastasis of hepatocellular carcinoma in nude mice
Chun Li Xiao
Liver Cancer Institute and Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China
BMC Cancer 11:150. 2011
..Here, we explored the preclinical effects and molecular mechanisms of isomalto oligosaccharide sulfate (IMOS), another novel sulfated oligosaccharide, in HCC cell lines and a xenograft model...
- Osteopontin combined with CD44, a novel prognostic biomarker for patients with hepatocellular carcinoma undergoing curative resection
Guo Huan Yang
Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, People Republic of China
Oncologist 13:1155-65. 2008
..Osteopontin (OPN) plays important roles in tumor progression and metastasis through binding to CD44 and integrin. The goal of this study was to elucidate the prognostic significance of OPN and CD44 in hepatocellular carcinoma patients...
- Radiation therapy for adrenal gland metastases from hepatocellular carcinoma
Zhao Chong Zeng
Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Jpn J Clin Oncol 35:61-7. 2005
..External beam radiation therapy has seldom been applied for patients with adrenal gland metastases...
- Diagnosis and surgical treatments of hepatocellular carcinoma with tumor thrombosis in bile duct: experience of 34 patients
Lun-Xiu Qin
Liver Cancer Institute, Fudan University, 136 Yi Xue Yuan Road, Shanghai 200032, China
World J Gastroenterol 10:1397-401. 2004
..0%). CONCLUSION: Surgical removal of primary tumors and BDT is safe and beneficial to the HCC patients with BDT. Early detection, diagnosis, and surgical treatment are the key points to prolong the survival time of patients...
- The PI3K-Akt pathway regulates calpain 6 expression, proliferation, and apoptosis
Yonglei Liu
Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Cell Signal 23:827-36. 2011
..In addition, CAPN6 promoted cancer cell proliferation and inhibited its apoptosis. The finding demonstrates that CAPN6 is regulated by the PI3K-Akt signaling pathway and provides evidence that it may be a therapeutic target of cancer...
- Circulating tumor cells: advances in detection methods, biological issues, and clinical relevance
Yun Fan Sun
Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education, Liver Cancer Institute, Zhong Shan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai 200032, People s Republic of China
J Cancer Res Clin Oncol 137:1151-73. 2011
....
- Twenty-year survivors after resection for hepatocellular carcinoma-analysis of 53 cases
Xin Da Zhou
Liver Cancer Institute, Zhong Shan Hospital, Fudan University, 136 Yi Xue Yuan Road, 200032 Shanghai, China
J Cancer Res Clin Oncol 135:1067-72. 2009
..To clarify the clinicopathologic features of patients surviving > or =20 years after resection for hepatocellular carcinoma (HCC)...
- [The effects of portal vein microscopic and macroscopic tumor thrombi on post-operation patients with hepatocellular carcinoma]
Jia Fan
Institute of Liver Cancer, Department of Hepatic Surgery, Zhongshan Hospital of Fudan University, Shanghai 200032, China
Zhonghua Wai Ke Za Zhi 43:433-5. 2005
..The period of microscopic PVTT was the landmark affecting post-operation survival...
- [Effect of postoperative transcatheter arterial chemoembolization on hepatocellular carcinoma patients with residual tumor]
Zheng-Gang Ren
Liver Cancer Intitute, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Zhonghua Zhong Liu Za Zhi 26:116-8. 2004
..CONCLUSION: The beneficial effect of postoperative TACE was only observed in high risk patients with residual tumor but not in the low risk patients with residual tumor...
- [Interferon-alpha upregulates thymidine phosphorylase expression via JAK-STAT transcriptional activation and mRNA stabilization in human hepatocellular carcinoma SMMC-7721 cells]
Yong Sheng Xiao
Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai 200032, China
Zhonghua Zhong Liu Za Zhi 30:444-7. 2008
..To examine how the thymidine phosphorylase (TP) gene expression is upregulated by interferon-alpha (IFN-alpha) in human hepatocellular carcinoma SMMC-7721 cells...
- [Survival of patients with liver metastasis from colorectal cancer by different modes of therapy: a report of 363 cases]
Jian Min Xu
Department of General Surgery, Zhongshan Hospital, China
Zhonghua Zhong Liu Za Zhi 29:54-7. 2007
....
- Prognostic role of diabetes mellitus in hepatocellular carcinoma patients after curative treatments: a meta-analysis
Wei Min Wang
Institute of Biomedical Sciences, Fudan University, Shanghai, China
Hepatobiliary Pancreat Dis Int 10:346-55. 2011
..The prognostic role of diabetes mellitus (DM) coexisting with hepatocellular carcinoma (HCC) remains controversial. To clarify its impact on survival in HCC patients after curative treatments, a meta-analysis was performed...
- Hepatic angiomyolipoma: various appearances on two-phase contrast scanning of spiral CT
Fuhua Yan
Department of Radiology, Zhongshan Hospital, Fudan University former Zhongshan Hospital, Shanghai Medical University, No 180 Fenglin Road, Shanghai 200032, People s Republic of China
Eur J Radiol 41:12-8. 2002
..As for atypical cases, the diagnosis remained difficult and should be differentiated from other hypervascular lesions by means of other imaging modalities or needle puncture biopsy...
- Role and limitation of FMPSPGR dynamic contrast scanning in the follow-up of patients with hepatocellular carcinoma treated by TACE
Fu hua Yan
Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China
World J Gastroenterol 8:658-62. 2002
..To evaluate the role and limitation of fast multiplanar spoiled gradient-recalled (FMPSPGR) MR dynamic contrast scanning in the follow-up of patients with HCC treated by transarterial chemoembolization (TACE)...
- A comparison of treatment combinations with and without radiotherapy for hepatocellular carcinoma with portal vein and/or inferior vena cava tumor thrombus
Zhao Chong Zeng
Radiation Oncology, Fudan University, Zhongshan Hospital, Shanghai 200032, China
Int J Radiat Oncol Biol Phys 61:432-43. 2005
..To evaluate the potential role of external beam radiation therapy (EBRT) in the treatment of patients with hepatocellular carcinoma (HCC) who have portal vein (PV) and/or inferior vena cava (IVC) tumor thrombi...
- [Comparison of the results and therapies for hepatocellular carcinoma with tumor thrombosis in portal vein]
Jia Fan
Institute of Liver Cancer, Zhongshan Hospital of Fudan University, Shanghai 200032, China
Zhonghua Wai Ke Za Zhi 41:801-4. 2003
..Surgical resection followed by postoperative chemotherapy would produce the best clinical result. 2. If patients' liver function is permissible, multiple chemotherapeutic courses should be given after resection of HCC with PVTT...
- [Segmentectomy for hepatoma originated from segment IX.]
Zhi-quan Wu
Liver Cancer Institute, Zhongshan Hospital of Fudan University, Shanghai 200032, China
Zhonghua Wai Ke Za Zhi 42:1033-5. 2004
..CONCLUSIONS: Segmentectomy without interruption of blood flow of the liver is safe and practical for hepatoma located in segment IX...
- Radiation therapy for the locoregional lymph node metastases from hepatocellular carcinoma, phase I clinical trial
Zhao Chong Zeng
Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China
Hepatogastroenterology 51:201-7. 2004
..In this paper, we report 29 hepatocellular carcinoma patients with abdominal lymph node metastasis who received EBRT over a period of 5 years...
- Postoperative adjuvant arterial chemoembolization improves survival of hepatocellular carcinoma patients with risk factors for residual tumor: a retrospective control study
Zheng-Gang Ren
Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai 200032, China
World J Gastroenterol 10:2791-4. 2004
..CONCLUSION: Postoperative adjuvant TACE can prolong the survival of patients with risk factors for residual tumor, but can not prolong the survival of patients without risk factors for residual tumor...
- Hepatectomy for liver metastasis of colorectal cancer
Jianmin Xu
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, People s Republic of China
Int J Colorectal Dis 24:419-25. 2009
..The objective of this study was to investigate whether hepatic resection (HR) can increase the survival of liver metastasis of colorectal cancer (CRC)...
- Incidence and prognostic values of lymph node metastasis in operable hepatocellular carcinoma and evaluation of routine complete lymphadenectomy
Hui Chuan Sun
Live Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People s Republic of China
J Surg Oncol 96:37-45. 2007
..To study lymph node metastasis (LNM) and prognosis in patients with operable hepatocellular carcinoma (HCC) as well as the value of routine complete lymphadenectomy. Few studies have been reported on LNM in patients with operable HCC...
- The prognostic factor for outcome following second resection for intrahepatic recurrence of hepatocellular carcinoma with a hepatitis B virus infection background
Hui-Chuan Sun
Liver Cancer Institute and Zhong Shan Hospital, Fudan University, 200032 Shanghai, PR China
J Cancer Res Clin Oncol 131:284-8. 2005
..008). CONCLUSIONS: Vascular invasion and time to recurrence were the prognostic factors for overall survival following second resection of intrahepatic recurrent HCC...
- [Focal adhesion kinase mRNA overexpression in hepatocellular carcinoma HCC) and correlation thereof with prognosis of HCC]
Zhou Yuan
Liver Cancer Institute, Fudan University, Shanghai 200032, China
Zhonghua Yi Xue Za Zhi 87:1256-9. 2007
..To investigate whether focal adhesion kinase (FAK) is involved in the progression of human hepatocellular carcinoma (HCC) and whether FAK mRNA expression has prognostic significance for HCC...
- Liver transplantation for patients with hepatocellular carcinoma at the Liver Cancer Institute of Fudan University, China
Jian Zhou
Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Chin Med J (Engl) 118:654-9. 2005
..Since there is a trend to expand the transplant criteria for HCC patients, we reviewed the data of patients with HCC who had received OLT at our institute to determine their survival and prognostic factors...
- Cytokeratin 10 and cytokeratin 19: predictive markers for poor prognosis in hepatocellular carcinoma patients after curative resection
Xin Rong Yang
Liver Cancer Institute, Zhong Shan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Shanghai Cancer Institute, Shanghai, PR China
Clin Cancer Res 14:3850-9. 2008
..The aim of this study was to assess the value of CK10 alone or in combination with cytokeratin 19 (CK19) in predicting tumor recurrence after curative resection in HCC patients...
- [Study of serum proteome biomarkers with relation to the formation of portal vein tumor thrombi in hepatocellular carcinoma patients]
Cheng Huang
Liver Cancer Institute and Department of Liver Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Zhonghua Yi Xue Za Zhi 85:781-5. 2005
..CONCLUSION: Sixteen candidate proteome biomarkers may be related with the formation of PVTT in HCC patients. Decision tree classification algorithm may have great clinical significance in predicting the formation of PVTT...
- Impact factors for microinvasion in patients with hepatocellular carcinoma: possible application to the definition of clinical tumor volume
Min Hua Wang
Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China
Int J Radiat Oncol Biol Phys 76:467-76. 2010
..To evaluate the degree of invasion of hepatocellular carcinoma (HCC) microscopically that will provide a potential application for gross tumor volume to clinical tumor volume (GTV-to-CTV) expansion...
- Surgery for large primary liver cancer more than 10 cm in diameter
Xin Da Zhou
The Liver Cancer Institute, Zhong Shan Hospital, Fudan University, 136 Yi Xue Yuan Road, 200032, Shanghai, China
J Cancer Res Clin Oncol 129:543-8. 2003
..Large primary liver cancer (PLC) more than 10 cm in diameter is not infrequently encountered in clinical practice. This study evaluated the clinicopathological features and long-term results after surgery for large PLC...
- Surgical treatment for early hepatocellular carcinoma: comparison of resection and liver transplantation
Jian Zhou
Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China
J Cancer Res Clin Oncol 136:1453-60. 2010
..The aim of this study was to compare and determine which strategy is optimal for HCC fulfilling the Milan criteria...
- Comparison between radioimmunotherapy and external beam radiation therapy for patients with hepatocellular carcinoma
Zhao Chong Zeng
Department of Radiation Oncology, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai, 200032, P R China
Eur J Nucl Med Mol Imaging 29:1657-68. 2002
..However, RIT is much less toxic than EBRT, the side-effects of which include radiation injury to the liver and disturbance of T lymphocyte subsets...
- Expression of X-linked inhibitor-of-apoptosis protein in hepatocellular carcinoma promotes metastasis and tumor recurrence
Ying Hong Shi
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China
Hepatology 48:497-507. 2008
....
- [The effects of different clinicopathologic variables on serum protein fingerprint in hepatocellular carcinoma patients]
Cheng Huang
Institute of Liver Cancer, Department of Hepatic Surgery, Zhongshan Hospital of Fudan University, Shanghai 200032, China
Zhonghua Wai Ke Za Zhi 44:445-9. 2006
..The most profound impact on the serum protein was attained when cutoff was chosen to be presence of Ma-PVTT compared to less effect from Mi-PVTT and 5cm for tumor size...
- [Quantitation of alpha-fetoprotein messenger RNA in peripheral blood of nude mice and its relationship with tumor recurrence and metastasis after curative resection of hepatocellular carcinoma]
Xiaofeng Wu
Liver Cancer Institute, Fudan University, Shanghai 200032, China
Zhonghua Gan Zang Bing Za Zhi 10:189-91. 2002
..To assess the level of alpha-fetoprotein (AFP) messenger RNA (mRNA) in peripheral blood of nude mice, and to study its relationship with tumor recurrence and metastasis after curative resection of hepatocellular carcinoma (HCC)...
- Three-dimensional contrast-enhanced MR angiography in diagnosis of portal vein involvement by hepatic tumors
Jiang Lin
Department of Radiology, Affiliated Zhongshan Hospital, Fudan University, Shanghai 200032, China
World J Gastroenterol 9:1114-8. 2003
..To assess the accuracy of three-dimensional contrast-enhanced magnetic resonance angiography (3D CE MRA) in evaluation of the portal vein involvement in patients with hepatic tumors...
